Romergryko G Geocadin

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Research priorities in neurocritical care
    R G Geocadin
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurocrit Care 16:35-41. 2012
  2. doi request reprint Cardiac arrest resuscitation: neurologic prognostication and brain death
    Romergryko G Geocadin
    Department of Neurology, Neurosurgery and Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Crit Care 14:261-8. 2008
  3. pmc Management of brain injury after resuscitation from cardiac arrest
    Romergryko G Geocadin
    Neurosciences Critical Care Division, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurol Clin 26:487-506, ix. 2008
  4. pmc Evolution of Somatosensory Evoked Potentials after Cardiac Arrest induced hypoxic-ischemic injury
    Wei Xiong
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Resuscitation 81:893-7. 2010
  5. pmc Early electrophysiologic markers predict functional outcome associated with temperature manipulation after cardiac arrest in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 36:1909-16. 2008
  6. doi request reprint Intraventricular orexin-A improves arousal and early EEG entropy in rats after cardiac arrest
    Matthew A Koenig
    The Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 8 140, Baltimore, MD 21287, USA
    Brain Res 1255:153-61. 2009
  7. pmc Quantitative assessment of somatosensory-evoked potentials after cardiac arrest in rats: prognostication of functional outcomes
    Jai Madhok
    Department of Biomedical Engineering, John Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 38:1709-17. 2010
  8. pmc Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoring
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 76:431-42. 2008
  9. ncbi request reprint Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest
    Hyun Chool Shin
    Dept of Biomed Eng, Johns Hopkins Univ Sch of Med, Baltimore, MD 21205, USA
    Conf Proc IEEE Eng Med Biol Soc 1:6229-32. 2006
  10. pmc Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 1111:166-75. 2006

Detail Information

Publications48

  1. doi request reprint Research priorities in neurocritical care
    R G Geocadin
    Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurocrit Care 16:35-41. 2012
    ..During the group discussion, interests in comparative effectiveness research, the use of physiological endpoints from monitoring and alternate trial design were expressed...
  2. doi request reprint Cardiac arrest resuscitation: neurologic prognostication and brain death
    Romergryko G Geocadin
    Department of Neurology, Neurosurgery and Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Crit Care 14:261-8. 2008
    ..Neurologic prognostication helps guide appropriate discussions between family members and healthcare providers. Recent advances in therapeutic care increase the challenges, both medical and financial, on local practitioners...
  3. pmc Management of brain injury after resuscitation from cardiac arrest
    Romergryko G Geocadin
    Neurosciences Critical Care Division, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurol Clin 26:487-506, ix. 2008
    ....
  4. pmc Evolution of Somatosensory Evoked Potentials after Cardiac Arrest induced hypoxic-ischemic injury
    Wei Xiong
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Resuscitation 81:893-7. 2010
    ..We tested the hypothesis that early recovery of cortical SEP would be associated with milder hypoxic-ischemic injury and better outcome after resuscitation from CA...
  5. pmc Early electrophysiologic markers predict functional outcome associated with temperature manipulation after cardiac arrest in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 36:1909-16. 2008
    ..We studied the recovery of cortical electrical function by quantitative electroencephalography after 7-min asphyxial cardiac arrest, using information quantity (IQ)...
  6. doi request reprint Intraventricular orexin-A improves arousal and early EEG entropy in rats after cardiac arrest
    Matthew A Koenig
    The Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 8 140, Baltimore, MD 21287, USA
    Brain Res 1255:153-61. 2009
    ..14). In rats resuscitated from CA, orexin-A transiently increased arousal and EEG entropy without worsening ischemic neuronal injury. The role of orexin-A in recovery of arousal after CA deserves further investigation...
  7. pmc Quantitative assessment of somatosensory-evoked potentials after cardiac arrest in rats: prognostication of functional outcomes
    Jai Madhok
    Department of Biomedical Engineering, John Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 38:1709-17. 2010
    ..Due to the vulnerability of these circuits to hypoxic-ischemic insults, we hypothesize that quantitative SSEP markers may indicate future neurologic status...
  8. pmc Improving neurological outcomes post-cardiac arrest in a rat model: immediate hypothermia and quantitative EEG monitoring
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 76:431-42. 2008
    ..To enhance the administration of TH, we studied brain electrophysiological monitoring in determining the benefit of early initiation of TH compared to conventional administration in a rat model...
  9. ncbi request reprint Quantitative EEG assessment of brain injury and hypothermic neuroprotection after cardiac arrest
    Hyun Chool Shin
    Dept of Biomed Eng, Johns Hopkins Univ Sch of Med, Baltimore, MD 21205, USA
    Conf Proc IEEE Eng Med Biol Soc 1:6229-32. 2006
    ..Experimental results show that the IQ is higher for hypothermic than normothermic rats. The results quantitatively support the hypothesis that hypothermia accelerates the recovery of brain injury after cardiac arrest...
  10. pmc Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res 1111:166-75. 2006
    ..These results demonstrate the potential utility of qEEG-IQ to track the response to neuroprotective hypothermia during the early phase of recovery from cardiac arrest...
  11. doi request reprint Third-line antiepileptic therapy and outcome in status epilepticus: the impact of vasopressor use and prolonged mechanical ventilation
    Robert G Kowalski
    Neurosciences Critical Care Division, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 40:2677-84. 2012
    ..other antiepileptic agents, and short-term outcomes, in status epilepticus. Furthermore, to evaluate the role of adverse hemodynamic and respiratory effects of these agents in status epilepticus treatment...
  12. pmc Post-cardiac arrest temperature manipulation alters early EEG bursting in rats
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 78:367-73. 2008
    ..EEG recovers through periodic bursting from isoelectricity after CA, the duration of which is associated with outcome in normothermia. We quantified burst frequency to study the effect of temperature on early EEG recovery after CA...
  13. ncbi request reprint Long-lasting cognitive injury in rats with apparent full gross neurological recovery after short-term cardiac arrest
    Matthew Schreckinger
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 75:105-13. 2007
    ..We used short (5 min) asphyxic-cardiac arrest that resulted in no apparent gross neurological deficits to study the long-term effects of mild hypoxic ischemia on the neurobehavioral status of rats...
  14. pmc A subband-based information measure of EEG during brain injury and recovery after cardiac arrest
    Hyun Chool Shin
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    IEEE Trans Biomed Eng 55:1985-90. 2008
    ..Thirteen rats, based on 7-min cardiac arrest were used. The experimental results show that the proposed measure was more highly correlated to neurological outcome than IQ...
  15. pmc Multiscale entropy analysis of EEG for assessment of post-cardiac arrest neurological recovery under hypothermia in rats
    Xiaoxu Kang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Trans Biomed Eng 56:1023-31. 2009
    ..These experiments point to the role of cortical rhythms in reporting early neurological response to ischemia and therapeutic hypothermia...
  16. ncbi request reprint Quantitative EEG assessment
    Nitish V Thakor
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 25:20-5. 2006
  17. pmc Ketogenic diet for adults in super-refractory status epilepticus
    Kiran T Thakur
    From the Departments of Neurology K T T, J C P, E H K, R G G, A L H, A V, M C C and Pediatrics E H K, A L H, Johns Hopkins Hospital, Baltimore, MD Department of Neurology S E H, Mayo Clinic, Rochester, MN Department of Food and Nutrition Services K R, Rush University Medical Center, Chicago, IL Institute for Clinical and Translational Research B H, Johns Hopkins University, Baltimore Department of Neurology P W K, Johns Hopkins Bayview Medical Center, Baltimore and Departments of Anesthesiology Critical Care Medicine, Neurosurgery, and Medicine R G G, Johns Hopkins University School of Medicine, Baltimore, MD
    Neurology 82:665-70. 2014
    ....
  18. pmc Short- and long-latency somatosensory neuronal responses reveal selective brain injury and effect of hypothermia in global hypoxic ischemia
    Dan Wu
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 107:1164-71. 2012
    ..In summary, our study reveals the vulnerability of the somatosensory neural structures to global HI and the differential effects of hypothermia on these structures...
  19. ncbi request reprint Intensive care for brain injury after cardiac arrest: therapeutic hypothermia and related neuroprotective strategies
    Romergryko G Geocadin
    Department of Neurology, Johns Hopkins School of Medicine, Meyer 8 140, Baltimore, MD 21287, USA
    Crit Care Clin 22:619-36; abstract viii. 2006
    ..This article discusses these advances and their potential impact on the care provided in the ICU...
  20. ncbi request reprint Effect of acute hypoxic preconditioning on qEEG and functional recovery after cardiac arrest in rats
    Romergryko G Geocadin
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Brain Res 1064:146-54. 2005
    ..05) was better than control injury group (52.2 +/- 8.4, P < 0.05) (ANOVA with Tukey test). We therefore conclude that AHPC confers acute neuroprotection at 24 h, which was detected by qEEG entropy during the first 5 h after injury...
