NICHOLAS R GAIANO
Affiliation: Johns Hopkins University
- The role of notch in promoting glial and neural stem cell fatesNicholas Gaiano
Developmental Genetics Program, and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA
Annu Rev Neurosci 25:471-90. 2002..This review examines the role of Notch during gliogenesis in both fruit flies and vertebrates, as well as evidence in vertebrates that some glia may be stem cells...
- Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitmentXiaobing Yu
Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell Stem Cell 2:461-71. 2008..These new insights into the roles of Notch in hESC-fate determination may help to efficiently direct hESC differentiation into therapeutically relevant cell types...
- Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortexNicholas Gaiano
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 60:189-91. 2008..In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the effects of Reelin on neuronal cell migration...
- Notch signaling in mammalian neural progenitorsNICHOLAS R GAIANO; Fiscal Year: 2010..In addition, this work will contribute to the treatment of nervous system disorders, including brain cancer and neurodegenerative diseases, and to the treatment of traumatic brain injury. ..
- NF-kappaB signaling in mammalian forebrain progenitorsNicholas Gaiano; Fiscal Year: 2007..Based upon the exploratory nature of this work we are requesting R21 level funding. The identification of NF-kB as relevant for mammalian forebrain development would be an important step in understanding this fundamental process. ..
- NOTCH AND FGF SIGNALING IN MAMMALIAN NEURAL PROGENITORSNicholas Gaiano; Fiscal Year: 2007..In particular, these studies are likely to facilitate the manipulation of stem cells for therapeutic use in the nervous system and elsewhere. ..