ROLAND GRIFFITHS

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds
    Roland R Griffiths
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Clin Psychiatry 66:31-41. 2005
  2. ncbi request reprint Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 13:336-47. 2005
  3. ncbi request reprint Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 63:1149-57. 2006
  4. ncbi request reprint Is caffeine a flavoring agent in cola soft drinks?
    R R Griffiths
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Fam Med 9:727-34. 2000
  5. pmc Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
    Rr Griffiths
    Department of Psychiatry and Behavioral Sciences and Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 22:621-32. 2008
  6. ncbi request reprint Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
    R R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006
  7. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
  8. ncbi request reprint Principles of initial experimental drug abuse liability assessment in humans
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 70:S41-54. 2003
  9. ncbi request reprint Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement
    R R Griffiths
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Nihon Shinkei Seishin Yakurigaku Zasshi 20:223-31. 2000
  10. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006

Research Grants

  1. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2009
  2. ANALYSIS OF INTRAVENOUS DRUG SELF-ADMINISTRATION
    ROLAND GRIFFITHS; Fiscal Year: 1980
  3. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1993
  4. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 2001
  5. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2006
  6. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
  7. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
  8. BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMS
    ROLAND GRIFFITHS; Fiscal Year: 2001
  9. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1993
  10. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1991

Detail Information

Publications38

  1. ncbi request reprint Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds
    Roland R Griffiths
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Clin Psychiatry 66:31-41. 2005
    ....
  2. ncbi request reprint Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 13:336-47. 2005
    ....
  3. ncbi request reprint Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects
    Matthew W Johnson
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 63:1149-57. 2006
    ..Ramelteon is a novel MT1 and MT2 melatonin receptor selective agonist recently approved for insomnia treatment. Most approved insomnia medications have potential for abuse and cause motor and cognitive impairment...
  4. ncbi request reprint Is caffeine a flavoring agent in cola soft drinks?
    R R Griffiths
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arch Fam Med 9:727-34. 2000
    ..The soft drink manufacturers' justification to regulatory agencies and the public for adding caffeine to soft drinks is that caffeine is a flavoring agent...
  5. pmc Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later
    Rr Griffiths
    Department of Psychiatry and Behavioral Sciences and Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    J Psychopharmacol 22:621-32. 2008
    ....
  6. ncbi request reprint Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance
    R R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006
    ..Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects...
  7. pmc Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 218:649-65. 2011
    ..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior...
  8. ncbi request reprint Principles of initial experimental drug abuse liability assessment in humans
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 70:S41-54. 2003
    ..g. behavioral performance, observer-rated assessments, physiological measures)...
  9. ncbi request reprint Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcement
    R R Griffiths
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Nihon Shinkei Seishin Yakurigaku Zasshi 20:223-31. 2000
    ..Survey data suggest that 9% to 30% percent of caffeine consumers may be caffeine dependent according to DSM-IV criteria...
  10. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006
    ..Abuse of gamma-hydroxybutyrate (GHB) and its precursors is a public health concern. Gamma-butyrolactone (GBL) is found in commercially available products and, when ingested, is metabolized to GHB...
  11. pmc Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers
    Lawrence P Carter
    Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Psychopharmacology (Berl) 206:141-54. 2009
    ..Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects...
  12. ncbi request reprint Relative abuse liability of GHB in humans: A comparison of psychomotor, subjective, and cognitive effects of supratherapeutic doses of triazolam, pentobarbital, and GHB
    Lawrence P Carter
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:2537-51. 2006
    ..Although the likelihood for GHB to be abused is intermediate to triazolam and pentobarbital, the possibility of accidental overdose (ie greater sedation than intended) with GHB appears to be greater...
  13. ncbi request reprint Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusers
    Bai Fang X Sobel
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 29:991-1003. 2004
    ..The results of the present study demonstrate that chronic nicotine maintenance produces tolerance to the effects of intravenous nicotine, but does not affect the subjective or reinforcing effects of cocaine or caffeine...
  14. ncbi request reprint Cognitive and subjective acute dose effects of intramuscular ketamine in healthy adults
    Michelle R Lofwall
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
    Exp Clin Psychopharmacol 14:439-49. 2006
    ....
  15. ncbi request reprint Relative abuse liability of indiplon and triazolam in humans: a comparison of psychomotor, subjective, and cognitive effects
    Lawrence P Carter
    Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 322:749-59. 2007
    ..Together, these data suggest that although the abuse potential of indiplon is not different from that of triazolam at these doses, psychomotor and cognitive impairment after large doses of indiplon might be less...
  16. ncbi request reprint Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokers
    Hendree E Jones
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Psychopharmacology (Berl) 165:280-90. 2003
    ..Epidemiological, clinical and pre-clinical observations suggest that caffeine can potentiate the reinforcing and discriminative effects of nicotine...
