L P Fried

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
  2. ncbi Preclinical mobility disability predicts incident mobility disability in older women
    L P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 55:M43-52. 2000
  3. pmc Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty
    A M Matteini
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr Health Aging 14:73-7. 2010
  4. pmc The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study
    K S Benke
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 46:1010-9. 2011
  5. pmc Diet quality and social support: factors associated with serum carotenoid concentrations among older disabled women (the Women's Health and Aging Study)
    E J Nicklett
    Johns Hopkins University, Center on Aging and Health, Baltimore, MD 21231, USA
    J Nutr Health Aging 16:511-8. 2012
  6. ncbi Frailty and the older man
    J Walston
    Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
    Med Clin North Am 83:1173-94. 1999
  7. pmc Low serum selenium is associated with anemia among older adults in the United States
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur J Clin Nutr 63:93-9. 2009
  8. ncbi Association between executive attention and physical functional performance in community-dwelling older women
    M C Carlson
    School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 54:S262-70. 1999
  9. ncbi Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    S P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 70:911-9. 1999
  10. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009

Collaborators

Detail Information

Publications31

  1. ncbi Frailty in older adults: evidence for a phenotype
    L P Fried
    Center on Aging and Health, The John Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 56:M146-56. 2001
    ..A standardized definition has not yet been established...
  2. ncbi Preclinical mobility disability predicts incident mobility disability in older women
    L P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 55:M43-52. 2000
    ..The objective of this study was to determine preclinical functional predictors of incident mobility difficulty and provide evidence for a preclinical stage of disability...
  3. pmc Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty
    A M Matteini
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr Health Aging 14:73-7. 2010
    ..The cross-sectional relationship between genetic variants within six candidate genes along this pathway with serum methylmalonic acid (MMA) levels and frailty was evaluated in this same population of older women...
  4. pmc The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study
    K S Benke
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 46:1010-9. 2011
    ....
  5. pmc Diet quality and social support: factors associated with serum carotenoid concentrations among older disabled women (the Women's Health and Aging Study)
    E J Nicklett
    Johns Hopkins University, Center on Aging and Health, Baltimore, MD 21231, USA
    J Nutr Health Aging 16:511-8. 2012
    ..This study investigated the relationship between social support (including instrumental support, emotional support, social interaction, social space, and family networks) and diet quality, as indicated by serum carotenoid levels...
  6. ncbi Frailty and the older man
    J Walston
    Department of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland, USA
    Med Clin North Am 83:1173-94. 1999
    ..There is also evidence that lower levels of activity and lower caloric intake in women as compared to men may also influence the phenotype of frailty and make women more vulnerable then men to the syndrome...
  7. pmc Low serum selenium is associated with anemia among older adults in the United States
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur J Clin Nutr 63:93-9. 2009
    ..We hypothesized that low serum selenium was associated with anemia in humans...
  8. ncbi Association between executive attention and physical functional performance in community-dwelling older women
    M C Carlson
    School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 54:S262-70. 1999
    ..This study examined whether executive attentional abilities were uniquely associated with the performance of complex, instrumental activities of daily living (IADLs) in cognitively intact and physically high-functioning older women...
  9. ncbi Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    S P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 70:911-9. 1999
    ..Many previous investigations of cobalamin and folate status were performed in white populations...
  10. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009
    ..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women...
  11. pmc Socioeconomic status is associated with frailty: the Women's Health and Aging Studies
    S L Szanton
    Johns Hopkins University Center on Aging and Health, 525 N Wolfe Street, Baltimore, MD 21205 424, USA
    J Epidemiol Community Health 64:63-7. 2010
    ..A study was undertaken to determine (1) the extent to which low SES was associated with increased odds of frailty and (2) whether race was associated with frailty, independent of SES...
  12. ncbi Vitamin D deficiency among older women with and without disability
    R D Semba
    Johns Hopkins Medical Institutions, Baltimore, and the Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD, USA
    Am J Clin Nutr 72:1529-34. 2000
    ..Vitamin D deficiency is associated with bone loss and bone fractures, and the identification of vulnerable populations is important to clinical practice and public health...
  13. doi Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women
    R R Kalyani
    Division of Endocrinology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nutr Health Aging 16:679-86. 2012
