Kristine Glunde

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Choline metabolism in malignant transformation
    Kristine Glunde
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, The Russell H Morgan Department of Radiology and Radiological Science, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Nat Rev Cancer 11:835-48. 2011
  2. ncbi request reprint Choline metabolism in cancer: implications for diagnosis and therapy
    Kristine Glunde
    The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Sciences and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Expert Rev Mol Diagn 6:821-9. 2006
  3. ncbi request reprint Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
    Kristine Glunde
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 212 Traylor Building Baltimore, MD 21205, USA
    Pharmacogenomics 7:1109-23. 2006
  4. ncbi request reprint Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic?
    Kristine Glunde
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 12:187-8. 2008
  5. ncbi request reprint Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Bioconjug Chem 16:843-51. 2005
  6. pmc Metabolic tumor imaging using magnetic resonance spectroscopy
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Semin Oncol 38:26-41. 2011
  7. pmc MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer
    Kristine Glunde
    Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 24:673-90. 2011
  8. pmc Hypoxic tumor microenvironments reduce collagen I fiber density
    Samata M Kakkad
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 12:608-17. 2010
  9. pmc Glucosamine-bound near-infrared fluorescent probes with lysosomal specificity for breast tumor imaging
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 10:389-98. 2008
  10. pmc Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells
    Tariq Shah
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 23:633-42. 2010

