NICHOLAS R GAIANO

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi The role of notch in promoting glial and neural stem cell fates
    Nicholas Gaiano
    Developmental Genetics Program, and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA
    Annu Rev Neurosci 25:471-90. 2002
  2. ncbi Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
    Xiaobing Yu
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:461-71. 2008
  3. ncbi Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex
    Nicholas Gaiano
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 60:189-91. 2008

Research Grants

  1. Notch signaling in mammalian neural progenitors
    NICHOLAS R GAIANO; Fiscal Year: 2010
  2. NF-kappaB signaling in mammalian forebrain progenitors
    Nicholas Gaiano; Fiscal Year: 2007
  3. NOTCH AND FGF SIGNALING IN MAMMALIAN NEURAL PROGENITORS
    Nicholas Gaiano; Fiscal Year: 2007

Detail Information

Publications3

  1. ncbi The role of notch in promoting glial and neural stem cell fates
    Nicholas Gaiano
    Developmental Genetics Program, and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10016, USA
    Annu Rev Neurosci 25:471-90. 2002
    ..This review examines the role of Notch during gliogenesis in both fruit flies and vertebrates, as well as evidence in vertebrates that some glia may be stem cells...
  2. ncbi Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment
    Xiaobing Yu
    Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 2:461-71. 2008
    ..These new insights into the roles of Notch in hESC-fate determination may help to efficiently direct hESC differentiation into therapeutically relevant cell types...
  3. ncbi Strange bedfellows: Reelin and Notch signaling interact to regulate cell migration in the developing neocortex
    Nicholas Gaiano
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 60:189-91. 2008
    ..In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the effects of Reelin on neuronal cell migration...

Research Grants8

  1. Notch signaling in mammalian neural progenitors
    NICHOLAS R GAIANO; Fiscal Year: 2010
    ..In addition, this work will contribute to the treatment of nervous system disorders, including brain cancer and neurodegenerative diseases, and to the treatment of traumatic brain injury. ..
  2. NF-kappaB signaling in mammalian forebrain progenitors
    Nicholas Gaiano; Fiscal Year: 2007
    ..Based upon the exploratory nature of this work we are requesting R21 level funding. The identification of NF-kB as relevant for mammalian forebrain development would be an important step in understanding this fundamental process. ..
  3. NOTCH AND FGF SIGNALING IN MAMMALIAN NEURAL PROGENITORS
    Nicholas Gaiano; Fiscal Year: 2007
    ..In particular, these studies are likely to facilitate the manipulation of stem cells for therapeutic use in the nervous system and elsewhere. ..