Jon T Giles

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Serious infections associated with anticytokine therapies in the rheumatic diseases
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Intensive Care Med 19:320-34. 2004
  2. pmc Assessment of myocardial abnormalities in rheumatoid arthritis using a comprehensive cardiac magnetic resonance approach: a pilot study
    Yasuyuki Kobayashi
    Department of Radiology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Arthritis Res Ther 12:R171. 2010
  3. pmc Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis
    Jon T Giles
    Department of Medicine, The Johns Hopkins University, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Arthritis Res Ther 11:R36. 2009
  4. pmc Association of body composition with disability in rheumatoid arthritis: impact of appendicular fat and lean tissue mass
    Jon T Giles
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 59:1407-15. 2008
  5. pmc Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics
    Jon T Giles
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 62:3173-82. 2010
  6. pmc Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies
    Jon T Giles
    Johns Hopkins University School of Medicine, The Johns Hopkins Arthritis Center, Baltimore, Maryland 21224, USA
    Arthritis Rheum 59:807-15. 2008
  7. ncbi request reprint Rheumatoid arthritis and reproduction
    Amit Golding
    Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Rheum Dis Clin North Am 33:319-43, vi-vii. 2007
  8. ncbi request reprint Assessing single joints in arthritis clinical trials
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Rheumatol 34:641-7. 2007
  9. pmc Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis
    Jon T Giles
    The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Arthritis Rheum 61:1248-56. 2009
  10. ncbi request reprint Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis
    Jon T Giles
    The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Suite 1B 1, Baltimore, MD 21224, USA
    Arthritis Rheum 55:333-7. 2006

