J D Groopman

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. doi request reprint Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review
    Gerald N Wogan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:249-57. 2012
  2. ncbi request reprint Role of metabolism and viruses in aflatoxin-induced liver cancer
    John D Groopman
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Toxicol Appl Pharmacol 206:131-7. 2005
  3. ncbi request reprint Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk
    John D Groopman
    Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Biomark 1:5-14. 2005
  4. ncbi request reprint Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries
    John D Groopman
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Public Health 29:187-203. 2008
  5. ncbi request reprint Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 6:603-10. 1997
  6. ncbi request reprint Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
    P E Jackson
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Cancer Res 61:33-5. 2001
  7. pmc Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations
    A Rashid
    Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Br J Cancer 80:59-66. 1999
  8. ncbi request reprint Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats
    M Walton
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 14:919-26. 2001
  9. ncbi request reprint Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China
    J S Wang
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 10:143-6. 2001
  10. ncbi request reprint Preneoplastic prostate lesions: an opportunity for prostate cancer prevention
    W G Nelson
    The Johns Hopkins Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
    Ann N Y Acad Sci 952:135-44. 2001

Research Grants

Collaborators

Detail Information

Publications53

  1. doi request reprint Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review
    Gerald N Wogan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:249-57. 2012
    ..This strategy could serve as a template for the development, validation and application of molecular and biochemical markers for other carcinogens and cancers as well as other chronic diseases resulting from environmental exposures...
  2. ncbi request reprint Role of metabolism and viruses in aflatoxin-induced liver cancer
    John D Groopman
    Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Toxicol Appl Pharmacol 206:131-7. 2005
    ..This systematic approach provides encouragement for preventive interventions and should serve as a template for the development, validation and application of other chemical-specific biomarkers to cancer or other chronic diseases...
  3. ncbi request reprint Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk
    John D Groopman
    Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Biomark 1:5-14. 2005
    ..This systematic approach provides encouragement for preventive interventions and should serve as a template for the development, validation and application of other chemical-specific biomarkers to cancer or other chronic diseases...
  4. ncbi request reprint Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries
    John D Groopman
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Annu Rev Public Health 29:187-203. 2008
    ..Therefore, many diverse and appropriate strategies for disease prevention are needed to decrease the incidence of aflatoxin carcinogenesis in developing countries...
  5. ncbi request reprint Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 6:603-10. 1997
    ..As a consequence, the use of this biomarker in quantitative risk assessment should be pursued cautiously...
  6. ncbi request reprint Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry
    P E Jackson
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Cancer Res 61:33-5. 2001
    ..Ten plasma samples from healthy individuals were all negative. This molecular diagnostic technique has implications for prevention trials and for the early diagnosis of HCC...
  7. pmc Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations
    A Rashid
    Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Br J Cancer 80:59-66. 1999
    ..01). These data indicate a possible interaction between p53 gene mutation and 4q loss in the pathogenesis of HCC...
  8. ncbi request reprint Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats
    M Walton
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 14:919-26. 2001
    ....
  9. ncbi request reprint Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China
    J S Wang
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 10:143-6. 2001
    ..9% (24 of 27) samples (range, 0.9-3569.7 ng/24-h urine). These data provide the exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in this high-risk population...
  10. ncbi request reprint Preneoplastic prostate lesions: an opportunity for prostate cancer prevention
    W G Nelson
    The Johns Hopkins Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
    Ann N Y Acad Sci 952:135-44. 2001
    ....
  11. ncbi request reprint Use of aflatoxin adducts as intermediate endpoints to assess the efficacy of chemopreventive interventions in animals and man
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Mutat Res 402:165-72. 1998
    ..The general approach that has been utilized for the development, validation and application of aflatoxin-DNA and protein adduct biomarkers to cancer chemoprevention trials is summarized...
  12. ncbi request reprint Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
    Shuang Yuan Kuang
    Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:380-4. 2005
    ....
  13. pmc Approaches to environmental exposure assessment in children
    V M Weaver
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 106:827-32. 1998
    ....
  14. pmc Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and high-performance liquid chromatography-fluorescence
    Peter F Scholl
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2103, USA
    Cancer Epidemiol Biomarkers Prev 17:1436-9. 2008
    ....
  15. pmc Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
    P A Egner
