Marco Grados

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Obsessive-compulsive disorder after traumatic brain injury
    Marco A Grados
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21211, USA
    Int Rev Psychiatry 15:350-8. 2003
  2. ncbi request reprint The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors?
    Marco A Grados
    Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 346, Baltimore, MD 21287, USA
    Curr Psychiatry Rep 11:162-6. 2009
  3. ncbi request reprint Genetics of obsessive-compulsive disorders: new findings and challenges
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
    Brain Dev 25:S55-61. 2003
  4. ncbi request reprint A new gene for Tourette's syndrome: a window into causal mechanisms?
    Marco A Grados
    Johns Hopkins Hospital, 600 North Wolfe Street, CMSC 364, Baltimore, MD 21287, USA
    Trends Genet 22:291-3. 2006
  5. ncbi request reprint Genetics of obsessive-compulsive disorder: a research update
    Marco Grados
    The Johns Hopkins University, CMSC 346, Baltimore, MD 21287 3325, USA
    Expert Rev Neurother 7:967-80. 2007
  6. doi request reprint Clinical phenomenology and phenotype variability in Tourette syndrome
    Marco A Grados
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Psychosom Res 67:491-6. 2009
  7. doi request reprint Do all obsessive-compulsive disorder subtypes respond to medication?
    Marco Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int Rev Psychiatry 20:189-93. 2008
  8. ncbi request reprint New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injury
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:398-407. 2008
  9. doi request reprint The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery
    Marco A Grados
    Johns Hopkins University School of Medicine
    J Am Acad Child Adolesc Psychiatry 49:810-9, 819.e1-2. 2010
  10. doi request reprint Social and communication difficulties and obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Psychopathology 41:194-200. 2008

