Research Topics
| DAVID GINTYSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Retrograde neurotrophin signaling: Trk-ing along the axonDavid D Ginty
Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
Curr Opin Neurobiol 12:268-74. 2002..Recent studies highlight the importance of the location of stimulation as a determinant of Trk signaling. Defects in signaling from distal axons to cell bodies may be causally related to neurodegenerative disorders...- A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signalingRejji Kuruvilla
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 118:243-55. 2004.... 
A model for neuronal competition during developmentChristopher D Deppmann
Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 320:369-73. 2008..We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects...- Evidence in support of signaling endosome-based retrograde survival of sympathetic neuronsHaihong Ye
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 39:57-68. 2003..Taken together, our results indicate that retrogradely transported NGF-TrkA complexes promote sympathetic neuron survival... - Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidanceAndrea B Huber
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Annu Rev Neurosci 26:509-63. 2003..We also discuss recent advances in understanding receptor cross talk and how the activities of guidance cues and their receptors are modulated during neural development... - Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neuronsS Rasika Wickramasinghe
The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
Neuron 58:532-45. 2008..These findings show that SRF is a major effector of both MEK/ERK and MAL signaling by NGF and that SRF is a key mediator of NGF-dependent target innervation by embryonic sensory neurons... - LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural developmentKenji Mandai
The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
Neuron 63:614-27. 2009..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching... - Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neuronsJean François Cloutier
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Neuron 33:877-92. 2002..Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system... - Growth and survival signals controlling sympathetic nervous system developmentNatalia O Glebova
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Annu Rev Neurosci 28:191-222. 2005..This knowledge allows us to integrate the various intricate processes involved in the formation of a functional sympathetic nervous system and thereby create a paradigm for understanding neuronal development in general... - Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREBBonnie E Lonze
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 34:371-85. 2002..Thus, during their period of neurotrophin dependency, peripheral neurons require CREB-mediated gene expression for both survival and growth in vivo... - Distinct roles for secreted semaphorin signaling in spinal motor axon guidanceAndrea B Huber
Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 48:949-64. 2005..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections... - Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance eventsAmar Sahay
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 23:6671-80. 2003..Thus, our results show that Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry... - Heterogeneous requirement of NGF for sympathetic target innervation in vivoNatalia O Glebova
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 24:743-51. 2004..Remarkably, target organs vary widely in their individual NGF requirements for sympathetic innervation... - Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular developmentChenghua Gu
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Dev Cell 5:45-57. 2003..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system... - A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neuronsWenqin Luo
The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 54:739-54. 2007..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways... - Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNSTracy S Tran
Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 462:1065-9. 2009.... - Functions and mechanisms of retrograde neurotrophin signallingLarry S Zweifel
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA
Nat Rev Neurosci 6:615-25. 2005..Recent work has established many of the cellular and molecular events that underlie retrograde signalling and the importance of these events for both development and maintenance of proper neural connectivity... - Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165Chenghua Gu
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 277:18069-76. 2002..These results establish the identity of contact sites between Npn-1 and its semaphorin ligands, and they provide a foundation for understanding how Npn-1 functions as a receptor for distinct classes of ligands in vivo... - Long-distance control of synapse assembly by target-derived NGFNikhil Sharma
The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 67:422-34. 2010.... - A chemical-genetic approach to studying neurotrophin signalingXi Chen
Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 46:13-21. 2005..Thus, Trk knockin mice provide valuable tools for selective, rapid, and reversible inhibition of neurotrophin signaling in vitro and in vivo... - Secreted semaphorins modulate synaptic transmission in the adult hippocampusAmar Sahay
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:3613-20. 2005..These results suggest a novel role for semaphorins as synaptic modulators and illustrate the diverse repertoire of these guidance cues in both the formation and function of neural circuits... - Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projectionsJean François Cloutier
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 24:9087-96. 2004..These results reveal discrete and complementary roles for secreted semaphorins and slits in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections... - Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilinsChenghua Gu
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
Science 307:265-8. 2005..These findings reveal an unexpected semaphorin signaling pathway and define a mechanism for controlling vascular patterning... - SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viabilityNarendrakumar Ramanan
Department of Neuroscience, 725 North Wolfe Street, Preclinical Teaching Building Room 1015, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Neurosci 8:759-67. 2005..These findings indicate that the transcriptional events underlying neuronal survival and plasticity are dissociable and that SRF plays a prominent role in use-dependent modification of synaptic strength in the adult brain... - The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive valueAlexander W Johnson
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
Eur J Neurosci 28:997-1002. 2008.... - Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closureJanna Merte
The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA
Nat Cell Biol 12:41-6; sup pp 1-8. 2010..Thus, during COPII vesicle formation, Sec24b shows cargo specificity for a core PCP component, Vangl2, of which proper ER-to-Golgi transport is essential for the establishment of PCP, convergent extension and closure of the neural tube... - Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signalingWenqin Luo
Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
Neuron 64:841-56. 2009..Thus, the early Ret(+) neurons are RA mechanoreceptors and Ret signaling is required for the assembly of neural circuits underlying touch perception... - SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cellsConstance Smith-Hicks
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 13:1082-9. 2010..Co-transfection of wild-type Arc and SRF engineered to bind mutated SRE 6.9 restored late-phase LTD in Arc-/-, SRE 6.9 mutant BAC cells. Thus, SRF binding to SRE 6.9 in the Arc promoter is required for the late phase of cerebellar LTD... - Function and regulation of CREB family transcription factors in the nervous systemBonnie E Lonze
Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 35:605-23. 2002..In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system... - Endothelins are vascular-derived axonal guidance cues for developing sympathetic neuronsTakako Makita
The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 452:759-63. 2008..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs... - Retrograde control of neural circuit formationChristopher D Deppmann
The Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 127:1306-7. 2006..In this issue, find that this retrograde GDNF-Pea3 signal controls dendrite patterning and assembly of a sensory-motor reflex circuit... - A nitric oxide signaling pathway controls CREB-mediated gene expression in neuronsAntonella Riccio
Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
Mol Cell 21:283-94. 2006..Thus, in conjunction with CREB phosphorylation, the NO pathway controls CREB-DNA binding and CRE-mediated gene expression... - Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerveQuenten Schwarz
Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
Genes Dev 18:2822-34. 2004..These observations demonstrate, for the first time, that VEGF contributes to neuronal patterning in vivo, and that different compartments of one cell can be co-ordinately patterned by structurally distinct ligands for a shared receptor... - CREB family transcription factors inhibit neuronal suicideTed M Dawson
Nat Med 8:450-1. 2002 - What a privilege to reside at the synapse: NMDA receptor signaling to CREBAntonella Riccio
Nat Neurosci 5:389-90. 2002 - Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptorsGregorio Valdez
Department of Neurobiology and Behavior, Center for Brain and Spinal Cord Research, State University of New York at Stony Brook, Stony Brook, New York 11794-5230, USA
J Neurosci 25:5236-47. 2005..Pincher is the first distinguishing molecular component of a novel mechanistic pathway for endosomal signaling in neurons... - Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survivalJunghee Lee
Neurology Department, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 280:40398-401. 2005....
Research Grants
- NEUROTROPHIN ACTIVATION OF CRE BINDING PROTEINDAVID GINTY; Fiscal Year: 2003....