Paul J Fitzgerald

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Is norepinephrine an etiological factor in some types of cancer?
    Paul J Fitzgerald
    Krieger Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    Int J Cancer 124:257-63. 2009
  2. doi request reprint Neuromodulating mice and men: Are there functional species differences in neurotransmitter concentration?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurosci Biobehav Rev 33:1037-41. 2009
  3. ncbi request reprint Prefrontal single-unit firing associated with deficient extinction in mice
    Paul J Fitzgerald
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA Electronic address
    Neurobiol Learn Mem 113:69-81. 2014
  4. pmc Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
    Clin Epidemiol 4:151-6. 2012
  5. pmc Testing whether drugs that weaken norepinephrine signaling prevent or treat various types of cancer
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
    Clin Epidemiol 2:1-3. 2010
  6. doi request reprint Is elevated norepinephrine an etiological factor in some cases of schizophrenia?
    Paul J Fitzgerald
    Department of Psychology, Texas A and M University, College Station, Room 3200 ILSB, TX 77843 4235, USA Electronic address
    Psychiatry Res 215:497-504. 2014
  7. doi request reprint Is elevated norepinephrine an etiological factor in some cases of Parkinson's disease?
    Paul J Fitzgerald
    Department of Psychology, Texas A and M University, Room 3200 ILSB, College Station, TX 77843 4235, United States Electronic address
    Med Hypotheses 82:462-9. 2014
  8. ncbi request reprint Gray colored glasses: is major depression partially a sensory perceptual disorder?
    Paul J Fitzgerald
    Department of Psychology, Room 3200 ILSB, Texas A and M University, College Station, TX 77843 4235, USA Electronic address
    J Affect Disord 151:418-22. 2013
  9. doi request reprint Black bile: are elevated monoamines an etiological factor in some cases of major depression?
    Paul J Fitzgerald
    Department of Psychology, Room 3200 ILSB, Texas A and M University, College Station, TX 77843 4235, USA
    Med Hypotheses 80:823-6. 2013
  10. doi request reprint Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Med Hypotheses 80:558-63. 2013

