A N Freed

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 87:1724-33. 1999
  2. ncbi request reprint Hyperventilation-induced airway injury and vascular leakage in dogs: effects of alpha1-adrenergic agonists
    A N Freed
    Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 83:1884-9. 1997
  3. ncbi request reprint Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Appl Physiol 87:1595-603. 1999
  4. ncbi request reprint Hyperventilation with dry air increases airway surface fluid osmolality in canine peripheral airways
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 159:1101-7. 1999
  5. ncbi request reprint Effect of furosemide on hyperpnea-induced airway obstruction, injury, and microvascular leakage
    A N Freed
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 81:2461-7. 1996
  6. ncbi request reprint Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition
    W M Foster
    Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 82:1378-82. 1997
  7. ncbi request reprint Dry air-induced late phase responses in the canine lung periphery
    A N Freed
    Dept of Environmental Health Sciences, John Hopkins University, Baltimore, Maryland 21205
    Eur Respir J 3:434-40. 1990
  8. ncbi request reprint Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs
    M S Davis
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins School of Public Health, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:785-9. 2001
  9. ncbi request reprint Aminophylline reduces air-flow-induced constriction in the canine lung periphery
    D Wang
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205
    Am Rev Respir Dis 137:31-7. 1988
  10. ncbi request reprint Regional clearance of solute from peripheral airway epithelia: recovery after sublobar exposure to ozone
    W M Foster
    Physiology Division, Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 86:641-6. 1999

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 87:1724-33. 1999
    ..These observations are consistent with the hypothesis that hyperventilation-induced mucosal damage initiates peripheral airway constriction via the release of biochemical mediators...
  2. ncbi request reprint Hyperventilation-induced airway injury and vascular leakage in dogs: effects of alpha1-adrenergic agonists
    A N Freed
    Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 83:1884-9. 1997
    ..In addition, our data suggest that alpha-agonists attenuate HIB in part by augmenting hyperventilation-induced bronchovascular leakage and by replacing airway water lost during a DAC...
  3. ncbi request reprint Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Appl Physiol 87:1595-603. 1999
    ..Finally, although anion transport mitigates the effect of O(3) on peripheral airway function, it contributes to the development of airway inflammation and may represent a possible target for anti-inflammatory prevention or therapy...
  4. ncbi request reprint Hyperventilation with dry air increases airway surface fluid osmolality in canine peripheral airways
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 159:1101-7. 1999
    ..These observations are consistent with the hypothesis that changes in airway osmolality during hyperventilation initiate peripheral airway constriction...
  5. ncbi request reprint Effect of furosemide on hyperpnea-induced airway obstruction, injury, and microvascular leakage
    A N Freed
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 81:2461-7. 1996
    ....
  6. ncbi request reprint Retention of soluble 99mTc-DTPA in the human lung: 24-h postdeposition
    W M Foster
    Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 82:1378-82. 1997
    ..This suggests that for normal healthy subjects a small amount of the 99mTc radioisotope, either in a dissociated or chelated form, is nonpermeable or slowly cleared from respiratory tisssues...
  7. ncbi request reprint Dry air-induced late phase responses in the canine lung periphery
    A N Freed
    Dept of Environmental Health Sciences, John Hopkins University, Baltimore, Maryland 21205
    Eur Respir J 3:434-40. 1990
    ..Leukotriene C4/D4 concentration in lavage was correlated (p less than 0.02) with neutrophil infiltration. Thus, we conclude that the canine lung periphery represents a reproducible model of a dry air-induced late phase reaction...
  8. ncbi request reprint Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs
    M S Davis
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins School of Public Health, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 164:785-9. 2001
    ..This suggests that other mechanisms in addition to increased smooth muscle tone may contribute to the development of repetitive hyperventilation-induced bronchial obstruction and hyperreactivity...
  9. ncbi request reprint Aminophylline reduces air-flow-induced constriction in the canine lung periphery
    D Wang
    Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205
    Am Rev Respir Dis 137:31-7. 1988
    ..Aminophylline could do this by facilitating the replacement of heat and water removed during dry air challenge by increasing bronchial or pulmonary blood flow, or by reducing heat and water loss via changes in mucosal permeability...
  10. ncbi request reprint Regional clearance of solute from peripheral airway epithelia: recovery after sublobar exposure to ozone
    W M Foster
    Physiology Division, Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol 86:641-6. 1999
    ....