Linda P Fried

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A social model for health promotion for an aging population: initial evidence on the Experience Corps model
    Linda P Fried
    Medicine, Epidemiology and Health Policy, Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, JHU School of Medicine, 2024 East Monument Street, Baltimore, MD 21205, USA
    J Urban Health 81:64-78. 2004
  2. ncbi request reprint From bedside to bench: research agenda for frailty
    Linda P Fried
    Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
    Sci Aging Knowledge Environ 2005:pe24. 2005
  3. doi request reprint Anemia in older adults living in the community
    Linda P Fried
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Postgrad Med 116:12-6. 2004
  4. ncbi request reprint Self-reported preclinical disability identifies older women with early declines in performance and early disease
    L P Fried
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Epidemiol 54:889-901. 2001
  5. ncbi request reprint A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender
    R Sato
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:37-44. 2006
  6. ncbi request reprint Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
  7. pmc Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women
    Paulo H M Chaves
    Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 56:1698-703. 2008
  8. pmc Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
  9. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol (1985) 103:17-20. 2007
  10. pmc Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study
    Anne R Cappola
    SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:1268-74. 2009

Research Grants

  1. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2003
  2. Conference Series: Bedside to Bench
    Linda Fried; Fiscal Year: 2003
  3. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2004
  4. Conference Series: Bedside to Bench
    Linda Fried; Fiscal Year: 2005
  5. EPIDEMIOLOGY AND BIOSTATISTICS OF AGING
    Linda Fried; Fiscal Year: 2007
  6. OLDER AMERICANS INDEPENDENCE CENTER
    Linda Fried; Fiscal Year: 2007
  7. Pathogenesis of physical disability in Aging women
    Linda Fried; Fiscal Year: 2007
  8. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2002
  9. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2001
  10. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2000

Collaborators

Detail Information

Publications137 found, 100 shown here

  1. pmc A social model for health promotion for an aging population: initial evidence on the Experience Corps model
    Linda P Fried
    Medicine, Epidemiology and Health Policy, Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, JHU School of Medicine, 2024 East Monument Street, Baltimore, MD 21205, USA
    J Urban Health 81:64-78. 2004
    ..In this pilot trial, physical, cognitive, and social activity increased, suggesting the potential for the Experience Corps to improve health for an aging population and simultaneously improve educational outcomes for children...
  2. ncbi request reprint From bedside to bench: research agenda for frailty
    Linda P Fried
    Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
    Sci Aging Knowledge Environ 2005:pe24. 2005
    ..This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty...
  3. doi request reprint Anemia in older adults living in the community
    Linda P Fried
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Postgrad Med 116:12-6. 2004
    ..In this article, Dr Fried examines current evidence related to such consequences, particularly those observed in studies of older adults living in the community...
  4. ncbi request reprint Self-reported preclinical disability identifies older women with early declines in performance and early disease
    L P Fried
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Epidemiol 54:889-901. 2001
    ..They also suggest new avenues for screening and intervention to prevent disability...
  5. ncbi request reprint A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender
    R Sato
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:37-44. 2006
    ..These mixed results do not provide strong evidence of an association between vitamin C concentrations or intake and cognitive function...
  6. ncbi request reprint Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
    ....
  7. pmc Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women
    Paulo H M Chaves
    Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 56:1698-703. 2008
    ..For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed...
  8. pmc Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
    ..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection...
  9. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol (1985) 103:17-20. 2007
    ..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults...
  10. pmc Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study
    Anne R Cappola
    SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:1268-74. 2009
    ..Assessment of an individual's ability to maintain a DHEAS set point, through examination of multiple DHEAS levels over time, may provide insight into biologic aging...
  11. pmc Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Age Ageing 36:62-7. 2007
    ..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women...
  12. ncbi request reprint Inflammation and frailty in older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Am Geriatr Soc 55:864-71. 2007
    ..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty...
  13. pmc Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Aging Clin Exp Res 21:182-90. 2009
    ..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality...
  14. pmc Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program
    Michelle C Carlson
    Department of Mental Health, Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 64:1275-82. 2009
    ..To determine whether Experience Corps (EC), a social service program, would improve age-vulnerable executive functions and increase activity in brain regions in a high-risk group through increased cognitive and physical activity...
  15. pmc White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 64:499-502. 2009
    ..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated...
  16. ncbi request reprint Frailty, hospitalization, and progression of disability in a cohort of disabled older women
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
    Am J Med 118:1225-31. 2005
    ..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability...
  17. pmc Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Age Ageing 38:283-9. 2009
    ..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia...
  18. pmc Experience Corps: design of an intergenerational program to boost social capital and promote the health of an aging society
    Thomas A Glass
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Urban Health 81:94-105. 2004
    ..This article explores how the linkage of concepts at multiple levels motivates a potentially cost-effective, feasible, and high-impact program...
  19. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  20. ncbi request reprint Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 167:240-8. 2008
    ..Together, these data suggest that a slightly constricted life space may be a marker and/or risk factor for the development of frailty that may prove useful as a screening tool or a target of intervention...
  21. pmc Short-term impact of Experience Corps participation on children and schools: results from a pilot randomized trial
    George W Rebok
    Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA
    J Urban Health 81:79-93. 2004
    ..In this pilot trial, the Experience Corps program led to selective improvements in student reading/academic achievement and classroom behavior while not burdening the school staff...
  22. pmc Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
    Am J Kidney Dis 53:51-8. 2009
    ..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized...
  23. pmc At the tipping point: predicting severe mobility difficulty in vulnerable older women
    Josette A Rivera
    Division of Geriatric Medicine and Gerontology, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Am Geriatr Soc 56:1417-23. 2008
    ..To identify clinical measures that aid detection of impending severe mobility difficulty in older women...
  24. pmc Modeled cost-effectiveness of the Experience Corps Baltimore based on a pilot randomized trial
    Kevin D Frick
    Health Services Research and Development Center, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205 1901, USA
    J Urban Health 81:106-17. 2004
    ....
  25. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  26. pmc Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
    Clin Nutr 29:600-4. 2010
    ..The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time...
  27. pmc Marketing public health through older adult volunteering: Experience Corps as a social marketing intervention
    Erwin J Tan
    Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
    Am J Public Health 100:727-34. 2010
    ....
  28. pmc Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?
    Qian Li Xue
    Department of Medicine, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Epidemiol 176:534-43. 2012
    ..24, 95% confidence interval: 0.63, 2.47). Our findings suggest that physical activity does not have to be vigorous to be beneficial and that the gain may be the greatest among women who reported the lowest levels of activity...
  29. pmc Low serum selenium concentrations are associated with poor grip strength among older women living in the community
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biofactors 29:37-44. 2007
    ..04). This study supports the idea that selenium is important to muscle strength in older women...
  30. pmc Potential for intensive volunteering to promote the health of older adults in fair health
    Jeremy S Barron
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Urban Health 86:641-53. 2009
    ..Productive activity such as volunteering may be an effective community-based approach to health promotion for older adults...
  31. ncbi request reprint Exploring the effects of an "everyday" activity program on executive function and memory in older adults: Experience Corps
    Michelle C Carlson
    Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Gerontologist 48:793-801. 2008
    ..This study sought to demonstrate in a short-term pilot randomized trial that such an activity program improves components of cognition critical to independent function among sedentary older adults at greatest risk...
  32. pmc The long-term relationship between high-intensity volunteering and physical activity in older African American women
    Erwin J Tan
    Johns Hopkins Center on Aging and Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol B Psychol Sci Soc Sci 64:304-11. 2009
    ..We sought to determine if there were sustained increases in physical activity with participation in EC...
  33. pmc Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nutrition 24:964-8. 2008
    ....
  34. pmc Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community
    Margaret Dayhoff-Brannigan
    John Hopkins Medical Institutes, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:179-83. 2008
    ..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6...
  35. ncbi request reprint What constitutes normal hemoglobin concentration in community-dwelling disabled older women?
    Paulo H M Chaves
    Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
    J Am Geriatr Soc 52:1811-6. 2004
    ....
  36. doi request reprint Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older women
    Rita R Kalyani
    Divisions of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Geriatr Soc 60:1701-7. 2012
    ..To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations...
  37. pmc Lifestyle activities and memory: variety may be the spice of life. The women's health and aging study II
    Michelle C Carlson
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 18:286-94. 2012
    ..Our findings offer new perspectives in promoting a diverse repertoire of activities to mitigate age-related cognitive declines...
  38. pmc Serum fibroblast growth factor-23 and risk of incident chronic kidney disease in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin J Am Soc Nephrol 7:85-91. 2012
    ..This study aimed to determine whether circulating FGF23 predicts incident CKD in community-dwelling women...
  39. pmc Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    J Gerontol A Biol Sci Med Sci 64:243-8. 2009
    ..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones...
  40. pmc Effect of financial strain on mortality in community-dwelling older women
    Sarah L Szanton
    Johns Hopkins University School of Nursing, 525 N Wolfe street 424, Baltimore, MD 21205, USA
    J Gerontol B Psychol Sci Soc Sci 63:S369-74. 2008
    ..We examined the extent to which financial strain was associated with increased mortality risk in older women and whether the relationship differed by race...
  41. pmc Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study
    Sevil Yasar
    The Johns Hopkins University, Baltimore, MD, USA
    Neurology 81:896-903. 2013
    ....
  42. ncbi request reprint Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study II
    Qian Li Xue
    Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:984-90. 2008
    ..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations...
  43. pmc Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study
    Sevil Yasar
    Division of Geriatric Medicine and Gerontology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Alzheimers Dement 8:188-95. 2012
    ..To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function...
  44. pmc Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and II
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biol Trace Elem Res 112:97-107. 2006
    ..47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. We conclude that low serum selenium is independently associated with anemia among older women living in the community...
  45. pmc Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study II
    Jennifer A Deal
    Department of Epidemiology, Center on Aging and Health, The Johns Hopkin Medical Institutions, 2024 E Monument St, Suite 2 700, Baltimore, MD 21205, USA
    J Am Geriatr Soc 57:1604-11. 2009
    ..To test the hypothesis that anemia (hemoglobin <12 g/dL) is associated with a faster rate of cognitive decline over 9 years in a community-dwelling sample of women aged 70 to 80 at baseline...
  46. ncbi request reprint Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studies
    Amanda L Ray
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr 136:172-6. 2006
    ..77, 95% CI 0.64-0.84/1 SD increase in log(e) total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death...
  47. pmc Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study II
    Paulo H M Chaves
    Center on Aging and Health and Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Am Geriatr Soc 54:1429-35. 2006
    ..To evaluate the relationship between mild anemia and executive function in community-dwelling older women...
  48. ncbi request reprint Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 40:982-7. 2005
    ..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults...
  49. ncbi request reprint Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  50. ncbi request reprint Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Exp Gerontol 44:511-6. 2009
    ..These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women...
  51. pmc Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men
    Loic Desquilbet
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 50:299-306. 2009
    ..Using a frailty-related phenotype (FRP), we investigated in the Multicenter AIDS Cohort Study whether progressive deterioration of the immune system among HIV-positive individuals independently predicts onset of FRP...
  52. pmc Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study II
    Michelle C Carlson
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 64:110-7. 2009
    ..This study characterized in the Women's Health and Aging Study (WHAS) II 9-year declines and transitions to impairment across domains of cognition...
  53. pmc Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indices
    Ravi Varadhan
    The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 64:682-7. 2009
    ..We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty...
  54. pmc Volunteering: a physical activity intervention for older adults--The Experience Corps program in Baltimore
    Erwin J Tan
    Division of Geriatric Medicine and Gerontology, Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
    J Urban Health 83:954-69. 2006
    ....
  55. pmc Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Gerontol A Biol Sci Med Sci 67:683-9. 2012
    ..Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women...
  56. pmc Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women
    Mansi Dalal
    Department of Ophthalmology, Johns Hopkins University School of Medicine, M015, Smith Building, 400 North Broadway, Baltimore, Maryland 21287, USA
    Eur J Endocrinol 165:797-803. 2011
    ..The aim of this study was to determine whether serum FGF23 is independently associated with cardiovascular disease in older community-dwelling women...
  57. pmc Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Age (Dordr) 33:607-14. 2011
    ....
  58. pmc Oxidative stress and severe walking disability among older women
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Med 120:1084-9. 2007
    ..Serum protein carbonyls are markers of oxidative damage to proteins and are caused by oxidative stress...
  59. pmc Exploring the hierarchy of mobility performance in high-functioning older women
    Carlos O Weiss
    Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 62:167-73. 2007
    ....
  60. ncbi request reprint Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging Studies
    Gerald J Jerome
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:1171-6. 2006
    ..This study sought to identify categories of functional deficits associated with activity levels and evaluated the potential for older women to increase their physical activity levels...
  61. pmc Elevated serum advanced glycation end products and poor grip strength in older community-dwelling women
    Mansi Dalal
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 64:132-7. 2009
    ..Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes, heart disease, and kidney failure and may potentially affect skeletal muscle. Whether AGEs are associated with poor muscle strength is unknown...
  62. ncbi request reprint Depressive symptoms, inflammation, and ischemic stroke in older adults: a prospective analysis in the cardiovascular health study
    Jose J Arbelaez
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1825-30. 2007
    ..To investigate the mediator role of inflammation in any relationship between depressive symptoms and ischemic stroke...
  63. pmc Relationship of race and poverty to lower extremity function and decline: findings from the Women's Health and Aging Study
    Roland James Thorpe
    Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Soc Sci Med 66:811-21. 2008
    ..Thus, while race and poverty status were associated with functional deficits in old age, they do not appear to impact the rate of functional decline or progression of disability over 3 years...
  64. pmc Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 46:679-84. 2011
    ..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly...
  65. ncbi request reprint Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women's Health and Aging Study I
    Cynthia M Boyd
    Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 60:888-93. 2005
    ..The objective of this study was to determine whether hospitalization predicts long-term Activities of Daily Living (ADL) dependence in previously ADL independent, although disabled, older women...
  66. ncbi request reprint Vitamin and carotenoid status in older women: associations with the frailty syndrome
    Elisabete Michelon
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:600-7. 2006
    ..We investigated the relationship of micronutrient deficiencies with the frailty syndrome in older women living in the community...
  67. ncbi request reprint Patterns of disability related to diabetes mellitus in older women
    Siobhan C Maty
    Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 59:148-53. 2004
    ..To identify pattern(s) of disability related to diabetes in older women and to determine the extent to which disability is mediated by selected diabetes complications...
  68. pmc Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women
    George C Wang
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 95:1161-8. 2010
    ..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women...
  69. pmc Blunted diurnal decline of cortisol among older adults with low socioeconomic status
    Owhofasa O Agbedia
    Department of Mental Health and Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1231:56-64. 2011
    ..These findings confirm prior evidence of a biologic pathway through which socioeconomic disadvantage is linked to biologic vulnerability, and through which the impact of volunteer service in Experience Corps may be measured...
  70. ncbi request reprint Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
    Jeremy Walston
    Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Am Geriatr Soc 54:991-1001. 2006
    ..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process...
  71. ncbi request reprint Phenotype of frailty: characterization in the women's health and aging studies
    Karen Bandeen-Roche
    Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 61:262-6. 2006
    ..This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS)...
  72. pmc Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study I
    Dae Hyun Kim
    Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Am Geriatr Soc 54:1751-7. 2006
    ..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment...
