M Haas

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE
    Susan A Boackle
    Department of Medicine and Immunology, Division of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Autoimmunity 37:111-23. 2004
  2. ncbi request reprint Histology and immunohistology of IgA nephropathy
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Nephrol 18:676-80. 2005
  3. ncbi request reprint C4d staining of perioperative renal transplant biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
    Transplantation 74:711-7. 2002
  4. ncbi request reprint Acute renal allograft rejection with intimal arteritis: histologic predictors of response to therapy and graft survival
    Mark Haas
    Department of Pathology and Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 61:1516-26. 2002
  5. doi request reprint Collapsing glomerulopathy: many means to a similar end
    M Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 73:669-71. 2008
  6. doi request reprint Arteriosclerosis in kidneys from healthy live donors: comparison of wedge and needle core perioperative biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 132:37-42. 2008
  7. ncbi request reprint Glomerular tip lesion in minimal change nephropathy: a study of autopsies before 1950
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Kidney Dis 39:1168-75. 2002
  8. doi request reprint IgA nephropathy in children and adults: comparison of histologic features and clinical outcomes
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nephrol Dial Transplant 23:2537-45. 2008
  9. ncbi request reprint Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts
    M Haas
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Transplant 7:576-85. 2007
  10. ncbi request reprint Thin glomerular basement membrane nephropathy: incidence in 3471 consecutive renal biopsies examined by electron microscopy
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 130:699-706. 2006

Collaborators

Detail Information

Publications74

  1. ncbi request reprint CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE
    Susan A Boackle
    Department of Medicine and Immunology, Division of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Autoimmunity 37:111-23. 2004
    ..Together these data support the concept that alterations in CR1/CR2 expression or function affect the regulation of autoantibody production and/or clearance and may have clinical consequences...
  2. ncbi request reprint Histology and immunohistology of IgA nephropathy
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Nephrol 18:676-80. 2005
    ..This review examines the histologic diversity as well as the immunohistologic features of IgA nephropathy...
  3. ncbi request reprint C4d staining of perioperative renal transplant biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
    Transplantation 74:711-7. 2002
    ..However, in other studies, PTC C4d deposits were noted in more than 40% of renal transplant biopsies performed for graft dysfunction and capillary C4d deposition in heart transplants may result from ischemic injury...
  4. ncbi request reprint Acute renal allograft rejection with intimal arteritis: histologic predictors of response to therapy and graft survival
    Mark Haas
    Department of Pathology and Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 61:1516-26. 2002
    ....
  5. doi request reprint Collapsing glomerulopathy: many means to a similar end
    M Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 73:669-71. 2008
    ....
  6. doi request reprint Arteriosclerosis in kidneys from healthy live donors: comparison of wedge and needle core perioperative biopsies
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 132:37-42. 2008
    ..There are many studies of histopathologic changes in deceased donor kidneys and how these changes affect subsequent graft function; most are based on wedge rather than needle core biopsies...
  7. ncbi request reprint Glomerular tip lesion in minimal change nephropathy: a study of autopsies before 1950
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Kidney Dis 39:1168-75. 2002
    ..These findings suggest that the glomerular tip lesion can occur in MCN and most likely represents a response to heavy proteinuria that is not disease specific...
  8. doi request reprint IgA nephropathy in children and adults: comparison of histologic features and clinical outcomes
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nephrol Dial Transplant 23:2537-45. 2008
    ..Some of this variability may be related to differences in histologic severity of cohorts of patients diagnosed as children versus adults...
  9. ncbi request reprint Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts
    M Haas
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Transplant 7:576-85. 2007
    ..5 +/- 2.5 versus 1.0 +/- 2.0, p = 0.01) than that in 24 recipients of HLA-incompatible grafts with no AMR over a similar interval (360 +/- 117 days), suggesting that subclinical AMR may contribute to development of CAN...
  10. ncbi request reprint Thin glomerular basement membrane nephropathy: incidence in 3471 consecutive renal biopsies examined by electron microscopy
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 130:699-706. 2006
    ....
  11. ncbi request reprint Hypertension, race, and glomeruli: more than simply a numbers game
    M Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 69:640-2. 2006
    ..However, although studies show a clear association between hypertension and glomerular number in whites, the situation in African-Americans appears more complex...
  12. ncbi request reprint Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases
    Mark Haas
    Department of Pathology and Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 65:2145-52. 2004
    ....
  13. ncbi request reprint HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Kidney Int 67:1381-90. 2005
    ..Data regarding clinical outcomes in patients with this form of glomerulonephritis are very limited...
  14. pmc C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Pathology 712, Baltimore, MD 21287, USA
    J Am Soc Nephrol 20:197-204. 2009
    ....
  15. ncbi request reprint Isometric tubular epithelial vacuolization in renal allograft biopsy specimens of patients receiving low-dose intravenous immunoglobulin for a positive crossmatch
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Pathology 712, Baltimore, MD 21287, USA
    Transplantation 78:549-56. 2004
    ..A common finding in biopsy specimens of these allografts is isometric vacuolization of proximal tubular epithelium. This finding presents a diagnostic dilemma because it may occur secondary to IVIG treatment or tacrolimus nephrotoxicity...
  16. ncbi request reprint Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases
    M Haas
    Departments of Pathology and Statistics and the Department of Medicine, Section of Nephrology, The University of Chicago, IL, USA
    Am J Kidney Dis 35:433-47. 2000
    ....
  17. ncbi request reprint The Na-K-Cl cotransporter of secretory epithelia
    M Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Physiol 62:515-34. 2000
    ..This review focuses on structure-function relationships within NKCC1 and on recent developments pertaining to NKCC1 regulation at cellular and molecular levels...
  18. ncbi request reprint ANCA-associated crescentic glomerulonephritis with mesangial IgA deposits
    M Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 36:709-18. 2000
    ..The findings suggest an overlap syndrome of ANCA-associated crescentic GN and IgA nephropathy that resembles the former both histologically and in its potential to respond to aggressive therapy if detected relatively early in its course...
  19. doi request reprint Alport syndrome and thin glomerular basement membrane nephropathy: a practical approach to diagnosis
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Pathol Lab Med 133:224-32. 2009
    ....
  20. ncbi request reprint C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: correlation with histologic findings
    M Haas
    Department of Pathology, John Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Transplant 6:1829-40. 2006
    ....
  21. ncbi request reprint The relationship of untreated borderline infiltrates by the Banff criteria to acute rejection in renal allograft biopsies
    S M Meehan
    Department of Pathology, University of Chicago, Illinois 60637, USA
    J Am Soc Nephrol 10:1806-14. 1999
    ....
  22. ncbi request reprint Smooth muscle-specific actin levels in the urine of renal transplant recipients: correlation with cyclosporine or tacrolimus nephrotoxicity
    M Haas
    Departments of Pathology and Statistics, University of Chicago, Chicago, IL, USA
    Am J Kidney Dis 34:69-84. 1999
    ....
  23. ncbi request reprint Drug-induced acute interstitial nephritis in renal allografts: histopathologic features and clinical course in six patients
    M A Josephson
    Section of Nephrology, Committee on Clinical Pharmacology, Chicago, IL, USA
    Am J Kidney Dis 34:540-8. 1999
    ..Drug-induced interstitial nephritis is a reversible lesion that should be considered in the differential diagnosis of acute renal allograft dysfunction...
  24. ncbi request reprint CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival
    S M Bagnasco
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Am J Transplant 7:1968-73. 2007
    ..Our data do not support association of B cell-rich infiltrates in allograft biopsies and worse outcome in acute rejection type I or II, but do not exclude the possible contribution of B cells to allograft rejection...
  25. ncbi request reprint Estimating renal function in lupus nephritis: comparison of the Modification of Diet in Renal Disease and Cockcroft Gault equations
    N Kasitanon
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Lupus 16:887-95. 2007
    ..58 mL/min/1.73 m(2), P = 0.003). In lupus nephritis patients, the CG equation was superior to the MDRD equation as an estimate of CrCl. However, both equations lacked precision in patients with CrCl > or = 60 mL/min/1.73 m(2)...
  26. doi request reprint Subclinical rejection in stable positive crossmatch kidney transplant patients: incidence and correlations
    E S Kraus
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 9:1826-34. 2009
    ..Surveillance biopsies during the first year post-transplantation for these high-risk patients uncover clinically occult processes and phenotypes, which without intervention diminish allograft survival and function...
  27. ncbi request reprint Mycophenolate mofetil as the primary treatment of membranous lupus nephritis with and without concurrent proliferative disease: a retrospective study of 29 cases
    N Kasitanon
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Lupus 17:40-5. 2008
    ..However, 12 months of therapy was necessary for best outcomes. Response rate was not different in the presence or absence of a proliferative lesion...
