P E Gravitt

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Evidence and impact of human papillomavirus latency
    Patti E Gravitt
    Perdana University Graduate School of Medicine, Jalan MAEPS Perdana, Serdang, Selangor MY 43400, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Open Virol J 6:198-203. 2012
  2. pmc Human papillomavirus genotypes detected in clinician-collected and self-collected specimens from women living in the Mississippi Delta
    Philip E Castle
    Global Cancer Imitative, Chestertown, MD, USA
    BMC Infect Dis 13:5. 2013
  3. pmc A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD21205, USA
    J Infect Dis 207:272-80. 2013
  4. pmc Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    Catterina Ferreccio
    P Universidad Catolica de Chile, Escuela de Medicina, Santiago Chile
    BMC Public Health 8:78. 2008
  5. pmc Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India
    A Pavani Sowjanya
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad, A P India
    BMC Infect Dis 5:116. 2005
  6. pmc Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus
    Charles G Eberhart
    Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
    BMC Cancer 5:19. 2005
  7. pmc Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6535, Baltimore, MD 21205, USA
    J Clin Microbiol 45:3245-50. 2007
  8. pmc High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2787-93. 2007
  9. ncbi request reprint Diagnosis and management of oncogenic cervical human papillomavirus infection
    Patti E Gravitt
    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 North Wolfe Street, Room E6535, Baltimore, MD 21205, USA
    Infect Dis Clin North Am 19:439-58. 2005
  10. pmc Suitability of self-collected vaginal samples for cervical cancer screening in periurban villages in Andhra Pradesh, India
    A Pavani Sowjanya
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 18:1373-8. 2009

Detail Information

Publications62

  1. pmc Evidence and impact of human papillomavirus latency
    Patti E Gravitt
    Perdana University Graduate School of Medicine, Jalan MAEPS Perdana, Serdang, Selangor MY 43400, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Open Virol J 6:198-203. 2012
    ....
  2. pmc Human papillomavirus genotypes detected in clinician-collected and self-collected specimens from women living in the Mississippi Delta
    Philip E Castle
    Global Cancer Imitative, Chestertown, MD, USA
    BMC Infect Dis 13:5. 2013
    ..The aim of this analysis was to report the age-specific prevalence of HPV in this population...
  3. pmc A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD21205, USA
    J Infect Dis 207:272-80. 2013
    ....
  4. pmc Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    Catterina Ferreccio
    P Universidad Catolica de Chile, Escuela de Medicina, Santiago Chile
    BMC Public Health 8:78. 2008
    ..A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus..
  5. pmc Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India
    A Pavani Sowjanya
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad, A P India
    BMC Infect Dis 5:116. 2005
    ..We investigated the genotype distribution of high-risk HPV types in squamous cell carcinomas and the prevalence of high-risk HPV in cervicovaginal samples in the southern state of Andhra Pradesh (AP), India...
  6. pmc Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus
    Charles G Eberhart
    Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
    BMC Cancer 5:19. 2005
    ..We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined...
  7. pmc Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6535, Baltimore, MD 21205, USA
    J Clin Microbiol 45:3245-50. 2007
    ....
  8. pmc High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2787-93. 2007
    ..The extent to which these observations can be translated into clinical practice must be rigorously examined in the context of the method of viral load measurement and the type-specific differences observed for incident >/=CIN2...
  9. ncbi request reprint Diagnosis and management of oncogenic cervical human papillomavirus infection
    Patti E Gravitt
    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 North Wolfe Street, Room E6535, Baltimore, MD 21205, USA
    Infect Dis Clin North Am 19:439-58. 2005
    ..In fact, the nature of screening programs should continue to be reevaluated in the context of effective but limited spectrum vaccines...
  10. pmc Suitability of self-collected vaginal samples for cervical cancer screening in periurban villages in Andhra Pradesh, India
    A Pavani Sowjanya
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 18:1373-8. 2009
    ....
