Steven N Goodman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint A dirty dozen: twelve p-value misconceptions
    Steven Goodman
    Departments of Oncology, Epidemiology, and Biostatistics, Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD, USA
    Semin Hematol 45:135-40. 2008
  2. ncbi request reprint Introduction to Bayesian methods I: measuring the strength of evidence
    Steven N Goodman
    Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Clin Trials 2:282-90; discussion 301-4, 364-78. 2005
  3. ncbi request reprint A Bayesian approach to randomized controlled trials in children utilizing information from adults: the case of Guillain-Barré syndrome
    Steven N Goodman
    Department of Oncology, Johns Hopkins School of Medicine and Public Health, USA
    Clin Trials 2:305-10; discussion 364-78. 2005
  4. ncbi request reprint Rashomon revisited: two views of monitoring the Women's Health Initiative trials
    Steven N Goodman
    Clin Trials 4:205-6. 2007
  5. pmc Confessions of a chagrined trialist
    Steven Goodman
    Johns Hopkins University, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
    BMJ Qual Saf 20:i97-8. 2011
  6. ncbi request reprint The methodologic ozone effect
    Steven N Goodman
    Departments of Oncology, Pediatrics, Epidemiology and Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Epidemiology 16:430-5. 2005
  7. ncbi request reprint Stopping at nothing? Some dilemmas of data monitoring in clinical trials
    Steven N Goodman
    Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Ann Intern Med 146:882-7. 2007
  8. ncbi request reprint Commentary: The P-value, devalued
    Steven Goodman
    Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
    Int J Epidemiol 32:699-702. 2003
  9. pmc High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease
    Leo Luznik
    Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Blood 115:3224-30. 2010
  10. ncbi request reprint Phase I study of low-dose interleukin-2, fludarabine, and cyclophosphamide for previously untreated indolent lymphoma and chronic lymphocytic leukemia
    Yvette L Kasamon
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 11:8413-7. 2005

