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Genomes and GenesSpecies | Linda P FriedSummaryAffiliation: Johns Hopkins University Country: USA Publications
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A social model for health promotion for an aging population: initial evidence on the Experience Corps modelLinda P Fried
Medicine, Epidemiology and Health Policy, Division of Geriatric Medicine and Gerontology, Johns Hopkins Medical Institutions, JHU School of Medicine, 2024 East Monument Street, Baltimore, MD 21205, USA
J Urban Health 81:64-78. 2004..In this pilot trial, physical, cognitive, and social activity increased, suggesting the potential for the Experience Corps to improve health for an aging population and simultaneously improve educational outcomes for children...
Self-reported preclinical disability identifies older women with early declines in performance and early diseaseL P Fried
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Epidemiol 54:889-901. 2001..They also suggest new avenues for screening and intervention to prevent disability...
Anemia in older adults living in the communityLinda P Fried
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Postgrad Med 116:12-6. 2004..In this article, Dr Fried examines current evidence related to such consequences, particularly those observed in studies of older adults living in the community...- A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of genderR Sato
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Nutr Health Aging 10:37-44. 2006..These mixed results do not provide strong evidence of an association between vitamin C concentrations or intake and cognitive function... - Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and careLinda P Fried
Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 59:255-63. 2004.... - From bedside to bench: research agenda for frailtyLinda P Fried
Center on Aging and Health and Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA corrected
Sci Aging Knowledge Environ 2005:pe24. 2005..This article summarizes the central theoretical observations on frailty and research needs and opportunities presented and discussed at this conference, and lays out an agenda for future research on frailty... - Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older womenPaulo H M Chaves
Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 56:1698-703. 2008..For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed... - Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort studyGeorge C Wang
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Epidemiol 171:1144-52. 2010..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection... - Oxidative protein damage is associated with poor grip strength among older women living in the communityCaitlin Howard
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Appl Physiol 103:17-20. 2007..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults... - Inflammation and frailty in older womenSean X Leng
Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
J Am Geriatr Soc 55:864-71. 2007..To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) and prevalent frailty... - Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Age Ageing 36:62-7. 2007..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women... - Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health studyAnne R Cappola
SCM, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 764 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 64:1268-74. 2009..Assessment of an individual's ability to maintain a DHEAS set point, through examination of multiple DHEAS levels over time, may provide insight into biologic aging... - Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling womenRichard D Semba
Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
Aging Clin Exp Res 21:182-90. 2009..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality... - White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Gerontol A Biol Sci Med Sci 64:499-502. 2009..WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated... - Frailty, hospitalization, and progression of disability in a cohort of disabled older womenCynthia M Boyd
Division of Geriatric Medicine and Gerontology, Center on Aging and Health, National Institute on Aging, Baltimore, MD, USA
Am J Med 118:1225-31. 2005..To determine the association between a previously validated frailty phenotype and the development of new-onset dependence in activities of daily living, independent of hospitalizations and other established predictors of disability... - Evidence for neurocognitive plasticity in at-risk older adults: the experience corps programMichelle C Carlson
Department of Mental Health, Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 64:1275-82. 2009..To determine whether Experience Corps (EC), a social service program, would improve age-vulnerable executive functions and increase activity in brain regions in a high-risk group through increased cognitive and physical activity... - Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study IRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Aging Clin Exp Res 19:259-64. 2007..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality... - Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study IQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Epidemiol 167:240-8. 2008..Together, these data suggest that a slightly constricted life space may be a marker and/or risk factor for the development of frailty that may prove useful as a screening tool or a target of intervention... - Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling womenRichard D Semba
