Research Topics
| J D GroopmanSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A reviewGerald N Wogan
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:249-57. 2012..This strategy could serve as a template for the development, validation and application of molecular and biochemical markers for other carcinogens and cancers as well as other chronic diseases resulting from environmental exposures...
Role of metabolism and viruses in aflatoxin-induced liver cancerJohn D Groopman
Department of Environmental Health Sciences, The Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Toxicol Appl Pharmacol 206:131-7. 2005..This systematic approach provides encouragement for preventive interventions and should serve as a template for the development, validation and application of other chemical-specific biomarkers to cancer or other chronic diseases...- Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer riskJohn D Groopman
Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Biomark 1:5-14. 2005..This systematic approach provides encouragement for preventive interventions and should serve as a template for the development, validation and application of other chemical-specific biomarkers to cancer or other chronic diseases... - Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countriesJohn D Groopman
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Annu Rev Public Health 29:187-203. 2008..Therefore, many diverse and appropriate strategies for disease prevention are needed to decrease the incidence of aflatoxin carcinogenesis in developing countries... - Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancerT W Kensler
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 6:603-10. 1997..As a consequence, the use of this biomarker in quantitative risk assessment should be pursued cautiously... - Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometryP E Jackson
Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Cancer Res 61:33-5. 2001..Ten plasma samples from healthy individuals were all negative. This molecular diagnostic technique has implications for prevention trials and for the early diagnosis of HCC... 
Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutationsA Rashid
Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
Br J Cancer 80:59-66. 1999..01). These data indicate a possible interaction between p53 gene mutation and 4q loss in the pathogenesis of HCC...- Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in ratsM Walton
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
Chem Res Toxicol 14:919-26. 2001.... - Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of ChinaJ S Wang
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 10:143-6. 2001..9% (24 of 27) samples (range, 0.9-3569.7 ng/24-h urine). These data provide the exposure and disease risk information for establishing intervention studies to diminish the impact of aflatoxin exposure in this high-risk population... - Preneoplastic prostate lesions: an opportunity for prostate cancer preventionW G Nelson
The Johns Hopkins Comprehensive Cancer Center, Baltimore, Maryland 21231 1000, USA
Ann N Y Acad Sci 952:135-44. 2001.... - Use of aflatoxin adducts as intermediate endpoints to assess the efficacy of chemopreventive interventions in animals and manT W Kensler
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
Mutat Res 402:165-72. 1998..The general approach that has been utilized for the development, validation and application of aflatoxin-DNA and protein adduct biomarkers to cancer chemoprevention trials is summarized... - Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from ThailandShuang Yuan Kuang
Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:380-4. 2005.... - Approaches to environmental exposure assessment in childrenV M Weaver
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Environ Health Perspect 106:827-32. 1998.... - Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and high-performance liquid chromatography-fluorescencePeter F Scholl
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2103, USA
Cancer Epidemiol Biomarkers Prev 17:1436-9. 2008.... - Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancerP A Egner
Department of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 98:14601-6. 2001.... - Role of phase 2 enzyme induction in chemoprotection by dithiolethionesM K Kwak
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Mutat Res 480:305-15. 2001.... - SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activityH Yoshikawa
The Johns Hopkins University School of Medicine, The Oncology Center, Baltimore, Maryland, USA
Nat Genet 28:29-35. 2001..Our results also indicate therapeutic strategies for the treatment of HCC including use of SOCS-1 in gene therapy and inhibition of JAK2 by small molecules, such as AG490... - Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometryPeter F Scholl
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205 2103, USA
Chem Res Toxicol 19:44-9. 2006.... - Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometryMatilde E Lleonart
Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Room E7032, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:2956-62. 2005..Potential applications for the quantification of 249(Ser) DNA in plasma include estimation of long-term, cumulative aflatoxin exposure and selection of appropriate high-risk individuals for targeted intervention... - Urinary biomarkers of 1,3-butadiene in environmental settings using liquid chromatography isotope dilution tandem mass spectrometryAmir Sapkota
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Chem Biol Interact 160:70-9. 2006.... - Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of ChinaThomas W Kensler
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions... - Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazoleMelinda S Yates
Johns Hopkins University, Baltimore, Maryland, USA
Cancer Res 66:2488-94. 2006..The unparalleled potency of CDDO-Im in vivo highlights the chemopreventive promise of targeting Nrf2 pathways with triterpenoids... - Quantitative comparison of aflatoxin B1 serum albumin adducts in humans by isotope dilution mass spectrometry and ELISAPeter F Scholl
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2103, USA
Cancer Epidemiol Biomarkers Prev 15:823-6. 2006..Identification of other adducts may clarify the mechanistic basis for using AF-protein biomarkers to assess exposure status in future epidemiologic studies of liver cancer... - Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometryPatricia A Egner
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Chem Res Toxicol 19:1191-5. 2006.... - Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometryDenise N Johnson
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Chem Res Toxicol 21:752-60. 2008..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo... - Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometryPatricia A Egner
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Chem Res Toxicol 21:1991-6. 2008..This method determines SFN and all four SFN glutathione-derived metabolites with minimal sample preparation and will be extremely useful in understanding the role of SFN-rich foods in preventing cancer and other chronic diseases... - Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials?Thomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Prev Res (Phila) 2:1003-7. 2009..We also reflect on what microdosing studies have taught us to date... - Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, ChinaPatricia A Egner
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Cancer Prev Res (Phila) 4:384-95. 2011..Cancer Prev Res; 4(3); 384-95. ©2011 AACR... - Strategies for chemoprevention of liver cancerThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Eur J Cancer Prev 11:S58-64. 2002..Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with protection... - Sensitivity of electrospray ionization mass spectrometry detection of codon 249 mutations in the p53 gene compared with RFLPGeng Sun Qian
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 11:1126-9. 2002..An additional 4 samples were found to be positive for the mutation when SOMA was repeated after HaeIII predigestion... - Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1Patricia A Egner
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Chem Res Toxicol 16:1174-80. 2003..Bioassays indicated that the tree shrew was considerably more resistant than the rat to AFB(1) hepatocarcinogenesis, which may reflect the significant differences in metabolic profiles of the two species... - Translational strategies for cancer prevention in liverThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Nat Rev Cancer 3:321-9. 2003..In the developing world--where the burden of liver cancer is highest--immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk... - Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areasThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, Maryland 21205, USA
Gastroenterology 127:S310-8. 2004.... - Biomarkers and surrogacy: relevance to chemopreventionT W Kensler
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
IARC Sci Publ 154:27-47. 2001..A critical but non-dichotomous element of risk biomarkers is their degree of surrogacy. A classification scheme is provided that relates the degree of surrogacy of risk biomarkers to their utility in preventive interventions... - Mass spectrometry for genotyping: an emerging tool for molecular medicineP E Jackson
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Mol Med Today 6:271-6. 2000..This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry... - Specific mutations of hepatitis B virus in plasma predict liver cancer developmentShuang-Yuan Kuang
Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:3575-80. 2004..022, two-tailed). We therefore found that a prediagnosis biomarker of specific HBV mutations can be measured in plasma and suggest this marker for use as an intermediate endpoint in prevention and intervention trials... - Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urineLeslie A Bransfield
Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
Chem Res Toxicol 21:1622-30. 2008.... - Phage display of ScFv peptides recognizing the thymidine(6-4)thymidine photoproductA G Zavala
Department of Environmental Health Sciences, The Johns Hopkins University School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205 2179, USA
Nucleic Acids Res 28:E24. 2000..In addition, this is the initial step towards immortalizing the antibody gene for genetic manipulation, structure-function studies and application to human investigations... - Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foodsV M Weaver