    Department of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:14601-6. 2001
    ....
  16. ncbi request reprint Role of phase 2 enzyme induction in chemoprotection by dithiolethiones
    M K Kwak
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Mutat Res 480:305-15. 2001
    ....
  17. ncbi request reprint SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    H Yoshikawa
    The Johns Hopkins University School of Medicine, The Oncology Center, Baltimore, Maryland, USA
    Nat Genet 28:29-35. 2001
    ..Our results also indicate therapeutic strategies for the treatment of HCC including use of SOCS-1 in gene therapy and inhibition of JAK2 by small molecules, such as AG490...
  18. ncbi request reprint Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry
    Peter F Scholl
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205 2103, USA
    Chem Res Toxicol 19:44-9. 2006
    ....
  19. ncbi request reprint Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometry
    Matilde E Lleonart
    Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Room E7032, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:2956-62. 2005
    ..Potential applications for the quantification of 249(Ser) DNA in plasma include estimation of long-term, cumulative aflatoxin exposure and selection of appropriate high-risk individuals for targeted intervention...
  20. ncbi request reprint Urinary biomarkers of 1,3-butadiene in environmental settings using liquid chromatography isotope dilution tandem mass spectrometry
    Amir Sapkota
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Chem Biol Interact 160:70-9. 2006
    ....
  21. ncbi request reprint Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005
    ..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions...
  22. ncbi request reprint Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole
    Melinda S Yates
    Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 66:2488-94. 2006
    ..The unparalleled potency of CDDO-Im in vivo highlights the chemopreventive promise of targeting Nrf2 pathways with triterpenoids...
  23. ncbi request reprint Quantitative comparison of aflatoxin B1 serum albumin adducts in humans by isotope dilution mass spectrometry and ELISA
    Peter F Scholl
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2103, USA
    Cancer Epidemiol Biomarkers Prev 15:823-6. 2006
    ..Identification of other adducts may clarify the mechanistic basis for using AF-protein biomarkers to assess exposure status in future epidemiologic studies of liver cancer...
  24. ncbi request reprint Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry
    Patricia A Egner
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 19:1191-5. 2006
    ....
  25. doi request reprint Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry
    Denise N Johnson
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:752-60. 2008
    ..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
  26. pmc Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry
    Patricia A Egner
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:1991-6. 2008
    ..This method determines SFN and all four SFN glutathione-derived metabolites with minimal sample preparation and will be extremely useful in understanding the role of SFN-rich foods in preventing cancer and other chronic diseases...
  27. doi request reprint Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials?
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 2:1003-7. 2009
    ..We also reflect on what microdosing studies have taught us to date...
  28. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  29. ncbi request reprint Strategies for chemoprevention of liver cancer
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Eur J Cancer Prev 11:S58-64. 2002
    ..Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with protection...
  30. ncbi request reprint Sensitivity of electrospray ionization mass spectrometry detection of codon 249 mutations in the p53 gene compared with RFLP
    Geng Sun Qian
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 11:1126-9. 2002
    ..An additional 4 samples were found to be positive for the mutation when SOMA was repeated after HaeIII predigestion...
  31. ncbi request reprint Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1
    Patricia A Egner
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 16:1174-80. 2003
    ..Bioassays indicated that the tree shrew was considerably more resistant than the rat to AFB(1) hepatocarcinogenesis, which may reflect the significant differences in metabolic profiles of the two species...
  32. ncbi request reprint Translational strategies for cancer prevention in liver
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 3:321-9. 2003
    ..In the developing world--where the burden of liver cancer is highest--immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk...
  33. ncbi request reprint Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, Maryland 21205, USA
    Gastroenterology 127:S310-8. 2004
    ....
  34. ncbi request reprint Biomarkers and surrogacy: relevance to chemoprevention
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    IARC Sci Publ 154:27-47. 2001
    ..A critical but non-dichotomous element of risk biomarkers is their degree of surrogacy. A classification scheme is provided that relates the degree of surrogacy of risk biomarkers to their utility in preventive interventions...
  35. ncbi request reprint Mass spectrometry for genotyping: an emerging tool for molecular medicine
    P E Jackson
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Med Today 6:271-6. 2000
    ..This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry...
  36. pmc Specific mutations of hepatitis B virus in plasma predict liver cancer development
    Shuang Yuan Kuang
    Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:3575-80. 2004
    ..022, two-tailed). We therefore found that a prediagnosis biomarker of specific HBV mutations can be measured in plasma and suggest this marker for use as an intermediate endpoint in prevention and intervention trials...
  37. pmc Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine
    Leslie A Bransfield
    Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Chem Res Toxicol 21:1622-30. 2008
    ....
  38. pmc Phage display of ScFv peptides recognizing the thymidine(6-4)thymidine photoproduct
    A G Zavala
    Department of Environmental Health Sciences, The Johns Hopkins University School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
    Nucleic Acids Res 28:E24. 2000
    ..In addition, this is the initial step towards immortalizing the antibody gene for genetic manipulation, structure-function studies and application to human investigations...
  39. ncbi request reprint Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods
    V M Weaver
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 9:749-55. 2000
    ..Development of methods to minimize and/or assess sorbic acid interference will improve MA specificity in such populations...
  40. ncbi request reprint Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients
    Peta E Jackson
    Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 24:1657-63. 2003
    ..We have therefore found that pre-diagnosis biomarkers of specific p53 mutations can be measured in plasma and this suggests a paradigm for developing these markers for use in prevention and intervention trials...
  41. doi request reprint Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal
    P F Scholl
    Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 N Wolfe St, Baltimore, MD 21205 2200, USA
    Placenta 33:424-32. 2012
    ..Measurement of changes in the maternal serum proteome, when linked with birth outcomes, may yield biomarkers for tracking reproductive health in resource poor settings in future studies...
  42. ncbi request reprint Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1
    C P Nelson
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Res 61:103-9. 2001
    ..Conversely, induction of GSTs in early-stage prostate carcinogenesis may be a useful protective strategy...
  43. pmc A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin
    Karen Liby
    Dartmouth Medical School, Hanover, NH 03755, USA
    Cancer Res 68:6727-33. 2008
    ....
  44. ncbi request reprint Measurement of aflatoxin and aflatoxin metabolites in urine by liquid chromatography-tandem mass spectrometry
    Robert A Everley
    Commonwealth of Virginia, Division of Consolidated Laboratories, 600 N 5th Street, Richmond, Virginia 23219, USA
    J Anal Toxicol 31:150-6. 2007
    ..This method is suitable for agricultural, forensic, and public health laboratories during an accidental outbreak or a chemical terrorism event where a rapid and accurate diagnosis of aflatoxicosis is needed...
  45. ncbi request reprint Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure
    Paul C Turner
    Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom LS2 9JT
    Cancer Epidemiol Biomarkers Prev 14:2053-5. 2005
    ....
  46. pmc Human exposure monitoring and evaluation in the Arctic: the importance of understanding exposures to the development of public health policy
    William A Suk
    Center for Risk and Integrated Strategies, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:113-20. 2004
    ..This approach could serve as a model for international environmental health initiatives, because it involves the participation of the local communities and seeks to builds trust between all stakeholders...
  47. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
    ..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon...
  48. ncbi request reprint Analysis of aflatoxin B1-lysine adduct in serum using isotope-dilution liquid chromatography/tandem mass spectrometry
    Leslie F McCoy
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Rapid Commun Mass Spectrom 19:2203-10. 2005
    ..4% for B1-Lys and 85.4 +/- 12.4% for the internal standard were based on the full extraction and reconstitution processes. The method can be used to quantitate B1-Lys at the 0.5 pg/mg albumin level and is suitable for routine analysis...
  49. ncbi request reprint Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry
    Jian Guo Chen
    Qidong Liver Cancer Institute, Qidong, Jiangsu Province, People s Republic of China
    Cancer Epidemiol Biomarkers Prev 16:1213-8. 2007
    ..04 for age 35 years to 1.0 for age 65 years with the 90% confidence band being above 1 for ages < 50 years. These findings provide a conceptual framework to explain the acceleration of mortality in individuals infected with HBV...
  50. ncbi request reprint DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice
    Paul L Skipper
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA skipper mit edu
    Chem Res Toxicol 19:1086-90. 2006
    ....
  51. pmc Sensitive and specific detection of K-ras mutations in colon tumors by short oligonucleotide mass analysis
    Matilde E Lleonart
    Unit of Gene Environment Interactions, International Agency for Research on Cancer, 69372 Lyon, France
    Nucleic Acids Res 32:e53. 2004
    ..These results provide the basis for a sensitive and specific method to detect c-K-ras codon 12-mutated DNA at levels below 10-12% of wild-type DNA...
  52. ncbi request reprint Toxicological resources for cumulative risk: an example with hazardous air pollutants
    Mary A Fox
    National Research Council, Washington, DC, USA
    Regul Toxicol Pharmacol 40:305-11. 2004
    ..Advancements in toxicological resources will improve cumulative risk assessment. Cumulative risk assessment will reduce risks to the extent that it can be integrated into prevention strategies to track and protect the public's health...
  53. pmc Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3
    Sridevi Bodreddigari
    Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
    Chem Res Toxicol 21:1134-42. 2008
    ..Overall, these results provide the first direct evidence of a role for rat AKR7A1 and human AKR7A3 in protection against AFB 1-induced cytotoxicity and protein adduct formation...

Research Grants4

  1. MOLECULAR BIOMARKERS FOR ENVIRONMENTAL CARCINOGENS
    John Groopman; Fiscal Year: 2007
    ..Underpinning the research in these Program areas are Core facilities with expertise in Analytical Chemistry and Biostatistics and Epidemiology. ..