  28. ncbi request reprint The clinical and pathologic implications of plasmacytic infiltrates in percutaneous renal allograft biopsies
    S M Meehan
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Hum Pathol 32:205-15. 2001
    ..Plasmacytic infiltrates in renal allografts comprise a spectrum of lesions from acute rejection to PTLD, with a generally poor prognosis for long-term graft survival...
  29. doi request reprint The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection
    J E Locke
    Deparmtent of Surgery, John Hopkins Medical Institutions, John Hopkins University, Baltimore, MD, USA
    Am J Transplant 9:231-5. 2009
    ..We show a marked decrease in C5b-C9 (MAC) complex deposition in the kidney after the administration of eculizumab...
  30. ncbi request reprint The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection
    J E Locke
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 7:842-6. 2007
    ..Five patients underwent immediate splenectomy followed by PP/IVIg and had return of allograft function within 48 h of the procedure. Emergent splenectomy followed by PP/IVIg may be an effective treatment for reversing severe AMR...
  31. ncbi request reprint Inhibiting the complement system does not reduce injury in renal ischemia reperfusion
    P Park
    Department of Medicine, Section of Nephrology, The University of Chicago, 4841 S Maryland, Chicago, IL 60637, USA
    J Am Soc Nephrol 12:1383-90. 2001
    ..Thus, renal IRI in mice may have a partial complement dependence, yet pharmacologic inhibition of the complement system does not seem to be effective, likely because of the presence of other mediator systems that operate in parallel...
  32. ncbi request reprint Platelets and capillary injury in acute humoral rejection of renal allografts
    Shane M Meehan
    Department of Pathology, University of Chicago Hospitals, IL, USA
    Hum Pathol 34:533-40. 2003
    ..Observations in this study suggest that intracapillary platelet activation occurs in response to graft capillary injury from many causes and may not be specific for antibody-mediated rejection...
  33. ncbi request reprint Granulomatous tubulointerstitial nephritis in the renal allograft
    S M Meehan
    Departments of Pathology and Nephrology, University of Chicago, Chicago, IL, USA
    Am J Kidney Dis 36:E27. 2000
    ..To our knowledge, there are no prior reports of granulomatous tubulointerstitial nephritis associated with C albicans and E coli infection or antibiotic therapy in human renal allografts...
  34. doi request reprint ABO antibody titer and risk of antibody-mediated rejection in ABO-incompatible renal transplantation
    A A R Tobian
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Transplant 10:1247-53. 2010
    ..1% with a specificity of 79.5%. The positive predictive value was 33.3% and the negative predictive value was 91.2%. Most individuals with AMR have an elevated titer, however, the positive predictive value of a high titer for AMR is poor...
  35. ncbi request reprint The Na-K-Cl cotransporters
    M Haas
    Department of Pathology, The University of Chicago, Illinois 60637, USA
    J Bioenerg Biomembr 30:161-72. 1998
    ....
  36. ncbi request reprint Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy
    Y Wang
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 70:882-91. 2006
    ..The podocyte is affected by paracrine and potentially autocrine effects of vitamin D, which may explain why db/db mice are resistant to progressive diabetic nephropathy...
  37. ncbi request reprint VEGF receptor 2 blockade leads to renal cyst formation in mice
    S McGrath-Morrow
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Kidney Int 69:1741-8. 2006
    ..Early disruption of VEGFR-2 signaling during the perinatal period results in renal cyst formation, impaired glomerulogenesis, and inflammation. VEGF could be a key link between vascular and cystic changes in kidney cyst formation...
  38. ncbi request reprint Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis
    N Kasitanon
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, USA
    Lupus 15:366-70. 2006
    ..Although hydroxychloroquine is frequently stopped in patients with lupus nephritis, this study suggests it should be started or maintained...
  39. ncbi request reprint Immune complex glomerulonephritis in C4- and C3-deficient mice
    R J Quigg
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Kidney Int 53:320-30. 1998
    ..These results illustrate the complex interplay between the effects of complement to process immune complexes and to lead to inflammation and tissue injury...
  40. pmc A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation
    P Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 158:2089-96. 2001
    ..Cytogenetic analysis reveals the identical t(6;11)(p21.1;q12) chromosome translocation as the sole abnormality in these two tumors, confirming their identity and distinctive nature...
  41. ncbi request reprint Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL 60637, USA
    Lab Invest 87:357-64. 2007
    ..Our findings suggest that activation of C3 is strongly associated with experimental ICGN while downstream formation of C5b-9 is of lesser pathogenic importance in this model...
  42. ncbi request reprint Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure
    Lihua Bao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 18:811-22. 2007
    ....