  17. ncbi request reprint A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousal
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 192:425-40. 2007
    ..Thus, it is possible that the observed amnestic effects are secondary to more global sedative effects and do not reflect a specific primary benzodiazepine effect on memory mechanisms...
  18. pmc Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Bayview Behavioral Biology Research Center, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 89:206-13. 2007
    ..These data indicate that GABA(B) agonists may reduce relapse to cocaine taking...
  19. ncbi request reprint Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processes
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Cogn Affect Behav Neurosci 7:120-9. 2007
    ..In addition, the results suggested greater overall slowing of working memory processes with lorazepam...
  20. pmc Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers
    Bethea A Kleykamp
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 18:1-16. 2010
    ..g., error detection on a choice reaction time task). Future research might examine the clinical implications of the performance impairments reported here given the widespread use of benzodiazepines and alcohol...
  21. pmc Dose effects of triazolam and scopolamine on metamemory
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 18:17-31. 2010
    ....
  22. ncbi request reprint Triazolam-amphetamine interaction: dissociation of effects on memory versus arousal
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioural Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Psychopharmacol 17:17-29. 2003
    ....
  23. ncbi request reprint Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 188:445-61. 2006
    ..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect...
  24. ncbi request reprint Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processes
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 6823, USA
    Exp Clin Psychopharmacol 11:56-72. 2003
    ....
  25. ncbi request reprint Principles of drug abuse liability assessment in laboratory animals
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins School of Medicine, Hopkins Bayview Campus, 5510 Nathan Shock Drive, Ste 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 70:S55-72. 2003
    ..A key consideration for cross-cutting and specific methodological issues is that choices made enable confident interpretation of both positive and negative results...
  26. ncbi request reprint A paradoxical dissociation in the effects of midazolam on recollection and automatic processes in the process dissociation procedure
    Miriam Z Mintzer
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Am J Psychol 116:213-37. 2003
    ..Such evidence raises important questions about the use of the PDP...
  27. ncbi request reprint Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure
    Miriam Z Mintzer
    Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 178:259-67. 2005
    ..However, few parametric studies have been conducted in human participants...
  28. ncbi request reprint Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 179:678-87. 2005
    ..gamma-Hydroxybuyrate (GHB) is a current drug of abuse that may produce physical dependence...
  29. ncbi request reprint Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:113-23. 2005
    ..Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance...
  30. ncbi request reprint Effects of GABAergic modulators on food and cocaine self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Behavioral Biology Research Center, 5510 Nathan Shock Dr Suite 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 80:369-76. 2005
    ..Thus, the effects of alprazolam were specific for cocaine-maintained behavior, where as the effects of baclofen and CGP44532 were not...
  31. ncbi request reprint Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboons
    Elise M Weerts
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
    Eur J Pharmacol 519:103-13. 2005
    ..Thus, bretazenil can function as an antagonist under conditions of benzodiazepine physical dependence...
  32. ncbi request reprint The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 168:155-63. 2003
    ..Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines)...
  33. pmc Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effects
    Stacey C Sigmon
    Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
    Psychopharmacology (Berl) 204:573-85. 2009
    ..Although the subjective effects of caffeine abstinence, acute and chronic administration, and tolerance are well described, the corresponding neurophysiological effects are not...
  34. pmc Caffeinated energy drinks--a growing problem
    CHAD J REISSIG
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Drug Alcohol Depend 99:1-10. 2009
    ..Several studies suggest that energy drinks may serve as a gateway to other forms of drug dependence. Regulatory implications concerning labeling and advertising, and the clinical implications for children and adolescents are discussed...
  35. pmc Illicit gamma-hydroxybutyrate (GHB) and pharmaceutical sodium oxybate (Xyrem): differences in characteristics and misuse
    Lawrence P Carter
    Department of Psychiatry, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
    Drug Alcohol Depend 104:1-10. 2009
    ..Differences in the accessibility, purity, dosing, and misuse of illicit GHB and sodium oxybate suggest that risks associated with illicit GHB are greater than those associated with the pharmaceutical product sodium oxybate...
  36. ncbi request reprint Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancy
    Dace S Svikis
    Department of Psychology, Virginia Commonwealth University, 1101 East Marshall St, Sanger Hall, Room 11 028, Box 980343, Richmond, VA 23298 0343, USA
    Am J Psychiatry 162:2344-51. 2005
    ..The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy...
  37. ncbi request reprint A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features
    Laura M Juliano
    Department of Psychology, American University, 4400 Massachusetts Avenue, Washington, DC 20016, USA
    Psychopharmacology (Berl) 176:1-29. 2004
    ..Although reports of caffeine withdrawal in the medical literature date back more than 170 years, the most rigorous experimental investigations of the phenomenon have been conducted only recently...
  38. ncbi request reprint Impact of formulation on the abuse liability, safety and regulation of medications: the expert panel report
    Charles Grudzinskas
    NDA Partners LLC, 720 Riverview Terrace, Annapolis, MD 21401, USA
    Drug Alcohol Depend 83:S77-82. 2006
    ..Finally, knowledge and experience are needed to translate scientific work into a predictable, transparent and reliable regulatory process...

