Research Topics
Species | Kristine GlundeSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Choline metabolism in malignant transformationKristine Glunde
The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, The Russell H Morgan Department of Radiology and Radiological Science, 720 Rutland Avenue, Baltimore, MD 21205, USA
Nat Rev Cancer 11:835-48. 2011..Furthermore, enzymes of choline metabolism, such as choline kinase, present novel targets for image-guided cancer therapy...
Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolismKristine Glunde
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 212 Traylor Building Baltimore, MD 21205, USA
Pharmacogenomics 7:1109-23. 2006....- Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic?Kristine Glunde
JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Mol Med 12:187-8. 2008 - Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumorsKristine Glunde
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Bioconjug Chem 16:843-51. 2005..We also demonstrated the feasibility of performing in vivo fluorescence imaging of 6'-O-lissamine-rhodamine B-glucosamine to image lysosomes in human breast cancer models... - Choline metabolism in cancer: implications for diagnosis and therapyKristine Glunde
The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Sciences and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
Expert Rev Mol Diagn 6:821-9. 2006.... 
MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancerKristine Glunde
Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 24:673-90. 2011..The emerging roles of MRS and MRSI in the development and detection of novel targeted anticancer therapies that target oncogenic signaling pathways or markers in choline or glucose metabolism are discussed...- Metabolic tumor imaging using magnetic resonance spectroscopyKristine Glunde
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Semin Oncol 38:26-41. 2011.... - Glucosamine-bound near-infrared fluorescent probes with lysosomal specificity for breast tumor imagingCong Li
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neoplasia 10:389-98. 2008..They are promising for diagnosing malignant lesions and may provide a means for evaluating and monitoring future lysosome-targeted anticancer therapies... - Hypoxic tumor microenvironments reduce collagen I fiber densitySamata M Kakkad
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neoplasia 12:608-17. 2010..These results suggest that hypoxia mediates Col1 fiber restructuring in tumors, which may impact delivery of macromolecular agents as well as dissemination of cells... - Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cellsTariq Shah
JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 23:633-42. 2010.... - Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cellsNoriko Mori
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 67:11284-90. 2007..Chk down-regulation with siRNA-chk may provide a novel alternative to enhance the effect of anticancer drugs in malignant cells... - Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograftBalaji Krishnamachary
Johns Hopkins University In Vivo Cellular Molecular Imaging Center Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 69:3464-71. 2009..This study shows the use of lentiviral vectors to target chk in a human breast cancer xenograft and noninvasive MRS detection of this targeting... - Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor modelsLu Jiang
The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Division of Cancer Imaging Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neoplasia 14:732-41. 2012..Our findings demonstrate that noninvasive MRSI can help delineate hypoxic regions in solid tumors by means of detecting the metabolic outcome of tumor hypoxia, which is characterized by elevated tCho and lipid CH3... - PSMA-targeted theranostic nanoplex for prostate cancer therapyZhihang Chen
JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
ACS Nano 6:7752-62. 2012..The nanoplex platform described can be easily modified and applied to different cancers, receptors, and pathways to achieve theranostic imaging, as a single agent or in combination with other treatment modalities... - Choline phospholipid metabolism: a target in cancer cells?Ellen Ackerstaff
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Cell Biochem 90:525-33. 2003..In this article, we have summarized some of the observations on the choline phospholipid metabolism of cancer cells and tumors, and make a case for targeting the aberrant choline phospholipid metabolism of cancer cells... - Extracellular acidification alters lysosomal trafficking in human breast cancer cellsKristine Glunde
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neoplasia 5:533-45. 2003..Filopodia formations, which were observed more frequently in highly metastatic breast cancer cells maintained at acidic pH(e), may also contribute to invasion... - Applications of molecular MRI and optical imaging in cancerMarie France Penet
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Future Med Chem 2:975-88. 2010..Here we have selected examples of MRI and optical imaging, to demonstrate how integrating imaging with novel probes can facilitate the successful treatment of this multifaceted disease... - Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cellsKristine Glunde
MR Oncology Section, Division of MR Research, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neoplasia 8:758-71. 2006.... - Molecular and functional imaging of cancer: advances in MRI and MRSArvind P Pathak
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Methods Enzymol 386:3-60. 2004 - Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancerMaria D Cao
The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 25:1033-42. 2012..Our study identified GDPD5 as a GPC-PDE that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with CHKA and PLD1... - Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer modelKristine Glunde
