Jonathan E Golub

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc AIDS-related tuberculosis in Rio de Janeiro, Brazil
    Antonio G Pacheco
    ENSP PROCC, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e3132. 2008
  2. doi request reprint Screening for active tuberculosis: methodological challenges in implementation and evaluation
    J E Golub
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Tuberc Lung Dis 17:856-65. 2013
  3. pmc Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules
    Stanzi M le Roux
    School of Child and Adolescent Health, University of Cape Town, South Africa
    BMC Med 7:67. 2009
  4. pmc Long-term effectiveness of diagnosing and treating latent tuberculosis infection in a cohort of HIV-infected and at-risk injection drug users
    Jonathan E Golub
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 49:532-7. 2008
  5. doi request reprint George W. Comstock--always a teacher
    Jonathan E Golub
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 168:669-70. 2008
  6. pmc Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort
    Jonathan E Golub
    Johns Hopkins University, School of Medicine, 1550 Orleans St, 1M 07 Baltimore, MD 21231, USA
    AIDS 23:631-6. 2009
  7. ncbi request reprint Delayed tuberculosis diagnosis and tuberculosis transmission
    J E Golub
    School of Medicine, Johns Hopkins University, 1820 Lancaster St, Suite 300, Baltimore, MD 21231, USA
    Int J Tuberc Lung Dis 10:24-30. 2006
  8. ncbi request reprint Active case finding of tuberculosis: historical perspective and future prospects
    J E Golub
    School of Medicine, Johns Hopkins University, 1820 Lancaster St, Suite 300, Baltimore, MD 21231, USA
    Int J Tuberc Lung Dis 9:1183-203. 2005
  9. ncbi request reprint Patient and health care system delays in pulmonary tuberculosis diagnosis in a low-incidence state
    J E Golub
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Int J Tuberc Lung Dis 9:992-8. 2005
  10. ncbi request reprint Impact of empiric antibiotics and chest radiograph on delays in the diagnosis of tuberculosis
    J E Golub
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Int J Tuberc Lung Dis 9:392-7. 2005