  11. doi request reprint New technologies in cervical cancer screening
    Patti E Gravitt
    Departments of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Vaccine 26:K42-52. 2008
    ..Clinical validation will be required before these tests are implemented in routine screening programs...
  12. ncbi request reprint A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation
    Patti E Gravitt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:477-84. 2003
    ..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer...
  13. pmc Improved amplification of genital human papillomaviruses
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California, USA
    J Clin Microbiol 38:357-61. 2000
    ..This new primer system will be useful in assessing the natural history of HPV infections, particularly when the analysis requires HPV typing...
  14. pmc Looking ahead: a case for human papillomavirus testing of self-sampled vaginal specimens as a cervical cancer screening strategy
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 129:517-27. 2011
    ....
  15. pmc Effectiveness of VIA, Pap, and HPV DNA testing in a cervical cancer screening program in a peri-urban community in Andhra Pradesh, India
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13711. 2010
    ....
  16. ncbi request reprint Oral contraceptives as risk factors for cervical adenocarcinomas and squamous cell carcinomas
    J V Lacey
    National Cancer Institute, Bethesda, Maryland 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 8:1079-85. 1999
    ....
  17. ncbi request reprint Evaluation of self-collected cervicovaginal cell samples for human papillomavirus testing by polymerase chain reaction
    P E Gravitt
    Department of Human Genetics, Roche Molecular Systems, Alameda, California 94501, USA
    Cancer Epidemiol Biomarkers Prev 10:95-100. 2001
    ..We have demonstrated that a self-collected Dacron swab sample of cervicovaginal cells is a technically feasible alternative to clinician-administered cervical cell collection in natural history studies of HPV and cervical cancer...
  18. doi request reprint Human papillomavirus prevalence, cervical abnormalities and risk factors among female sex workers in Lima, Peru
    B Brown
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J STD AIDS 23:242-7. 2012
    ..77, 95% confidence interval [CI] = 0.60-0.97). Our data confirm the high rates of HPV transmission among FSWs in Peru, highlighting the need for early and effective strategies to prevent cervical cancer...
  19. ncbi request reprint Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions
    Mark E Sherman
    Department of Health and Human Services, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland 20892 7374, USA
    Cancer Epidemiol Biomarkers Prev 12:1038-44. 2003
    ..These factors severely limit the clinical use of load measurements irrespective of HPV testing methodology...
  20. ncbi request reprint Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
    Sex Transm Dis 34:429-36. 2007
    ..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...
  21. pmc Correlates of cervicovaginal human papillomavirus detection in perimenopausal women
    Keri N Althoff
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Womens Health (Larchmt) 18:1341-6. 2009
    ..The aim of this research was to determine correlates of prevalent cervicovaginal human papillomavirus (HPV) infection in perimenopausal women...
  22. pmc Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda
    Mahboobeh Safaeian
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 17:1300-7. 2008
    ..We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda...
  23. pmc Kinetics of DNA load predict HPV 16 viral clearance
    M Marks
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States
    J Clin Virol 51:44-9. 2011
    ..While high HPV 16 viral load measured at a single time point is associated with cervical disease outcomes, few studies have assessed changes in HPV 16 viral load on viral clearance...
  24. ncbi request reprint Comparisons of HPV DNA detection by MY09/11 PCR methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Med Virol 68:417-23. 2002
    ..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
  25. pmc A comparison of linear array and hybrid capture 2 for detection of carcinogenic human papillomavirus and cervical precancer in ASCUS-LSIL triage study
    Patti E Gravitt
    Department of Epidemiology and Molecular Microbiology, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 17:1248-54. 2008
    ..We were interested in comparing the performance of Linear Array (LA; Roche Molecular Systems) to Hybrid Capture 2 (hc2; Digene) for the detection of carcinogenic human papillomavirus (HPV) and cervical precancer...
