- MOV10 RNA helicase is a potent inhibitor of retrotransposition in cellsJohn L Goodier
McKusick Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS Genet 8:e1002941. 2012..With homologs in other vertebrates, insects, and plants, MOV10 may represent an ancient and innate form of immunity against both infective viruses and endogenous retroelements...
- Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotranspositionJohn L Goodier
McKusick Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine
Nucleic Acids Res 41:7401-19. 2013..These data suggest candidate cofactors that interact with the L1 to modulate its activity and increase our understanding of the means by which the cell coexists with these genomic 'parasites'. ..
- The Broad-Spectrum Antiviral Protein ZAP Restricts Human RetrotranspositionJohn L Goodier
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS Genet 11:e1005252. 2015..The association of the ZAP ribonucleoprotein particle with many interferon-stimulated gene products indicates it may be a key player in the interferon response...