  43. ncbi request reprint Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice
    Lihua Bao
    Section of Nephrology, The University of Chicago, Illinois 60637, USA
    J Am Soc Nephrol 14:670-9. 2003
    ..Thus, inhibition of complement activation with Crry-Ig significantly reduces renal disease in MRL/lpr lupus mice. The data support the strategy of using recombinant complement C3 inhibitors to treat human lupus nephritis...
  44. ncbi request reprint Antibody-mediated rejection in renal allografts: lessons from pathology
    Lorraine C Racusen
    Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Pathology 712, Baltimore, MD 21287, USA
    Clin J Am Soc Nephrol 1:415-20. 2006
    ....
  45. ncbi request reprint Cocaine use and hypertensive renal changes in HIV-infected individuals
    Derek M Fine
    Department of Medicine, Johns Hopkins School of Medicine and the Johns Hopkins Hospital, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 2:1125-30. 2007
    ..This study was conducted to evaluate the possible association of cocaine use and histopathologic findings on biopsy in this population...
  46. ncbi request reprint A complement-dependent model of thrombotic thrombocytopenic purpura induced by antibodies reactive with endothelial cells
    Guohui Ren
    Section of Nephrology, The University of Chicago, Chicago, Illinois 60637, USA
    Clin Immunol 103:43-53. 2002
    ..Antibody-directed complement activation leads to stimulation of platelets, through direct interactions with complement fragments and/or indirectly through endothelial cell activation or injury, with the subsequent development of TTP...
  47. ncbi request reprint Mouse podocyte complement factor H: the functional analog to human complement receptor 1
    Jessy J Alexander
    Section of Nephrology, University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 18:1157-66. 2007
    ..Just as in platelets, rodent podocytes seem to use Cfh as the functional surrogate for human complement receptor 1...
  48. ncbi request reprint Long-term outcome of renal transplantation from older donors
    Mark Haas
    N Engl J Med 354:2071-4; author reply 2071-4. 2006
  49. ncbi request reprint Successful retransplantation after renal allograft loss to polyoma virus interstitial nephritis
    Rajiv D Poduval
    Division of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Transplantation 73:1166-9. 2002
    ..We present the first reported case of successful retransplantation after polyoma virus-induced renal allograft loss...
  50. pmc VEGF inhibition and renal thrombotic microangiopathy
    Vera Eremina
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1129-36. 2008
    ..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy...
  51. doi request reprint IgA-dominant postinfectious glomerulonephritis: a report of 13 cases with common ultrastructural features
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Pathol 39:1309-16. 2008
    ....
  52. ncbi request reprint Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes
    Pierce Park
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Renal Physiol 282:F352-7. 2002
    ..Thus Igs and mature T lymphocytes do not appear to play a significant role in the pathogenesis of IRI in the kidney...
  53. ncbi request reprint Incidental healed postinfectious glomerulonephritis: a study of 1012 renal biopsy specimens examined by electron microscopy
    Mark Haas
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Pathol 34:3-10. 2003
    ..The recognition of such lesions is potentially important in the interpretation of certain renal biopsy specimens...
  54. ncbi request reprint Renal biopsy in lupus patients with low levels of proteinuria
    Lisa Christopher-Stine
    Divisions of Nephrology and Rheumatology, Johns Hopkins University Department of Medicine, Baltimore, Maryland, USA
    J Rheumatol 34:332-5. 2007
    ..We investigated whether patients with lower levels of proteinuria without ARF have significant renal disease and should be routinely biopsied...
  55. ncbi request reprint Anti-vascular endothelial growth factor receptor-2 antibody accelerates renal disease in the NZB/W F1 murine systemic lupus erythematosus model
    Hideaki Watanabe
    Clin Cancer Res 11:407-9. 2005
  56. ncbi request reprint Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy
    Christopher J Sonnenday
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Transplant 4:1315-22. 2004
    ..The use of rituximab, allowing avoidance of splenectomy, may further remove one of the significant disincentives to ABOi transplantation, and eliminate the risk of post-splenectomy infections...
  57. ncbi request reprint Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness
    Jessy J Alexander
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 16:52-7. 2005
    ..Once deposited in glomeruli, excessive complement activation can lead to glomerular inflammation and the rapid development of a scarring phenotype...
  58. ncbi request reprint Excellent outcomes after transplantation of deceased donor kidneys with high terminal creatinine and mild pathologic lesions
    Richard Ugarte
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Transplantation 80:794-800. 2005
    ..Utility of renal biopsy of these kidneys is similarly not well established...
