Steven N Goodman
Affiliation: Johns Hopkins University
- A dirty dozen: twelve p-value misconceptionsSteven Goodman
Departments of Oncology, Epidemiology, and Biostatistics, Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD, USA
Semin Hematol 45:135-40. 2008....
- Introduction to Bayesian methods I: measuring the strength of evidenceSteven N Goodman
Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Clin Trials 2:282-90; discussion 301-4, 364-78. 2005..With the emphasis moved from "error rates" to evidence, content experts have an opportunity for their input to be meaningfully incorporated, making it easier for regulatory decisions to be made correctly...
- A Bayesian approach to randomized controlled trials in children utilizing information from adults: the case of Guillain-Barré syndromeSteven N Goodman
Department of Oncology, Johns Hopkins School of Medicine and Public Health, USA
Clin Trials 2:305-10; discussion 364-78. 2005..If one could capture all eligible patients in the United States, only about 100-300 children would be available for a trial annually...
- Rashomon revisited: two views of monitoring the Women's Health Initiative trialsSteven N Goodman
Clin Trials 4:205-6. 2007
- Confessions of a chagrined trialistSteven Goodman
Johns Hopkins University, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
BMJ Qual Saf 20:i97-8. 2011..However, some personal experiences and participation in the Cliveden conference led me to a new appreciation of the methodological and conceptual challenges faced by those trying to improve medical systems...
- The methodologic ozone effectSteven N Goodman
Departments of Oncology, Pediatrics, Epidemiology and Biostatistics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Epidemiology 16:430-5. 2005
- Stopping at nothing? Some dilemmas of data monitoring in clinical trialsSteven N Goodman
Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
Ann Intern Med 146:882-7. 2007....
- Commentary: The P-value, devaluedSteven Goodman
Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine, 550 N Broadway, Suite 1103, Baltimore, MD 21205, USA
Int J Epidemiol 32:699-702. 2003
- High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host diseaseLeo Luznik
Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Blood 115:3224-30. 2010..These results suggest that high-dose posttransplantation cyclophosphamide is an effective single-agent prophylaxis of acute and chronic GVHD after BuCy conditioning and HLA-matched BMT (clinicaltrials.gov no. NCT00134017)...
- Phase I study of low-dose interleukin-2, fludarabine, and cyclophosphamide for previously untreated indolent lymphoma and chronic lymphocytic leukemiaYvette L Kasamon
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Clin Cancer Res 11:8413-7. 2005....
- Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trialsDavid J Bradley
Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
JAMA 289:730-40. 2003..Cardiac resynchronization, a pacemaker-based therapy for heart failure, enhances cardiac performance and quality of life, but its effect on mortality is uncertain...
- Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphomaManel Esteller
Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
J Natl Cancer Inst 94:26-32. 2002..MGMT promoter hypermethylation is a favorable prognostic marker in patients with brain tumors treated with alkylating agents...
- Ethical issues in evidence-based surgeryIngrid Burger
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Surg Clin North Am 86:151-68, x. 2006..Good ethics requires good facts, and evidence from well-controlled experiments provides best information upon which to base decisions in these areas and to build ethical surgical practice...
- High-dose cyclophosphamide for severe aplastic anemia: long-term follow-upRobert A Brodsky
Division of Hematology, Department of Medicine, Johns Hopkins University School ofMedicine, 720 Rutland Ave, Ross Bldg, Rm 1025, Baltimore, MD 21205, USA
Blood 115:2136-41. 2010....
- An epigenetic marker panel for detection of lung cancer using cell-free serum DNAShahnaz Begum
Department of Otolaryngology and Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Cancer Res 17:4494-503. 2011..We investigated the feasibility of detecting aberrant DNA methylation of some novel and known genes in the serum of lung cancer patients...
- A systematic examination of the citation of prior research in reports of randomized, controlled trialsKaren A Robinson
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
Ann Intern Med 154:50-5. 2011..Research has suggested that evidence from prior trials is often not accounted for in reports of subsequent RCTs...
- Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanningYvette L Kasamon
Johns Hopkins University, Baltimore, Maryland, USA
Biol Blood Marrow Transplant 15:242-8. 2009..The favorable outcome achieved here in historically poor-risk patients warrants further, more definitive investigation of treatment modification based on early PET scanning...
- RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapyAnju Singh
Department of Environmental Health Sciences, Division of Toxicology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Cancer Res 68:7975-84. 2008..Thus, targeting Nrf2 activity in lung cancers, particularly those with Keap1 mutations, could be a promising strategy to inhibit tumor growth and circumvent chemoresistance...
- Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..However, measurements of such imbalances are difficult. We used a new, quantitative approach to investigate the prognostic value of chromosome imbalances in early-stage colorectal cancers...
- A blinded, crossover study of the efficacy of the ketogenic dietJohn M Freeman
Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Baltimore, Maryland, USA
Epilepsia 50:322-5. 2009..5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm...
- Lung cancer screening with helical computed tomography in older adult smokers: a decision and cost-effectiveness analysisParthiv J Mahadevia
Robert Wood Johnson Clinical Scholars Program, Johns Hopkins School of Medicine, Baltimore, MD, USA
JAMA 289:313-22. 2003..Encouraged by direct-to-consumer marketing, smokers and their physicians are contemplating lung cancer screening with a promising but unproven imaging procedure, helical computed tomography (CT)...
- Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic reviewChristine A Szekely
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Neuroepidemiology 23:159-69. 2004..The purpose of this meta-analysis is to summarize and evaluate available evidence regarding exposure to nonaspirin NSAIDs and risk of Alzheimer's disease using meta-analyses of published studies...
- How statistical expertise is used in medical researchDouglas G Altman
Centre for Statistics in Medicine, Cancer Research UK NHS, Institute of Health Sciences, Old Rd, Headington, Oxford OX3 7LF, England
JAMA 287:2817-20. 2002..Investigation of the nature and frequency of statistician involvement in medical research and its relation to the final editorial decision...
- Acne therapy: a methodologic reviewHarold P Lehmann
Department of Pediatrics, Johns Hopkins School of Medicine and Bloomberg School of Public Health, USA
J Am Acad Dermatol 47:231-40. 2002..Therefore, we performed an evidence review to provide researchers a basis for further studies, and to provide clinicians the background needed to interpret current and future clinical studies...
- Toward protecting the safety of participants in clinical trialsRobert M Califf
Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
Control Clin Trials 24:256-71. 2003..DMC composition and functions should be standardized and regulations should be harmonized nationally and internationally. Finally, there should be a concerted effort to study the efficacy of various components of the system...
- The mammography dilemma: a crisis for evidence-based medicine?Steven N Goodman
Ann Intern Med 137:363-5. 2002
- Ethics and evidence in clinical trialsSteven N Goodman
Clin Trials 2:195-6. 2005