Stephen J Freedland

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 100:1633-8. 2004
  2. ncbi request reprint Obesity does not adversely affect health-related quality-of-life outcomes after anatomic retropubic radical prostatectomy
    Stephen J Freedland
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 65:1131-6. 2005
  3. ncbi request reprint Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years
    Stephen J Freedland
    Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:2883-8. 2005
  4. ncbi request reprint Obesity and prostate cancer
    Stephen J Freedland
    Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 65:433-9. 2005
  5. ncbi request reprint Serum leptin and pathological findings at the time of radical prostatectomy
    Stephen J Freedland
    James Buchanan Brady Urological Institute and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:773-6. 2005
  6. ncbi request reprint Explaining racial differences in prostate cancer in the United States: sociology or biology?
    Stephen J Freedland
    The Brady Urological Institute, Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Prostate 62:243-52. 2005
  7. ncbi request reprint Obesity and biochemical outcome following radical prostatectomy for organ confined disease with negative surgical margins
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287 2101, USA
    J Urol 172:520-4. 2004
  8. ncbi request reprint Prostate cancer--Fourth International Congress
    Stephen J Freedland
    Johns Hopkins Hospital, Brady Urological Institute, Marburg 130, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    IDrugs 7:717-20. 2004
  9. ncbi request reprint Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    J Clin Oncol 22:446-53. 2004
  10. ncbi request reprint Body mass index as a predictor of prostate cancer: development versus detection on biopsy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 66:108-13. 2005

Detail Information

Publications86

  1. ncbi request reprint Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 100:1633-8. 2004
    ..The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival...
  2. ncbi request reprint Obesity does not adversely affect health-related quality-of-life outcomes after anatomic retropubic radical prostatectomy
    Stephen J Freedland
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 65:1131-6. 2005
    ..To study the impact of obesity on the health-related quality-of-life (HRQOL) outcomes after radical prostatectomy (RP)...
  3. ncbi request reprint Stronger association between obesity and biochemical progression after radical prostatectomy among men treated in the last 10 years
    Stephen J Freedland
    Departments of Urology, and Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:2883-8. 2005
    ..Whether the association between obesity and aggressive disease has changed as a result of these temporal changes is unclear...
  4. ncbi request reprint Obesity and prostate cancer
    Stephen J Freedland
    Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 65:433-9. 2005
  5. ncbi request reprint Serum leptin and pathological findings at the time of radical prostatectomy
    Stephen J Freedland
    James Buchanan Brady Urological Institute and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 173:773-6. 2005
    ..Obese men have higher serum leptin, a hormone produced by adipocytes, which has also been shown to be an in vitro prostate cancer growth factor. We examined whether serum leptin correlates with advanced pathological findings at RP...
  6. ncbi request reprint Explaining racial differences in prostate cancer in the United States: sociology or biology?
    Stephen J Freedland
    The Brady Urological Institute, Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Prostate 62:243-52. 2005
    ..Finally, we conclude with some thoughts as to how to integrate the findings from sociological as well as biological studies and touch upon methods to reduce the disparate burden of prostate cancer among blacks in the United States...
  7. ncbi request reprint Obesity and biochemical outcome following radical prostatectomy for organ confined disease with negative surgical margins
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287 2101, USA
    J Urol 172:520-4. 2004
    ....
  8. ncbi request reprint Prostate cancer--Fourth International Congress
    Stephen J Freedland
    Johns Hopkins Hospital, Brady Urological Institute, Marburg 130, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    IDrugs 7:717-20. 2004
  9. ncbi request reprint Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    J Clin Oncol 22:446-53. 2004
    ..Given the limited information regarding the impact of obesity on treatment outcomes for prostate cancer, we sought to examine the relationship between body mass index (BMI) and cancer control after radical prostatectomy (RP)...
  10. ncbi request reprint Body mass index as a predictor of prostate cancer: development versus detection on biopsy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 66:108-13. 2005
    ..To determine whether obesity is biologically associated with an increased risk of prostate cancer development, especially aggressive disease and to explore whether a bias may exist in our ability to detect these cancers in obese patients...