Research Grants

  1. Epidemiologic Strategies for Tuberculosis Control
    Jonathan Golub; Fiscal Year: 2007

Collaborators

Detail Information

Publications35

  1. pmc AIDS-related tuberculosis in Rio de Janeiro, Brazil
    Antonio G Pacheco
    ENSP PROCC, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e3132. 2008
    ..We studied the incidence of tuberculosis, AIDS, AIDS deaths and AIDS-TB co-infection at the population level in Rio de Janeiro, Brazil where universal and free access to combination antiretroviral therapy has been available since 1997...
  2. doi request reprint Screening for active tuberculosis: methodological challenges in implementation and evaluation
    J E Golub
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Tuberc Lung Dis 17:856-65. 2013
    ..In this review, we provide a discussion of these challenges to help guide development of TB screening strategies that will be effective in a given epidemiological setting...
  3. pmc Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules
    Stanzi M le Roux
    School of Child and Adolescent Health, University of Cape Town, South Africa
    BMC Med 7:67. 2009
    ..We investigated adherence to isoniazid prophylaxis administered daily, compared to three times a week, and predictors of adherence amongst HIV-infected children...
  4. pmc Long-term effectiveness of diagnosing and treating latent tuberculosis infection in a cohort of HIV-infected and at-risk injection drug users
    Jonathan E Golub
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 49:532-7. 2008
    ..Between 1990 and 1998, tuberculin skin tests (TST) and isoniazid preventive therapy (IPT) were provided to injection drug users participating in the AIDS Linked to the Intravenous Experiences cohort...
  5. doi request reprint George W. Comstock--always a teacher
    Jonathan E Golub
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am J Epidemiol 168:669-70. 2008
  6. pmc Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort
    Jonathan E Golub
    Johns Hopkins University, School of Medicine, 1550 Orleans St, 1M 07 Baltimore, MD 21231, USA
    AIDS 23:631-6. 2009
    ..There is less information on the combined effect of IPT and HAART. We assessed the effect of IPT, HAART or both IPT and HAART on tuberculosis incidence in HIV-infected adults in South Africa...
  7. ncbi request reprint Delayed tuberculosis diagnosis and tuberculosis transmission
    J E Golub
    School of Medicine, Johns Hopkins University, 1820 Lancaster St, Suite 300, Baltimore, MD 21231, USA
    Int J Tuberc Lung Dis 10:24-30. 2006
    ..Tuberculosis (TB) patients and their close contacts reported to the Maryland Department of Health and Mental Hygiene from 1 June 2000 to 30 November 2001...
  8. ncbi request reprint Active case finding of tuberculosis: historical perspective and future prospects
    J E Golub
    School of Medicine, Johns Hopkins University, 1820 Lancaster St, Suite 300, Baltimore, MD 21231, USA
    Int J Tuberc Lung Dis 9:1183-203. 2005
    ..The report concludes with a discussion and recommendations for future case finding strategies. Understanding the strengths and weaknesses of these methods will help inform and shape ACF as a TB control policy in the twenty-first century...
  9. ncbi request reprint Patient and health care system delays in pulmonary tuberculosis diagnosis in a low-incidence state
    J E Golub
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Int J Tuberc Lung Dis 9:992-8. 2005
    ..Tuberculosis (TB) patients reported to the Maryland Department of Health and Mental Hygiene from 1 June 2000 to 30 November 2001...
  10. ncbi request reprint Impact of empiric antibiotics and chest radiograph on delays in the diagnosis of tuberculosis
    J E Golub
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Int J Tuberc Lung Dis 9:392-7. 2005
    ..Maryland Department of Health and Mental Hygiene, Division of Tuberculosis (TB) Control...
  11. pmc Recurrent tuberculosis in HIV-infected patients in Rio de Janeiro, Brazil
    Jonathan E Golub
    Johns Hopkins University, School of Medicine, Baltimore, Maryland 21231, USA
    AIDS 22:2527-33. 2008
    ..We measured the frequency of and determined risk factors for recurrent tuberculosis in a cohort of HIV-infected patients in Rio de Janeiro, Brazil...
  12. pmc The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil
    Jonathan E Golub
    Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland 21231, USA
    AIDS 21:1441-8. 2007
    ..Antiretroviral therapy (ART) lowers the risk of tuberculosis, but may not be sufficient to control HIV-related tuberculosis. Isoniazid preventive therapy (IPT) reduces tuberculosis incidence significantly, but is not widely used...
  13. pmc Effect of improved tuberculosis screening and isoniazid preventive therapy on incidence of tuberculosis and death in patients with HIV in clinics in Rio de Janeiro, Brazil: a stepped wedge, cluster-randomised trial
    Betina Durovni
    Municipal Health Secretariat, Rio de Janeiro, Brazil Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Lancet Infect Dis 13:852-8. 2013
    ..We assessed the effect of widespread use of isoniazid preventive therapy on rates of tuberculosis and death in people with HIV in Brazil...
  14. pmc The implementation of isoniazid preventive therapy in HIV clinics: the experience from the TB/HIV in Rio (THRio) study
    Betina Durovni
    Municipal Health Secretariat, Rio de Janeiro, Rio de Janeiro, Brazil
    AIDS 24:S49-56. 2010
    ..The TB/HIV in Rio (THRio) study was launched in September 2005 to assess the impact of integrated tuberculosis (TB) and HIV treatment strategies in 29 HIV clinics in Rio de Janeiro, Brazil...
  15. ncbi request reprint Statistical design of THRio: a phased implementation clinic-randomized study of a tuberculosis preventive therapy intervention
    Lawrence H Moulton
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 20912, USA
    Clin Trials 4:190-9. 2007
    ..In practice, although Brazil is a model for provision of antiretroviral therapy to patients with advanced HIV disease, relatively few such patients receive TB testing and prevention services...
  16. pmc Estimating the extent of underreporting of mortality among HIV-infected individuals in Rio de Janeiro, Brazil
    Antonio G Pacheco
    FIOCRUZ, Rio de Janeiro, Brazil
    AIDS Res Hum Retroviruses 27:25-8. 2011
    ....
  17. pmc A comparative analysis of clinical and molecular factors with the stage of cervical cancer in a Brazilian cohort
    Sergio M Amaro-Filho
    Laboratory of Interdisciplinary Medical Research LIPMED, IOC FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 8:e57810. 2013
    ..Cell cycle protein expression plays an important role in the pathophysiology of cervical cancer. However, few studies have attempted to correlate the use of these biomarkers with the clinical progression of the tumor...
  18. pmc Impact and cost-effectiveness of culture for diagnosis of tuberculosis in HIV-infected Brazilian adults
    David W Dowdy
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 3:e4057. 2008
    ....
