T I Gerasimova

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Chromatin insulators and boundaries: effects on transcription and nuclear organization
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, UDA
    Annu Rev Genet 35:193-208. 2001
  2. ncbi request reprint Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
  3. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
  4. pmc Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function
    D Ghosh
    Department of Biology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    EMBO J 20:2518-27. 2001
  5. pmc Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila
    D A Gdula
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 93:9378-83. 1996
  6. ncbi request reprint A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation
    T I Gerasimova
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 82:587-97. 1995
  7. ncbi request reprint Boundary and insulator elements in chromosomes
    T I Gerasimova
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Curr Opin Genet Dev 6:185-92. 1996
  8. ncbi request reprint Protein encoding by both DNA strands
    M Labrador
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nature 409:1000. 2001
  9. pmc Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster
    K K Hoover
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genetics 132:691-7. 1992
  10. doi request reprint Assembling the human IFN-beta enhanceosome in solution
    A I Dragan
    Department of Biology, Johns Hopkins University, Baltimore, MD, USA
    J Mol Biol 384:335-48. 2008

Collaborators

  • F Mongelard
  • O B Simonova
  • N A Tchurikov
  • V G Corces
  • A I Dragan
  • D Ghosh
  • M Labrador
  • R Carrillo
  • P L Privalov
  • I D Zorin
  • D A Gdula
  • P Plata-Rengifo
  • E M Baxter
  • P G Georgiev
  • V A Mogila
  • M A Khatypova
  • K K Hoover
  • G P Georgiev
  • A B Ladvishenko
  • A J Brown
  • A J Chien
  • S L Kiselev
  • A B Ladvishchenko
  • L J Mizrokhi
  • A J Flavell
  • A F Priim├Ągi
  • S J Ross
  • Y V Ilyin
  • E M Buff
  • L S Alphey
  • S G Georgieva