Research Grants

Detail Information

Publications42

  1. ncbi request reprint Obsessive-compulsive disorder after traumatic brain injury
    Marco A Grados
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21211, USA
    Int Rev Psychiatry 15:350-8. 2003
    ..This information along with the management of family and environmental stressors and the enhanced clinical identification of symptoms of anxiety and OCD can be used in the rehabilitation process to improve prognosis after TBI...
  2. ncbi request reprint The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors?
    Marco A Grados
    Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 346, Baltimore, MD 21287, USA
    Curr Psychiatry Rep 11:162-6. 2009
    ..Questions on common genetic substrates, the use of endophenotypes, and the utility of genetic data to inform pharmacologic treatment are also addressed...
  3. ncbi request reprint Genetics of obsessive-compulsive disorders: new findings and challenges
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
    Brain Dev 25:S55-61. 2003
    ..A better understanding of environmental triggers, OCD subtypes and OCD pathophysiology will lead to locating genes that confer risk to OCD...
  4. ncbi request reprint A new gene for Tourette's syndrome: a window into causal mechanisms?
    Marco A Grados
    Johns Hopkins Hospital, 600 North Wolfe Street, CMSC 364, Baltimore, MD 21287, USA
    Trends Genet 22:291-3. 2006
    ..Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease...
  5. ncbi request reprint Genetics of obsessive-compulsive disorder: a research update
    Marco Grados
    The Johns Hopkins University, CMSC 346, Baltimore, MD 21287 3325, USA
    Expert Rev Neurother 7:967-80. 2007
    ..While OCD appears to have a genetic component, additional innovative research is needed to unravel the genetic influences in the disorder...
  6. doi request reprint Clinical phenomenology and phenotype variability in Tourette syndrome
    Marco A Grados
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Psychosom Res 67:491-6. 2009
    ..Data reduction techniques have been used more recently to define a "simple" and "complex" tic symptom clusters or factors. Phenomenologic approaches can be used in TS to guide future pathophysiologic research...
  7. doi request reprint Do all obsessive-compulsive disorder subtypes respond to medication?
    Marco Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int Rev Psychiatry 20:189-93. 2008
    ..Strategies for treatment of the tic-related subtype of OCD, while strongly supporting the use of antipsychotic-augmentation for enhanced response in adults, are lacking controlled data in pediatric OCD...
  8. ncbi request reprint New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injury
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:398-407. 2008
    ..05). OCS are common after severe pediatric TBI and are associated with greater comorbidities. New onset obsessions are associated with female sex, psychosocial adversity, and mesial prefrontal and temporal lesions...
  9. doi request reprint The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery
    Marco A Grados
    Johns Hopkins University School of Medicine
    J Am Acad Child Adolesc Psychiatry 49:810-9, 819.e1-2. 2010
    ..To provide a contemporary perspective on genetic discovery methods applied to obsessive-compulsive disorder (OCD) and Tourette syndrome (TS)...
  10. doi request reprint Social and communication difficulties and obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Psychopathology 41:194-200. 2008
    ..In this study we sought to establish if there is any association between the presence of abnormal pragmatic behaviors and OCD and whether this association delineates a familial subtype of OCD...
  11. ncbi request reprint Factor analysis of the Yale-Brown Obsessive Compulsive Scale in a family study of obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Depress Anxiety 24:130-8. 2007
    ..There were specific clinical correlates for these factors, and significant intrafamilial sib-sib correlations were found for the Symmetry/Order and Hoarding factors...
  12. doi request reprint The association between parental bonding and obsessive compulsive disorder in offspring at high familial risk
    Holly C Wilcox
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7228, USA
    J Affect Disord 111:31-9. 2008
    ..The aim of the current study is to estimate the association between parenting factors derived from the Parental Bonding Instrument (PBI) and a lifetime DSM-IV diagnosis of OCD...
  13. ncbi request reprint Utility of the Leyton Obsessional Inventory to distinguish OCD and OCPD
    David Wellen
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Depress Anxiety 24:301-6. 2007
    ..These findings may contribute to effective diagnosis and treatment by allowing the LOI to screen for OCD and OCPD in a population exhibiting obsessional symptoms and traits...
  14. pmc Replication study supports evidence for linkage to 9p24 in obsessive-compulsive disorder
    Virginia L Willour
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Hum Genet 75:508-13. 2004
    ..046 and .02, respectively) for association...
  15. ncbi request reprint Neuroimaging correlates of anxiety after pediatric traumatic brain injury
    Roma A Vasa
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biol Psychiatry 55:208-16. 2004
    ..Data on the neural correlates of these conditions are lacking. This study examines the relationship between brain damage, particularly to the orbitofrontal cortex (OFC) and temporal lobe, and anxiety symptoms and disorders...
  16. ncbi request reprint Clinical predictors of posttraumatic stress disorder after closed head injury in children
    Joan P Gerring
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Acad Child Adolesc Psychiatry 41:157-65. 2002
    ..To describe injury, demographic, and neuropsychiatric characteristics of children who develop posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) after closed head injury (CHI)...
  17. doi request reprint Evidence for potential relationship between SLC1A1 and a putative genetic linkage region on chromosome 14q to obsessive-compulsive disorder with compulsive hoarding
    Kung Yee Liang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1000-2. 2008
    ....
  18. pmc Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 64:219-25. 2008
    ..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes...
  19. pmc Prevalence of aggressive behaviour after severe paediatric traumatic brain injury
    Wesley R Cole
    Kennedy Krieger Institute, Baltimore, MD 21202, USA
    Brain Inj 22:932-9. 2008
