Amy K Goodwin

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): Time course and severity of withdrawal in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA Electronic address
    Drug Alcohol Depend 132:427-33. 2013
  2. pmc Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Drug Alcohol Depend 114:217-24. 2011
  3. pmc Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons
    A K Goodwin
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 204:465-76. 2009
  4. ncbi request reprint Serotonergic-dopaminergic mediation of MDMA's discriminative stimulus effects in a three-choice discrimination
    Amy K Goodwin
    Western Michigan University, Kalamazoo, MI, USA
    Pharmacol Biochem Behav 74:987-95. 2003
  5. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006
  6. pmc Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 225:637-46. 2013
  7. ncbi request reprint Environmental cues, alcohol seeking, and consumption in baboons: effects of response requirement and duration of alcohol abstinence
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 30:2026-36. 2006
  8. ncbi request reprint Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons
    Amy K Goodwin
    Johns Hopkins Bayview, Behavioral Biology Research Center, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 180:342-51. 2005
  9. pmc Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboons
    Barbara J Kaminski
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 32:1014-22. 2008
  10. pmc Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons
    Amy K Goodwin
    Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224 6823
    J Pharmacol Exp Ther 345:342-53. 2013

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Physical dependence on gamma-hydroxybutrate (GHB) prodrug 1,4-butanediol (1,4-BD): Time course and severity of withdrawal in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA Electronic address
    Drug Alcohol Depend 132:427-33. 2013
    ..Although there are case reports of a withdrawal syndrome following 1,4-BD use, no studies have evaluated the physical dependence potential of 1,4-BD and characterized the time course of withdrawal...
  2. pmc Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Drug Alcohol Depend 114:217-24. 2011
    ....
  3. pmc Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons
    A K Goodwin
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 204:465-76. 2009
    ..Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are prodrugs for gamma-hydroxybutyrate (GHB). Like GHB, GBL and 1,4-BD are drugs of abuse, but their behavioral effects may differ from GHB under some conditions...
  4. ncbi request reprint Serotonergic-dopaminergic mediation of MDMA's discriminative stimulus effects in a three-choice discrimination
    Amy K Goodwin
    Western Michigan University, Kalamazoo, MI, USA
    Pharmacol Biochem Behav 74:987-95. 2003
    ..These results indicate that 5-HT release is a salient feature to MDMA's discriminative stimulus effects but that MDMA produces a compound discriminative stimulus...
  5. ncbi request reprint Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 189:71-82. 2006
    ..Abuse of gamma-hydroxybutyrate (GHB) and its precursors is a public health concern. Gamma-butyrolactone (GBL) is found in commercially available products and, when ingested, is metabolized to GHB...
  6. pmc Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons
    Amy K Goodwin
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 225:637-46. 2013
    ..Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are gamma-hydroxybutyrate (GHB) pro-drugs and drugs of abuse...
  7. ncbi request reprint Environmental cues, alcohol seeking, and consumption in baboons: effects of response requirement and duration of alcohol abstinence
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 30:2026-36. 2006
    ..Animal models using chained schedules of alcohol reinforcement may be useful for examining such complex interactions...
  8. ncbi request reprint Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons
    Amy K Goodwin
    Johns Hopkins Bayview, Behavioral Biology Research Center, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 180:342-51. 2005
    ..Gamma-hydroxybutyrate (GHB) is used for the treatment of narcolepsy, but it is also a drug of abuse. The behavioral pharmacology of GHB is not well defined...
  9. pmc Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboons
    Barbara J Kaminski
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Alcohol Clin Exp Res 32:1014-22. 2008
    ..Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption...
  10. pmc Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons
    Amy K Goodwin
    Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224 6823
    J Pharmacol Exp Ther 345:342-53. 2013
    ..Similar to humans, blood levels of MDMA after oral administration may not be predictive of the behavioral effects of MDMA. Metabolites, particularly HHMA, may play a significant role in the behavioral effects of MDMA...
  11. ncbi request reprint The value of nonhuman primates in drug abuse research
    Elise M Weerts
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 15:309-27. 2007
    ..This review focuses on important species differences between rodents and NHP and on the value of NHP in bridging the gap between rodents and humans to enhance the ability to generalize preclinical findings to human drug abuse...
  12. ncbi request reprint Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons
    Elise M Weerts
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 179:678-87. 2005
    ..gamma-Hydroxybuyrate (GHB) is a current drug of abuse that may produce physical dependence...
  13. pmc Metabolism and disposition of 3,4-methylenedioxymethamphetamine ("ecstasy") in baboons after oral administration: comparison with humans reveals marked differences
    Melanie Mueller
    Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 338:310-7. 2011
    ....

Research Grants1

  1. Self-administration of GHB, GBL and 1,4-BD in baboons
    AMY GOODWIN; Fiscal Year: 2005
    ..The results of the proposed study will characterize the abuse liability of GHB, GBL, and 1,4-BD by use of a well-established method of abuse liability testing in non-human primates. ..