  73. ncbi request reprint Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  74. ncbi request reprint Why do older adults decide they are having difficulty with a task?
    Patricia C Gregory
    Departments of Physical Medicine and Rehabilitation, The Johns Hopkins Unviersity School of Medicine, Baltimore, Maryland 21239, USA
    Am J Phys Med Rehabil 82:9-16. 2003
    ..Previous studies have identified risk factors for decline in physical function, but they have not examined specific reasons older adults report difficulty with mobility tasks...
  75. ncbi request reprint Frailty and the older man
    J Walston
    Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
    Med Clin North Am 83:1173-94. 1999
    ..There is also evidence that lower levels of activity and lower caloric intake in women as compared to men may also influence the phenotype of frailty and make women more vulnerable then men to the syndrome...
  76. ncbi request reprint Knee osteoarthritis compromises early mobility function: The Women's Health and Aging Study II
    Shari M Ling
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Rheumatol 30:114-20. 2003
    ..Functional limitation was assessed using validated performance measures and self-report measures of task modification and task difficulty...
  77. ncbi request reprint Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated?
    Paulo H M Chaves
    Division of Internal Medicine, Department of Medicine, School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 50:1257-64. 2002
    ..To explore their clinical appropriateness, we evaluated the relationship between hemoglobin (Hb) concentration, prevalent mobility difficulty, and the Summary Performance Score (SPS)...
  78. ncbi request reprint Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women
    Dan E Arking
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA
    J Am Geriatr Soc 54:823-6. 2006
    ..To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women...
  79. ncbi request reprint Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    S P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 70:911-9. 1999
    ..Many previous investigations of cobalamin and folate status were performed in white populations...
  80. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    ..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
  81. ncbi request reprint "Successful aging": effect of subclinical cardiovascular disease
    Anne B Newman
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 163:2315-22. 2003
    ..Among those without clinical disease, high levels of subclinical disease are associated with poor survival. The effect of the extent of subclinical cardiovascular disease on the quality of the remaining years has not been defined...
  82. ncbi request reprint Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women's Health and Aging Study II cohort
    M J Seibert
    Johns Hopkins University School of Medicine, Department of Medicine, Division of Geriatric Medicine and Gerontology, Baltimore, Maryland, USA
    J Am Geriatr Soc 49:1093-6. 2001
    ..To determine whether polymorphic variation in the myostatin gene differentially influences the maintenance of muscle strength in older adults, and to find supportive evidence in a cohort of older women...
  83. ncbi request reprint Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the community
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Aging Clin Exp Res 15:482-7. 2003
    ..The aim was to determine whether dietary carotenoids and alpha-tocopherol are associated with sarcopenia, as indicated by low grip, hip, and knee strength...
  84. doi request reprint A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication use
    Victor Crentsil
    Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Geriatr Pharmacother 8:215-24. 2010
    ..Although disabled older adults may be among the subpopulation of adults with the highest risk for adverse drug events (ADEs), reliable data on their use of medications are limited...
  85. ncbi request reprint Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement
    Crystal F Simpson
    Center on Aging and Health Division of Geriatric Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:123-7. 2004
    ..To determine the agreement between self-report of chronic disease and validated evidence of disease using multiple ascertainment methods and to assess effects of cognition, education, age, and comorbidity...
  86. ncbi request reprint Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging study
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 53:198-203. 2005
    ..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women...
  87. pmc Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
    Nutr Res 29:525-30. 2009
    ..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death...
  88. pmc Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women
    Carlos O Weiss
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 65:287-94. 2010
    ..We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status...
  89. pmc Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II
    Michelle M Mielke
    Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 63:619-24. 2008
    ..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains...
  90. ncbi request reprint The Johns Hopkins Geriatric Summer Scholars Program: a model to increase diversity in geriatric medicine
    Crystal F Simpson
    Johns Hopkins Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Am Geriatr Soc 53:1607-12. 2005
    ..This article describes the outcomes of the first 3 years of the program, with an emphasis on curriculum development and the recruitment and retention of underrepresented minority medical students...
