Timothy J George

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A novel method of measuring cardiac preservation injury demonstrates University of Wisconsin solution is associated with less ischemic necrosis than Celsior in early cardiac allograft biopsy specimens
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Heart Lung Transplant 31:410-8. 2012
  2. doi request reprint Organ storage with University of Wisconsin solution is associated with improved outcomes after orthotopic heart transplantation
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 30:1033-43. 2011
  3. ncbi request reprint The effect of center volume on the incidence of postoperative complications and their impact on survival after lung transplantation
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 144:1502-8; discussion 1508-9. 2012
  4. doi request reprint Should orthotopic heart transplantation using marginal donors be limited to higher volume centers?
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:695-702. 2012
  5. doi request reprint Should patients 60 years and older undergo bridge to transplantation with continuous-flow left ventricular assist devices?
    Jeremiah G Allen
    Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:2017-24. 2012
  6. pmc Risk factors for early death in patients bridged to transplant with continuous-flow left ventricular assist devices
    George J Arnaoutakis
    Division of Cardiac Surgery, The Bloomberg School of Public Health, The Johns Hopkins Hospital, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:1549-54; discussion 1555. 2012
  7. ncbi request reprint A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform
    Timothy J George
    Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Surg Res 183:75-83. 2013
  8. ncbi request reprint Outcomes and temporal trends among high-risk patients after lung transplantation in the United States
    Timothy J George
    Division of Cardiac Surgery at the Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Heart Lung Transplant 31:1182-91. 2012
  9. ncbi request reprint Valve surgery for infective endocarditis is associated with high hospital charges
    Clinton D Kemp
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Heart Valve Dis 22:110-7. 2013
  10. doi request reprint The spectrum of complications following left ventricular assist device placement
    Nance Yuan
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Card Surg 27:630-8. 2012