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Age Ageing 38:283-9. 2009..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia... - Experience Corps: design of an intergenerational program to boost social capital and promote the health of an aging societyThomas A Glass
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
J Urban Health 81:94-105. 2004..This article explores how the linkage of concepts at multiple levels motivates a potentially cost-effective, feasible, and high-impact program... - Marketing public health through older adult volunteering: Experience Corps as a social marketing interventionErwin J Tan
Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
Am J Public Health 100:727-34. 2010.... - At the tipping point: predicting severe mobility difficulty in vulnerable older womenJosette A Rivera
Division of Geriatric Medicine and Gerontology, Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Am Geriatr Soc 56:1417-23. 2008..To identify clinical measures that aid detection of impending severe mobility difficulty in older women... - Short-term impact of Experience Corps participation on children and schools: results from a pilot randomized trialGeorge W Rebok
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA
J Urban Health 81:79-93. 2004..In this pilot trial, the Experience Corps program led to selective improvements in student reading/academic achievement and classroom behavior while not burdening the school staff... - Modeled cost-effectiveness of the Experience Corps Baltimore based on a pilot randomized trialKevin D Frick
Health Services Research and Development Center, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205 1901, USA
J Urban Health 81:106-17. 2004.... - Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling womenRichard D Semba
Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
Am J Kidney Dis 53:51-8. 2009..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized... - Oxidative stress is associated with greater mortality in older women living in the communityRichard D Semba
Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
J Am Geriatr Soc 55:1421-5. 2007..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community... - Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study IRichard D Semba
Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States
Clin Nutr 29:600-4. 2010..The aims were to determine whether total serum carotenoids, α-tocopherol, selenium, protein carbonyls, and interleukin-6 (IL-6) are associated with RDW and predict RDW over time... - Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?Qian Li Xue
Department of Medicine, Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Am J Epidemiol 176:534-43. 2012..24, 95% confidence interval: 0.63, 2.47). Our findings suggest that physical activity does not have to be vigorous to be beneficial and that the gain may be the greatest among women who reported the lowest levels of activity... - The long-term relationship between high-intensity volunteering and physical activity in older African American womenErwin J Tan
Johns Hopkins Center on Aging and Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol B Psychol Sci Soc Sci 64:304-11. 2009..We sought to determine if there were sustained increases in physical activity with participation in EC... - Potential for intensive volunteering to promote the health of older adults in fair healthJeremy S Barron
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Urban Health 86:641-53. 2009..Productive activity such as volunteering may be an effective community-based approach to health promotion for older adults... - What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Paulo H M Chaves
Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Geriatr Soc 52:1811-6. 2004.... - Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the communityMargaret Dayhoff-Brannigan
John Hopkins Medical Institutes, Baltimore, MD, USA
J Gerontol A Biol Sci Med Sci 63:179-83. 2008..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6... - Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling womenJustine Beck
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Nutrition 24:964-8. 2008.... - Low serum selenium concentrations are associated with poor grip strength among older women living in the communityJustine Beck
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biofactors 29:37-44. 2007..04). This study supports the idea that selenium is important to muscle strength in older women... - Exploring the effects of an "everyday" activity program on executive function and memory in older adults: Experience CorpsMichelle C Carlson
Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
Gerontologist 48:793-801. 2008..This study sought to demonstrate in a short-term pilot randomized trial that such an activity program improves components of cognition critical to independent function among sedentary older adults at greatest risk... - Hyperglycemia and incidence of frailty and lower extremity mobility limitations in older womenRita R Kalyani
Divisions of Endocrinology, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Am Geriatr Soc 60:1701-7. 2012..To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations... - Serum fibroblast growth factor-23 and risk of incident chronic kidney disease in older community-dwelling womenRichard D Semba
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 7:85-91. 2012..This study aimed to determine whether circulating FGF23 predicts incident CKD in community-dwelling women... - Lifestyle activities and memory: variety may be the spice of life. The women's health and aging study IIMichelle C Carlson
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Int Neuropsychol Soc 18:286-94. 2012..Our findings offer new perspectives in promoting a diverse repertoire of activities to mitigate age-related cognitive declines... - Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studiesAnne R Cappola
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
J Gerontol A Biol Sci Med Sci 64:243-8. 2009..We hypothesized that associations with frailty would most likely manifest in the presence of deficits in multiple anabolic hormones... - Initial manifestations of frailty criteria and the development of frailty phenotype in the Women's Health and Aging Study IIQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, 2024 E Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:984-90. 2008..This study aims to characterize natural history by which commonly used frailty criteria manifest and to assess whether the rate of progression to frailty depends on initial manifestations... - Effect of financial strain on mortality in community-dwelling older womenSarah L Szanton
Johns Hopkins University School of Nursing, 525 N Wolfe street 424, Baltimore, MD 21205, USA
J Gerontol B Psychol Sci Soc Sci 63:S369-74. 2008..We examined the extent to which financial strain was associated with increased mortality risk in older women and whether the relationship differed by race... - Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory StudySevil Yasar
Division of Geriatric Medicine and Gerontology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Alzheimers Dement 8:188-95. 2012..To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function... - Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older womenSean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 40:982-7. 2005..They provide a basis for further investigation into the role of leukocytes in age-related inflammation and its associated adverse outcomes in older adults... - Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study IIPaulo H M Chaves
Center on Aging and Health and Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 54:1429-35. 2006..To evaluate the relationship between mild anemia and executive function in community-dwelling older women... - Volunteering: a physical activity intervention for older adults--The Experience Corps program in BaltimoreErwin J Tan
Division of Geriatric Medicine and Gerontology, Johns Hopkins Center on Aging and Health, Baltimore, MD 21205, USA
J Urban Health 83:954-69. 2006.... - Low Serum Selenium Is Associated with Anemia Among Older Women Living in the Community: the Women's Health and Aging Studies I and IIRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Biol Trace Elem Res 112:97-107. 2006..47-0.84), adjusting for age, education, chronic diseases, iron status, and serum interleukin-6. We conclude that low serum selenium is independently associated with anemia among older women living in the community... - Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study IIMichelle C Carlson
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 64:110-7. 2009..This study characterized in the Women's Health and Aging Study (WHAS) II 9-year declines and transitions to impairment across domains of cognition... - Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studiesAmanda L Ray
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nutr 136:172-6. 2006..77, 95% CI 0.64-0.84/1 SD increase in log(e) total carotenoids; P = 0.009) were associated with a lower risk of mortality. Women living in the community who have higher serum selenium and carotenoids are at a lower risk of death... - Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies ISean X Leng
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Exp Gerontol 44:511-6. 2009..These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women... - Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study IIJennifer A Deal
Department of Epidemiology, Center on Aging and Health, The Johns Hopkin Medical Institutions, 2024 E Monument St, Suite 2 700, Baltimore, MD 21205, USA
J Am Geriatr Soc 57:1604-11. 2009..To test the hypothesis that anemia (hemoglobin <12 g/dL) is associated with a faster rate of cognitive decline over 9 years in a community-dwelling sample of women aged 70 to 80 at baseline... - Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected menLoic Desquilbet
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 50:299-306. 2009..Using a frailty-related phenotype (FRP), we investigated in the Multicenter AIDS Cohort Study whether progressive deterioration of the immune system among HIV-positive individuals independently predicts onset of FRP... - Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indicesRavi Varadhan
The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 64:682-7. 2009..We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty... - Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus reportLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
J Am Geriatr Soc 52:625-34. 2004.... - Serum 25-hydroxyvitamin D and pulmonary function in older disabled community-dwelling womenRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Gerontol A Biol Sci Med Sci 67:683-9. 2012..Our objective was to examine the relationship between serum 25-hydroxyvitamin D (25[OH]D), serum parathyroid hormone, and pulmonary function in older women... - Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling womenMansi Dalal
