Fernando S Goes

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genome-wide association of mood-incongruent psychotic bipolar disorder
    F S Goes
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Transl Psychiatry 2:e180. 2012
  2. pmc Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder
    F S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1449-59. 2012
  3. pmc Exonic DNA sequencing of ERBB4 in bipolar disorder
    Fernando S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20242. 2011
  4. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
  5. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
  6. pmc Systematic review of genome-wide gene expression studies of bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BMC Psychiatry 13:213. 2013
  7. pmc Association study of serotonin pathway genes in attempted suicide
    Jennifer T Judy
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012
  8. pmc Meta-analysis of genetic association studies on bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:508-18. 2012
  9. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
  10. pmc Case-control association study of TGOLN2 in attempted suicide
    Pamela B Mahon
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010

Detail Information

Publications21

  1. pmc Genome-wide association of mood-incongruent psychotic bipolar disorder
    F S Goes
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Transl Psychiatry 2:e180. 2012
    ..The results of our polygenic analysis provides support for a modest degree of genetic overlap between BP with MICP and SZ, highlighting that phenotypic correlations across syndromes may be due to the influence of polygenic risk factors...
  2. pmc Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder
    F S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Psychol Med 42:1449-59. 2012
    ..This study investigates clinical correlates and familiality of four anxiety disorders in a large sample of bipolar disorder (BP) and major depressive disorder (MDD) pedigrees...
  3. pmc Exonic DNA sequencing of ERBB4 in bipolar disorder
    Fernando S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20242. 2011
    ..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association...
  4. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    ....
  5. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  6. pmc Systematic review of genome-wide gene expression studies of bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BMC Psychiatry 13:213. 2013
    ..These studies are heterogeneous, underpowered and use overlapping samples. We conducted a systematic review of these studies to synthesize the current findings...
  7. pmc Association study of serotonin pathway genes in attempted suicide
    Jennifer T Judy
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012
    ..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior...
  8. pmc Meta-analysis of genetic association studies on bipolar disorder
    Fayaz Seifuddin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 159:508-18. 2012
    ..The results of this meta-analysis and from other on-going genomic experiments in BP are available online at Metamoodics (http://metamoodics.igm.jhmi.edu)...
  9. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  10. pmc Case-control association study of TGOLN2 in attempted suicide
    Pamela B Mahon
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1016-23. 2010
    ..Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders...
  11. pmc Family-based association of YWHAH in psychotic bipolar disorder
    Deepak Grover
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009
    ....
  12. ncbi request reprint The genetics of psychotic bipolar disorder
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe Street, Meyer 4 119, Baltimore, MD 21287, USA
    Curr Psychiatry Rep 10:178-89. 2008
    ..These tentative results are consistent with the hypothesis that the subphenotype of psychotic BP may represent a clinical manifestation of "overlap" genes between schizophrenia and mood disorder syndromes...
  13. ncbi request reprint Psychotic features in bipolar and unipolar depression
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Bipolar Disord 9:901-6. 2007
    ..We examined the relationship of psychotic depression to polarity in several large familial samples of mood disorder...
  14. pmc A hybrid likelihood model for sequence-based disease association studies
    Yun Ching Chen
    Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Genet 9:e1003224. 2013
    ..05, of which one MAPK signaling pathway (KEGG) reaches trend-level significance after correcting for multiple testing...
  15. pmc Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011
    ..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles...
  16. ncbi request reprint Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Am J Med Genet B Neuropsychiatr Genet 165:326-36. 2014
    ..Specific regions of chromosomes 12 and X are linked to OCD in high-PRS families. Thus, pragmatic impairment may distinguish a clinically and genetically homogeneous subtype of OCD...
  17. pmc Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder
    Jennifer Toolan Judy
    Department of Psychiatry, Johns Hopkins School of Medicine Baltimore, MD, USA
    Front Genet 4:87. 2013
    ..The interactions between ANK3 and KCNQ2 merit further investigation, and if confirmed, may motivate a new line of research into a novel therapeutic target for BP...
  18. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  19. pmc SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studies
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Source Code Biol Med 8:8. 2013
    ..Using SVA increases the biological accuracy and reproducibility of gene expression studies by identifying these sources of heterogeneity and correctly accounting for them in the analysis...
  20. pmc SynaptomeDB: an ontology-based knowledgebase for synaptic genes
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA
    Bioinformatics 28:897-9. 2012
    ..However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking...
  21. doi request reprint Separation anxiety disorder in OCD
    Megan M Mroczkowski
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 1629 Thames Street, Baltimore, MD 21287, USA
    Depress Anxiety 28:256-62. 2011
    ..The purpose of this study was to determine if there are clinical differences between OCD-affected individuals with, versus without, a history of SAD...