  11. ncbi request reprint Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    JAMA 294:433-9. 2005
    ....
  12. ncbi request reprint Are findings from studies of obesity and prostate cancer really in conflict?
    Stephen J Freedland
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cancer Causes Control 17:5-9. 2006
    ..Finally, additional methodological issues are discussed that investigators need to be aware of to be able to draw inferences across studies of obesity and prostate cancer outcomes...
  13. ncbi request reprint Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:7735-42. 2005
    ..However, hormonal activity and diets vary between races. We examined whether height was significantly associated with biochemical progression following radical prostatectomy and whether there was an interaction between height and race...
  14. ncbi request reprint Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2101, USA
    J Clin Oncol 23:7546-54. 2005
    ..We examined whether prostate weight was associated with tumor grade, advanced disease, or risk of biochemical progression after radical prostatectomy (RP)...
  15. ncbi request reprint Obesity and capsular incision at the time of open retropubic radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1798-801; discussion 1801. 2005
    ..Therefore, we examined the association between body mass index (BMI) and capsular incision at RP as a surrogate of a poor technical operation in men treated for prostate cancer by several high volume surgeons at a center of excellence...
  16. ncbi request reprint The prostatic specific antigen era is alive and well: prostatic specific antigen and biochemical progression following radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1276-81; discussion 1281; author reply 1281. 2005
    ..We examined the association between PSA and clinical progression in men undergoing RP...
  17. ncbi request reprint Obesity and prostate cancer: a growing problem
    Stephen J Freedland
    Jmaes Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Clin Cancer Res 11:6763-6. 2005
  18. ncbi request reprint Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomy
    Stephen J Freedland
    The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    J Urol 174:1266-70. 2005
    ..Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series. We examined whether serum adiponectin is associated with advanced disease stage at RP...
  19. ncbi request reprint Obesity and risk of biochemical progression following radical prostatectomy at a tertiary care referral center
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    J Urol 174:919-22. 2005
    ..We sought to validate or refute these findings using data on men treated by multiple other surgeons at our institution...
  20. ncbi request reprint Biochemical failure after radical prostatectomy in men with pathologic organ-confined disease: pT2a versus pT2b
    Stephen J Freedland
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cancer 100:1646-9. 2004
    ..Whether this distinction provides prognostic significance is unclear. The authors evaluated biochemical outcomes between men with pT2aN0 and pT2bN0 disease...
  21. ncbi request reprint Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:742-7. 2003
    ..We compared the total percentage of biopsy tissue with cancer to the percentage of cores positive for their ability to predict adverse pathologic findings and biochemical failure after radical prostatectomy (RP)...
  22. ncbi request reprint Improved clinical staging system combining biopsy laterality and TNM stage for men with T1c and T2 prostate cancer: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine and Department of Surgery, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    J Urol 169:2129-35. 2003
    ..We determined whether we could improve the prognostic value of the TNM staging system in men with cT1c and cT2 cancers by including information on whether prostate needle biopsy was unilaterally or bilaterally positive...
  23. ncbi request reprint Do younger men have better biochemical outcomes after radical prostatectomy?
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 63:518-22. 2004
    ..Prior studies have suggested that younger men have lower prostate-specific antigen recurrence rates after RP, although none of the prior studies had controlled for the year of surgery...
  24. ncbi request reprint Time trends in biochemical recurrence after radical prostatectomy: results of the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:736-41. 2003
    ..We also examined whether the biochemical recurrence rates after RP have changed with time...
  25. ncbi request reprint Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 60:670-4. 2002
    ....
  26. ncbi request reprint Percent of prostate needle biopsy cores with cancer is significant independent predictor of prostate specific antigen recurrence following radical prostatectomy: results from SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles, Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2136-41. 2003
    ..We evaluate whether either percent of cores with cancer or percent of cores positive from the most and least involved side of the prostate needle biopsy was associated with a worse outcome among men treated with radical prostatectomy...