Detail Information

Publications41

  1. doi request reprint Choline metabolism in malignant transformation
    Kristine Glunde
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, The Russell H Morgan Department of Radiology and Radiological Science, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Nat Rev Cancer 11:835-48. 2011
    ..Furthermore, enzymes of choline metabolism, such as choline kinase, present novel targets for image-guided cancer therapy...
  2. ncbi request reprint Choline metabolism in cancer: implications for diagnosis and therapy
    Kristine Glunde
    The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Sciences and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Expert Rev Mol Diagn 6:821-9. 2006
    ....
  3. ncbi request reprint Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
    Kristine Glunde
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 212 Traylor Building Baltimore, MD 21205, USA
    Pharmacogenomics 7:1109-23. 2006
    ....
  4. ncbi request reprint Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic?
    Kristine Glunde
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 12:187-8. 2008
  5. ncbi request reprint Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Bioconjug Chem 16:843-51. 2005
    ..We also demonstrated the feasibility of performing in vivo fluorescence imaging of 6'-O-lissamine-rhodamine B-glucosamine to image lysosomes in human breast cancer models...
  6. pmc Metabolic tumor imaging using magnetic resonance spectroscopy
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Semin Oncol 38:26-41. 2011
    ....
  7. pmc MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer
    Kristine Glunde
    Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 24:673-90. 2011
    ..The emerging roles of MRS and MRSI in the development and detection of novel targeted anticancer therapies that target oncogenic signaling pathways or markers in choline or glucose metabolism are discussed...
  8. pmc Hypoxic tumor microenvironments reduce collagen I fiber density
    Samata M Kakkad
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 12:608-17. 2010
    ..These results suggest that hypoxia mediates Col1 fiber restructuring in tumors, which may impact delivery of macromolecular agents as well as dissemination of cells...
  9. pmc Glucosamine-bound near-infrared fluorescent probes with lysosomal specificity for breast tumor imaging
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 10:389-98. 2008
    ..They are promising for diagnosing malignant lesions and may provide a means for evaluating and monitoring future lysosome-targeted anticancer therapies...
  10. pmc Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells
    Tariq Shah
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 23:633-42. 2010
    ....
  11. ncbi request reprint Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells
    Noriko Mori
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 67:11284-90. 2007
    ..Chk down-regulation with siRNA-chk may provide a novel alternative to enhance the effect of anticancer drugs in malignant cells...
  12. pmc Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft
    Balaji Krishnamachary
    Johns Hopkins University In Vivo Cellular Molecular Imaging Center Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 69:3464-71. 2009
    ..This study shows the use of lentiviral vectors to target chk in a human breast cancer xenograft and noninvasive MRS detection of this targeting...
  13. pmc Localized hypoxia results in spatially heterogeneous metabolic signatures in breast tumor models
    Lu Jiang
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Division of Cancer Imaging Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 14:732-41. 2012
    ..Our findings demonstrate that noninvasive MRSI can help delineate hypoxic regions in solid tumors by means of detecting the metabolic outcome of tumor hypoxia, which is characterized by elevated tCho and lipid CH3...
  14. pmc PSMA-targeted theranostic nanoplex for prostate cancer therapy
    Zhihang Chen
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
    ACS Nano 6:7752-62. 2012
    ..The nanoplex platform described can be easily modified and applied to different cancers, receptors, and pathways to achieve theranostic imaging, as a single agent or in combination with other treatment modalities...
  15. pmc Extracellular acidification alters lysosomal trafficking in human breast cancer cells
    Kristine Glunde
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 5:533-45. 2003
    ..Filopodia formations, which were observed more frequently in highly metastatic breast cancer cells maintained at acidic pH(e), may also contribute to invasion...
  16. ncbi request reprint Choline phospholipid metabolism: a target in cancer cells?
    Ellen Ackerstaff
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biochem 90:525-33. 2003
    ..In this article, we have summarized some of the observations on the choline phospholipid metabolism of cancer cells and tumors, and make a case for targeting the aberrant choline phospholipid metabolism of cancer cells...
  17. pmc Characterization of choline kinase in human endothelial cells
    Noriko Mori
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    NMR Biomed 26:1501-7. 2013
    ....
  18. ncbi request reprint Molecular and functional imaging of cancer: advances in MRI and MRS
    Arvind P Pathak
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:3-60. 2004
  19. pmc Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells
    Kristine Glunde
    MR Oncology Section, Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 8:758-71. 2006
    ....
  20. pmc Applications of molecular MRI and optical imaging in cancer
    Marie France Penet
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Future Med Chem 2:975-88. 2010
    ..Here we have selected examples of MRI and optical imaging, to demonstrate how integrating imaging with novel probes can facilitate the successful treatment of this multifaceted disease...
  21. ncbi request reprint Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft model
    Lu Jiang
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 26:285-98. 2013
    ..Three-dimensional human breast tumor datasets were successfully reconstructed and fused with this platform...
  22. doi request reprint Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer
    Maria D Cao
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 25:1033-42. 2012
