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Genomes and Genes | Yun GuanSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Spinal cord stimulation: neurophysiological and neurochemical mechanisms of actionYun Guan
Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
Curr Pain Headache Rep 16:217-25. 2012....- Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic ratsYun Guan
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
Anesthesiology 113:1392-405. 2010..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear... - Wide-dynamic-range neurons are heterogeneous in windup responsiveness to changes in stimulus intensity and isoflurane anesthesia level in miceYun Guan
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurosci Res 88:2272-83. 2010..We also elucidate the usefulness and potential limitations of two widely used methods for calculating and presenting windup data... 
A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic painYun Guan
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
Neurosci Lett 471:43-7. 2010....- Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injuryYun Guan
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
Pain 138:318-29. 2008..Therefore, peripherally acting MOR agonists may represent a promising therapeutic approach for alleviating neuropathic pain... - A subpopulation of nociceptors specifically linked to itchLiang Han
The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 16:174-82. 2013..These data suggest that MrgprA3 defines a specific subpopulation of DRG neurons mediating itch. Our study opens new avenues for studying itch and developing anti-pruritic therapies... - Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in miceYun Guan
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
Mol Pain 3:29. 2007..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury... - Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory painJang Su Park
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Pain 4:67. 2008..These findings suggest that spinal AMPARs might participate in the central spinal mechanism of persistent inflammatory pain... - Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibersMatthias Ringkamp
Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 7:e42105. 2012..These results suggest that loperamide reversal of behavioral signs of neuropathic pain may be mediated, at least in part, by mechanisms independent of opioid receptors, most probably by local anesthetic actions... 
Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in ratsYun Guan
Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm. 5A12, 666 W. Baltimore Street, Baltimore, MD 21201, USA
Neurosci Lett 366:201-5. 2004..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation...- Electrical stimulation at distinct peripheral sites in spinal nerve injured rats leads to different afferent activation profilesFei Yang
Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Neurosci Lett 505:52-7. 2011..Electrical stimulation of different peripheral targets induced distinctive profiles of A-fiber afferent activation, suggesting that the neuronal substrates for the various forms of peripheral neuromodulatory therapies may differ... - Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanismsYun Guan
Department ofAnesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 26:4298-307. 2006..However, MORs may play an important role in endogenous inhibitory mechanisms that regulate the development of spinal neuronal sensitization... - Enhanced thermal avoidance in mice lacking the ATP receptor P2X3Isao Shimizu
Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
Pain 116:96-108. 2005..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation... - Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent painYa Chun Chu
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Pain 119:113-23. 2005..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain... - Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injuryOm V Singh
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proteomics 9:1241-53. 2009..These changes might participate in the central mechanism that underlies the maintenance of neuropathic pain... - Mas-related G-protein-coupled receptors inhibit pathological pain in miceYun Guan
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:15933-8. 2010..Agonists for these receptors may, therefore, represent a class of antihyperalgesics for treating persistent pain with minimal side effects because of the highly specific expression of their targets... - Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injuryChun yi Lee
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Eur J Pain 15:669-75. 2011..These temporal and anatomically specific changes in mOR expression following nerve injury are likely to have functional consequences on pain-associated behaviors and opioid analgesia... - TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociceptionUna Park
Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 31:11425-36. 2011..Thus, TRPV2 is important for perinatal viability but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse... - Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitryYun Guan
Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
Pain 104:401-13. 2003.... - Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritusQin Liu
The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Cell 139:1353-65. 2009..Therefore, Mrgprs may provide molecular access to itch-selective neurons and constitute novel targets for itch therapeutics... - Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesiaWei Guo
Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201-1586, USA
J Neurosci 22:6208-17. 2002.... - Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammationYun Guan
Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Pharmacol Exp Ther 300:513-20. 2002..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition...