Ping Gao

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    Ping Gao
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 458:762-5. 2009
  2. pmc MYC-induced cancer cell energy metabolism and therapeutic opportunities
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 15:6479-83. 2009
  3. pmc Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
    Tsung Cheng Chang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3384-9. 2009
  4. pmc Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors
    Krupa Shukla
    Department of Neurology and Brain Science Institute, Johns Hopkins University, Baltimore, Maryland 21205, United States
    J Med Chem 55:10551-63. 2012
  5. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
  6. pmc Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    Huafeng Zhang
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:19579-86. 2008
  7. pmc Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
    Jason T Yustein
    Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:3534-9. 2010
  8. pmc Therapeutic targeting of cancer cell metabolism
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21212, USA
    J Mol Med (Berl) 89:205-12. 2011
  9. ncbi request reprint The interplay between MYC and HIF in cancer
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 8:51-6. 2008
  10. ncbi request reprint HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    Huafeng Zhang
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 11:407-20. 2007

Collaborators

Detail Information

Publications15

  1. pmc c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    Ping Gao
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 458:762-5. 2009
    ..The unique means by which Myc regulates glutaminase uncovers a previously unsuspected link between Myc regulation of miRNAs, glutamine metabolism, and energy and reactive oxygen species homeostasis...
  2. pmc MYC-induced cancer cell energy metabolism and therapeutic opportunities
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 15:6479-83. 2009
    ..Collectively, these studies indicate that Myc-mediated altered cancer cell energy metabolism could be translated for the development of new anticancer therapies...
  3. pmc Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation
    Tsung Cheng Chang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:3384-9. 2009
    ..These findings highlight an important role for Lin-28B in Myc-driven cellular phenotypes and uncover an orchestration of transcriptional and posttranscriptional mechanisms in Myc-mediated reprogramming of miRNA expression...
  4. pmc Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors
    Krupa Shukla
    Department of Neurology and Brain Science Institute, Johns Hopkins University, Baltimore, Maryland 21205, United States
    J Med Chem 55:10551-63. 2012
    ....
  5. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ....
  6. pmc Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    Huafeng Zhang
    Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:19579-86. 2008
    ....
  7. pmc Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
    Jason T Yustein
    Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:3534-9. 2010
    ..Furthermore, the expression of Jagged2 in P493-6 tumors often overlapped with regions of hypoxia. These observations suggest that Notch signaling downstream of Myc enables cells to adapt in the tumor hypoxic microenvironment...
  8. pmc Therapeutic targeting of cancer cell metabolism
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21212, USA
    J Mol Med (Berl) 89:205-12. 2011
    ....
  9. ncbi request reprint The interplay between MYC and HIF in cancer
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 8:51-6. 2008
    ..This Perspective emphasizes the differences between the transcriptional network that operates under normal homeostatic conditions and the network in a tumorigenic milieu...
  10. ncbi request reprint HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    Huafeng Zhang
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 11:407-20. 2007
    ..We demonstrate that transcription of the gene encoding the coactivator PGC-1beta is C-MYC dependent and that loss of PGC-1beta expression is a major factor contributing to reduced respiration in VHL-deficient renal carcinoma cells...
  11. pmc Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
    Meghan J Seltzer
    Department of Neurosurgery, and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 70:8981-7. 2010
    ..The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy...
  12. ncbi request reprint Effects of hypoxia on tumor metabolism
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Metastasis Rev 26:291-8. 2007
    ..These new insights into hypoxic metabolic alterations in tumors will hopefully lead us to target tumor bioenergetics for the treatment of cancers...
  13. doi request reprint Muscle fatigue from losing your PHD
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Metab 7:191-2. 2008
    ..A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2alpha- and PPARalpha-dependent fashion...
  14. pmc Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins
    Ping Gao
    Department of Medicine, Division of Hematology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Assoc Lab Anim Sci 47:37-40. 2008
    ..The mechanism for this synergy is unknown and deserves further investigation. Fenbendazole should be used with caution during tumor studies because it may interact with other treatments and confound research results...
  15. pmc HIF-dependent antitumorigenic effect of antioxidants in vivo
    Ping Gao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 12:230-8. 2007
    ..These findings challenge the paradigm that antioxidants diminish tumorigenesis primarily through decreasing DNA damage and mutations and provide significant support for a key antitumorigenic effect of diminishing HIF levels...