Yun Guan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action
    Yun Guan
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pain Headache Rep 16:217-25. 2012
  2. pmc A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neurosci Lett 471:43-7. 2010
  3. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
  4. ncbi request reprint Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
  5. ncbi request reprint Wide-dynamic-range neurons are heterogeneous in windup responsiveness to changes in stimulus intensity and isoflurane anesthesia level in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurosci Res 88:2272-83. 2010
  6. pmc Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Pain 154:2477-86. 2013
  7. pmc A subpopulation of nociceptors specifically linked to itch
    Liang Han
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:174-82. 2013
  8. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
  9. pmc Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:67. 2008
  10. pmc Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers
    Matthias Ringkamp
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42105. 2012

Collaborators

Detail Information

Publications28

  1. doi request reprint Spinal cord stimulation: neurophysiological and neurochemical mechanisms of action
    Yun Guan
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pain Headache Rep 16:217-25. 2012
    ....
  2. pmc A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Neurosci Lett 471:43-7. 2010
    ....
  3. pmc Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, 720 Rutland Avenue, Ross 350, Baltimore, MD 21205, USA
    Pain 138:318-29. 2008
    ..Therefore, peripherally acting MOR agonists may represent a promising therapeutic approach for alleviating neuropathic pain...
  4. ncbi request reprint Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
    ..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear...
  5. ncbi request reprint Wide-dynamic-range neurons are heterogeneous in windup responsiveness to changes in stimulus intensity and isoflurane anesthesia level in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurosci Res 88:2272-83. 2010
    ..We also elucidate the usefulness and potential limitations of two widely used methods for calculating and presenting windup data...
  6. pmc Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Pain 154:2477-86. 2013
    ..Our findings indicate that animals with neuropathic pain may develop acute tolerance to the antiallodynic effects of peripherally acting opioids after repetitive systemic and local drug administration...
  7. pmc A subpopulation of nociceptors specifically linked to itch
    Liang Han
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:174-82. 2013
    ..These data suggest that MrgprA3 defines a specific subpopulation of DRG neurons mediating itch. Our study opens new avenues for studying itch and developing anti-pruritic therapies...
  8. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
    ..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury...
  9. pmc Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain
    Jang Su Park
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:67. 2008
    ..These findings suggest that spinal AMPARs might participate in the central spinal mechanism of persistent inflammatory pain...
  10. pmc Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers
    Matthias Ringkamp
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42105. 2012
    ..These results suggest that loperamide reversal of behavioral signs of neuropathic pain may be mediated, at least in part, by mechanisms independent of opioid receptors, most probably by local anesthetic actions...
  11. ncbi request reprint Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats
    Yun Guan
    Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm 5A12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 366:201-5. 2004
    ..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation...
  12. ncbi request reprint Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice
    Zhe Li
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Pain 155:1613-21. 2014
    ....
  13. pmc Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury
    Qian Xu
    Department of Clinical Pharmacology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurosci Lett 566:194-9. 2014
    ..These findings suggest that in the spinal cord, the enhanced function of astroglial gap junctions, especially those formed by Cx43, may be important to neuropathic pain in SNL rats. ..
  14. doi request reprint Electrical stimulation at distinct peripheral sites in spinal nerve injured rats leads to different afferent activation profiles
    Fei Yang
    Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neurosci Lett 505:52-7. 2011
    ..Electrical stimulation of different peripheral targets induced distinctive profiles of A-fiber afferent activation, suggesting that the neuronal substrates for the various forms of peripheral neuromodulatory therapies may differ...
  15. pmc Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain
    Ronen Shechter
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 119:422-32. 2013
    ..Spinal cord stimulation (SCS) is a useful neuromodulatory technique for treatment of certain neuropathic pain conditions. However, the optimal stimulation parameters remain unclear...
  16. ncbi request reprint Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms
    Yun Guan
    Department ofAnesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:4298-307. 2006
    ..However, MORs may play an important role in endogenous inhibitory mechanisms that regulate the development of spinal neuronal sensitization...
  17. ncbi request reprint Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
    Ya Chun Chu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 119:113-23. 2005
    ..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain...
  18. ncbi request reprint Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005
    ..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation...
  19. pmc Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury
    Om V Singh
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proteomics 9:1241-53. 2009
    ..These changes might participate in the central mechanism that underlies the maintenance of neuropathic pain...
  20. pmc Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury
    Chun yi Lee
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Eur J Pain 15:669-75. 2011
    ..These temporal and anatomically specific changes in mOR expression following nerve injury are likely to have functional consequences on pain-associated behaviors and opioid analgesia...
  21. pmc Mas-related G-protein-coupled receptors inhibit pathological pain in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:15933-8. 2010
    ..Agonists for these receptors may, therefore, represent a class of antihyperalgesics for treating persistent pain with minimal side effects because of the highly specific expression of their targets...
  22. pmc MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain
    Shao Qiu He
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Pain 155:534-44. 2014
    ....
  23. pmc TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception
    Una Park
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:11425-36. 2011
    ..Thus, TRPV2 is important for perinatal viability but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse...
  24. ncbi request reprint Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry
    Yun Guan
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Pain 104:401-13. 2003
    ....
  25. pmc Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury
    Qian Xu
    Department of Clinical Pharmacology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurosci Lett 563:45-50. 2014
    ....
  26. pmc Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus
    Qin Liu
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 139:1353-65. 2009
    ..Therefore, Mrgprs may provide molecular access to itch-selective neurons and constitute novel targets for itch therapeutics...
  27. ncbi request reprint Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia
    Wei Guo
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Neurosci 22:6208-17. 2002
    ....
  28. ncbi request reprint Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation
    Yun Guan
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Pharmacol Exp Ther 300:513-20. 2002
    ..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition...