S N Georas

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Room 4B 41, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 1:215-21. 2004
  2. ncbi request reprint What is eotaxin doing in the pleura? Insights into innate immunity from pleural mesothelial cells
    Steve N Georas
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:384-7. 2002
  3. ncbi request reprint T-helper cell type-2 regulation in allergic disease
    S N Georas
    Johns Hopkins Asthma and Allergy Center, Rm 4B 41 JHAAC 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    Eur Respir J 26:1119-37. 2005
  4. ncbi request reprint Stat6 inhibits human interleukin-4 promoter activity in T cells
    S N Georas
    Divisions of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, The Johns Hopkins University Asthma and Allergy Center, Baltimore, MD, USA
    Blood 92:4529-38. 1998
  5. ncbi request reprint Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter
    R Chen
    Division of Pulmonary Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Immunol 164:825-32. 2000
  6. ncbi request reprint Yin-Yang 1 activates interleukin-4 gene expression in T cells
    J Guo
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 276:48871-8. 2001
  7. ncbi request reprint Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression
    J C Keen
    Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:58-65. 2001
  8. ncbi request reprint Human eosinophils constitutively express nuclear factor of activated T cells p and c
    M C Seminario
    Department of Medicine, Division of Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 107:143-52. 2001
  9. ncbi request reprint Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter
    V Casolaro
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 275:36605-11. 2000
  10. ncbi request reprint Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism
    S Matsukura
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:755-61. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases
    Steve N Georas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Room 4B 41, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 1:215-21. 2004
    ..Thus, this article also reviews the mechanisms of DC maturation and DC:T cell cross-talk, including new evidence that corticosteroids might act at this level to inhibit antigen-specific immunity...
  2. ncbi request reprint What is eotaxin doing in the pleura? Insights into innate immunity from pleural mesothelial cells
    Steve N Georas
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:384-7. 2002
  3. ncbi request reprint T-helper cell type-2 regulation in allergic disease
    S N Georas
    Johns Hopkins Asthma and Allergy Center, Rm 4B 41 JHAAC 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    Eur Respir J 26:1119-37. 2005
    ....
  4. ncbi request reprint Stat6 inhibits human interleukin-4 promoter activity in T cells
    S N Georas
    Divisions of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, The Johns Hopkins University Asthma and Allergy Center, Baltimore, MD, USA
    Blood 92:4529-38. 1998
    ..We conclude that the function of Stat6 is highly dependent on promoter context and that this factor promotes IL-4 gene expression in an indirect manner...
  5. ncbi request reprint Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter
    R Chen
    Division of Pulmonary Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Immunol 164:825-32. 2000
    ..Taken together, our results show that GC inhibit IL-4 gene expression by interfering with NF-AT-dependent transactivation of the proximal human IL-4 promoter...
  6. ncbi request reprint Yin-Yang 1 activates interleukin-4 gene expression in T cells
    J Guo
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    J Biol Chem 276:48871-8. 2001
    ..In addition, cotransfected YY-1 enhanced both IL-4 promoter activity and endogenous IL-4 gene expression in nontransformed peripheral blood T cells. Thus, YY-1 positively regulates IL-4 gene expression in lymphocytes...
  7. ncbi request reprint Preferential activation of nuclear factor of activated T cells c correlates with mouse strain susceptibility to allergic responses and interleukin-4 gene expression
    J C Keen
    Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:58-65. 2001
    ..In conclusion, our data link dysregulated activation of a specific transcription factor with susceptibility to allergic airway inflammation...
  8. ncbi request reprint Human eosinophils constitutively express nuclear factor of activated T cells p and c
    M C Seminario
    Department of Medicine, Division of Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 107:143-52. 2001
    ..CONCLUSION: NFATp and NFATc can regulate the expression of cytokines and other genes in eosinophils but appear to be regulated by a novel signal transduction mechanism in these cells...
  9. ncbi request reprint Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter
    V Casolaro
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 275:36605-11. 2000
    ..Taken together, these findings point to CP2 as a critical IL-4 transactivator in Th cells...
  10. ncbi request reprint Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a STAT6-dependent mechanism
    S Matsukura
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 24:755-61. 2001
    ..These results indicate that IL-13 stimulates eotaxin expression in airway epithelial cells and that STAT6 plays a pivotal role in this response...