    ..Frailty status is associated with altered glucose-insulin dynamics. Here, we sought to investigate whether alteration in the dynamics of other circulating energy metabolism hormones after oral glucose is associated with frailty status...
  14. ncbi Serum carotenoids and pulmonary function in older community-dwelling women
    R D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Nutr Health Aging 16:291-6. 2012
    ..Serum carotenoids are considered the most reliable indicator of fruit and vegetable intake...
  15. ncbi Association of IGF-I levels with muscle strength and mobility in older women
    A R Cappola
    Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 86:4139-46. 2001
    ..These findings suggest a role for IGF-I in disability as well as a potential target population for interventions to raise IGF-I levels...
  16. pmc Markers of B-vitamin deficiency and frailty in older women
    A M Matteini
    Johns Hopkins Institutions, Baltimore, MD, USA
    J Nutr Health Aging 12:303-8. 2008
    ..To evaluate the association between markers of vitamins B12, B6 and folate deficiency and the geriatric syndrome of frailty...
  17. ncbi Denture use, malnutrition, frailty, and mortality among older women living in the community
    R D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:161-7. 2006
    ..The relationships between denture use, malnutrition, frailty, and mortality in older women have not been well characterized...
  18. ncbi Serum antioxidants, inflammation, and total mortality in older women
    J Walston
    School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Epidemiol 163:18-26. 2006
    ..54, 95% confidence interval: 1.03, 2.32). These findings suggest that specific antioxidant nutrients may play an important role in suppressing IL-6 levels in disabled older women...
  19. ncbi Self-reported preclinical disability identifies older women with early declines in performance and early disease
    L P Fried
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Epidemiol 54:889-901. 2001
    ..They also suggest new avenues for screening and intervention to prevent disability...
  20. ncbi Predicting the risk of mobility difficulty in older women with screening nomograms: the Women's Health and Aging Study II
    P H Chaves
    Center on Aging and Health, The Johns Hopkins University School of Medicine, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205 2223, USA
    Arch Intern Med 160:2525-33. 2000
    ..The goal of this study was to develop easy-to-use clinical nomograms for estimation of the probability of incident mobility difficulty...
  21. pmc Allostatic load and frailty in the women's health and aging studies
    S L Szanton
    Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA
    Biol Res Nurs 10:248-56. 2009
    ..The purpose of this study was to evaluate whether allostatic load (AL) was associated with the geriatric syndrome of frailty in older community-dwelling women...
  22. ncbi Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project
    S K West
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA
    JAMA 280:714-8. 1998
    ..Exposure to UV-B radiation in sunlight has been shown to increase the risk of cataract formation in high-risk occupational groups, but risk to the population has not been quantified...
  23. ncbi Correlates of performance-based measures of muscle function in the elderly: the Cardiovascular Health Study
    C H Hirsch
    Department of Medicine, University of California, Davis, USA
    J Gerontol A Biol Sci Med Sci 52:M192-200. 1997
    ....
  24. ncbi The association of multiple visual impairments with self-reported visual disability: SEE project
    G S Rubin
    Lions Vision Center, Department of Biostatistics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:64-72. 2001
    ..This report examines the relationship between psychophysical measures of visual impairment and self-reported difficulty with everyday visual tasks in a population-based sample of individuals 65 years of age and older...
  25. ncbi Left ventricular mass in the elderly. The Cardiovascular Health Study
    J M Gardin
    Department of Medicine, University of California, Irvine, USA
    Hypertension 29:1095-103. 1997
    ....
  26. ncbi Importance of generativity for healthy aging in older women
    M C Carlson
    Department of Mental Hygiene, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Aging (Milano) 12:132-40. 2000
    ....
  27. ncbi Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women
    Y J Cao
    National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Clin Pharmacol Ther 83:422-9. 2008
    ....
  28. ncbi A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender
    R Sato
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:37-44. 2006
    ..These mixed results do not provide strong evidence of an association between vitamin C concentrations or intake and cognitive function...
  29. ncbi IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women
    J Walston
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Gerontol 40:344-52. 2005
    ..These results suggest that IL-6 gene variation may not be an important factor in the determination of elevated IL-6 levels and related phenotypes found in older women...
  30. ncbi Diabetes, hyperglycaemia and mortality in disabled older women: The Women's Health and Ageing Study I
    C S Blaum
    Department of Medicine, The University of Michigan, Ann Arbor, MI 48109 0926, USA
    Diabet Med 22:543-50. 2005
    ..We evaluated whether cardiovascular disease, comorbidities, or degree of hyperglycaemia, particularly severe hyperglycaemia, affected diabetes-related mortality risk in older, disabled women...
  31. pmc Building communities that promote successful aging
    L P Fried
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    West J Med 167:216-9. 1997
    ..Gerontologically designed opportunities for contribution on a large social scale could well provide a national approach to primary prevention to maintain health and function in older adults...