DAVID GINTY

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
    Janna Merte
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA
    Nat Cell Biol 12:41-6; sup pp 1-8. 2010
  2. pmc Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS
    Tracy S Tran
    Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 462:1065-9. 2009
  3. pmc An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates
    Ting Guo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:31-6. 2011
  4. ncbi request reprint Retrograde neurotrophin signaling: Trk-ing along the axon
    David D Ginty
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Curr Opin Neurobiol 12:268-74. 2002
  5. ncbi request reprint A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    Rejji Kuruvilla
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 118:243-55. 2004
  6. pmc A model for neuronal competition during development
    Christopher D Deppmann
    Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 320:369-73. 2008
  7. pmc LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development
    Kenji Mandai
    The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
    Neuron 63:614-27. 2009
  8. pmc Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons
    S Rasika Wickramasinghe
    The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
    Neuron 58:532-45. 2008
  9. ncbi request reprint Growth and survival signals controlling sympathetic nervous system development
    Natalia O Glebova
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:191-222. 2005
  10. ncbi request reprint Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons
    Haihong Ye
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 39:57-68. 2003

Collaborators

Detail Information

Publications39

  1. pmc Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
    Janna Merte
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA
    Nat Cell Biol 12:41-6; sup pp 1-8. 2010
    ..Thus, during COPII vesicle formation, Sec24b shows cargo specificity for a core PCP component, Vangl2, of which proper ER-to-Golgi transport is essential for the establishment of PCP, convergent extension and closure of the neural tube...
  2. pmc Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS
    Tracy S Tran
    Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 462:1065-9. 2009
    ....
  3. pmc An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates
    Ting Guo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 14:31-6. 2011
    ..Thus, conserved growth factors control divergent neuronal transcriptional events that mediate interspecies differences in neural circuits and the behaviors that they control...
  4. ncbi request reprint Retrograde neurotrophin signaling: Trk-ing along the axon
    David D Ginty
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Curr Opin Neurobiol 12:268-74. 2002
    ..Recent studies highlight the importance of the location of stimulation as a determinant of Trk signaling. Defects in signaling from distal axons to cell bodies may be causally related to neurodegenerative disorders...
  5. ncbi request reprint A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling
    Rejji Kuruvilla
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 118:243-55. 2004
    ....
  6. pmc A model for neuronal competition during development
    Christopher D Deppmann
    Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 320:369-73. 2008
    ..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...
  7. pmc LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development
    Kenji Mandai
    The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
    Neuron 63:614-27. 2009
    ..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching...
  8. pmc Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons
    S Rasika Wickramasinghe
    The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
    Neuron 58:532-45. 2008
    ..These findings show that SRF is a major effector of both MEK/ERK and MAL signaling by NGF and that SRF is a key mediator of NGF-dependent target innervation by embryonic sensory neurons...
  9. ncbi request reprint Growth and survival signals controlling sympathetic nervous system development
    Natalia O Glebova
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:191-222. 2005
    ..This knowledge allows us to integrate the various intricate processes involved in the formation of a functional sympathetic nervous system and thereby create a paradigm for understanding neuronal development in general...
  10. ncbi request reprint Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons
    Haihong Ye
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 39:57-68. 2003
    ..Taken together, our results indicate that retrogradely transported NGF-TrkA complexes promote sympathetic neuron survival...
  11. ncbi request reprint Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance
    Andrea B Huber
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 26:509-63. 2003
    ..We also discuss recent advances in understanding receptor cross talk and how the activities of guidance cues and their receptors are modulated during neural development...
  12. ncbi request reprint Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons
    Jean François Cloutier
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 33:877-92. 2002
    ..Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system...
  13. ncbi request reprint Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events
    Amar Sahay
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 23:6671-80. 2003
    ..Thus, our results show that Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry...
  14. ncbi request reprint Heterogeneous requirement of NGF for sympathetic target innervation in vivo
    Natalia O Glebova
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:743-51. 2004
    ..Remarkably, target organs vary widely in their individual NGF requirements for sympathetic innervation...
  15. ncbi request reprint Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB
    Bonnie E Lonze
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 34:371-85. 2002
    ..Thus, during their period of neurotrophin dependency, peripheral neurons require CREB-mediated gene expression for both survival and growth in vivo...
  16. ncbi request reprint Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  17. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  18. ncbi request reprint A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons
    Wenqin Luo