Collaborators

Detail Information

Publications43

  1. pmc A novel method of measuring cardiac preservation injury demonstrates University of Wisconsin solution is associated with less ischemic necrosis than Celsior in early cardiac allograft biopsy specimens
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Heart Lung Transplant 31:410-8. 2012
    ..The significance of varying degrees of acute ischemic necrosis (AIN) in early transplant biopsy specimens is unknown. We investigated the effects of HPS on early cardiac histopathology by developing a novel grading system of AIN...
  2. doi request reprint Organ storage with University of Wisconsin solution is associated with improved outcomes after orthotopic heart transplantation
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 30:1033-43. 2011
    ..We evaluated the impact of the most commonly used solutions in the USA, the University of Wisconsin solution (UW) and Celsior solution (CS), on outcomes after orthotopic heart transplantation (OHT)...
  3. ncbi request reprint The effect of center volume on the incidence of postoperative complications and their impact on survival after lung transplantation
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 144:1502-8; discussion 1508-9. 2012
    ..The aim of this study was to evaluate the effect of center volume on the incidence of postoperative complications and their impact on survival after lung transplantation (LTx)...
  4. doi request reprint Should orthotopic heart transplantation using marginal donors be limited to higher volume centers?
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:695-702. 2012
    ..This study examined whether institutional volume impacts outcomes after orthotopic heart transplantation (OHT) utilizing marginal donors...
  5. doi request reprint Should patients 60 years and older undergo bridge to transplantation with continuous-flow left ventricular assist devices?
    Jeremiah G Allen
    Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:2017-24. 2012
    ..The purpose of this study was to examine outcomes in patients 60 years and older undergoing BTT with continuous-flow LVADs...
  6. pmc Risk factors for early death in patients bridged to transplant with continuous-flow left ventricular assist devices
    George J Arnaoutakis
    Division of Cardiac Surgery, The Bloomberg School of Public Health, The Johns Hopkins Hospital, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:1549-54; discussion 1555. 2012
    ..Recent evidence suggests patients bridged to heart transplant (BTT) have equivalent outcomes as those undergoing conventional orthotopic heart transplantation (OHT). However, data on risk factors for early death in BTT patients are limited...
  7. ncbi request reprint A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform
    Timothy J George
    Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Surg Res 183:75-83. 2013
    ..In this study, we examined the physiology and biochemistry of human lungs on an EVLP circuit...
  8. ncbi request reprint Outcomes and temporal trends among high-risk patients after lung transplantation in the United States
    Timothy J George
    Division of Cardiac Surgery at the Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Heart Lung Transplant 31:1182-91. 2012
    ..We undertook this study to evaluate the effect of high lung allocation scores (LAS), ventilator support, and extracorporeal membrane oxygenation (ECMO) support on outcomes after LTx...
  9. ncbi request reprint Valve surgery for infective endocarditis is associated with high hospital charges
    Clinton D Kemp
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Heart Valve Dis 22:110-7. 2013
    ..Although the surgical management of IE is effective, the financial impact of the disease has never been assessed...
  10. doi request reprint The spectrum of complications following left ventricular assist device placement
    Nance Yuan
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Card Surg 27:630-8. 2012
    ..Left ventricular assist device (LVAD) support is associated with many complications, but relatively few studies have examined the full spectrum of complications beyond infectious and bleeding events...
  11. ncbi request reprint Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation
    Timothy J George
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Surg Res 178:593-600. 2012
    ..We hypothesized that pretreatment with inhaled H(2)S would improve graft function in an ex vivo model of LTx...
  12. pmc Hemoglobin drift after cardiac surgery
    Timothy J George
    Division of Cardiac Surgery, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:703-9. 2012
    ..The purpose of this study was to define the natural progression of hemoglobin levels in postoperative cardiac surgery patients...
  13. ncbi request reprint Pre-transplant malignancy: an analysis of outcomes after thoracic organ transplantation
    Claude A Beaty
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 32:202-11. 2013
    ..Studies examining the effect of PTM on outcomes after lung transplantation (LTx) or orthotopic heart transplantation (OHT) are limited. We evaluated the effect of PTM on outcomes after LTx and OHT...
  14. doi request reprint Valve-sparing aortic root replacement in Loeys-Dietz syndrome
    Nishant D Patel
    Johns Hopkins Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 92:556-60; discussion 560-1. 2011
    ..The results of prophylactic root replacement using valve-sparing procedures (valve-sparing root replacement [VSRR]) in patients with LDS is not known...
  15. pmc Reoperative sternotomy is associated with increased mortality after heart transplantation
    Timothy J George
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 94:2025-32. 2012
    ..We undertook this study to examine the incidence and impact of repeat sternotomies on OHT outcomes...
  16. pmc Acute kidney injury increases mortality after lung transplantation
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:185-92. 2012
    ..Studies examining the impact of RRT after lung transplantation (LTx) are limited. We evaluated risk factors and outcomes associated with RRT after LTx...
  17. doi request reprint Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: update in a modern cohort
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 142:1236-45, 1245.e1. 2011
    ..We used United Network for Organ Sharing data to examine panel reactive antibody titers in patients bridged to transplant with left ventricular assist devices...
  18. pmc Severe acute kidney injury according to the RIFLE (risk, injury, failure, loss, end stage) criteria affects mortality in lung transplantation
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Heart Lung Transplant 30:1161-8. 2011
    ..Using the RIFLE criteria, we examined the effect of AKI on outcomes and cost in LTx...
  19. pmc Septuagenarians bridged to heart transplantation with a ventricular assist device have outcomes similar to younger patients
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 95:1251-60; discussion 1260-1. 2013
    ..We undertook this study to characterize the outcomes of septuagenarians bridged to transplantation (BTT) in the modern era...
  20. doi request reprint Marital status improves survival after orthotopic heart transplantation
    Vernissia Tam
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Heart Lung Transplant 30:1389-94. 2011
    ..We examined our institutional database to identify social factors associated with improved outcomes after orthotopic heart transplantation (OHT)...
  21. doi request reprint What predicts long-term survival after heart transplantation? An analysis of 9,400 ten-year survivors
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:699-704. 2012
    ..This case-control study was conducted to identify factors predictive of 10-year survival after orthotopic heart transplantation (OHT)...
  22. pmc Society of Thoracic Surgeons Risk Score predicts hospital charges and resource use after aortic valve replacement
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 142:650-5. 2011
    ..We hypothesize that increasing Society of Thoracic Surgeons risk scores in patients undergoing aortic valve replacement are associated with greater hospital charges...
