Research Topics
Species | Marco GradosSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Obsessive-compulsive disorder after traumatic brain injuryMarco A Grados
Johns Hopkins University School of Medicine, Baltimore, Maryland 21211, USA
Int Rev Psychiatry 15:350-8. 2003..This information along with the management of family and environmental stressors and the enhanced clinical identification of symptoms of anxiety and OCD can be used in the rehabilitation process to improve prognosis after TBI...
The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discoveryMarco A Grados
Johns Hopkins University School of Medicine
J Am Acad Child Adolesc Psychiatry 49:810-9, 819.e1-2. 2010..To provide a contemporary perspective on genetic discovery methods applied to obsessive-compulsive disorder (OCD) and Tourette syndrome (TS)...- Genetics of obsessive-compulsive disorders: new findings and challengesMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
Brain Dev 25:S55-61. 2003..A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD... - A new gene for Tourette's syndrome: a window into causal mechanisms?Marco A Grados
Johns Hopkins Hospital, 600 North Wolfe Street, CMSC 364, Baltimore, MD 21287, USA
Trends Genet 22:291-3. 2006..Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease... - Genetics of obsessive-compulsive disorder: a research updateMarco Grados
The Johns Hopkins University, CMSC 346, Baltimore, MD 21287 3325, USA
Expert Rev Neurother 7:967-80. 2007..While OCD appears to have a genetic component, additional innovative research is needed to unravel the genetic influences in the disorder... - Clinical phenomenology and phenotype variability in Tourette syndromeMarco A Grados
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Psychosom Res 67:491-6. 2009..Data reduction techniques have been used more recently to define a "simple" and "complex" tic symptom clusters or factors. Phenomenologic approaches can be used in TS to guide future pathophysiologic research... - Do all obsessive-compulsive disorder subtypes respond to medication?Marco Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int Rev Psychiatry 20:189-93. 2008..Strategies for treatment of the tic-related subtype of OCD, while strongly supporting the use of antipsychotic-augmentation for enhanced response in adults, are lacking controlled data in pediatric OCD... - New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injuryMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:398-407. 2008..05). OCS are common after severe pediatric TBI and are associated with greater comorbidities. New onset obsessions are associated with female sex, psychosocial adversity, and mesial prefrontal and temporal lesions... - The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors?Marco A Grados
Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 346, Baltimore, MD 21287, USA
Curr Psychiatry Rep 11:162-6. 2009..Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed... - Social and communication difficulties and obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Psychopathology 41:194-200. 2008..In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD... - Utility of the Leyton Obsessional Inventory to distinguish OCD and OCPDDavid Wellen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Depress Anxiety 24:301-6. 2007..These findings may contribute to effective diagnosis and treatment by allowing the LOI to screen for OCD and OCPD in a population exhibiting obsessional symptoms and traits... - Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Depress Anxiety 24:130-8. 2007..There were specific clinical correlates for these factors, and significant intrafamilial sib-sib correlations were found for the Symmetry/Order and Hoarding factors... - The association between parental bonding and obsessive compulsive disorder in offspring at high familial riskHolly C Wilcox
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7228, USA
J Affect Disord 111:31-9. 2008..The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD... 
Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorderVirginia L Willour
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
Am J Hum Genet 75:508-13. 2004..046 and .02, respectively) for association...- Neuroimaging correlates of anxiety after pediatric traumatic brain injuryRoma A Vasa
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biol Psychiatry 55:208-16. 2004..Similar to adult data, these findings implicate OFC dysfunction in childhood anxiety. Temporal lobe damage did not correlate with anxiety, in contrast to the findings for PTSD... - Clinical predictors of posttraumatic stress disorder after closed head injury in childrenJoan P Gerring
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Acad Child Adolesc Psychiatry 41:157-65. 2002..To describe injury, demographic, and neuropsychiatric characteristics of children who develop posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) after closed head injury (CHI)... - Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoardingKung Yee Liang
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 147:1000-2. 2008.... - Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implicationsMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 64:219-25. 2008..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes... - Prevalence of aggressive behaviour after severe paediatric traumatic brain injuryWesley R Cole
Kennedy Krieger Institute, Baltimore, MD 21202, USA
Brain Inj 22:932-9. 2008..The goals of this study were to explore the prevalence of aggressive behaviours after severe paediatric traumatic brain injury (TBI) and identify predictors of aggressive behaviours 1 year post-injury... - The OCD collaborative genetics study: methods and sample descriptionJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7228, USA
Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006.... - The identification of OCD-related subgroups based on comorbidityGerald Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Biol Psychiatry 53:914-20. 2003..This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups... - Predictors of treatment response in pediatric obsessive-compulsive disorderGolda S Ginsburg
Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe Street CMSC 340, Baltimore, MD 21287 3325, USA