  26. pmc A study of Amplicor human papillomavirus DNA detection in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:1341-9. 2009
    ..Amplicor at the 1.5 cutoff had comparable performance with hc2. Whereas Amplicor missed more disease related to nontargeted types, hc2 was more likely to miss disease related to targeted types...
  27. pmc Hierarchical clustering of human papilloma virus genotype patterns in the ASCUS-LSIL triage study
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
    Cancer Res 70:8578-86. 2010
    ..Our novel approach to study multiple genotype infections in cervical disease with the use of unsupervised hierarchical clustering can address complex genotype distributions on a population level...
  28. pmc Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  29. doi request reprint Oral sex practices, oral human papillomavirus and correlations between oral and cervical human papillomavirus prevalence among female sex workers in Lima, Peru
    B Brown
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J STD AIDS 22:655-8. 2011
    ..3% of women with cervical HPV were HPV-positive in the oral cavity. The prevalence of oral HPV was relatively low, considering the high rates of oral sex practiced by these women...
  30. ncbi request reprint Associations between smoking and adenocarcinomas and squamous cell carcinomas of the uterine cervix (United States)
    J V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Cancer Causes Control 12:153-61. 2001
    ..Few studies of smoking and cervical carcinoma have addressed the rare cervical adenocarcinomas or used DNA-based tests to control for human papillomavirus (HPV) infection...
  31. doi request reprint Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, Uganda
    M Safaeian
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    Sex Transm Infect 84:306-11. 2008
    ..To investigate self-administered vaginal swabs for assessing prevalence and correlates of carcinogenic human papillomavirus (HPV) infection in rural Rakai, Uganda...
  32. ncbi request reprint Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Cancer 98:814-21. 2003
    ..The authors evaluated whether obesity, which can influence hormone levels, was associated with adenocarcinoma and squamous cell carcinoma...
  33. ncbi request reprint Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6014 Baltimore, MD 21205, USA
    J Virol Methods 112:23-33. 2003
    ..87, respectively). These HPV 16 and HPV 18 quantitative PCR assays with GAPDH normalization are reproducibly quantitative over a broad linear dynamic range allowing for application in epidemiologic studies for measurement of viral load...
  34. pmc Comparison of two PCR-based human papillomavirus genotyping methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234
    J Clin Microbiol 46:3437-45. 2008
    ..Both approaches are suitable for monitoring the impact of HPV16/18 vaccines in clinical trials...
  35. ncbi request reprint Comparison of human papillomavirus genotypes, sexual, and reproductive risk factors of cervical adenocarcinoma and squamous cell carcinoma: Northeastern United States
    Sean F Altekruse
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 188:657-63. 2003
    ..We examined human papillomavirus genotypes and sexual and reproductive risk factors for cervical adenocarcinoma and squamous cell carcinoma...
  36. doi request reprint Confirmation and quantitation of human papillomavirus type 52 by Roche Linear Array using HPV52-specific TaqMan E6/E7 quantitative real-time PCR
    Morgan Marks
    Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm W3716, Baltimore, MD 21218, USA
    J Virol Methods 156:152-6. 2009
    ..279 copies/1000 cell equivalents, p<0.05). Accurate ascertainment of infection status is important in understanding HPV 52's role in the etiology of cervical cancer as well as for the development of type-specific vaccines...
  37. pmc Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1675-81. 2010
    ..There are few large case series describing the human papillomavirus (HPV) genotypes found in women diagnosed with rigorously reviewed cervical intraepithelial neoplasia grade 3 (CIN3), cervical precancer...
  38. pmc Progesterone and 17beta-estradiol enhance regulatory responses to human papillomavirus type 16 virus-like particles in peripheral blood mononuclear cells from healthy women
    Morgan A Marks
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E6133, Baltimore, MD 21205, USA
    Clin Vaccine Immunol 17:609-17. 2010
    ....
  39. ncbi request reprint Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    J Infect Dis 189:686-98. 2004
    ..8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection...
  40. pmc Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
    ..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression...