  21. pmc Quantitative EEG and effect of hypothermia on brain recovery after cardiac arrest
    Hyun Chool Shin
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    IEEE Trans Biomed Eng 53:1016-23. 2006
    ..20 (0.20 +/- 0.11 is 95% condidence interval). The results quantitatively support the hypothesis that hypothermia accelerates the electrical recovery from brain injury after cardiac arrest...
  22. doi request reprint Prediction of survival to discharge following cardiopulmonary resuscitation using classification and regression trees
    Mark H Ebell
    1Department of Epidemiology and Biostatistics and the Institute for Evidence Based Health Professions Education, University of Georgia, Athens, GA 2Duke University School of Medicine, Durham, NC 3Departments of Neurology, Anesthesiology Critical Care Medicine, and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD
    Crit Care Med 41:2688-97. 2013
    ....
  23. pmc Predictors of outcome in acute encephalitis
    Kiran T Thakur
    Johns Hopkins Encephalitis Center, Department of Neurology, The Johns Hopkins University School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 81:793-800. 2013
    ..To investigate predictors of outcome in patients with all-cause encephalitis receiving care in the intensive care unit...
  24. pmc Hypothermia amplifies somatosensory-evoked potentials in uninjured rats
    Jai Madhok
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosurg Anesthesiol 24:197-202. 2012
    ..Hypothermia also suppressed EEGs at different regions of the brain by different degrees. The changes to SSEP and EEG are both reversible with subsequent rewarming...
  25. pmc Time jitter of somatosensory evoked potentials in recovery from hypoxic-ischemic brain injury
    Ying Ma
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosci Methods 201:355-60. 2011
    ..The SOBI technique is an efficient method in the identification of peak detection and offers a favorable alternative to reveal the neural transmission variation...
  26. doi request reprint Post-cardiac arrest encephalopathy
    Wei Xiong
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Semin Neurol 31:216-25. 2011
    ..Also reviewed are a wide spectrum of postarrest neurologic complications and their targeted treatments...
  27. ncbi request reprint Management of cardiac arrest patients to maximize neurologic outcome
    Hans Adrian Puttgen
    Neurosciences Critical Care Division, Johns Hopkins Hospital and Department of Emergency Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Crit Care 15:118-24. 2009
    ..Much of this ability depends on preserving the nervous system from a complicated sequence of secondary injuries, which ensue from global ischemia...
  28. doi request reprint Coma after global ischemic brain injury: pathophysiology and emerging therapies
    Robert E Hoesch
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Crit Care Clin 24:25-44, vii-viii. 2008
    ..We then describe the potential therapeutic mechanisms of hypothermia and deep brain stimulation, which provide hope for better neurological outcomes after global cerebral ischemia...
  29. doi request reprint Brain code and coma recovery: aggressive management of cerebral herniation
    Atul A Kalanuria
    Division of Neurosciences Critical Care Medicine, Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Semin Neurol 33:133-41. 2013
    ..In this article, the authors discuss the mechanisms that lead to coma in brain-herniating patients and the treatment choices that have been successfully used in this patient population. ..
  30. doi request reprint Cerebral herniation associated with central venous catheter insertion: risk assessment
    Wendy C Ziai
    Department of Neurology, Division of Neurosciences Critical Care, Anesthesia and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Crit Care 28:189-95. 2013
    ..Four cases of cerebral herniation immediately following central venous catheterization were the impetus for an investigation of clinical and radiologic parameters associated with this complication...
  31. doi request reprint Early prognostication in acute brain damage: where is the evidence?
    Atul A Kalanuria
    Division of Neurosciences Critical Care Medicine, Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Curr Opin Crit Care 19:113-22. 2013
    ..There remains controversy over the most optimal methods that can be utilized to predict outcome. The utility of recently reported prognostic biomarkers and clinical methods will be reviewed...
  32. ncbi request reprint Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report
    Marthew A Koenig
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosurg 102:371-5. 2005
    ..Despite aggressive measures, including tumor resection, ventriculoperitoneal shunt placement, and the initiation of conventional radiation therapy, the ensuing leptomeningeal carcinomatosis proved to be rapidly fatal...
  33. ncbi request reprint Intracerebral hemorrhage and postpartum cerebral vasculopathy
    Romergryko G Geocadin
    Department of Neurology, Neurosciences Critical Care Division, Johns Hopkins Medical Institutions, Meyer 8 140, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Neurol Sci 205:29-34. 2002
    ..We describe the clinical course of two patients with ICH due to postpartum cerebral vasculopathy in the absence of toxemia...
