Research Topics
| J M FreemanSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Rights, respect for dignity and end-of-life care: time for a change in the concept of informed consentJ M Freeman
J Med Ethics 36:61-2. 2010..They may impinge on the dignity of the patient as well as subject society to unwarranted expense. In order to provide affordable healthcare for all, these concepts are in need of modification...
Less testing is needed in the emergency room after a first afebrile seizureJohn M Freeman
Johns Hopkins Medical Institutions, Baltimore, MD 21247-7247, USA
Pediatrics 111:194-6. 2003- Expert medical testimony: Responsibilities of medical societiesJohn M Freeman
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Neurology 63:1557-8. 2004..Specialty societies, such as the American Academy of Neurology, should be willing to review complaints about unsubstantiated testimony and, at times, publicly discipline offending experts... 
Ethical theory and medical ethics: a personal perspectiveJ M Freeman
Meyer 2-147, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Med Ethics 32:617-8. 2006- The ketogenic diet: one decade laterJohn M Freeman
John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 7247, USA
Pediatrics 119:535-43. 2007..Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy... - The use of amplitude-integrated electroencephalography: beware of its unintended consequencesJohn M Freeman
John M. Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 119:615-7. 2007 - Beware: the misuse of technology and the law of unintended consequencesJohn M Freeman
Department of Neurology and the Berman Institute of Bioethics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Neurotherapeutics 4:549-54. 2007..What are the ethics of continued approval and introduction of unevaluated technology? What is the wisdom of its use? Beware of the unintended consequences... - The ketogenic diet: additional information from a crossover studyJohn M Freeman
Pediatric Epilepsy Center, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Child Neurol 24:509-12. 2009..The diet remained effective in decreasing seizures of the Lennox-Gastaut syndrome at 12 days, 6 months, and 12 months. In conclusion, the ketogenic diet is effective in decreasing the drop seizures of the Lennox-Gastaut syndrome... - The outcome of children with intractable seizures: a 3- to 6-year follow-up of 67 children who remained on the ketogenic diet less than one yearElisabeth B Marsh
John M. Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MS 21287-1000, U.S.A
Epilepsia 47:425-30. 2006..Whether or not the diet was effective, most families did not regret trying it and would recommend it to others... - The ketogenic diet: a 3- to 6-year follow-up of 150 children enrolled prospectivelyC Hemingway
Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 108:898-905. 2001..The diet often allows decrease or discontinuation of medication. It is more effective than many of the newer anticonvulsants and is well-tolerated when it is effective... - The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketonesD L Gilbert
Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Child Neurol 15:787-90. 2000..At present, however, urine ketones are the only readily available inexpensive approach to ketone assessment... - The ketogenic diet: adolescents can do it, tooMackenzie A Mady
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Epilepsia 44:847-51. 2003..CONCLUSIONS: The ketogenic diet is as well tolerated and efficacious for adolescents with epilepsy as for the general childhood population... - Risk factors for urolithiasis in children on the ketogenic dietS L Furth
Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 2535, USA
Pediatr Nephrol 15:125-8. 2000..In conjunction with low fluid intake, these patients are at high risk for both uric acid and calcium stone formation... - The postoperative course and management of 106 hemidecorticationsE H Kossoff
Department of Neurology and Pediatrics, The Pediatric Epilepsy Center, Johns Hopkins Medicla Institutions, Baltimore, MD, USA
Pediatr Neurosurg 37:298-303. 2002..The purpose of this study was to evaluate the short-term issues surrounding hemispherectomy and their management in a series of patients from our institution... - The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomiesCarlos A Pardo
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Epilepsia 45:516-26. 2004..To characterize the profile of cortical involvement in RS, we studied the pathological changes in the cerebral cortex of 45 hemispherectomies performed at Johns Hopkins Hospital between 1985 and 2002... - Experience in the use of the ketogenic diet as early therapyJames E Rubenstein
Department of Neurology, Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
J Child Neurol 20:31-4. 2005..6). The ketogenic diet can be a valuable therapy before epilepsy becomes intractable. In the 13 patients reported, efficacy without side effects was achieved similarly to that with patients with intractable epilepsy... - Growth of children on the ketogenic dietEileen P G Vining
The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Dev Med Child Neurol 44:796-802. 2002..The ketogenic diet generally provides sufficient nutrition to maintain growth within normal parameters over a defined period. Very young children grow poorly on the diet and should be followed-up carefully over long periods of use... - Kidney stones, carbonic anhydrase inhibitors, and the ketogenic dietEric H Kossoff
The Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, and Division of Pediatric Nephrology, Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 1000, USA
Epilepsia 43:1168-71. 2002..The objective of this study was to establish the prevalence of nephrolithiasis in children in this combination-therapy population... - Outcomes of 32 hemispherectomies for Sturge-Weber syndrome worldwideEric H Kossoff
Pediatric Epilepsy Center, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Neurology 59:1735-8. 2002..Epilepsy affects 80% of patients with Sturge-Weber syndrome; the majority of seizures begin before the age of 1. When seizures are intractable to medications and unihemispheric, hemispherectomy is often advised... - Efficacy of the ketogenic diet for infantile spasmsEric H Kossoff