Research Grants

Detail Information

Publications27

  1. ncbi request reprint Serious infections associated with anticytokine therapies in the rheumatic diseases
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Intensive Care Med 19:320-34. 2004
    ..In addition, relevant animal data illustrating potential mechanistic roles for TNF-alpha in host responses to infection are also reviewed...
  2. pmc Assessment of myocardial abnormalities in rheumatoid arthritis using a comprehensive cardiac magnetic resonance approach: a pilot study
    Yasuyuki Kobayashi
    Department of Radiology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa 216 8511, Japan
    Arthritis Res Ther 12:R171. 2010
    ..We sought to assess cardiac involvement using a comprehensive cardiac magnetic resonance imaging (cMRI) approach and to determine its association with disease characteristics in RA patients without symptomatic cardiac disease...
  3. pmc Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis
    Jon T Giles
    Department of Medicine, The Johns Hopkins University, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Arthritis Res Ther 11:R36. 2009
    ..Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients...
  4. pmc Association of body composition with disability in rheumatoid arthritis: impact of appendicular fat and lean tissue mass
    Jon T Giles
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 59:1407-15. 2008
    ..To explore the association of measures of body composition with disability in patients with rheumatoid arthritis (RA)...
  5. pmc Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics
    Jon T Giles
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 62:3173-82. 2010
    ..This study was undertaken to investigate how abdominal fat is distributed in rheumatoid arthritis (RA), and its RA-related determinants...
  6. pmc Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies
    Jon T Giles
    Johns Hopkins University School of Medicine, The Johns Hopkins Arthritis Center, Baltimore, Maryland 21224, USA
    Arthritis Rheum 59:807-15. 2008
    ....
  7. ncbi request reprint Rheumatoid arthritis and reproduction
    Amit Golding
    Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Rheum Dis Clin North Am 33:319-43, vi-vii. 2007
    ....
  8. ncbi request reprint Assessing single joints in arthritis clinical trials
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Rheumatol 34:641-7. 2007
    ..At OMERACT 8, the group developed a research agenda to perform additional validation studies of clinical and functional indices, imaging, synovial histopathology, and soluble biomarkers...
  9. pmc Adiponectin is a mediator of the inverse association of adiposity with radiographic damage in rheumatoid arthritis
    Jon T Giles
    The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Arthritis Rheum 61:1248-56. 2009
    ..Recent reports have suggested that increasing adiposity may protect against radiographic damage in rheumatoid arthritis (RA). We explored the role of serum adipokines (adiponectin, resistin, and leptin) in mediating this association...
  10. ncbi request reprint Tumor necrosis factor inhibitor therapy and risk of serious postoperative orthopedic infection in rheumatoid arthritis
    Jon T Giles
    The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Suite 1B 1, Baltimore, MD 21224, USA
    Arthritis Rheum 55:333-7. 2006
  11. pmc Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis
    Jon T Giles
    Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arthritis Res Ther 7:195-207. 2005
    ..At present, however, the direct effects of inflammatory cytokines (and rheumatoid arthritis therapies) on the myocardia of rheumatoid arthritis patients are incompletely understood...
  12. pmc Association of body fat with C-reactive protein in rheumatoid arthritis
    Jon T Giles
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 58:2632-41. 2008
    ..However, other tissues, such as adipose tissue, can induce CRP production. This study was undertaken to explore the associations between measures of adiposity and CRP levels in RA...
  13. doi request reprint Increased prevalence of carotid artery atherosclerosis in rheumatoid arthritis is artery-specific
    Hitomi Kobayashi
    Divisions of Rheumatology, Cardiology, and Immunogenetics, Department of Medicine, and Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    J Rheumatol 37:730-9. 2010
    ..We compared carotid intima-media thickness (IMT) of both the common carotid (CCA) and proximal internal carotid (bulb-ICA) arteries, and plaque prevalence, between RA and non-RA participants...
  14. pmc Prevalence of traditional modifiable cardiovascular risk factors in patients with rheumatoid arthritis: comparison with control subjects from the multi-ethnic study of atherosclerosis
    Cecilia P Chung
    Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA
    Semin Arthritis Rheum 41:535-44. 2012
    ..We tested the hypotheses that major modifiable cardiovascular risk factors were more frequent and rates of treatment, detection, and control were lower in patients with RA than in non-RA controls...
  15. pmc Association of vitamin D with cardiometabolic risk factors in rheumatoid arthritis
    Uzma J Haque
    Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Arthritis Care Res (Hoboken) 64:1497-504. 2012
    ..Since patients with RA have a high prevalence of vitamin D deficiency, we investigated the association of vitamin D levels with cardiometabolic risk factors in a cohort of RA patients with no prior history of CVD...
  16. pmc Left ventricular structure and function in patients with rheumatoid arthritis, as assessed by cardiac magnetic resonance imaging
    Jon T Giles
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 62:940-51. 2010
    ..This study was undertaken to assess the factors associated with progression to heart failure in patients with RA...
  17. ncbi request reprint Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritis
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21224, USA
    Nat Clin Pract Rheumatol 2:320-9. 2006
    ....
  18. pmc Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity
    Erika Darrah
    Division of Rheumatology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA
    Sci Transl Med 5:186ra65. 2013
    ..PAD3 autoantibodies may therefore identify RA patients who would benefit from early aggressive treatment or addition of PAD inhibitor therapy...
  19. pmc Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritis
    Jon T Giles
    Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Ann Rheum Dis 70:1562-8. 2011
    ..The association of serum adipokine levels with progression of radiographic joint damage in patients with rheumatoid arthritis (RA) was prospectively explored...
  20. pmc Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study
    Dimitrios A Pappas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E, Monument Street, 5th Floor, Baltimore, MD 21202, USA
    Arthritis Res Ther 12:R104. 2010
    ....
  21. doi request reprint Do antitumor necrosis factor agents increase the risk of postoperative orthopedic infections?
    Dimitrios A Pappas
    Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Rheumatol 20:450-6. 2008
    ..These patients may be at risk for serious postoperative infections as antitumor necrosis factor agents may be associated with impaired immunity against usual and opportunistic pathogens...
  22. pmc Muscle density in rheumatoid arthritis: associations with disease features and functional outcomes
    Henry R Kramer
    Johns Hopkins University, Baltimore, Maryland, USA
    Arthritis Rheum 64:2438-50. 2012
    ..To explore the associations between measures of body composition derived from computed tomography (CT) of the thigh and functional outcomes in patients with rheumatoid arthritis (RA)...
  23. pmc Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis
    Jin Kyun Park
    Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42659. 2012
    ..Tissue-infiltrating multinucleated giant cells (MNGs) within geographic necrosis are pathologic hallmarks of granulomatosis with polyangiitis (GPA). However, the origin, phenotype, and function of these cells in GPA remain undefined...
  24. pmc Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis
    Michelle L Harris
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 58:1958-67. 2008
    ..This study was undertaken to investigate whether anti-PAD-4 antibodies are specific to RA, are associated with disease phenotype or severity, and whether PAD-4 polymorphisms influence the anti-PAD-4 autoantibody response...
  25. pmc Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis
    Erika Darrah
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Ann Rheum Dis 71:92-8. 2012
    ..To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA)...
  26. doi request reprint A 73-year-old woman with rheumatoid arthritis and shortness of breath
    Dimitrios A Pappas
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 59:892-9. 2008
  27. doi request reprint Cardiac magnetic resonance imaging with pharmacological stress perfusion and delayed enhancement in asymptomatic patients with systemic sclerosis
    Hitomi Kobayashi
    Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Suite 4100, Baltimore, MD 21224, USA
    J Rheumatol 36:106-12. 2009
    ..To assess cardiac involvement in asymptomatic patients with systemic sclerosis (SSc) by cardiac magnetic resonance imaging (MRI)...

Research Grants2

  1. Determinats of Body Composition in Rheumatoid Arthritis
    Jon Giles; Fiscal Year: 2007
    ..3. Identify the inflammatory and non-inflammatory factors associated with altered body composition phenotypes, adipokine profiles, and insulin resistance in patients with RA . ..