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 9:749-55. 2000..Development of methods to minimize and/or assess sorbic acid interference will improve MA specificity in such populations... - Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patientsPeta E Jackson
Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Carcinogenesis 24:1657-63. 2003..We have therefore found that pre-diagnosis biomarkers of specific p53 mutations can be measured in plasma and this suggests a paradigm for developing these markers for use in prevention and intervention trials... - Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern NepalP F Scholl
Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 N Wolfe St, Baltimore, MD 21205 2200, USA
Placenta 33:424-32. 2012..Measurement of changes in the maternal serum proteome, when linked with birth outcomes, may yield biomarkers for tracking reproductive health in resource poor settings in future studies... - Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1C P Nelson
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Cancer Res 61:103-9. 2001..Conversely, induction of GSTs in early-stage prostate carcinogenesis may be a useful protective strategy... - A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxinKaren Liby
Dartmouth Medical School, Hanover, NH 03755, USA
Cancer Res 68:6727-33. 2008.... - Measurement of aflatoxin and aflatoxin metabolites in urine by liquid chromatography-tandem mass spectrometryRobert A Everley
Commonwealth of Virginia, Division of Consolidated Laboratories, 600 N 5th Street, Richmond, Virginia 23219, USA
J Anal Toxicol 31:150-6. 2007..This method is suitable for agricultural, forensic, and public health laboratories during an accidental outbreak or a chemical terrorism event where a rapid and accurate diagnosis of aflatoxicosis is needed... - Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposurePaul C Turner
Molecular Epidemiology Unit, Centre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom LS2 9JT
Cancer Epidemiol Biomarkers Prev 14:2053-5. 2005.... - Human exposure monitoring and evaluation in the Arctic: the importance of understanding exposures to the development of public health policyWilliam A Suk
Center for Risk and Integrated Strategies, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 112:113-20. 2004..This approach could serve as a model for international environmental health initiatives, because it involves the participation of the local communities and seeks to builds trust between all stakeholders... - Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the ratMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1294-302. 2007..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon... - Analysis of aflatoxin B1-lysine adduct in serum using isotope-dilution liquid chromatography/tandem mass spectrometryLeslie F McCoy
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Rapid Commun Mass Spectrom 19:2203-10. 2005..4% for B1-Lys and 85.4 +/- 12.4% for the internal standard were based on the full extraction and reconstitution processes. The method can be used to quantitate B1-Lys at the 0.5 pg/mg albumin level and is suitable for routine analysis... - Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometryJian Guo Chen
Qidong Liver Cancer Institute, Qidong, Jiangsu Province, People s Republic of China
Cancer Epidemiol Biomarkers Prev 16:1213-8. 2007..04 for age 35 years to 1.0 for age 65 years with the 90% confidence band being above 1 for ages < 50 years. These findings provide a conceptual framework to explain the acceleration of mortality in individuals infected with HBV... - DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in micePaul L Skipper
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. skipper@ mit.edu
Chem Res Toxicol 19:1086-90. 2006.... - Sensitive and specific detection of K-ras mutations in colon tumors by short oligonucleotide mass analysisMatilde E Lleonart
Unit of Gene-Environment Interactions, International Agency for Research on Cancer, 69372 Lyon, France
Nucleic Acids Res 32:e53. 2004..These results provide the basis for a sensitive and specific method to detect c-K-ras codon 12-mutated DNA at levels below 10-12% of wild-type DNA... - Toxicological resources for cumulative risk: an example with hazardous air pollutantsMary A Fox
National Research Council, Washington, DC, USA
Regul Toxicol Pharmacol 40:305-11. 2004..Advancements in toxicological resources will improve cumulative risk assessment. Cumulative risk assessment will reduce risks to the extent that it can be integrated into prevention strategies to track and protect the public's health... - Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3Sridevi Bodreddigari
Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
Chem Res Toxicol 21:1134-42. 2008..Overall, these results provide the first direct evidence of a role for rat AKR7A1 and human AKR7A3 in protection against AFB 1-induced cytotoxicity and protein adduct formation...
Research Grants
- MOLECULAR BIOMARKERS FOR ENVIRONMENTAL CARCINOGENSJohn Groopman; Fiscal Year: 2007..Underpinning the research in these Program areas are Core facilities with expertise in Analytical Chemistry and Biostatistics and Epidemiology. ..