    ..The goals of this study were to explore the prevalence of aggressive behaviours after severe paediatric traumatic brain injury (TBI) and identify predictors of aggressive behaviours 1 year post-injury...
  20. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  21. ncbi request reprint The identification of OCD-related subgroups based on comorbidity
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Biol Psychiatry 53:914-20. 2003
    ..This study employed latent class analysis (LCA) to explore whether there are underlying clinical constructs that distinguish "OCD-related" subgroups...
  22. doi request reprint Predictors of treatment response in pediatric obsessive-compulsive disorder
    Golda S Ginsburg
    Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe Street CMSC 340, Baltimore, MD 21287 3325, USA
    J Am Acad Child Adolesc Psychiatry 47:868-78. 2008
    ..To examine predictors of treatment response in pediatric obsessive-compulsive disorder (OCD)...
  23. pmc Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 46:1040-6. 2008
    ..These findings indicate that specific clinical correlates of hoarding in OCD are different in men and women and may reflect sex-specific differences in the course, expression, and/or etiology of hoarding behavior in OCD...
  24. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  25. ncbi request reprint Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Am J Psychiatry 164:493-9. 2007
    ..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
  26. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...
  27. doi request reprint Disruptive behaviour disorders and disruptive symptoms after severe paediatric traumatic brain injury
    Joan P Gerring
    Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Brain Inj 23:944-55. 2009
    ....
  28. pmc Prevalence and correlates of hoarding behavior in a community-based sample
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 109, Baltimore, MD 21287 7228, USA
    Behav Res Ther 46:836-44. 2008
    ..These findings suggest that hoarding may be relatively prevalent and that alcohol dependence, personality disorder traits, and specific childhood adversities are associated with hoarding in the community...
  29. pmc Genetics of obsessive-compulsive disorder
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Psychiatr Clin North Am 33:141-58. 2010
    ..The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition...
  30. ncbi request reprint Obsessive-compulsive disorder: defining the phenotype
    Gerald Nestadt
    Department of Psychiatry and Behavioral Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    J Clin Psychiatry 63:5-7. 2002
    ..This article describes a family-study approach for identifying the spectrum of conditions related to OCD and subtyping OCD cases into homogeneous subtypes...
  31. ncbi request reprint Differences in attention, executive functioning, and memory in children with and without ADHD after severe traumatic brain injury
    Beth S Slomine
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    J Int Neuropsychol Soc 11:645-53. 2005
    ..Although findings provide preliminary support for distinguishing P-ADHD from S-ADHD, further research is needed to investigate neuropsychological differences between these subgroups of children with severe TBI...
  32. doi request reprint Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study
    George T Capone
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    J Dev Behav Pediatr 29:106-16. 2008
    ..We hypothesized that hyperactivity and disruptive behaviors would improve in response to risperidone treatment consistent with previous studies of children with ASD...
  33. ncbi request reprint Performance on measures of executive function following pediatric traumatic brain injury
    Beth S Slomine
    Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain Inj 16:759-72. 2002
    ..To investigate the relationships among age at injury, neuroanatomic lesion location, and measures of executive function (EF) following paediatric traumatic brain injury (TBI)...
  34. ncbi request reprint Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklist
    George T Capone
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Am J Med Genet A 134:373-80. 2005
    ..This study demonstrates the feasibility of using the ABC to characterize the neurobehavioral phenotype of a cohort of children with trisomy 21 and ASD for ongoing research purposes...
  35. ncbi request reprint Anxiety after severe pediatric closed head injury
    Roma A Vasa
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Acad Child Adolesc Psychiatry 41:148-56. 2002
    ..To assess the frequency of anxiety symptoms and disorders 1 year after severe pediatric closed head injury (CHI) and to determine the risk factors associated with these postinjury outcomes...
  36. doi request reprint Glutamatergic modulatory therapy for Tourette syndrome
    Harvey S Singer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Hypotheses 74:862-7. 2010
    ..If validated, modulation of the glutamate system could provide a valuable new pharmacological approach in the treatment of tics associated with Tourette syndrome...
  37. ncbi request reprint Neuroanatomic correlates of CVLT-C performance following pediatric traumatic brain injury
    Cynthia F Salorio
    Department of Pediatric Rehabilitation, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    J Int Neuropsychol Soc 11:686-96. 2005
    ..This finding may relate to widespread diffuse axonal injury, which potentially disconnects brain circuits mediating memory following moderate to severe TBI...
  38. doi request reprint Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS
    Colin Gause
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    J Neuroimmunol 214:118-24. 2009
    ..ASO titers were similar in all groups and did not correlate with immunoassays. It remains controversial whether childhood OCD is associated with autoimmune mechanisms...
  39. doi request reprint Intensive care unit variables and outcome after pediatric traumatic brain injury: a retrospective study of survivors
    Cynthia F Salorio
    Kennedy Krieger Institute, Baltimore, MD, USA
    Pediatr Crit Care Med 9:47-53. 2008
    ..The objective was to obtain acute physiologic variables during the early hospitalization period in a cohort of children prospectively enrolled in another study...
  40. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  41. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  42. doi request reprint Two times four is four: OCD dimensions, classes, and categories
    Marco A Grados
    J Am Acad Child Adolesc Psychiatry 47:731-3. 2008

Research Grants1

  1. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..