Research Topics
| TOMAS GUILARTESummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposureT R Guilarte
Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205, USA
Brain Res 790:98-107. 1998....
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonismTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Neurochem 107:1236-47. 2008..These findings provide compelling evidence that the effects of Mn on DA synapses in the striatum are mediated by inhibition of DA neurotransmission and are responsible for the motor deficits documented in these animals...- Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Neurochem 105:1948-59. 2008..These changes may explain the subtle cognitive deficits previously demonstrated in these same animals... 
Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effectsTomas R Guilarte
Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, United States
Neurotoxicology 28:1147-52. 2007....- Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI studyTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Toxicol Sci 94:351-8. 2006..This is supported by a significantly decreased, in the parietal cortex, NAA/Cr ratio suggestive of ongoing neuronal degeneration or dysfunction... - Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primatesTomas R Guilarte
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Exp Neurol 202:381-90. 2006.... - Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticityT R Guilarte
Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, 615 North Wolfe Street, Room W2001, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neuroscience 122:499-513. 2003..However, the DAT and 5-HTT deficits in brain regions lacking a deficit in VMAT-2 and glial cell activation may reflect drug-induced modulation of these plasma membrane proteins... - Selective decrease in NR1 subunit splice variant mRNA in the hippocampus of Pb2+-exposed rats: implications for synaptic targeting and cell surface expression of NMDAR complexesTomas R Guilarte
Molecular Neurotoxicology Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Brain Res Mol Brain Res 113:37-43. 2003.... - Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposureTomas R Guilarte
Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Ann Neurol 53:50-6. 2003..We propose environmental enrichment as a basis for the treatment of childhood Pb2+ intoxication... - Is methamphetamine abuse a risk factor in parkinsonism?T R Guilarte
Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Neurotoxicology 22:725-31. 2001..Resolving this question is important because the irreversible loss of dopaminergic function may increase the likelihood of Parkinsonism with advancing age... - Hippocampal expression of N-methyl-D-aspartate receptor (NMDAR1) subunit splice variant mRNA is altered by developmental exposure to Pb(2+)T R Guilarte
Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Room 2001, Baltimore, MD 21205, USA
Brain Res Mol Brain Res 76:299-305. 2000..This study provides further support to the hypothesis that NMDARs are important targets for Pb(2+)-induced neurotoxicity... - APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primatesTomas R Guilarte
Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St Rm E6622, Baltimore, MD 21205, USA
Neurotoxicology 31:572-4. 2010..These changes may help explain the cognitive and working memory deficits expressed by these animals... - Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult ratsT Verina
Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Room E6622, Baltimore, MD 21205, USA
Neuroscience 145:1037-47. 2007..They provide a cellular and morphological basis for the deficits in synaptic plasticity and spatial learning documented in Pb(2+)-exposed animals... - Low level Pb(2+) exposure affects hippocampal protein kinase C gamma gene and protein expression in ratsM K Nihei
Department of Environmental Health Sciences, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Room W2001, Baltimore, MD 21205, USA
Neurosci Lett 298:212-6. 2001.... - Molecular changes in glutamatergic synapses induced by Pb2+: association with deficits of LTP and spatial learningM K Nihei
Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
Neurotoxicology 22:635-43. 2001....
Research Grants
- Molecular & Behavioral Effects of Low Level Mn ExposureTOMAS GUILARTE; Fiscal Year: 2009..A major advantage of our unique collaboration is that behavioral and in vivo brain chemistry changes are monitored prospectively and in parallel with Mn exposure in non-human primates. ..
- NMDA Reception Function in Lead NeurotoxicityTOMAS GUILARTE; Fiscal Year: 2009....
- Molecular & Behavioral Effects of Low Level Mn ExposureTOMAS GUILARTE; Fiscal Year: 2006..The proposed studies will help us understand potential interactions between exposure to environmental agents and neurodegenerative disease. ..
- Peripheral BDZ Receptor: A Biomarker of NeurotoxicityTOMAS GUILARTE; Fiscal Year: 2007..We will test this hypothesis in an animal model of demyelination. These studies may have important implications in the development of a novel therapeutic strategy for the treatment of brain injury. ..
- NMDA RECEPTOR FUNCTION IN LEAD NEUROTOXICITYTOMAS GUILARTE; Fiscal Year: 2007..It is important to determine whether environmental enrichment is an intervention strategy that benefits children of any age and if the benefits are long lasting. ..
- Peripheral BDZ Receptor: A Biomarker of NeurotoxicityTOMAS GUILARTE; Fiscal Year: 2009..We will test this hypothesis in an animal model of demyelination. These studies may have important implications in the development of a novel therapeutic strategy for the treatment of brain injury. ..
- PERIPHERAL BDZ RECEPTOR--A BIOMARKER OF NEUROTOXICITYTOMAS GUILARTE; Fiscal Year: 2003....
- NMDA RECEPTOR FUNCTION IN LEAD NEUROTOXICITYTOMAS GUILARTE; Fiscal Year: 2002..The investigator's findings will also help elucidate preventative and/or therapeutic strategies for the treatment of Pb neurotoxicity. ..