  91. ncbi request reprint Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study
    Jeremy Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Arch Intern Med 162:2333-41. 2002
    ..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness...
  92. ncbi request reprint Relationship between lung function and physical performance in disabled older women
    Crystal F Simpson
    MHS, Center on Aging and Health and Division of Geriatric Medicine, The Johns Hopkins School of Medicne, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 60:350-4. 2005
    ..The aim of this study was to determine the association of lung function with objective and self-reported physical performance in community-dwelling disabled older women...
  93. ncbi request reprint Low serum micronutrient concentrations predict frailty among older women living in the community
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 61:594-9. 2006
    ..Micronutrient deficiencies are common among older adults. We hypothesized that low serum micronutrient concentrations were predictive of frailty among older disabled women living in the community...
  94. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009
    ..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women...
  95. pmc Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty
    A M Matteini
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr Health Aging 14:73-7. 2010
    ..The cross-sectional relationship between genetic variants within six candidate genes along this pathway with serum methylmalonic acid (MMA) levels and frailty was evaluated in this same population of older women...
  96. ncbi request reprint Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study
    S Volpato
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
    Circulation 103:947-53. 2001
    ..We investigated whether specific chronic conditions, particularly cardiovascular disease (CVD), affect the association between high interleukin (IL)-6 level and mortality in a sample of disabled older women...
  97. ncbi request reprint Serum antioxidants, inflammation, and total mortality in older women
    J Walston
    School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Epidemiol 163:18-26. 2006
    ..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women...
  98. ncbi request reprint IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
    J Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 40:344-52. 2005
    ..These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women...
  99. pmc Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty
    R Varadhan
    The Center on Aging and Health, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, United States
    Mech Ageing Dev 129:666-70. 2008
    ....
  100. pmc Low serum selenium is associated with anemia among older adults in the United States
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur J Clin Nutr 63:93-9. 2009
    ..We hypothesized that low serum selenium was associated with anemia in humans...
  101. ncbi request reprint Denture use, malnutrition, frailty, and mortality among older women living in the community
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:161-7. 2006
    ..The relationships between denture use, malnutrition, frailty, and mortality in older women have not been well characterized...

Research Grants20

  1. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2003
    ..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
  2. Conference Series: Bedside to Bench
    Linda Fried; Fiscal Year: 2003
    ..The meetings themselves will be organized by the staff of the American Geriatrics Society. ..
  3. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2004
    ..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
  4. Conference Series: Bedside to Bench
    Linda Fried; Fiscal Year: 2005
    ..The meetings themselves will be organized by the staff of the American Geriatrics Society. ..
  5. EPIDEMIOLOGY AND BIOSTATISTICS OF AGING
    Linda Fried; Fiscal Year: 2007
    ..Graduates will be effective leaders of multidisciplinary research teams tackling the health problems associated with the aging US population. ..
  6. OLDER AMERICANS INDEPENDENCE CENTER
    Linda Fried; Fiscal Year: 2007
    ..Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults. ..
  7. Pathogenesis of physical disability in Aging women
    Linda Fried; Fiscal Year: 2007
    ..These 3 levels of evaluation are anticipated, singly and together, to provide substantive new understanding of opportunities for effective prevention and treatment of disability in older women. ..
  8. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2002
    ..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
  9. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2001
    ..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
  10. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 2000
    ..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
  11. RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMEN
    Linda Fried; Fiscal Year: 1999
    ..The results of this study will help to define those older women at risk of disability, and the potentially alterable risk factors that could be developed into effective interventions to prevent disability in aging women. ..
  12. Experience Corps Trial: Improving Health of Older Populations through Generativit
    Linda Fried; Fiscal Year: 2007
    ..Overall, this program project is designed to evaluate the utility and effectiveness of Experience Corps as a social model for health promotionfor an aging society. ..