  27. ncbi request reprint Clinical and pathologic outcome after radical prostatectomy for prostate cancer patients with a preoperative Gleason sum of 8 to 10
    Patrick J Bastian
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 107:1265-72. 2006
    ....
  28. ncbi request reprint Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? Results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles and Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2142-6. 2003
    ..We examined the significance of the pathological features of positive surgical margin and extracapsular extension for predicting biochemical failure following radical prostatectomy...
  29. ncbi request reprint Comparison of preoperative prostate specific antigen density and prostate specific antigen for predicting recurrence after radical prostatectomy: results from the search data base
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine, USA
    J Urol 169:969-73. 2003
    ..We determined whether preoperative PSA density calculated using transrectal ultrasound prostate volume was a better predictor of advanced pathological findings or biochemical recurrence after radical prostatectomy relative to PSA...
  30. ncbi request reprint The percentage of prostate needle biopsy cores with carcinoma from the more involved side of the biopsy as a predictor of prostate specific antigen recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEAR
    Stephen J Freedland
    Department of Urology, University of California Los Angeles, Los Angeles, California, USA
    Cancer 98:2344-50. 2003
    ....
  31. ncbi request reprint Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 171:2215-20. 2004
    ..We developed a preoperative model to risk stratify patients for prostate specific antigen (PSA) failure following radical prostatectomy (RP) and identify those at high risk who would be potential candidates for neoadjuvant clinical trials...
  32. ncbi request reprint Biochemical outcome after radical prostatectomy among men with normal preoperative serum prostate-specific antigen levels
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Cancer 101:748-53. 2004
    ..Whether malignancies in such men are associated with better outcomes is unclear. The authors compared the risk of biochemical failure after radical prostatectomy (RP) between men with normal PSA levels and men with elevated PSA levels...
  33. ncbi request reprint Multiinstitutional validation of the UCSF cancer of the prostate risk assessment for prediction of recurrence after radical prostatectomy
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Cancer 107:2384-91. 2006
    ..This study used a large external dataset to validate CAPRA...
  34. ncbi request reprint Radical prostatectomy for clinical stage T3a disease
    Stephen J Freedland
    Departments of Urology and Oncology, James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, Maryland, USA
    Cancer 109:1273-8. 2007
    ..The long-term outcomes among men treated with radical prostatectomy for clinical stage T3a disease were examined...
  35. ncbi request reprint Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system
    Stephen J Freedland
    Department of Urology, UCLA, Los Angeles, California 90095 1738, USA
    Prostate 55:299-307. 2003
    ..To study gene expression during prostate cancer progression and to identify molecular targets for therapy, a pure clonal tumor system was generated...
  36. pmc Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy
    Bruce J Trock
    Brady Urological Institute, Johns Hopkins School of Medicine, 600 N Wolfe St, 546 Phipps Bldg, Baltimore, MD 21287, USA
    JAMA 299:2760-9. 2008
    ....
  37. doi request reprint Freedom from a detectable ultrasensitive prostate-specific antigen at two years after radical prostatectomy predicts a favorable clinical outcome: analysis of the SEARCH database
    Steven L Chang
    Department of Urology, Stanford University Medical Center, Stanford, California 94305, USA
    Urology 75:439-44. 2010
    ..Previous studies demonstrate that a PSADT < 9 months after radical prostatectomy is associated with prostate cancer-specific mortality. Conventionally, PSADT has been calculated after biochemical failure (PSA > or = 2 0.2 ng/mL)...
  38. ncbi request reprint Preoperative p27 status is an independent predictor of prostate specific antigen failure following radical prostatectomy
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, 90095 1738, USA
    J Urol 169:1325-30. 2003
    ..To our knowledge no prior study has shown that preoperative p27 status independently predicts recurrence after radical prostatectomy...
  39. ncbi request reprint Death in patients with recurrent prostate cancer after radical prostatectomy: prostate-specific antigen doubling time subgroups and their associated contributions to all-cause mortality
    Stephen J Freedland
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, MD, USA
    J Clin Oncol 25:1765-71. 2007
    ..However, given the small number of patients in the highest risk PSADT subgroup, it is unclear which PSADT subgroups contribute the greatest to prostate cancer-specific death and how this influences all-cause mortality...
  40. ncbi request reprint Improved risk stratification for biochemical recurrence after radical prostatectomy using a novel risk group system based on prostate specific antigen density and biopsy Gleason score
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine and Veterans Administration Greater Los Angeles Healthcare System, 90095 1738, USA
    J Urol 168:110-5. 2002
    ..We also examined whether combining pathological PSA density with biopsy Gleason score improved risk stratification compared with serum PSA and biopsy Gleason score for predicting PSA recurrence after prostatectomy...
  41. ncbi request reprint Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:1187-92. 2003
    ..We sought to determine whether p27 staining in the PNBx specimen might serve as a molecular marker for PSA failure in the subset of patients who develop PSA recurrence despite organ-confined disease at RP...
  42. ncbi request reprint Clinical utility of percent prostate needle biopsy tissue with cancer cutpoints to risk stratify patients before radical prostatectomy
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 60:84-8. 2002
    ..We then examined whether we could further stratify low, intermediate, and high-risk groups (on the basis of the PSA level and biopsy Gleason score) using the percentage of prostate needle biopsy tissue with cancer...
  43. ncbi request reprint Pathological outcomes and biochemical progression in men with T1c prostate cancer undergoing radical prostatectomy with prostate specific antigen 2.6 to 4.0 vs 4.1 to 6.0 ng/ml
    Danil V Makarov
    James Buchanan Brady Urological Institute, and the Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 176:554-8. 2006
    ..5 ng/ml as opposed to the more traditional greater than 4.0 ng/ml. We compared outcomes between men with clinical stage T1c disease undergoing radical prostatectomy who had a low vs slightly increased prostate specific antigen...
  44. pmc Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era
    Corinne E Joshu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Rm E6137, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 4:544-51. 2011
    ..Physical activity (≥ 5 h/wk) did not attenuate risk in men who gained more than 2.2 kg. By avoiding weight gain, men with prostate cancer may both prevent recurrence and improve overall well-being...
  45. ncbi request reprint Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:500-4; discussion 504. 2006
    ..We examined the association between BMI, and PSA and prostate weight in a cohort of men undergoing RP...
  46. ncbi request reprint Defining the ideal cutpoint for determining PSA recurrence after radical prostatectomy. Prostate-specific antigen
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 61:365-9. 2003
    ..To determine the ideal cutpoint for defining prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Although various cutpoints have been used, a recent study suggested that 0.4 ng/mL may be the most appropriate...
  47. ncbi request reprint Time to prostate specific antigen recurrence after radical prostatectomy and risk of prostate cancer specific mortality
    Stephen J Freedland
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medicine, Baltimore, Maryland, USA
    J Urol 176:1404-8. 2006
    ..We performed a more thorough examination of the association of time from surgery to biochemical recurrence and the risk of prostate cancer death...
  48. ncbi request reprint Biopsy indication--a predictor of pathologic stage among men with preoperative serum PSA levels of 4.0 ng/mL or less and T1c disease
    Stephen J Freedland
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 63:887-91. 2004
    ..It is not uncommon for men to undergo radical prostatectomy (RP) with a prostate-specific antigen (PSA) level of 4 ng/mL or less and T1c disease...
  49. ncbi request reprint Health-related quality-of-life outcomes after anatomic retropubic radical prostatectomy in the phosphodiesterase type 5 ERA: impact of neurovascular bundle preservation
    Michael C Haffner
    Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 66:371-6. 2005
    ..To examine the impact of neurovascular bundle preservation on longitudinal health-related quality-of-life (HRQOL) outcomes after anatomic radical retropubic prostatectomy (RP) using a validated questionnaire...
  50. ncbi request reprint Delay of radical prostatectomy and risk of biochemical progression in men with low risk prostate cancer
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:1298-302; discussion 1302-3. 2006
    ..Whether delays and especially prolonged delays, eg greater than 180 days, before RP negatively impact the disease outcome is unclear...
  51. ncbi request reprint Multi-institutional validation of the CAPRA-S score to predict disease recurrence and mortality after radical prostatectomy
    Sanoj Punnen
    Department of Urology, UCSF Comprehensive Cancer Center, University of California, San Francisco, CA, USA
    Eur Urol 65:1171-7. 2014
    ..However, this clinical tool has never been validated externally...
  52. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  53. ncbi request reprint Black race does not independently predict adverse outcome following radical retropubic prostatectomy at a tertiary referral center
    Matthew E Nielsen
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 176:515-9. 2006
    ..To address this issue we examined the outcomes of a cohort of black and white men treated by multiple surgeons at our institution...
  54. pmc Evaluating the Prostate Cancer Prevention Trial High Grade prostate cancer risk calculator in 10 international biopsy cohorts: results from the Prostate Biopsy Collaborative Group
    Donna P Ankerst
    Department of Urology, University of Texas Health Science Center at San Antonio UTHSCSA, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA
    World J Urol 32:185-91. 2014
    ..To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade ≥ 7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations...
  55. ncbi request reprint Predictors of metastatic disease in men with biochemical failure following radical prostatectomy
    Onisuru T Okotie
    Department of Urology, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    J Urol 171:2260-4. 2004
    ..We determined clinical and pathological predictors of positive bone scans and computerized tomography (CT) in patients with biochemical recurrence after radical prostatectomy (RP)...
  56. pmc Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy
    William J Aronson
    Department of Urology, School of Medicine, University of California Los Angeles, Box 951738, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 4:2062-71. 2011
    ..These results support further studies evaluating reduction of dietary fat with fish oil supplementation on modulating prostate cancer biology...
  57. doi request reprint Active surveillance for prostate cancer: a systematic review of the literature
    Marc A Dall'Era
    Department of Urology, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Eur Urol 62:976-83. 2012
    ..Prostate cancer (PCa) remains an increasingly common malignancy worldwide. The optimal management of clinically localized, early-stage disease remains unknown, and profound quality of life issues surround PCa interventions...
  58. pmc Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group
    Donna P Ankerst
    Department of Urology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    World J Urol 30:181-7. 2012
    ....
  59. pmc Early detection of prostate cancer: AUA Guideline
    H Ballentine Carter
    American Urological Association Education and Research, Inc, Linthicum, Maryland, USA
    J Urol 190:419-26. 2013
    ..The guideline purpose is to provide the urologist with a framework for the early detection of prostate cancer in asymptomatic average risk men...
  60. doi request reprint Castration-resistant prostate cancer: AUA Guideline
    Michael S Cookson
    American Urological Association Education and Research, Inc, Linthicum, Maryland, USA
    J Urol 190:429-38. 2013
    ..This Guideline is intended to provide a rational basis for the management of patients with castration-resistant prostate cancer based on currently available published data...
  61. pmc Statin drugs, serum cholesterol, and prostate-specific antigen in the National Health and Nutrition Examination Survey 2001-2004
    Alison M Mondul
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Causes Control 21:671-8. 2010
    ..We evaluated the associations of statins and serum cholesterol with PSA to understand whether the inverse associations of statins and low cholesterol with aggressive prostate cancer are explained by detection bias...
  62. ncbi request reprint Management of biochemical recurrence after primary treatment of prostate cancer: a systematic review of the literature
    Sanoj Punnen
    Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
    Eur Urol 64:905-15. 2013
    ..Despite excellent cancer control with the treatment of localized prostate cancer (PCa), some men will experience a recurrence of disease. The optimal management of recurrent disease remains uncertain...
  63. ncbi request reprint Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer
    Stephen J Freedland
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90095 1738, USA
    Prostate 55:71-80. 2003
    ....
  64. ncbi request reprint Insight on pathogenesis of varicoceles: relationship of varicocele and body mass index
    Matthew E Nielsen
    Department of Urology, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Urology 68:392-6. 2006
    ..We examined this hypothesis in a large adult population...
  65. ncbi request reprint Quality of life, pain and return to normal activities following laparoscopic donor nephrectomy versus open mini-incision donor nephrectomy
    Kent T Perry
    Department of Urology, University of California Los Angeles, Los Angeles, California, USA
    J Urol 169:2018-21. 2003
    ..We evaluated pain, convalescence and health related quality of life in patients undergoing laparoscopic and open mini-incision donor nephrectomy...
  66. ncbi request reprint Collecting duct renal cell carcinoma: clinical study of a rare tumor
    Debby Chao
    Department of Urology, Division of Urologic Oncology, University of California School of Medicine Los Angeles, Los Angeles, CA, USA
    J Urol 167:71-4. 2002
    ..The clinical and pathological features of 6 patients with collecting duct carcinoma treated at a single institution are described...
  67. ncbi request reprint Predicting unilateral prostate cancer based on biopsy features: implications for focal ablative therapy--results from the SEARCH database
    Charles D Scales
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 178:1249-52. 2007
    ..However, few studies have assessed the correlation between biopsy parameters and pathological outcome (unilateral vs bilateral disease)...
  68. ncbi request reprint Percent prostate needle biopsy tissue with cancer is more predictive of biochemical failure or adverse pathology after radical prostatectomy than prostate specific antigen or Gleason score
    Stephen J Freedland
    Departments of Urology and Biostatistics, UCLA School of Medicine, Los Angeles 90095 1738, USA
    J Urol 167:516-20. 2002
    ..We determine whether various prostate needle biopsy parameters were predictive of either adverse pathological findings or disease recurrence after radical prostatectomy...
  69. ncbi request reprint Optimal timing, cutoff, and method of calculation of preoperative prostate-specific antigen velocity to predict relapse after prostatectomy: a report from SEARCH
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:732-7. 2007
    ..We studied the timing, cutoff levels, and method of calculation to better define its usefulness...
  70. pmc Upgrading and downgrading of prostate needle biopsy specimens: risk factors and clinical implications
    Stephen J Freedland
    Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Urology 69:495-9. 2007
    ..Given the critical role that needle biopsy plays in treatment decisions, we sought to determine the risk factors for upgrading and downgrading the prostate biopsy specimen...
  71. ncbi request reprint Impact of obesity on the utility of preoperative prostate-specific antigen velocity to predict for relapse after prostatectomy: a report from the SEARCH database
    Christopher R King
    Division of Urologic Oncology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:921-6. 2007
    ....
  72. ncbi request reprint Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort
    Carmen Rodriguez
    Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road Northeast, Atlanta, GA 30329 4251, USA
    Cancer Epidemiol Biomarkers Prev 16:63-9. 2007
    ..Obesity has been associated with aggressive prostate cancer. The extent of this association, which varies by stage and grade, remains unclear. The role of recent weight change had not been previously examined...
  73. ncbi request reprint Is biopsy Gleason score independently associated with biochemical progression following radical prostatectomy after adjusting for pathological Gleason score?
    Nicholas J Fitzsimons
    Division of Urologic Surgery, Duke Prostate Center, University Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    J Urol 176:2453-8; discussion 2458. 2006
    ..However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known...
  74. ncbi request reprint Obesity and prostate cancer: making sense out of apparently conflicting data
    Stephen J Freedland
    Department of Surgery, Veterans Affairs Medical Center, Durham, NC 27710, USA
    Epidemiol Rev 29:88-97. 2007
    ..Emerging data suggest a differential effect of obesity by disease aggressiveness: obesity may reduce the risk of nonaggressive disease while it may promote aggressive disease...