  19. pmc Body mass index and risk of tuberculosis and death
    Colleen F Hanrahan
    Johns Hopkins Bloomberg School of Public Heath, Baltimore, Maryland, USA
    AIDS 24:1501-8. 2010
    ..We examined the effect of BMI on all-cause mortality and TB incidence among a cohort of HIV-infected adults in Soweto, South Africa...
  20. doi request reprint Community-based targeted case finding for tuberculosis and HIV in household contacts of patients with tuberculosis in South Africa
    Adrienne E Shapiro
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Respir Crit Care Med 185:1110-6. 2012
    ..South Africa has a high prevalence of tuberculosis (TB) and HIV-coinfected adults in whom TB is often diagnosed late in the course of disease...
  21. ncbi request reprint Impact of isoniazid preventive therapy for HIV-infected adults in Rio de Janeiro, Brazil: an epidemiological model
    David W Dowdy
    Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Subsecretariat for Primary Care, Surveillance, and Health Promotion, Municipal Health Secretariat, Rio de Janeiro, Brazil Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Program of Scientific Computing, FIOCRUZ, Rio de Janeiro, Brazil Evandro Chagas Institute of Clinical Research, FIOCRUZ, Rio de Janeiro, Brazil and Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 66:552-8. 2014
    ..The potential epidemiological impact of isoniazid preventive therapy (IPT), delivered at levels that could be feasibly scaled up among people living with HIV (PLHIV) in modern, moderate-burden settings, remains uncertain...
  22. pmc Evaluation of MCM-2 expression in TMA cervical specimens
    Alcina F Nicol
    Laboratory Interdisciplinary of Medical Research, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
    PLoS ONE 7:e32936. 2012
    ..The need for biological markers for cervical carcinoma and its precursor lesions is emerging. Our main aim was to determine the immunohistochemical expression of MCM-2 in HIV-positive and -negative dysplastic cervical specimens...
  23. pmc The impact of expanded testing for multidrug resistant tuberculosis using genotype [correction of geontype] MTBDRplus in South Africa: an observational cohort study
    Colleen F Hanrahan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    PLoS ONE 7:e49898. 2012
    ..We assessed the clinical impact of routine DST using MTBDRplus in a single health district in South Africa...
  24. pmc Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis
    Kelly E Dooley
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Trop Med Hyg 80:634-9. 2009
    ..51). In conclusion, DM was a risk factor for death in Maryland TB patients. There was a trend toward increased time to culture conversion; two-month culture conversion proportions, however, were similar...
  25. pmc Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting
    Maunank Shah
    Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 52:145-51. 2009
    ..Effective tuberculosis (TB) control in HIV-prevalent settings is hindered by absence of accurate, rapid TB diagnostic tests. We evaluated the accuracy of a urine lipoarabinomannan (LAM) test for TB diagnosis in South Africa...
  26. pmc Point-of-care Arkansas method for measuring adherence to treatment with isoniazid
    Renata L Guerra
    Tuberculosis Clinical Research Laboratory, Institute of Thoracic Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Respir Med 104:754-7. 2010
    ..This test accurately detected INH metabolites 24h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure...
  27. pmc Heterogeneity in tuberculosis transmission and the role of geographic hotspots in propagating epidemics
    David W Dowdy
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:9557-62. 2012
    ..Achieving TB control targets in a hotspot containing 6% of a city's population can have similar impact on city-wide TB incidence as achieving the same targets throughout the remaining community...
  28. ncbi request reprint Transmission of Mycobacterium tuberculosis through casual contact with an infectious case
    J E Golub
    Department of Epidemiology, The Johns Hopkins University, 424 N Bond St, Baltimore, MD 21231-1001, USA
    Arch Intern Med 161:2254-8. 2001
    ..In addition, this outbreak emphasizes the importance of DNA fingerprinting data for identifying unusual transmission in unexpected settings...
  29. pmc Molecular epidemiology of tuberculosis in a low- to moderate-incidence state: are contact investigations enough?
    Wendy A Cronin
    Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 21201, USA
    Emerg Infect Dis 8:1271-9. 2002
    ..8 vs. 8.5 weeks, respectively; p<0.01). Molecular epidemiologic studies showed that reducing diagnostic delays can prevent TB transmission in nontraditional settings, which elude contact investigations...
  30. ncbi request reprint AIDS-related Kaposi's sarcoma in Brazil: trends and geopolitical distribution
    Valeria Saraceni
    Rio de Janeiro City Health Secretariat, Rio de Janeiro, Brazil
    Int J Dermatol 52:1525-9. 2013
    ..The goal was to determine the distribution of KS cases among Brazilian geopolitical regions, looking at the ecological relationship with median CD4 cell count...
  31. ncbi request reprint An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
    Alcina F Nicol
    Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Mem Inst Oswaldo Cruz 107:571-7. 2012
    ..HIV-1 infection, however, is associated with relatively reduced p16(INK4a) expression in CIN 2-3...
  32. pmc Lower levels of interleukin-12 precede the development of tuberculosis among HIV-infected women
    Jose Bordon
    Department of Medicine, Section of Infectious Diseases, Providence Hospital, and Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
    Cytokine 56:325-31. 2011
    ....
  33. ncbi request reprint Evaluation of an extensive tuberculosis contact investigation in an urban community and jail
    S Bur
    Division of Tuberculosis Control, Refugee and Migrant Health, Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 21201, USA
    Int J Tuberc Lung Dis 7:S417-23. 2003
    ..Urban community and jail...
  34. ncbi request reprint Controlled trial of active tuberculosis case finding in a Brazilian favela
    A C Miller
    Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA
    Int J Tuberc Lung Dis 14:720-6. 2010
    ..A large, impoverished squatters' settlement (favela), Rio de Janeiro, Brazil...
  35. ncbi request reprint New approaches to reduce Staphylococcus aureus nosocomial infection rates: treating S. aureus nasal carriage
    T M Perl
    School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Ann Pharmacother 32:S7-16. 1998
    ..Staphylococcus aureus has long been recognized as an important pathogen in human disease and is the most common cause of nosocomial infections...

Research Grants2

  1. Epidemiologic Strategies for Tuberculosis Control
    Jonathan Golub; Fiscal Year: 2007
    ..This K01 award will provide the epidemiological training and experience necessary to become a successful, independent public health investigator. ..