    ..Our study identified GDPD5 as a GPC-PDE that probably participates in the regulation of choline phospholipid metabolism in breast cancer, which possibly occurs in cooperation with CHKA and PLD1...
  23. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008
    ..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments...
  24. ncbi request reprint Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pharm 3:496-506. 2006
    ..In this contextual review, we have outlined the insight we have gained from these studies and have discussed some of the enzymes and pathways that may present novel targets for pharmaceutical interventions in cancer...
  25. ncbi request reprint Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
    Kristine Glunde
    Magnetic Resonance Oncology Section, Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:4270-6. 2004
    ..These observations were consistent with the overexpression of choline kinase and phospholipase C detected in the microarray analyses...
  26. pmc Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21231, USA
    Neoplasia 11:477-84. 2009
    ....
  27. pmc Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport
    Samata M Kakkad
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Universit├Ąt Bremen, Fachbereich 2, Bremen, Germany
    PLoS ONE 8:e81869. 2013
    ..High Col1 fiber density observed around hypoxic regions may facilitate the escape of aggressive cancer cells from hypoxic regions. ..
  28. ncbi request reprint Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells
    Ioannis Stasinopoulos
    Department of Radiology, The Johns Hopkins University School of Medicine, Room 208C, Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Cancer Res 5:435-42. 2007
    ..These data show that silencing of COX-2 abolishes the metastatic potential of MDA-MB-231 cells in vivo...
  29. pmc Molecular and functional MRI of the tumor microenvironment
    Marie France Penet
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Nucl Med 49:687-90. 2008
  30. pmc Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments
    Wei Liu
    Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 72:3677-86. 2012
    ..Together, our findings offer new insights into the metabolic reprogramming of tumor cells present within a hostile microenvironment and suggest that proline metabolism is a potential target for cancer therapeutics...
  31. ncbi request reprint Magnetic resonance imaging and spectroscopy of transgenic models of cancer
    Venu Raman
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 20:186-99. 2007
    ....
  32. ncbi request reprint RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
    Kristine Glunde
    John Hopkins University In Vivo Cellular Molecular Imaging Center Program, Russell H Morgan Department of Radiology and Radiological Science, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:11034-43. 2005
    ..These results strongly support the targeting of choline kinase in breast cancer cells with RNAi and show the potential ability of noninvasive MRS to detect and evaluate future treatments incorporating such strategies...
  33. ncbi request reprint A novel method of imaging lysosomes in living human mammary epithelial cells
    Kristine Glunde
    Johns Hopkins University School of Medicine, 208C Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Imaging 2:24-36. 2003
    ..This novel method of labeling lysosomes biosynthetically was used to image lysosomes in living HMECs perfused in a microscopy-compatible cell perfusion system...
  34. pmc Exploiting the tumor microenvironment for theranostic imaging
    Ioannis Stasinopoulos
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 24:636-47. 2011
    ....
  35. pmc Collagen I fiber density increases in lymph node positive breast cancers: pilot study
    Samata M Kakkad
    The Johns Hopkins University School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, Maryland, USA
    J Biomed Opt 17:116017. 2012
    ..High Col1 fiber density in primary breast tumors is associated with breast cancer metastasis and may serve as an imaging biomarker of metastasis...
  36. pmc Prostaglandin E2 promotes the nuclear accumulation of lymphoid enhancer factor-1 in poorly differentiated breast cancer cells
    Ioannis Stasinopoulos
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD 21205, USA
    Prostaglandins Other Lipid Mediat 99:9-14. 2012
    ..Further, we demonstrate that, like parental COX-2 containing MDA-MB-231 cells, COX-2-silenced cells maintain nuclear localization of ╬▓-catenin...
  37. ncbi request reprint Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Org Lett 8:3623-6. 2006
    ..In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines...
  38. ncbi request reprint Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin
    Kristine Glunde
    MR Oncology Section, Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 48:819-25. 2002
    ..These changes were not related to alterations of intra- or extracellular pH...
  39. ncbi request reprint Molecular-functional imaging of cancer: to image and imagine
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Mol Med 13:287-97. 2007
    ....
  40. ncbi request reprint Na(+)/H(+) exchange subtype 1 inhibition during extracellular acidification and hypoxia in glioma cells
    Kristine Glunde
    Department of Chemistry, University of Bremen, Bremen, Germany
    J Neurochem 80:36-44. 2002
    ..NHE-1 inhibition with HOE642 during acidification caused exacerbated metabolic disorders which were prolonged during extracellular pH recovery. However, NHE-1 inhibition during hypoxia protected the energy state of glial cells...
  41. ncbi request reprint Choline kinase alpha in cancer prognosis and treatment
    Kristine Glunde
    Lancet Oncol 8:855-7. 2007

Research Grants4

  1. Imaging lysosomes to predict metastasis in breast cancer
    Kristine Glunde; Fiscal Year: 2006
    ..Disruption of lysosomal trafficking may prove useful, therapeutically, to prevent metastasic disease. ..
  2. Imaging hypoxia-driven signaling pathways in the breast tumor microenvironment
    Kristine Glunde; Fiscal Year: 2009
    ..Such hypoxia-related biomolecules may, in the future, provide novel molecular targets for innovative hypoxia-targeted breast cancer therapies. ..
  3. Imaging hypoxia-driven signaling pathways in the breast tumor microenvironment
    Kristine Glunde; Fiscal Year: 2010
    ..Such hypoxia-related biomolecules may, in the future, provide novel molecular targets for innovative hypoxia-targeted breast cancer therapies. ..