Michael G Goggins
Affiliation: Johns Hopkins University
Poruk K, Griffin J, Makary M, He J, Cameron J, Weiss M, et al
. Blood Type as a Predictor of High-Grade Dysplasia and Associated Malignancy in Patients with Intraductal Papillary Mucinous Neoplasms. J Gastrointest Surg. 2018;: pubmed publisher
..These results indicate blood group status may have different effects on the risk and progression of IPMNs. ..
Akshintala V, Talukdar R, Singh V, Goggins M. The Gut Microbiome in Pancreatic Disease. Clin Gastroenterol Hepatol. 2018;: pubmed publisher
..Further mechanistic and epidemiological studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value. ..
Eshleman J, Norris A, Sadakari Y, Debeljak M, Borges M, Harrington C, et al
. KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Clin Gastroenterol Hepatol. 2015;13:963-9.e4 pubmed publisher
..Mutations detected in individuals without pancreatic abnormalities, based on imaging analyses, likely arise from small pancreatic intraepithelial neoplasia lesions. ClinicalTrials.gov no: NCT00438906 and NCT00714701. ..
Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, et al
. Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A. 2018;115:4767-4772 pubmed publisher
..Our study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. ..
Hata T, Suenaga M, Marchionni L, Macgregor Das A, Yu J, Shindo K, et al
. Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia. Am J Pathol. 2018;188:1723-1733 pubmed publisher
..HG-PanIN harbors widespread copy number alterations and commonly shows evidence of biallelic inactivation of CDKN2A and TP53 but not SMAD4. Chromothripsis events contribute to the copy number alterations of HG-PanIN. ..
Hata T, Dal Molin M, Suenaga M, Yu J, Pittman M, Weiss M, et al
. Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas. Clin Cancer Res. 2016;22:5141-5151 pubmed
..Cyst fluid telomerase activity can be a useful predictor of the neoplastic grade of pancreatic cysts. Clin Cancer Res; 22(20); 5141-51. Â©2016 AACRSee related commentary by Allen et al., p. 4966. ..
Suenaga M, Yu J, Shindo K, Tamura K, Almario J, Zaykoski C, et al
. Pancreatic Juice Mutation Concentrations Can Help Predict the Grade of Dysplasia in Patients Undergoing Pancreatic Surveillance. Clin Cancer Res. 2018;24:2963-2974 pubmed publisher
..i>Clin Cancer Res; 24(12); 2963-74. ©2018 AACRSee related commentary by Lipner and Yeh, p. 2713. ..
Dal Molin M, Blackford A, Siddiqui A, Brant A, Cho C, Rezaee N, et al
. Duodenal Involvement is an Independent Prognostic Factor for Patients with Surgically Resected Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2017;24:2379-2386 pubmed publisher
..67). Inclusion of duodenal involvement in the staging of PDAC adds independent prognostic information. ..
Goggins M. Identifying molecular markers for the early detection of pancreatic neoplasia. Semin Oncol. 2007;34:303-10 pubmed
..As we continue to characterize the genetic, epigenetic, and proteomics alterations that occur in pancreatic cancers and their percursors, better diagnostic markers of pancreatic cancer are expected to follow...