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 68:172-80. 2008..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments... - Pharmacodynamic markers for choline kinase down-regulation in breast cancer cellsSridhar Nimmagadda
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21231, USA
Neoplasia 11:477-84. 2009.... - Molecular causes of the aberrant choline phospholipid metabolism in breast cancerKristine Glunde
Magnetic Resonance Oncology Section, Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 64:4270-6. 2004..These observations were consistent with the overexpression of choline kinase and phospholipase C detected in the microarray analyses... - Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventionsKristine Glunde
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Pharm 3:496-506. 2006..In this contextual review, we have outlined the insight we have gained from these studies and have discussed some of the enzymes and pathways that may present novel targets for pharmaceutical interventions in cancer... - Molecular and functional MRI of the tumor microenvironmentMarie-France Penet
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Nucl Med 49:687-90. 2008 - Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cellsIoannis Stasinopoulos
Department of Radiology, The Johns Hopkins University School of Medicine, Room 208C, Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Mol Cancer Res 5:435-42. 2007..These data show that silencing of COX-2 abolishes the metastatic potential of MDA-MB-231 cells in vivo... - Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft modelLu Jiang
The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 26:285-98. 2013..Three-dimensional human breast tumor datasets were successfully reconstructed and fused with this platform... - Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironmentsWei Liu
Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
Cancer Res 72:3677-86. 2012..Together, our findings offer new insights into the metabolic reprogramming of tumor cells present within a hostile microenvironment and suggest that proline metabolism is a potential target for cancer therapeutics... - RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferationKristine Glunde
John Hopkins University In Vivo Cellular Molecular Imaging Center Program, Russell H. Morgan Department of Radiology and Radiological Science, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 65:11034-43. 2005..These results strongly support the targeting of choline kinase in breast cancer cells with RNAi and show the potential ability of noninvasive MRS to detect and evaluate future treatments incorporating such strategies... - Exploiting the tumor microenvironment for theranostic imagingIoannis Stasinopoulos
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
NMR Biomed 24:636-47. 2011.... - A novel method of imaging lysosomes in living human mammary epithelial cellsKristine Glunde
Johns Hopkins University School of Medicine, 208C Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Mol Imaging 2:24-36. 2003..This novel method of labeling lysosomes biosynthetically was used to image lysosomes in living HMECs perfused in a microscopy-compatible cell perfusion system... - Magnetic resonance imaging and spectroscopy of transgenic models of cancerVenu Raman
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
NMR Biomed 20:186-99. 2007.... - Collagen I fiber density increases in lymph node positive breast cancers: pilot studySamata M Kakkad
The Johns Hopkins University School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, Maryland, USA
J Biomed Opt 17:116017. 2012..High Col1 fiber density in primary breast tumors is associated with breast cancer metastasis and may serve as an imaging biomarker of metastasis... - Prostaglandin E2 promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cellsIoannis Stasinopoulos
JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD 21205, USA
Prostaglandins Other Lipid Mediat 99:9-14. 2012..Further, we demonstrate that, like parental COX-2 containing MDA-MB-231 cells, COX-2-silenced cells maintain nuclear localization of β-catenin... - Synthesis and characterization of glucosamine-bound near-infrared probes for optical imagingCong Li
JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Org Lett 8:3623-6. 2006..In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines... - Molecular-functional imaging of cancer: to image and imagineKristine Glunde
JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Trends Mol Med 13:287-97. 2007.... - Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacinKristine Glunde
MR Oncology Section, Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 48:819-25. 2002..These changes were not related to alterations of intra- or extracellular pH... - Choline kinase alpha in cancer prognosis and treatmentKristine Glunde
Lancet Oncol 8:855-7. 2007 - Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cellsKristine Glunde
Department of Chemistry, University of Bremen, Bremen, Germany
J Neurochem 80:36-44. 2002..NHE-1 inhibition with HOE642 during acidification caused exacerbated metabolic disorders which were prolonged during extracellular pH recovery. However, NHE-1 inhibition during hypoxia protected the energy state of glial cells...
Research Grants
- Imaging lysosomes to predict metastasis in breast cancerKristine Glunde; Fiscal Year: 2006..Disruption of lysosomal trafficking may prove useful, therapeutically, to prevent metastasic disease. ..
- Imaging hypoxia-driven signaling pathways in the breast tumor microenvironmentKristine Glunde; Fiscal Year: 2010..Such hypoxia-related biomolecules may, in the future, provide novel molecular targets for innovative hypoxia-targeted breast cancer therapies. ..