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:739-54. 2007
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways...
  19. ncbi request reprint Functions and mechanisms of retrograde neurotrophin signalling
    Larry S Zweifel
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Nat Rev Neurosci 6:615-25. 2005
    ..Recent work has established many of the cellular and molecular events that underlie retrograde signalling and the importance of these events for both development and maintenance of proper neural connectivity...
  20. pmc Long-distance control of synapse assembly by target-derived NGF
    Nikhil Sharma
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 67:422-34. 2010
    ....
  21. ncbi request reprint Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165
    Chenghua Gu
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 277:18069-76. 2002
    ..These results establish the identity of contact sites between Npn-1 and its semaphorin ligands, and they provide a foundation for understanding how Npn-1 functions as a receptor for distinct classes of ligands in vivo...
  22. ncbi request reprint Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections
    Jean François Cloutier
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:9087-96. 2004
    ..These results reveal discrete and complementary roles for secreted semaphorins and slits in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections...
  23. ncbi request reprint A chemical-genetic approach to studying neurotrophin signaling
    Xi Chen
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 46:13-21. 2005
    ..Thus, Trk knockin mice provide valuable tools for selective, rapid, and reversible inhibition of neurotrophin signaling in vitro and in vivo...
  24. ncbi request reprint Secreted semaphorins modulate synaptic transmission in the adult hippocampus
    Amar Sahay
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:3613-20. 2005
    ..These results suggest a novel role for semaphorins as synaptic modulators and illustrate the diverse repertoire of these guidance cues in both the formation and function of neural circuits...
  25. ncbi request reprint Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins
    Chenghua Gu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Science 307:265-8. 2005
    ..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning...
  26. pmc SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells
    Constance Smith-Hicks
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:1082-9. 2010
    ..Co-transfection of wild-type Arc and SRF engineered to bind mutated SRE 6.9 restored late-phase LTD in Arc-/-, SRE 6.9 mutant BAC cells. Thus, SRF binding to SRE 6.9 in the Arc promoter is required for the late phase of cerebellar LTD...
  27. pmc Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling
    Wenqin Luo
    Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Neuron 64:841-56. 2009
    ..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception...
  28. ncbi request reprint Function and regulation of CREB family transcription factors in the nervous system
    Bonnie E Lonze
    Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 35:605-23. 2002
    ..In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system...
  29. pmc The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value
    Alexander W Johnson
    Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
    Eur J Neurosci 28:997-1002. 2008
    ....
  30. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
    ..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs...
  31. ncbi request reprint Retrograde control of neural circuit formation
    Christopher D Deppmann
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 127:1306-7. 2006
    ..In this issue, find that this retrograde GDNF-Pea3 signal controls dendrite patterning and assembly of a sensory-motor reflex circuit...
  32. ncbi request reprint A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons
    Antonella Riccio
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
    Mol Cell 21:283-94. 2006
    ..Thus, in conjunction with CREB phosphorylation, the NO pathway controls CREB-DNA binding and CRE-mediated gene expression...
  33. ncbi request reprint SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability
    Narendrakumar Ramanan
    Department of Neuroscience, 725 North Wolfe Street, Preclinical Teaching Building Room 1015, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Neurosci 8:759-67. 2005
    ..These findings indicate that the transcriptional events underlying neuronal survival and plasticity are dissociable and that SRF plays a prominent role in use-dependent modification of synaptic strength in the adult brain...
  34. pmc Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
    ..These observations demonstrate, for the first time, that VEGF contributes to neuronal patterning in vivo, and that different compartments of one cell can be co-ordinately patterned by structurally distinct ligands for a shared receptor...
  35. ncbi request reprint CREB family transcription factors inhibit neuronal suicide
    Ted M Dawson
    Nat Med 8:450-1. 2002
  36. ncbi request reprint What a privilege to reside at the synapse: NMDA receptor signaling to CREB
    Antonella Riccio
    Nat Neurosci 5:389-90. 2002
  37. ncbi request reprint Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors
    Gregorio Valdez
    Department of Neurobiology and Behavior, Center for Brain and Spinal Cord Research, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Neurosci 25:5236-47. 2005
    ..Pincher is the first distinguishing molecular component of a novel mechanistic pathway for endosomal signaling in neurons...
  38. pmc Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival
    Junghee Lee
    Neurology Department, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:40398-401. 2005
    ....

Research Grants8

  1. NEUROTROPHIN ACTIVATION OF cAMP RESPONSE ELEMENT BINDING
    DAVID GINTY; Fiscal Year: 1999
    ....
  2. NEUROTROPHIN ACTIVATION OF cAMP RESPONSE ELEMENT BINDING
    DAVID GINTY; Fiscal Year: 1999
    ....
  3. NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2000
    ....
  4. NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2000
    ....
  5. NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2001
    ....
  6. NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2002
    ....
  7. NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEIN
    DAVID GINTY; Fiscal Year: 2003
    ....