Department of Neurology, Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 109:780-3. 2002..The objective of this study was to determine whether the ketogenic diet is safe, well-tolerated, and efficacious in the treatment of infantile spasms... - Efficacy of the Atkins diet as therapy for intractable epilepsyEric H Kossoff
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
Neurology 61:1789-91. 2003..This provides preliminary evidence that the Atkins diet may have a role as therapy for patients with medically resistant epilepsy... - A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasmsEric H Kossoff
Department of Neurology, John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287 1000, USA
Epilepsia 49:1504-9. 2008..We hypothesized the ketogenic diet (KD), previously reported as beneficial for intractable infantile spasms, would have similar efficacy, but better tolerability than ACTH when used first-line... - Landau-Kleffner syndrome responsive to levetiracetamEric H Kossoff
Department of Neurology, The Johns Hopkins Hospital, Jefferson 128, 600 North Wolfe Street, Baltimore, MD 21287 1000, USA
Epilepsy Behav 4:571-5. 2003..Levetiracetam should be considered as therapy for Landau-Kleffner syndrome... - Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in childrenPeter O Kwiterovich
Lipid Research Atherosclerosis Division, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
JAMA 290:912-20. 2003..Little prospective long-term information is available on the effect of a ketogenic diet on plasma lipoproteins in children with difficult-to-control seizures... - Tuberous sclerosis complex and the ketogenic dietEric H Kossoff
Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins University, Baltimore, MD 212871000, USA
Epilepsia 46:1684-6. 2005..If medications fail and no clear epileptogenic tuber is identified, nonpharmacologic therapies are often attempted. The use of the ketogenic diet specifically for children with TSC and epilepsy has not been previously described... - The importance of parental expectations of cognitive improvement for their children with epilepsy prior to starting the ketogenic dietSharifeh Farasat
Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Epilepsy Behav 8:406-10. 2006..001) and >90% seizure reduction (P=0.04) at 6 months positively correlated with longer eventual diet duration. Expectations for cognitive improvement need to be discussed prior to beginning the ketogenic diet... - A blinded, crossover study of the efficacy of the ketogenic dietJohn M Freeman
Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Baltimore, Maryland, USA
Epilepsia 50:322-5. 2009..5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm... - Hemispherectomy for intractable unihemispheric epilepsy etiology vs outcomeE H Kossoff
Department of Neurology, The Pediatric Epilepsy Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Neurology 61:887-90. 2003..A prior case series focused on the outcomes after 58 surgeries at Johns Hopkins Hospital in 1997. This series, and an additional 53 cases, were reviewed to bring the outcomes up to date... - Effects of ketogenic diet on development and behavior: preliminary report of a prospective studyM B Pulsifer
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
Dev Med Child Neurol 43:301-6. 2001..These preliminary results support prior anecdotal reports of the beneficial effects of the diet on cognition and behavior... - Levetiracetam psychosis in children with epilepsyE H Kossoff
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 7247, USA
Epilepsia 42:1611-3. 2001..Observations in children are limited; levetiracetam is not yet approved by the Food and Drug Administration for use in children... - Energy requirements of spasticityC Hemingway
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore 21287-7247, USA
Dev Med Child Neurol 43:277-8. 2001..It was concluded that when calculation of calories is critical, energy utilization by spasticity must be taken into consideration... - Hemispherectomy sustained before adulthood does not cause persistent hemispatial neglectElisabeth B Marsh
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cortex 45:677-85. 2009.... - Rasmussen's syndrome: progressive autoimmune multi-focal encephalopathyJohn M Freeman
Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-7247, USA
Pediatr Neurol 32:295-9. 2005..Hemispherectomy of one form or another is the only curative therapy, and there is no evidence that one form of hemispherectomy is preferable to another. Immuno-ablative therapy may be a therapy of the future... - EEG is an essential clinical tool: pro and conNathan B Fountain
Comprehensive Epilepsy Program, University of Virginia, Charlottesville, Virginia 22908, USA
Epilepsia 47:23-5. 2006..Both authors agree that the EEG should only be ordered with forethought to answer a specific question... - Benefits of an all-liquid ketogenic dietEric H Kossoff
Epilepsia 45:1163. 2004 - The cognitive outcome of hemispherectomy in 71 childrenMargaret B Pulsifer
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
Epilepsia 45:243-54. 2004..Seizures were due to cortical dysplasias (n = 27), Rasmussen syndrome (n = 37), or vascular malformations or strokes (n = 7). Both presurgical and follow-up results are available and reported for 53 patients... - A progressive anterior fibrosis syndrome in patients with postsurgical congenital aniridiaJulie H Tsai
University of Cincinnati and Cincinnati Eye Institute, Cincinnati, Ohio, USA
Am J Ophthalmol 140:1075-9. 2005..Patients with aniridia with a history of penetrating keratoplasty, intraocular lenses, and tube shunts should be monitored for aniridic fibrosis syndrome; early surgical intervention is recommended... - On learning humility: a thirty-year journeyJohn M Freeman
Johns Hopkins University School of Medicine, USA
Hastings Cent Rep 34:13-6. 2004 - Chorioamnionitis, cytokines, and brain injuryJohn M Freeman
Pediatrics 112:206-7; author reply 206-7. 2003