Research Grants62

  1. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2009
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  2. ANALYSIS OF INTRAVENOUS DRUG SELF-ADMINISTRATION
    ROLAND GRIFFITHS; Fiscal Year: 1980
    ..Another set of studies will use a discrete-trial choice procedure to explore the influence of a series of mixed agonist/antagonists on intravenous heroin reinforcement...
  3. LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTION
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
  4. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 2001
    ..This research should contribute to efforts to develop new classes of sedative-anxiolytic compounds which have reduced potential for abuse by drug abusers as well as reduced potential for inappropriate chronic use among patients. ..
  5. Licit and Illicit Abused Stimulant Drugs
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
  6. Experimental Analysis of Novel Drugs of Abuse
    ROLAND GRIFFITHS; Fiscal Year: 2006
    ....
  7. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 2002
    ....
  8. BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMS
    ROLAND GRIFFITHS; Fiscal Year: 2001
    ..Ultimately, these data may also contribute to the development of improved drug abuse treatment strategies and to the development of anxiolytic/hypnotic compounds with reduced memory-impairing potential. ..
  9. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1993
    ..More generally, the data will contribute to an understanding of anziolytic-sedative drug abuse and will ultimately contribute to development of improved prevention, control and treatment procedures...
  10. EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSE
    ROLAND GRIFFITHS; Fiscal Year: 1991
    ....
  11. ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINE
    ROLAND GRIFFITHS; Fiscal Year: 1992
    ..Two experiments will investigate optimal conditions for maintaining maximal intravenous and oral caffine self- administration and one experiment will characterize spontaneous withdrawal effects after high chronic doses of caffine...