  34. doi request reprint Critical care of traumatic spinal cord injury
    Xiaofeng Jia
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Intensive Care Med 28:12-23. 2013
    ....
  35. doi request reprint "Any possible restoration of function could not occur": Harvey Cushing and the early description of brain death
    Courtney Pendleton
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 77:394-7. 2012
    ..To describe a case from 1908 of apparent brain death after operative intervention by Harvey Cushing at the Johns Hopkins Hospital...
  36. doi request reprint Neurologic critical care. Preface
    Robert D Stevens
    Division of Neurosciences Critical Care, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurol Clin 26:xiii-xv. 2008
  37. ncbi request reprint Safety of induced hypertension therapy in patients with acute ischemic stroke
    Matthew A Koenig
    Neurosciences Critical Care, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurocrit Care 4:3-7. 2006
    ..Small pilot studies have suggested that blood pressure augmentation improves short-term neurological function, but the rate of adverse events with induced hypertension (IH) therapy is unknown...
  38. ncbi request reprint Ethical issues in critical care and cardiac arrest: clinical research, brain death, and organ donation
    Luke A Donatelli
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Semin Neurol 26:452-9. 2006
    ..This article also discusses ethical concerns pertaining to the design and conduct of resuscitation research that is necessary for the development of effective therapies to prevent anoxic brain injury or promote neurological recovery...
  39. ncbi request reprint Intensive care after resuscitation from cardiac arrest: a focus on heart and brain injury
    Steven P Schulman
    Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurol Clin 24:41-59, vi. 2006
    ..This article addresses the acute care, with emphasis on the cardiac and neurologic aspects,that patients who have post cardiac arrest are provided in the cardiac ICU...
  40. ncbi request reprint Therapeutic hypothermia for global and focal ischemic brain injury--a cool way to improve neurologic outcomes
    Robert E Hoesch
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    Neurologist 13:331-42. 2007
    ..A review of preclinical and clinical reports on TH in adult patients is provided in this article...
  41. ncbi request reprint Neurological recovery by EEG bursting after resuscitation from cardiac arrest in rats
    Romergryko G Geocadin
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Resuscitation 55:193-200. 2002
    ..We report the temporal analysis of EEG bursting pattern during the very early periods after resuscitation...
  42. doi request reprint Treatment of elevated intracranial pressure with hyperosmolar therapy in patients with renal failure
    Karen G Hirsch
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Neurocrit Care 17:388-94. 2012
    ..To evaluate the use of hyperosmolar therapy in the management of elevated intracranial pressure (ICP) and transtentorial herniation (TTH) in patients with renal failure and supratentorial lesions...
  43. doi request reprint The ketogenic diet for medically and surgically refractory status epilepticus in the neurocritical care unit
    Mackenzie C Cervenka
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287 7247, USA
    Neurocrit Care 15:519-24. 2011
    ..Dietary therapies have been used for almost a century in children for controlling medically refractory seizures and status epilepticus and recent studies suggest efficacy and safety in adults as well...
  44. ncbi request reprint Medivance Arctic sun temperature management system
    Romergryko G Geocadin
    Division of Neurosciences Critical Care, Department of Neurology, Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurocrit Care 3:63-7. 2005
  45. ncbi request reprint Patient flow variability and unplanned readmissions to an intensive care unit
    David R Baker
    Center for Innovation in Quality Patient Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 37:2882-7. 2009
    ..To determine whether high patient inflow volumes to an intensive care unit are associated with unplanned readmissions to the unit...
  46. ncbi request reprint Hypothermia for neuroprotection after cardiac arrest: mechanisms, clinical trials and patient care
    Michael T Froehler
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe Street, Meyer 8 140, Baltimore, MD 21287, USA
    J Neurol Sci 261:118-26. 2007
    ....
  47. ncbi request reprint Continuous intracranial pressure monitoring via the shunt reservoir to assess suspected shunt malfunction in adults with hydrocephalus
    Romergryko G Geocadin
    Department of Neurology and Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Neurosurg Focus 22:E10. 2007
    ....
  48. ncbi request reprint Postresuscitative intensive care: neuroprotective strategies after cardiac arrest
    Wendy L Wright
    Departments of Neurology and Neurosurgery, Emory University Hospital, Atlanta, Georgia, USA
    Semin Neurol 26:396-402. 2006
    ..Future treatment options and advanced monitoring techniques are also discussed. Further study to optimize neuroprotective strategies when treating patients who survive cardiac arrest is needed...