  11. ncbi request reprint Selective inhibition of interleukin-4 gene expression in human T cells by aspirin
    A Cianferoni
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Blood 97:1742-9. 2001
    ....
  12. pmc Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets
    V Casolaro
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 92:11623-7. 1995
    ..Thus, competition between two general transcriptional activators, RelA and NF-ATp, mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells...
  13. ncbi request reprint Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells
    N M Heller
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 34:1690-700. 2004
    ..While these responses are all inhibited by glucocorticoids (GC) administered systemically or by inhalation, the inhibitory mechanisms are unknown...
  14. doi request reprint Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms
    N N Hansel
    Division Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Allergy 63:366-9. 2008
    ..T-cell activation results in changes in gene expression, but the optimal method to study gene expression profiles in T cells, and how this changes over time, are not known...
  15. ncbi request reprint Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge
    S N Georas
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 37:311-22. 2007
    ..LPA binds to receptors expressed on circulating and structural lung cells and affects cell growth and activation. Whether LPA is present in the lung has not been previously reported...
  16. ncbi request reprint Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells
    Rongbing Chen
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21212, USA
    Stem Cells Dev 15:797-804. 2006
    ..Lysophosphatidic acid fine-tunes the effects of LPS on human myeloid DC maturation, but does not exert a dominant effect on the ability of DC to influence Th cell polarization...
  17. pmc Diesel-enriched particulate matter functionally activates human dendritic cells
    Michael Porter
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 37:706-19. 2007
    ..Our data support the hypothesis that DEP (and to a lesser extent CEP) regulate important functional aspects of human DC, supporting an adjuvant role for this material...
  18. doi request reprint Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses
    Jia Guo
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY, USA
    J Allergy Clin Immunol 122:195-201, 201.e1-5. 2008
    ..The transcription factor Yin-Yang 1 (YY-1) binds to the promoter regions of several T-cell cytokine genes, but the expression and contribution of this factor to cytokine gene expression and T-cell activation in vivo is not clear...
  19. ncbi request reprint Ambient particulate matter directs nonclassic dendritic cell activation and a mixed TH1/TH2-like cytokine response by naive CD4+ T cells
    Marc A Williams
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 119:488-97. 2007
    ..Ambient particulate matter (APM) is ubiquitous and associated with allergic diseases, but it is unknown whether APM directly activates DCs...
  20. pmc Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells
    Judith C Keen
    Department of Environmental Health Sciences, Johns Hopkins University School of Medicine, Balitmore, MD 21224, USA
    Immunology 117:29-37. 2006
    ..This promoter region supported the binding of both constitutive and PMA-inducible nuclear factors in gel shift assays...
  21. pmc Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 202:47-59. 2005
    ..Our studies suggest that the responsiveness of Nrf2-directed antioxidant pathways may act as a major determinant of susceptibility to allergen-mediated asthma...
  22. ncbi request reprint Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma
    Nadia N Hansel
    Children s National Medical Center, Johns Hopkins University, Baltimore, MD 21205, USA
    J Lab Clin Med 145:263-74. 2005
    ..These differentially expressed genes identify potential molecular targets for preventive and therapeutic options for severe asthma...
  23. ncbi request reprint Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells
    Nicola M Heller
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 31:573-82. 2004
    ..These observations have important implications for the regulation of epithelial cell activation by the balance of Th1/Th2-type cytokines in the airways in allergic disease...
  24. ncbi request reprint Histone deacetylation inhibits IL4 gene expression in T cells
    Maryam Valapour
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 109:238-45. 2002
    ..In addition, alterations in chromatin structure are thought to play a role in regulating the expression of cytokines in the T(H)2 gene cluster, although the biochemical basis for these alterations in human T cells is not well understood...
  25. pmc Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells
    Bahman Saatian
    Division of Pulmonary and Critical Care Medicine and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem J 393:657-68. 2006
    ..These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs...
  26. ncbi request reprint Epigenetic studies should focus on specific cell types
    Jia Guo
    Am J Respir Crit Care Med 178:882-3; author reply 883. 2008