  41. doi request reprint Endocervical adenocarcinomas with prominent endometrial or endomyometrial involvement simulating primary endometrial carcinomas: utility of HPV DNA detection and immunohistochemical expression of p16 and hormone receptors to confirm the cervical origin of
    Anna Yemelyanova
    Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:914-24. 2009
    ..A subset of misclassified endocervical adenocarcinomas may account for some HPV-positive uterine carcinomas reported as primary endometrial carcinomas...
  42. pmc Impact of improved classification on the association of human papillomavirus with cervical precancer
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 171:155-63. 2010
    ..Finding increasingly strong associations when both test and diagnostic misclassification are reduced is a useful sign of "true association" in molecular epidemiology...
  43. ncbi request reprint Human papillomavirus prevalence and cytopathology correlation in young Ugandan women using a low-cost liquid-based Pap preparation
    Janis M Taube
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Diagn Cytopathol 38:555-63. 2010
    ..Notably, the manual low-cost liquid-based Pap preparation is practical in this setting and offers an alternate method for local studies of HPV vaccine efficacy...
  44. ncbi request reprint Absence of simian virus 40 in human brain tumors from northern India
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    Int J Cancer 101:348-52. 2002
    ..Our findings do not support a role for SV40 in choroid plexus tumors or ependymomas from northern India...
  45. pmc Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2
    Ratish Gambhira
    Department of Pathology, Johns Hopkins School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    J Virol 81:11585-92. 2007
    ..Further, vaccination with HPV16 L2 11-200 generates broadly cross-neutralizing serum antibody, suggesting the potential of L2 as a second-generation preventive HPV vaccine antigen...
  46. pmc Comparison of linear array and line blot assay for detection of human papillomavirus and diagnosis of cervical precancer and cancer in the atypical squamous cell of undetermined significance and low-grade squamous intraepithelial lesion triage study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5004, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    J Clin Microbiol 46:109-17. 2008
    ..In conclusion, we found LA to be a promising assay for the detection of HPV genotypes and carcinogenic HPV, and it may be clinically useful for the detection of cervical precancer and cancer in women with equivocal cytology...
  47. doi request reprint An analysis of high-risk human papillomavirus DNA-negative cervical precancers in the ASCUS-LSIL Triage Study (ALTS)
    Philip E Castle
    Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Obstet Gynecol 111:847-56. 2008
    ....
  48. ncbi request reprint Correlates of IL-10 and IL-12 concentrations in cervical secretions
    Patti E Gravitt
    Interdisciplinary Studies Section, Environmental Epidemiology Branch, DCEG, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Bethesda, Maryland 20852, USA
    J Clin Immunol 23:175-83. 2003
    ..Future analyses of cervical cytokine levels and HPV infection should control for the inherent variation of local cytokine levels due to hormonal influences, hemoglobin contamination, pH, and cervical secretion volume differences...
  49. pmc Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests
    Steven L Kahn
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 114:57-64. 2008
    ....
  50. pmc Human papillomavirus genotype specificity of hybrid capture 2
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5030, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    J Clin Microbiol 46:2595-604. 2008
    ..In conclusion, hc2 cross-reacts with certain untargeted, noncarcinogenic HPV genotypes that are phylogenetically related to the targeted genotypes, but the degree of cross-reactivity may be less than previously reported...
  51. ncbi request reprint Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms
    Brigitte M Ronnett
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1835-53. 2008
    ....
  52. ncbi request reprint Vaccination of healthy volunteers with human papillomavirus type 16 L2E7E6 fusion protein induces serum antibody that neutralizes across papillomavirus species
    Ratish Gambhira
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 66:11120-4. 2006
    ..001). Vaccination of healthy volunteers thrice with 533-mug HPV16 L2E7E6 at monthly intervals induced L2-specific serum antibodies that neutralized across papillomavirus species. Responses in AGIN patients were infrequent...