  59. ncbi request reprint Successful renal transplantation across simultaneous ABO incompatible and positive crossmatch barriers
    Daniel S Warren
    The Department of Surgery, The Johns Hopkins University School of Medicine, Balitmore, Maryland, USA
    Am J Transplant 4:561-8. 2004
    ..The ability to cross these two barriers simultaneously is clinically important as sensitized patients have often exhausted their blood type compatible living donors during previous transplants...
  60. ncbi request reprint Sarcoidosis: the nephrologist's perspective
    Adam R Berliner
    Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 48:856-70. 2006
  61. ncbi request reprint Specific and durable elimination of antibody to donor HLA antigens in renal-transplant patients
    Andrea A Zachary
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2222, USA
    Transplantation 76:1519-25. 2003
    ..Attempts to deal with this problem have used plasmapheresis to remove antibodies or high-dose pooled immunoglobulin (IVIg) to down-regulate DSA. However, elimination of antibodies by these methods has been limited in duration or scope...
  62. ncbi request reprint Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease
    Jessy J Alexander
    Section of Nephrology, The University of Chicago, AMB S 508, MC 5100, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Am Soc Nephrol 17:1354-61. 2006
    ..These data show that plasma Cfh limits complement activation in the circulation and other accessible sites such as the glomerulus, whereas platelet Cfh is responsible for immune complex processing...
  63. ncbi request reprint The glomerular tip lesion: what does it really mean?
    Mark Haas
    Kidney Int 67:1188-9. 2005
  64. ncbi request reprint Bartter syndrome complicated by immune complex nephropathy. Case report and literature review
    Yahya Sardani
    Department of Pediatrics, The University of Chicago Pritzker School of Medicine, 5839 S Maryland Avenue, Chicago, IL 60637 1470, USA
    Pediatr Nephrol 18:913-8. 2003
    ..These findings add to the evidence of a possible association between the congenital syndrome and acquired immune complex nephropathy...
  65. ncbi request reprint Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice
    Lihua Bao
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:3601-7. 2002
    ..Thus, long-term complement inhibition reduces renal disease in MRL/lpr mice, which translates into improved survival. MRL/lpr mice in which complement is inhibited still have spontaneous mortality, yet this is not from renal disease...
  66. ncbi request reprint Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis
    Lihua Bao
    Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:1947-55. 2005
    ..These data illustrate that C3aR is relevant in experimental lupus nephritis and may be a target for therapeutic intervention in the human disease...
  67. pmc CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus
    Roman Puliaev
    Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    J Immunol 181:47-61. 2008
    ....
  68. ncbi request reprint The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury
    Siddhartha Ghosh
    Department of Internal Medicine, Division of Nephrology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Med Sci 324:296-304. 2002
    ..We investigated the role of the renin-angiotensin system, particularly with regard to AT1 and AT2 receptor dynamics, in PAN and cholesterol-mediated GS...
  69. ncbi request reprint Prominent renal expression of a murine leukemia retrovirus in experimental systemic lupus erythematosus
    Jessy J Alexander
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Am Soc Nephrol 13:2869-77. 2002
    ..The remarkable upregulation of the EDV transcript only in the setting of active disease suggests this transcript is involved in inflammatory disease...
  70. ncbi request reprint Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma
    Min Wang
    Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Medical School, Houston, Texas, USA
    J Neuropathol Exp Neurol 64:875-81. 2005
    ..Overall, the tumors were biologically indolent except for one that recurred and ultimately proved fatal...
  71. ncbi request reprint Postinfectious glomerulonephritis complicating diabetic nephropathy: a frequent association, but how clinically important?
    Mark Haas
    Hum Pathol 34:1225-7. 2003
  72. ncbi request reprint C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL, USA
    Eur J Immunol 35:2496-506. 2005
    ..These data support an important role for the C5a anaphylatoxin in lupus nephritis, and that blockade of C5aR represents a potentially viable treatment for human lupus nephritis...
  73. ncbi request reprint Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 62:2010-21. 2002
    ..DAF is present in human glomeruli and on cultured human glomerular visceral epithelial cells (GEC). We studied the distribution and function of rat DAF...
  74. doi request reprint Effects of acid aspiration-induced acute lung injury on kidney function
    Jeffrey B Hoag
    Dept of Medicine and Anesthesiology, The Johns Hopkins Univ, 600 North Wolfe St, Tower 711, Baltimore, MD 21287 8711, USA
    Am J Physiol Renal Physiol 294:F900-8. 2008
    ..Kidney injury in large animal models may be more similar to humans and may differ from results seen in small animal models...