Collaborators

Detail Information

Publications27

  1. doi request reprint A dirty dozen: twelve p-value misconceptions
    Steven Goodman
    Departments of Oncology, Epidemiology, and Biostatistics, Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD, USA
    Semin Hematol 45:135-40. 2008
    ....
  2. ncbi request reprint Introduction to Bayesian methods I: measuring the strength of evidence
    Steven N Goodman
    Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Clin Trials 2:282-90; discussion 301-4, 364-78. 2005
    ..With the emphasis moved from "error rates" to evidence, content experts have an opportunity for their input to be meaningfully incorporated, making it easier for regulatory decisions to be made correctly...
  3. ncbi request reprint A Bayesian approach to randomized controlled trials in children utilizing information from adults: the case of Guillain-Barré syndrome
    Steven N Goodman
    Department of Oncology, Johns Hopkins School of Medicine and Public Health, USA
    Clin Trials 2:305-10; discussion 364-78. 2005
    ..If one could capture all eligible patients in the United States, only about 100-300 children would be available for a trial annually...
  4. ncbi request reprint Rashomon revisited: two views of monitoring the Women's Health Initiative trials
    Steven N Goodman
    Clin Trials 4:205-6. 2007
  5. pmc Confessions of a chagrined trialist
    Steven Goodman
    Johns Hopkins University, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
    BMJ Qual Saf 20:i97-8. 2011
    ..However, some personal experiences and participation in the Cliveden conference led me to a new appreciation of the methodological and conceptual challenges faced by those trying to improve medical systems...
  6. ncbi request reprint The methodologic ozone effect
    Steven N Goodman
    Departments of Oncology, Pediatrics, Epidemiology and Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Epidemiology 16:430-5. 2005
  7. ncbi request reprint Stopping at nothing? Some dilemmas of data monitoring in clinical trials
    Steven N Goodman
    Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Ann Intern Med 146:882-7. 2007
    ....
  8. ncbi request reprint Commentary: The P-value, devalued
    Steven Goodman
    Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
    Int J Epidemiol 32:699-702. 2003
  9. pmc High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease
    Leo Luznik
    Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Blood 115:3224-30. 2010
    ..These results suggest that high-dose posttransplantation cyclophosphamide is an effective single-agent prophylaxis of acute and chronic GVHD after BuCy conditioning and HLA-matched BMT (clinicaltrials.gov no. NCT00134017)...
  10. ncbi request reprint Phase I study of low-dose interleukin-2, fludarabine, and cyclophosphamide for previously untreated indolent lymphoma and chronic lymphocytic leukemia
    Yvette L Kasamon
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Clin Cancer Res 11:8413-7. 2005
    ....
  11. ncbi request reprint Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials
    David J Bradley
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    JAMA 289:730-40. 2003
    ..Cardiac resynchronization, a pacemaker-based therapy for heart failure, enhances cardiac performance and quality of life, but its effect on mortality is uncertain...
  12. ncbi request reprint Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    Manel Esteller
    Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:26-32. 2002
    ..MGMT promoter hypermethylation is a favorable prognostic marker in patients with brain tumors treated with alkylating agents...
  13. ncbi request reprint Ethical issues in evidence-based surgery
    Ingrid Burger
    Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Surg Clin North Am 86:151-68, x. 2006
    ..Good ethics requires good facts, and evidence from well-controlled experiments provides best information upon which to base decisions in these areas and to build ethical surgical practice...
  14. pmc High-dose cyclophosphamide for severe aplastic anemia: long-term follow-up
    Robert A Brodsky
    Division of Hematology, Department of Medicine, Johns Hopkins University School ofMedicine, 720 Rutland Ave, Ross Bldg, Rm 1025, Baltimore, MD 21205, USA
    Blood 115:2136-41. 2010
    ....
  15. pmc An epigenetic marker panel for detection of lung cancer using cell-free serum DNA
    Shahnaz Begum
    Department of Otolaryngology and Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 17:4494-503. 2011
    ..We investigated the feasibility of detecting aberrant DNA methylation of some novel and known genes in the serum of lung cancer patients...
  16. doi request reprint A systematic examination of the citation of prior research in reports of randomized, controlled trials
    Karen A Robinson
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
    Ann Intern Med 154:50-5. 2011
    ..Research has suggested that evidence from prior trials is often not accounted for in reports of subsequent RCTs...
  17. doi request reprint Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanning
    Yvette L Kasamon
    Johns Hopkins University, Baltimore, Maryland, USA
    Biol Blood Marrow Transplant 15:242-8. 2009
    ..The favorable outcome achieved here in historically poor-risk patients warrants further, more definitive investigation of treatment modification based on early PET scanning...
  18. pmc RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
    Anju Singh
    Department of Environmental Health Sciences, Division of Toxicology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer Res 68:7975-84. 2008
    ..Thus, targeting Nrf2 activity in lung cancers, particularly those with Keap1 mutations, could be a promising strategy to inhibit tumor growth and circumvent chemoresistance...
  19. ncbi request reprint Counting alleles to predict recurrence of early-stage colorectal cancers
    Wei Zhou
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Lancet 359:219-25. 2002
    ..However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers...
  20. doi request reprint A blinded, crossover study of the efficacy of the ketogenic diet
    John M Freeman
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Baltimore, Maryland, USA
    Epilepsia 50:322-5. 2009
    ..5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm...
  21. ncbi request reprint Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysis
    Parthiv J Mahadevia
    Robert Wood Johnson Clinical Scholars Program, Johns Hopkins School of Medicine, Baltimore, MD, USA
    JAMA 289:313-22. 2003
    ..Encouraged by direct-to-consumer marketing, smokers and their physicians are contemplating lung cancer screening with a promising but unproven imaging procedure, helical computed tomography (CT)...
  22. ncbi request reprint Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
    Christine A Szekely
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroepidemiology 23:159-69. 2004
    ..The purpose of this meta-analysis is to summarize and evaluate available evidence regarding exposure to nonaspirin NSAIDs and risk of Alzheimer's disease using meta-analyses of published studies...
  23. ncbi request reprint How statistical expertise is used in medical research
    Douglas G Altman
    Centre for Statistics in Medicine, Cancer Research UK NHS, Institute of Health Sciences, Old Rd, Headington, Oxford OX3 7LF, England
    JAMA 287:2817-20. 2002
    ..Investigation of the nature and frequency of statistician involvement in medical research and its relation to the final editorial decision...
  24. ncbi request reprint Acne therapy: a methodologic review
    Harold P Lehmann
    Department of Pediatrics, Johns Hopkins School of Medicine and Bloomberg School of Public Health, USA
    J Am Acad Dermatol 47:231-40. 2002
    ..Therefore, we performed an evidence review to provide researchers a basis for further studies, and to provide clinicians the background needed to interpret current and future clinical studies...
  25. ncbi request reprint Toward protecting the safety of participants in clinical trials
    Robert M Califf
    Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
    Control Clin Trials 24:256-71. 2003
    ..DMC composition and functions should be standardized and regulations should be harmonized nationally and internationally. Finally, there should be a concerted effort to study the efficacy of various components of the system...
  26. ncbi request reprint The mammography dilemma: a crisis for evidence-based medicine?
    Steven N Goodman
    Ann Intern Med 137:363-5. 2002
  27. ncbi request reprint Ethics and evidence in clinical trials
    Steven N Goodman
    Clin Trials 2:195-6. 2005