  23. doi request reprint Identifying recipients at high risk for graft failure after heart retransplantation
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 93:712-6. 2012
    ..The aim of this study was to identify recipient factors that are associated with a high risk of graft failure after heart retransplantation (HRT)...
  24. ncbi request reprint Disclosure of physician-specific behavior improves blood utilization protocol adherence in cardiac surgery
    Claude A Beaty
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland
    Ann Thorac Surg 96:2168-74. 2013
    ..We hypothesized that weekly physician feedback would improve adherence to such a protocol, but that the public identification of individual physician behavior would have an additive effect...
  25. pmc The role of head computed tomography imaging in the evaluation of postoperative neurologic deficits in cardiac surgery patients
    Claude A Beaty
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 95:548-54. 2013
    ..We evaluated our experience with this imaging modality to determine its value...
  26. doi request reprint Adult-derived Index for Mortality Prediction After Cardiac Transplantation (IMPACT) risk score predicts short-term mortality after pediatric heart transplantation
    Arman Kilic
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 93:1228-34; discussion 1234-5. 2012
    ..This study evaluated the predictive accuracy of the IMPACT score in pediatric OHT...
  27. doi request reprint Creation of a quantitative recipient risk index for mortality prediction after cardiac transplantation (IMPACT)
    Eric S Weiss
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 92:914-21; discussion 921-2. 2011
    ..No recipient risk index exists predicting short-term mortality after orthotopic heart transplantation (OHT). We utilized United Network for Organ Sharing (UNOS) data to develop a novel quantitative recipient risk score for use in OHT...
  28. doi request reprint Institutional volume and the effect of recipient risk on short-term mortality after orthotopic heart transplant
    George J Arnaoutakis
    Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 143:157-67, 167.e1. 2012
    ..We developed a validated 50-point recipient risk index predicting short-term mortality after orthotopic heart transplant (OHT). This study examined the relationship between institutional volume and recipient risk on post-OHT mortality...
  29. ncbi request reprint Unilateral humoral rejection after reoperative single-lung transplant
    Claude A Beaty
    Division of Cardiac Surgery, Department of Surgical Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 95:e79-81. 2013
    ..The process of allograft sensitization is dynamic, and further study is warranted to better understand this process...
  30. doi request reprint Surgical treatment of advanced heart failure: alternatives to heart transplantation and mechanical circulatory assist devices
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Prog Cardiovasc Dis 54:115-31. 2011
    ..Although cardiac surgery in patients with severe ventricular dysfunction can be complicated by significant morbidity and mortality, experienced centers have demonstrated acceptable outcomes in carefully selected patients...
  31. pmc Contemporary etiologies, risk factors, and outcomes after pericardiectomy
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:445-51. 2012
    ..We evaluated our single-center experience to define the etiologies, risk factors, and outcomes of pericardiectomy in a modern cohort...
  32. doi request reprint Valve-sparing aortic root replacement in children: intermediate-term results
    Nishant D Patel
    Johns Hopkins Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Interact Cardiovasc Thorac Surg 12:415-9, discussion 419. 2011
    ..In this particular group of patients with connective tissue disorders and proclivity toward annular dilation and late AI, reimplantation is superior to remodeling...
  33. doi request reprint Association of operative time of day with outcomes after thoracic organ transplant
    Timothy J George
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    JAMA 305:2193-9. 2011
    ..Recent emphasis on systems-based approaches to patient safety has led to several studies demonstrating worse outcomes associated with surgery at night...
  34. ncbi request reprint Increased exposure improves recruitment: early results of a program designed to attract medical students into surgical careers
    Kara A Haggerty
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
    Ann Thorac Surg 97:2111-4. 2014
    ..A summer research program was designed to introduce interested medical students to surgical careers...
  35. ncbi request reprint Respiratory support with venovenous extracorporeal membrane oxygenation during stenting of tracheobronchomalacia
    Timothy J George
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Ann Thorac Surg 94:1736-7. 2012
    ..We report the successful respiratory support of a patient with severe tracheobronchomalacia with venovenous extracorporeal membrane oxygenation during rigid bronchoscopy with stent removal and stent placement...
  36. pmc Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation
    Timothy J George
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Surg Res 178:494-501. 2012
    ..Hydrogen sulfide (H(2)S) is a novel agent that has been previously shown to scavenge ROS and slow metabolism. We evaluated the effect of infused H(2)S on the presence of ROS after reperfusion in an ex vivo model of lung transplantation...
  37. ncbi request reprint Novel approach to recurrent cavoatrial renal cell carcinoma
    Jennifer L Alejo
    Division of Cardiac Surgery, Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:e119-21. 2012
    ..We used a thoracoabdominal approach, peripheral cannulation, and hypothermic circulatory arrest. We advocate this novel approach as a successful means of avoiding a more difficult reoperation...
  38. doi request reprint Successful repair of an atrioesophageal fistula after catheter ablation for atrial fibrillation
    Kara A Haggerty
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryand 21224, USA
    Ann Thorac Surg 93:313-5. 2012
    ..Herein, we report the successful repair of an atrioesophageal fistula after catheter ablation for atrial fibrillation...
  39. pmc Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest
    George J Arnaoutakis
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 142:902-910.e1. 2011
    ..We hypothesize that UCHL1 would be an effective serum biomarker for brain injury as tested in canine models of hypothermic circulatory arrest (HCA) and cardiopulmonary bypass (CPB)...
  40. doi request reprint Acute cholecystitis preceding mycotic aortic pseudoaneurysm in a heart transplant recipient
    Charles D Fraser
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Card Surg 25:749-51. 2010
    ..The region of involved aorta was effectively repaired using a patch of bovine pericardium and a brief period of hypothermic circulatory arrest...
  41. doi request reprint Allograft cardiectomy and biventricular assist device placement as a salvage maneuver in a heart transplant recipient
    Chase W Robinson
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Card Surg 26:114-6. 2011
    ..We present the case of a young man with a failing cardiac allograft who underwent allograft cardiectomy, atrial pouch formation, and biventricular assist device (BiVAD) placement as a salvage maneuver...
  42. doi request reprint Lung transplant in idiopathic pulmonary fibrosis
    Timothy J George
    Division of Cardiac Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Arch Surg 146:1204-9. 2011
    ..To review the present status of lung transplant (LTx) in patients with idiopathic pulmonary fibrosis (IPF)...
  43. pmc Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database
    George J Arnaoutakis
    Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 94:436-43; discussion 443-4. 2012
    ..We examined The Society of Thoracic Surgeons database to characterize patients undergoing surgical repair of post-MI VSD and to identify risk factors for poor outcomes...