TOMAS GUILARTE

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
    T R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Brain Res 790:98-107. 1998
  2. pmc Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 107:1236-47. 2008
  3. doi request reprint Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:1948-59. 2008
  4. pmc Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, United States
    Neurotoxicology 28:1147-52. 2007
  5. ncbi request reprint Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 94:351-8. 2006
  6. ncbi request reprint Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 202:381-90. 2006
  7. ncbi request reprint Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity
    T R Guilarte
    Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, 615 North Wolfe Street, Room W2001, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroscience 122:499-513. 2003
  8. ncbi request reprint Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes
    Tomas R Guilarte
    Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 113:37-43. 2003
  9. ncbi request reprint Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
    Tomas R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Neurol 53:50-6. 2003
  10. ncbi request reprint Is methamphetamine abuse a risk factor in parkinsonism?
    T R Guilarte
    Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Neurotoxicology 22:725-31. 2001

Research Grants

Detail Information

Publications15

  1. ncbi request reprint Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure
    T R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Brain Res 790:98-107. 1998
    ....
  2. pmc Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 107:1236-47. 2008
    ..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals...
  3. doi request reprint Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Neurochem 105:1948-59. 2008
    ..These changes may explain the subtle cognitive deficits previously demonstrated in these same animals...
  4. pmc Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, United States
    Neurotoxicology 28:1147-52. 2007
    ....
  5. ncbi request reprint Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Toxicol Sci 94:351-8. 2006
    ..This is supported by a significantly decreased, in the parietal cortex, NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction...
  6. ncbi request reprint Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
    Tomas R Guilarte
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Exp Neurol 202:381-90. 2006
    ....
  7. ncbi request reprint Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticity
    T R Guilarte
    Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, 615 North Wolfe Street, Room W2001, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroscience 122:499-513. 2003
    ..However, the DAT and 5-HTT deficits in brain regions lacking a deficit in VMAT-2 and glial cell activation may reflect drug-induced modulation of these plasma membrane proteins...
  8. ncbi request reprint Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexes
    Tomas R Guilarte
    Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 113:37-43. 2003
    ....
  9. ncbi request reprint Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
    Tomas R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Neurol 53:50-6. 2003
    ..We propose environmental enrichment as a basis for the treatment of childhood Pb2+ intoxication...
  10. ncbi request reprint Is methamphetamine abuse a risk factor in parkinsonism?
    T R Guilarte
    Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Neurotoxicology 22:725-31. 2001
    ..Resolving this question is important because the irreversible loss of dopaminergic function may increase the likelihood of Parkinsonism with advancing age...
  11. ncbi request reprint Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb(2+)
    T R Guilarte
    Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Room 2001, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 76:299-305. 2000
    ..This study provides further support to the hypothesis that NMDARs are important targets for Pb(2+)-induced neurotoxicity...
  12. pmc APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St Rm E6622, Baltimore, MD 21205, USA
    Neurotoxicology 31:572-4. 2010
    ..These changes may help explain the cognitive and working memory deficits expressed by these animals...
  13. pmc Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats
    T Verina
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Room E6622, Baltimore, MD 21205, USA
    Neuroscience 145:1037-47. 2007
    ..They provide a cellular and morphological basis for the deficits in synaptic plasticity and spatial learning documented in Pb(2+)-exposed animals...
  14. ncbi request reprint Low level Pb(2+) exposure affects hippocampal protein kinase C gamma gene and protein expression in rats
    M K Nihei
    Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Room W2001, Baltimore, MD 21205, USA
    Neurosci Lett 298:212-6. 2001
    ....
  15. ncbi request reprint Molecular changes in glutamatergic synapses induced by Pb2+: association with deficits of LTP and spatial learning
    M K Nihei
    Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Neurotoxicology 22:635-43. 2001
    ....

Research Grants31

  1. Molecular & Behavioral Effects of Low Level Mn Exposure
    TOMAS GUILARTE; Fiscal Year: 2009
    ..A major advantage of our unique collaboration is that behavioral and in vivo brain chemistry changes are monitored prospectively and in parallel with Mn exposure in non-human primates. ..
  2. NMDA Reception Function in Lead Neurotoxicity
    TOMAS GUILARTE; Fiscal Year: 2009
    ....
  3. Molecular & Behavioral Effects of Low Level Mn Exposure
    TOMAS GUILARTE; Fiscal Year: 2006
    ..The proposed studies will help us understand potential interactions between exposure to environmental agents and neurodegenerative disease. ..
  4. Peripheral BDZ Receptor: A Biomarker of Neurotoxicity
    TOMAS GUILARTE; Fiscal Year: 2007
    ..We will test this hypothesis in an animal model of demyelination. These studies may have important implications in the development of a novel therapeutic strategy for the treatment of brain injury. ..
  5. NMDA RECEPTOR FUNCTION IN LEAD NEUROTOXICITY
    TOMAS GUILARTE; Fiscal Year: 2007
    ..It is important to determine whether environmental enrichment is an intervention strategy that benefits children of any age and if the benefits are long lasting. ..
  6. Peripheral BDZ Receptor: A Biomarker of Neurotoxicity
    TOMAS GUILARTE; Fiscal Year: 2009
    ..We will test this hypothesis in an animal model of demyelination. These studies may have important implications in the development of a novel therapeutic strategy for the treatment of brain injury. ..
  7. PERIPHERAL BDZ RECEPTOR--A BIOMARKER OF NEUROTOXICITY
    TOMAS GUILARTE; Fiscal Year: 2003
    ....
  8. NMDA RECEPTOR FUNCTION IN LEAD NEUROTOXICITY
    TOMAS GUILARTE; Fiscal Year: 2002
    ..The investigator's findings will also help elucidate preventative and/or therapeutic strategies for the treatment of Pb neurotoxicity. ..