  53. pmc Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2
    Zhenhua Lin
    Department of Pathology, Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 174:136-43. 2009
    ..In contrast, L2 was primarily diffuse within the nucleus and distinct from ND-10 as defined by PML immunofluorescent staining in CIN lesions, condylomata, and HPV16-transduced organotypic cultures...
  54. ncbi request reprint Validation of a low-cost, liquid-based screening method for cervical intraepithelial neoplasia
    Judy M Lee
    Department of Gynecology and Obstetrics, Division of Gynecologic Specialties, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 195:965-70. 2006
    ..The objective of the study was to validate a low-cost, liquid-based method for cervical cancer screening...
  55. pmc Shedding of Epstein-Barr virus and cytomegalovirus from the genital tract of women in a periurban community in Andhra Pradesh, India
    Michelle I Silver
    Departments of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Clin Microbiol 49:2435-9. 2011
    ..The strong association between the presence of EBV and cervical disease warrants future exploration to determine whether EBV plays a causal role in disease development or if it is merely a bystander in the process...
  56. ncbi request reprint Human papillomavirus type distribution in cervical cancer in Delhi, India
    Neerja Bhatla
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
    Int J Gynecol Pathol 25:398-402. 2006
    ..Increasing the genotype spectrum (e.g. valency) if the existing vaccines would be expected to have only a modest impact on the potential for cervical protection...
  57. doi request reprint Detection of human papillomavirus from self-collected vaginal samples of women in Chiang Mai, Thailand
    Kanlaya Wongworapat
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    Sex Transm Dis 35:172-3. 2008
  58. ncbi request reprint Viral load of human papillomavirus and risk of CIN3 or cervical cancer
    Attila T Lorincz
    Digene Corporation, Gaithersburg, MD 20708, USA
    Lancet 360:228-9. 2002
    ..Results were stratified into four groups (RLU/PC 1 to <10, 10 to <100, 100 to <1000, > or = 1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+...
  59. ncbi request reprint Human papillomavirus genotype prevalence in high-grade squamous intraepithelial lesions and colposcopically normal women from Zimbabwe
    Patti E Gravitt
    Int J Cancer 100:729-32. 2002
  60. ncbi request reprint Evaluation of adjunctive tests for cervical cancer screening in low resource settings
    Neerja Bhatla
    Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India
    Indian J Cancer 44:51-5. 2007
    ..Adjunctive testing may overcome this drawback...
  61. pmc Human papillomavirus-type distribution in women with and without cervical neoplasia in north India
    Neerja Bhatla
    Department of Obstetrics, All India Institute of Medical Sciences, New Delhi, India
    Int J Gynecol Pathol 27:426-30. 2008
    ..A wide spectrum of HPV types is seen in north Indian women, with the majority being HPV-16 in all grades of histology. A vaccine against HPV-16 and HPV-18 could prevent two thirds of cases of high-grade cervical neoplasia...
  62. ncbi request reprint Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix
    Robert D Burk
    Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Cancer Res 63:7215-20. 2003
    ..Non-European HPV16 and/or HPV18 variants are commonly seen in AC. A possible hormonal mechanism is suggested to explain the observed findings...

Research Grants4

  1. HPV Infection Among Perimenopausal Women in the 1945-64 Birth Cohor
    Patti Gravitt; Fiscal Year: 2007
    ..The complementary molecular studies will add important biological information that may lead to new approaches in screening and treatment of cervical HPV infections and neoplasia. ..
  2. HPV Infection Among Perimenopausal Women in the 1945-64 Birth Cohor
    Patti Gravitt; Fiscal Year: 2009
    ..The complementary molecular studies will add important biological information that may lead to new approaches in screening and treatment of cervical HPV infections and neoplasia. ..
  3. HPV Infection Among Perimenopausal Women in the 1945-64 Birth Cohor
    Patti E Gravitt; Fiscal Year: 2010
    ..The complementary molecular studies will add important biological information that may lead to new approaches in screening and treatment of cervical HPV infections and neoplasia. ..