J Am Acad Child Adolesc Psychiatry 47:868-78. 2008..To examine predictors of treatment response in pediatric obsessive-compulsive disorder (OCD)... - Sex-specific clinical correlates of hoarding in obsessive-compulsive disorderJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:1040-6. 2008..These findings indicate that specific clinical correlates of hoarding in OCD are different in men and women and may reflect sex-specific differences in the course, expression, and/or etiology of hoarding behavior in OCD... - Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorderBernadette Cullen
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Depress Anxiety 25:218-24. 2008..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner... - Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
Am J Psychiatry 164:493-9. 2007..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder... - Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics StudyJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
Behav Res Ther 45:673-86. 2007..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families... - Disruptive behaviour disorders and disruptive symptoms after severe paediatric traumatic brain injuryJoan P Gerring
Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Brain Inj 23:944-55. 2009.... - Prevalence and correlates of hoarding behavior in a community-based sampleJack F Samuels
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 109, Baltimore, MD 21287 7228, USA
Behav Res Ther 46:836-44. 2008..These findings suggest that hoarding may be relatively prevalent and that alcohol dependence, personality disorder traits, and specific childhood adversities are associated with hoarding in the community... - Genetics of obsessive-compulsive disorderGerald Nestadt
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
Psychiatr Clin North Am 33:141-58. 2010..The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition... - Obsessive-compulsive disorder: defining the phenotypeGerald Nestadt
Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
J Clin Psychiatry 63:5-7. 2002..This article describes a family-study approach for identifying the spectrum of conditions related to OCD and subtyping OCD cases into homogeneous subtypes... - Differences in attention, executive functioning, and memory in children with and without ADHD after severe traumatic brain injuryBeth S Slomine
Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
J Int Neuropsychol Soc 11:645-53. 2005..Although findings provide preliminary support for distinguishing P-ADHD from S-ADHD, further research is needed to investigate neuropsychological differences between these subgroups of children with severe TBI... - Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic studyGeorge T Capone
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
J Dev Behav Pediatr 29:106-16. 2008..We hypothesized that hyperactivity and disruptive behaviors would improve in response to risperidone treatment consistent with previous studies of children with ASD... - Performance on measures of executive function following pediatric traumatic brain injuryBeth S Slomine
Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Brain Inj 16:759-72. 2002..To investigate the relationships among age at injury, neuroanatomic lesion location, and measures of executive function (EF) following paediatric traumatic brain injury (TBI)... - Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklistGeorge T Capone
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Am J Med Genet A 134:373-80. 2005..This study demonstrates the feasibility of using the ABC to characterize the neurobehavioral phenotype of a cohort of children with trisomy 21 and ASD for ongoing research purposes... - Anxiety after severe pediatric closed head injuryRoma A Vasa
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Acad Child Adolesc Psychiatry 41:148-56. 2002..To assess the frequency of anxiety symptoms and disorders 1 year after severe pediatric closed head injury (CHI) and to determine the risk factors associated with these postinjury outcomes... - Glutamatergic modulatory therapy for Tourette syndromeHarvey S Singer
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Med Hypotheses 74:862-7. 2010..If validated, modulation of the glutamate system could provide a valuable new pharmacological approach in the treatment of tics associated with Tourette syndrome... - Neuroanatomic correlates of CVLT-C performance following pediatric traumatic brain injuryCynthia F Salorio
Department of Pediatric Rehabilitation, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
J Int Neuropsychol Soc 11:686-96. 2005..This finding may relate to widespread diffuse axonal injury, which potentially disconnects brain circuits mediating memory following moderate to severe TBI... - Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDASColin Gause
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
J Neuroimmunol 214:118-24. 2009..ASO titers were similar in all groups and did not correlate with immunoassays. It remains controversial whether childhood OCD is associated with autoimmune mechanisms... - Intensive care unit variables and outcome after pediatric traumatic brain injury: a retrospective study of survivorsCynthia F Salorio
Kennedy Krieger Institute, Baltimore, MD, USA
Pediatr Crit Care Med 9:47-53. 2008..The objective was to obtain acute physiologic variables during the early hospitalization period in a cohort of children prospectively enrolled in another study... - Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics StudyGregor Hasler
Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Biol Psychiatry 61:617-25. 2007..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions... - Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categoriesAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
Psychiatry Res 160:83-93. 2008..The results support investigation of this multidimensional model in OCD genetic linkage studies... - Two times four is four: OCD dimensions, classes, and categoriesMarco A Grados
J Am Acad Child Adolesc Psychiatry 47:731-3. 2008
Research Grants
- LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDERMarco Grados; Fiscal Year: 2006..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..