  75. pmc What are the factors associated with short prostate specific antigen doubling time after radical prostatectomy? A report from the SEARCH database group
    Anna E Teeter
    Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Urol 180:1980-4; discussion 1985. 2008
    ..We determined which demographic and clinicopathological variables were predictive of a short prostate specific antigen doubling time in a cohort of men with clinically localized prostate cancer treated with radical prostatectomy...
  76. pmc Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    Jayakrishnan Jayachandran
    Urology Section, Veterans Affairs Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 102:964-8. 2008
    ....
  77. pmc Risk stratification of men with Gleason score 7 to 10 tumors by primary and secondary Gleason score: results from the SEARCH database
    David E Kang
    Division of Urologic Surgery, Department of Surgery and Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    Urology 70:277-82. 2007
    ..Whether the increased risk associated with Gleason score 4+3 disease is equivalent to that of Gleason score 4+4 or greater is unclear...
  78. ncbi request reprint PSA in the new millennium: a powerful predictor of prostate cancer prognosis and radical prostatectomy outcomes--results from the SEARCH database
    Stephen J Freedland
    Urology Section, Veterans Affairs Medical Center, Durham, NC, USA
    Eur Urol 53:758-64; discussion 765-6. 2008
    ..We examined the prognostic significance of preoperative PSA to predict pathologic stage and biochemical progression among men undergoing radical prostatectomy in the new millennium (2000-2006)...
  79. ncbi request reprint Prostate specific antigen recurrence after definitive therapy
    Stephen J Freedland
    Division of Surgery, Durham Veterans Affairs Medical Center, Durham, NC, USA
    J Urol 177:1985-91. 2007
    ..However, to do so the risks and benefits of the various options must be known. Therefore, we provide a comprehensive overview of the natural history and treatment options for men with prostate specific antigen-only recurrence...
  80. ncbi request reprint Small transrectal ultrasound volume predicts clinically significant Gleason score upgrading after radical prostatectomy: results from the SEARCH database
    Ryan S Turley
    Division of Urological Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    J Urol 179:523-7; discussion 527-8. 2008
    ..We examined the likelihood of clinically relevant upgrading after radical prostatectomy as a function of transrectal ultrasound volume...
  81. ncbi request reprint Rising PSA in nonmetastatic prostate cancer
    Judd W Moul
    Division of Urologic Surgery, Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    Oncology (Williston Park) 21:1436-45; discussion 1449, 1452, 1454. 2007
    ..In this article, we will explore these prostate cancer disease states with an emphasis on practical, clinically applicable approaches...
  82. doi request reprint The effect of race/ethnicity on the accuracy of the 2001 Partin Tables for predicting pathologic stage of localized prostate cancer
    Elisabeth I Heath
    Barbara Ann Karmanos Cancer Institute, Department of Hematology and Oncology, Wayne State University, 4100 John R, 4 HWCRC, Detroit, MI 48201, USA
    Urology 71:151-5. 2008
    ..To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States...
  83. pmc Risk stratification for biochemical recurrence in men with positive surgical margins or extracapsular disease after radical prostatectomy: results from the SEARCH database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 179:1791-6; discussion 1796. 2008
    ..We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred...
  84. doi request reprint Percent tumor involvement and risk of biochemical progression after radical prostatectomy
    Edward N Rampersaud
    Division of Urologic Surgery, Duke Prostate Center, Durham, North Carolina, USA
    J Urol 180:571-6; discussion 576. 2008
    ..We hypothesized percent tumor involvement may be a good correlate of outcome in all stages of prostate cancer...
  85. doi request reprint Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases
    Stephen J Freedland
    Urology Section, Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 102:969-74. 2008
    ....
  86. ncbi request reprint Is a positive bladder neck margin truly a T4 lesion in the prostate specific antigen era? Results from the SEARCH Database
    W Cooper Buschemeyer
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine and Urology Section, Surgical Service, Veterans Affairs Medical Center Durham, Durham, North Carolina 27710, USA
    J Urol 179:124-9; discussion 129. 2008
    ..We examined the association between positive bladder neck margins and prostate specific antigen recurrence relative to other pathological findings...