Detail Information

Publications22

  1. ncbi request reprint Chromatin insulators and boundaries: effects on transcription and nuclear organization
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, UDA
    Annu Rev Genet 35:193-208. 2001
    ..Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure...
  2. ncbi request reprint Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
  3. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
    ..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
  4. pmc Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function
    D Ghosh
    Department of Biology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    EMBO J 20:2518-27. 2001
    ..The results provide a biochemical basis for the aggregation of multiple insulator sites and support the role of the gypsy insulator in nuclear organization...
  5. pmc Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila
    D A Gdula
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 93:9378-83. 1996
    ..The modifier of mdg4 [mod(mdg4)] protein interacts with su(Hw) to transform this bi-directional repression into the polar effect characteristic of insulators. These effects seem to be modulated by changes in chromatin structure...
  6. ncbi request reprint A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation
    T I Gerasimova
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 82:587-97. 1995
    ....
  7. ncbi request reprint Boundary and insulator elements in chromosomes
    T I Gerasimova
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Curr Opin Genet Dev 6:185-92. 1996
    ..The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function...
  8. ncbi request reprint Protein encoding by both DNA strands
    M Labrador
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Nature 409:1000. 2001
  9. pmc Dominant effects of suppressor of Hairy-wing mutations on gypsy-induced alleles of forked and cut in Drosophila melanogaster
    K K Hoover
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    Genetics 132:691-7. 1992
    ..We propose that these disruptions alter the affinity and interaction of su(Hw) protein with gypsy DNA, thereby sensitizing the mutant phenotype to fluctuations in su(Hw) product...
  10. doi request reprint Assembling the human IFN-beta enhanceosome in solution
    A I Dragan
    Department of Biology, Johns Hopkins University, Baltimore, MD, USA
    J Mol Biol 384:335-48. 2008
    ....
  11. ncbi request reprint Novel genes influencing the expression of the yellow locus and mdg4 (gypsy) in Drosophila melanogaster
    P G Georgiev
    N I Vavilov Institute of General Genetics, USSR Academy of Sciences, Moscow
    Mol Gen Genet 220:121-6. 1989
    ..All e(y)n genes are located in different regions of the X chromosome. One may speculate that e(y)n genes are involved in trans-regulation of the yellow locus and possibly of some other loci...
  12. ncbi request reprint A chromatin insulator determines the nuclear localization of DNA
    T I Gerasimova
    Department of Biology The Johns Hopkins University, Baltimore, MD 21218, USA
    Mol Cell 6:1025-35. 2000
    ..The results suggest that the nuclear organization imposed by the gypsy insulator on the chromatin fiber is important for gene expression...
  13. ncbi request reprint Genetic instability at the cut locus of Drosophila melanogaster induced by the MR-h12 chromosome
    T I Gerasimova
    Mol Gen Genet 184:544-7. 1981
    ..The genetic system constructed in the present work affords an opportunity for molecular studies of the cut locus and the MR-transposon, as a sequence from the cut locus has recently been cloned (Tchurikov et al. 1981)...
  14. ncbi request reprint Intragenic suppression: Stalker, a retrovirus-like transposable element, can compensate for a deficiency at the cut locus of Drosophila melanogaster
    V A Mogila
    Institute of Gene Biology, Academy of Sciences of the USSR, Moscow, Russia
    Genetica 86:305-11. 1992
    ..3 kb deletion. Thus an insertion of a retrovirus-like mobile element can suppress the deficiency at the regulatory region of a gene...
  15. ncbi request reprint [Suppressor mutation, interacting with the white alleles of Drosophila melanogaster]
    M A Khatypova
    Genetika 28:176-8. 1992
    ..However, Su(wa4) does not interact with other w mutations. So, we suggested that Su(wa4) is trans-regulatory gene and its product involves in the expression regulation the white locus, probably, on the transcriptional level...
  16. ncbi request reprint [Transpositional bursts and chromosome rearrangements in unstable lines of Drosophila]
    T I Gerasimova
    Genetika 26:399-411. 1990
    ..This once again proves multiple and coordinated character of changes taking place during hybrid dysgenesis...
  17. pmc A novel transposition system in Drosophila melanogaster depending on the Stalker mobile genetic element
    P G Georgiev
    Vavilov Institute of General Genetics, USSR Academy of Sciences, Moscow
    EMBO J 9:2037-44. 1990
    ..Many known and novel mutations have been obtained. Comparison of their genetic localization with Stalker distribution suggests that the majority of them have been induced by the Stalker insertion...
  18. ncbi request reprint [Superunstable systems in Drosophila melanogaster. Analysis of mutations in signed and cut loci]
    A B Ladvishchenko
    Genetika 26:1133-43. 1990
    ..The authors discuss possible effects of inserting the complicated constructions, based on the combinations of P-element and the Stalker, on the induction of superinstability...
  19. ncbi request reprint Instability in the ctMR2 strain of Drosophila melanogaster: role of P element functions and structure of revertants
    A J Brown
    Department of Genetics, University of Edinburgh, Scotland
    Mol Gen Genet 218:208-13. 1989
    ..Molecular analysis of X chromosomes from some ct+ progeny indicates that phenotypic reversion of the ct mutation can arise through two unrelated mechanisms...
  20. ncbi request reprint Mobile elements and transposition events in the cut locus of Drosophila melanogaster
    N A Tchurikov
    Institute of Molecular Biology, USSR Academy of Sciences, Moscow
    Mol Gen Genet 219:241-8. 1989
    ....
  21. ncbi request reprint Mobile genetic elements in Drosophila melanogaster (recent experiments)
    G P Georgiev
    Department of Nucleic Acid Biosynthesis, Engelhardt Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow
    Genome 31:920-8. 1989
    ..Several novel genes were detected using mobilized Stalker. They include a modifier of mdg4 and six enhancers of yellow mutations...
  22. ncbi request reprint Superunstable alleles at the cut locus in Drosophila melanogaster
    T I Gerasimova
    Mol Gen Genet 190:390-3. 1983
    ..In some cases the mutant transitions are somehow strongly stimulated leading to superinstability, reaching the rate of 0.5...