Department of Ophthalmology, Johns Hopkins University School of Medicine, M015, Smith Building, 400 North Broadway, Baltimore, Maryland 21287, USA
Eur J Endocrinol 165:797-803. 2011..The aim of this study was to determine whether serum FGF23 is independently associated with cardiovascular disease in older community-dwelling women... - Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8+ T cells in older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Age (Dordr) 33:607-14. 2011.... - Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adultsSean X Leng
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Gerontol 46:679-84. 2011..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly... - Relationship of race and poverty to lower extremity function and decline: findings from the Women's Health and Aging StudyRoland James Thorpe
Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Soc Sci Med 66:811-21. 2008..Thus, while race and poverty status were associated with functional deficits in old age, they do not appear to impact the rate of functional decline or progression of disability over 3 years... - Depressive symptoms, inflammation, and ischemic stroke in older adults: a prospective analysis in the cardiovascular health studyJose J Arbelaez
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 55:1825-30. 2007..To investigate the mediator role of inflammation in any relationship between depressive symptoms and ischemic stroke... - Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging StudiesGerald J Jerome
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 61:1171-6. 2006..This study sought to identify categories of functional deficits associated with activity levels and evaluated the potential for older women to increase their physical activity levels... - Oxidative stress and severe walking disability among older womenRichard D Semba
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Med 120:1084-9. 2007..Serum protein carbonyls are markers of oxidative damage to proteins and are caused by oxidative stress... - Exploring the hierarchy of mobility performance in high-functioning older womenCarlos O Weiss
Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 62:167-73. 2007.... - Vitamin and carotenoid status in older women: associations with the frailty syndromeElisabete Michelon
The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 61:600-7. 2006..Future longitudinal studies are needed to examine the relationships between micronutrient concentrations and frailty in older women... - Elevated serum advanced glycation end products and poor grip strength in older community-dwelling womenMansi Dalal
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 64:132-7. 2009..Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes, heart disease, and kidney failure and may potentially affect skeletal muscle. Whether AGEs are associated with poor muscle strength is unknown... - Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: the Women's Health and Aging Study ICynthia M Boyd
Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:888-93. 2005..The objective of this study was to determine whether hospitalization predicts long-term Activities of Daily Living (ADL) dependence in previously ADL independent, although disabled, older women... - Patterns of disability related to diabetes mellitus in older womenSiobhan C Maty
Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 59:148-53. 2004..Other complications of diabetes (e.g., neuropathy, peripheral vascular disease) may mediate diabetes-associated disability in older adults... - Blunted diurnal decline of cortisol among older adults with low socioeconomic statusOwhofasa O Agbedia
Department of Mental Health and Center on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann N Y Acad Sci 1231:56-64. 2011..These findings confirm prior evidence of a biologic pathway through which socioeconomic disadvantage is linked to biologic vulnerability, and through which the impact of volunteer service in Experience Corps may be measured... - Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older AdultsJeremy Walston
Department of Medicine, Johns Hopkins Medical Institutions, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Am Geriatr Soc 54:991-1001. 2006..This meeting and subsequent article were not meant to be a comprehensive review of frailty research; instead, they were and are meant to provide a more-targeted research agenda-setting process... - Phenotype of frailty: characterization in the women's health and aging studiesKaren Bandeen-Roche
Department of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 61:262-6. 2006..This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS)... - Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older womenGeorge C Wang
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 95:1161-8. 2010..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women... - Why do older adults decide they are having difficulty with a task?Patricia C Gregory
Departments of Physical Medicine and Rehabilitation, The Johns Hopkins Unviersity School of Medicine, Baltimore, Maryland 21239, USA
Am J Phys Med Rehabil 82:9-16. 2003..Previous studies have identified risk factors for decline in physical function, but they have not examined specific reasons older adults report difficulty with mobility tasks... - Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older womenAnne R Cappola
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 88:2019-25. 2003..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging... - Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study IDae Hyun Kim
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Am Geriatr Soc 54:1751-7. 2006..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment... - Frailty and the older manJ Walston
Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
Med Clin North Am 83:1173-94. 1999..There is also evidence that lower levels of activity and lower caloric intake in women as compared to men may also influence the phenotype of frailty and make women more vulnerable then men to the syndrome... - Knee osteoarthritis compromises early mobility function: The Women's Health and Aging Study IIShari M Ling
Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
J Rheumatol 30:114-20. 2003..The extent to which modification of these factors attenuates knee OA associated functional decline should be investigated... - Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated?Paulo H M Chaves
Division of Internal Medicine, Department of Medicine, School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 50:1257-64. 2002..To explore their clinical appropriateness, we evaluated the relationship between hemoglobin (Hb) concentration, prevalent mobility difficulty, and the Summary Performance Score (SPS)... - Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian womenDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205, USA
J Am Geriatr Soc 54:823-6. 2006..To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women... - Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly womenS P Stabler
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Clin Nutr 70:911-9. 1999..Many previous investigations of cobalamin and folate status were performed in white populations... - "Successful aging": effect of subclinical cardiovascular diseaseAnne B Newman
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Intern Med 163:2315-22. 2003..Among those without clinical disease, high levels of subclinical disease are associated with poor survival. The effect of the extent of subclinical cardiovascular disease on the quality of the remaining years has not been defined... - Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
Lancet 375:2073-81. 2010..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality... - Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women's Health and Aging Study II cohortM J Seibert
Johns Hopkins University School of Medicine, Department of Medicine, Division of Geriatric Medicine and Gerontology, Baltimore, Maryland, USA
J Am Geriatr Soc 49:1093-6. 2001..To determine whether polymorphic variation in the myostatin gene differentially influences the maintenance of muscle strength in older adults, and to find supportive evidence in a cohort of older women... - Just get out the door! Importance of walking outside the home for maintaining mobility: findings from the women's health and aging studyEleanor M Simonsick
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 53:198-203. 2005..To determine the association between volitional walking behavior and change in walking ability and lower extremity function over 1 year in functionally limited older women... - Carotenoid and vitamin E status are associated with indicators of sarcopenia among older women living in the communityRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Aging Clin Exp Res 15:482-7. 2003..The aim was to determine whether dietary carotenoids and alpha-tocopherol are associated with sarcopenia, as indicated by low grip, hip, and knee strength... - Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreementCrystal F Simpson
Center on Aging and Health Division of Geriatric Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Am Geriatr Soc 52:123-7. 2004..To determine the agreement between self-report of chronic disease and validated evidence of disease using multiple ascertainment methods and to assess effects of cognition, education, age, and comorbidity... - Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study IIMichelle M Mielke
Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:619-24. 2008..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains... - A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication useVictor Crentsil
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Geriatr Pharmacother 8:215-24. 2010..Although disabled older adults may be among the subpopulation of adults with the highest risk for adverse drug events (ADEs), reliable data on their use of medications are limited... - Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling womenRichard D Semba
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21287, USA
Nutr Res 29:525-30. 2009..4 nmol/L) of 25(OH)D in a multivariate Cox proportional hazards model adjusting for demographics, season, and conventional risk factors. Older community-dwelling women with low 25(OH)D levels are at an increased risk of death... - Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health StudyJeremy Walston
Johns Hopkins Medical Institutions, Baltimore, MD, USA
Arch Intern Med 162:2333-41. 2002..The biological basis of frailty has been difficult to establish owing to the lack of a standard definition, its complexity, and its frequent coexistence with illness... - Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older womenCarlos O Weiss
Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 65:287-94. 2010..We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status... - Low serum micronutrient concentrations predict frailty among older women living in the communityRichard D Semba
The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 61:594-9. 2006..Micronutrient deficiencies are common among older adults. We hypothesized that low serum micronutrient concentrations were predictive of frailty among older disabled women living in the community... - Relationship between lung function and physical performance in disabled older womenCrystal F Simpson
MHS, Center on Aging and Health and Division of Geriatric Medicine, The Johns Hopkins School of Medicne, Baltimore, Maryland 21205, USA
J Gerontol A Biol Sci Med Sci 60:350-4. 2005..The aim of this study was to determine the association of lung function with objective and self-reported physical performance in community-dwelling disabled older women... - The Johns Hopkins Geriatric Summer Scholars Program: a model to increase diversity in geriatric medicineCrystal F Simpson
Johns Hopkins Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland 21224, USA
J Am Geriatr Soc 53:1607-12. 2005..This article describes the outcomes of the first 3 years of the program, with an emphasis on curriculum development and the recruitment and retention of underrepresented minority medical students... - Allostatic load and frailty in the women's health and aging studiesS L Szanton
Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA
Biol Res Nurs 10:248-56. 2009..The purpose of this study was to evaluate whether allostatic load (AL) was associated with the geriatric syndrome of frailty in older community-dwelling women... - Vitamin D deficiency among older women with and without disabilityR D Semba
Johns Hopkins Medical Institutions, Baltimore, and the Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
Am J Clin Nutr 72:1529-34. 2000..Vitamin D deficiency is associated with bone loss and bone fractures, and the identification of vulnerable populations is important to clinical practice and public health... - Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging studyS Volpato
Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
Circulation 103:947-53. 2001..We investigated whether specific chronic conditions, particularly cardiovascular disease (CVD), affect the association between high interleukin (IL)-6 level and mortality in a sample of disabled older women... - Low serum carotenoids are associated with a decline in walking speed in older womenN Alipanah
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nutr Health Aging 13:170-5. 2009..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women... - Serum antioxidants, inflammation, and total mortality in older womenJ Walston
School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Am J Epidemiol 163:18-26. 2006..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women... - Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailtyA M Matteini
Johns Hopkins University, Baltimore, MD 21205, USA
J Nutr Health Aging 14:73-7. 2010..The cross-sectional relationship between genetic variants within six candidate genes along this pathway with serum methylmalonic acid (MMA) levels and frailty was evaluated in this same population of older women... - Frailty in older adults: evidence for a phenotypeL P Fried
Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Gerontol A Biol Sci Med Sci 56:M146-56. 2001..A standardized definition has not yet been established... - Socioeconomic status is associated with frailty: the Women's Health and Aging StudiesS L Szanton
Johns Hopkins University Center on Aging and Health, 525 N Wolfe Street, Baltimore, MD 21205 424, USA
J Epidemiol Community Health 64:63-7. 2010..A study was undertaken to determine (1) the extent to which low SES was associated with increased odds of frailty and (2) whether race was associated with frailty, independent of SES... - Denture use, malnutrition, frailty, and mortality among older women living in the communityR D Semba
The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Nutr Health Aging 10:161-7. 2006..The relationships between denture use, malnutrition, frailty, and mortality in older women have not been well characterized...
Research Grants
- RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMENLinda Fried; Fiscal Year: 2004..The resulting insights should provide new opportunities for screening and prevention of physcial disability in older women- the population subgroup at highest risk for disability at older ages. ..
- Conference Series: Bedside to BenchLinda Fried; Fiscal Year: 2005..The meetings themselves will be organized by the staff of the American Geriatrics Society. ..
- EPIDEMIOLOGY AND BIOSTATISTICS OF AGINGLinda Fried; Fiscal Year: 2007..Graduates will be effective leaders of multidisciplinary research teams tackling the health problems associated with the aging US population. ..
- OLDER AMERICANS INDEPENDENCE CENTERLinda Fried; Fiscal Year: 2007..Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults. ..
- Pathogenesis of physical disability in Aging womenLinda Fried; Fiscal Year: 2007..These 3 levels of evaluation are anticipated, singly and together, to provide substantive new understanding of opportunities for effective prevention and treatment of disability in older women. ..
- RISK FACTORS FOR PHYSICAL DISABILITY IN AGING WOMENLinda Fried; Fiscal Year: 1999..The results of this study will help to define those older women at risk of disability, and the potentially alterable risk factors that could be developed into effective interventions to prevent disability in aging women. ..
- Experience Corps Trial: Improving Health of Older Populations through GenerativitLinda Fried; Fiscal Year: 2007..Overall, this program project is designed to evaluate the utility and effectiveness of Experience Corps as a social model for health promotionfor an aging society. ..