Detail Information

Publications27

  1. doi request reprint Is norepinephrine an etiological factor in some types of cancer?
    Paul J Fitzgerald
    Krieger Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    Int J Cancer 124:257-63. 2009
    ....
  2. doi request reprint Neuromodulating mice and men: Are there functional species differences in neurotransmitter concentration?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurosci Biobehav Rev 33:1037-41. 2009
    ....
  3. ncbi request reprint Prefrontal single-unit firing associated with deficient extinction in mice
    Paul J Fitzgerald
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA Electronic address
    Neurobiol Learn Mem 113:69-81. 2014
    ..Elucidating the precise nature of these roles could help inform understanding of the pathophysiology of fear-related anxiety disorders. ..
  4. pmc Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
    Clin Epidemiol 4:151-6. 2012
    ..NE/EPI-based drugs other than beta blockers also may prevent or treat various types of cancer, as may cholinesterase inhibitors that inhibit the sympathetic nervous system, which could be tested epidemiologically...
  5. pmc Testing whether drugs that weaken norepinephrine signaling prevent or treat various types of cancer
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
    Clin Epidemiol 2:1-3. 2010
    ....
  6. doi request reprint Is elevated norepinephrine an etiological factor in some cases of schizophrenia?
    Paul J Fitzgerald
    Department of Psychology, Texas A and M University, College Station, Room 3200 ILSB, TX 77843 4235, USA Electronic address
    Psychiatry Res 215:497-504. 2014
    ....
  7. doi request reprint Is elevated norepinephrine an etiological factor in some cases of Parkinson's disease?
    Paul J Fitzgerald
    Department of Psychology, Texas A and M University, Room 3200 ILSB, College Station, TX 77843 4235, United States Electronic address
    Med Hypotheses 82:462-9. 2014
    ..If elevated NE signaling really is an etiological factor in this disease, then early identification of susceptible individuals and long-term treatment with NE transmission reducing drugs, may help prevent or slow progression of PD. ..
  8. ncbi request reprint Gray colored glasses: is major depression partially a sensory perceptual disorder?
    Paul J Fitzgerald
    Department of Psychology, Room 3200 ILSB, Texas A and M University, College Station, TX 77843 4235, USA Electronic address
    J Affect Disord 151:418-22. 2013
    ..Recent studies have shown that visual processing, in as early a stage as the retina, is impaired in depression. This paper examines the hypothesis that major depression can involve alterations in sensory perception...
  9. doi request reprint Black bile: are elevated monoamines an etiological factor in some cases of major depression?
    Paul J Fitzgerald
    Department of Psychology, Room 3200 ILSB, Texas A and M University, College Station, TX 77843 4235, USA
    Med Hypotheses 80:823-6. 2013
    ..One possibility is that atypical depression involves elevated noradrenergic signaling...
  10. doi request reprint Elevated norepinephrine may be an etiological factor in a wide range of diseases: age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, metabolic syndrome
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Med Hypotheses 80:558-63. 2013
    ..If the hypothesis is correct, perhaps a large number of individuals would benefit from chronically taking drugs that systemically diminish noradrenergic signaling, thereby helping prevent or treat a wide variety of diseases...
  11. doi request reprint Neurodrinking: is alcohol a substrate in a novel, endogenous synthetic pathway for norepinephrine?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Med Hypotheses 78:760-2. 2012
    ..Importantly, the hypothesis is directly testable in rodents by presenting ethanol to DBH knockout mice, which are thought to lack NE, and then measuring if NE is synthesized in these animals...
  12. doi request reprint Whose side are you on: does serotonin preferentially activate the right hemisphere and norepinephrine the left?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Med Hypotheses 79:250-4. 2012
    ....
  13. doi request reprint The NMDA receptor may participate in widespread suppression of circuit level neural activity, in addition to a similarly prominent role in circuit level activation
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Behav Brain Res 230:291-8. 2012
    ..The data suggest the NMDAR participates in activation, as well as widespread suppression, of circuit level neural activity, where the suppression may be particularly prominent in limbic circuits...
  14. ncbi request reprint Is elevated norepinephrine an etiological factor in some cases of Alzheimer's disease?
    Paul J Fitzgerald
    Zanvyl Krieger Mind Bran Institute, Solomon H Snyder, Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Curr Alzheimer Res 7:506-16. 2010
    ..These lines of evidence tend to support the elevated NE etiological hypothesis...
  15. doi request reprint Is elevated norepinephrine an etiological factor in some cases of epilepsy?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 338 Krieger Hall, 3400N Charles St, Baltimore, MD 21218, USA
    Seizure 19:311-8. 2010
    ..The body of evidence supporting the NE proconvulsant hypothesis is consistent with the notion that elevated, endogenous noradrenergic transmission is an etiological factor in some cases of epilepsy...
  16. doi request reprint A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?
    Paul J Fitzgerald
    The Zanvyl Krieger Mind Brain Institute, Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA
    Psychopharmacology (Berl) 213:171-82. 2011
    ..A large number of studies have shown that these two neurotransmitter systems, and drugs that affect them, modulate the functional properties of the PFC in both humans and animal models...
  17. pmc Receptive field (RF) properties of the macaque second somatosensory cortex: RF size, shape, and somatotopic organization
    Paul J Fitzgerald
    Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:6485-95. 2006
    ..We hypothesize that these RFs represent the kernels underlying the representation of tactile shape...
  18. pmc Second-order receptive fields reveal multidigit interactions in area 3b of the macaque monkey
    Pramodsingh H Thakur
    Department of Neuroscience, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
    J Neurophysiol 108:243-62. 2012
    ....
  19. pmc Receptive field properties of the macaque second somatosensory cortex: nonlinear mechanisms underlying the representation of orientation within a finger pad
    Pramodsingh H Thakur
    Zanvyl Krieger Mind Brain Institute, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:13567-75. 2006
    ..We hypothesize that invariant neurons play an important role in tactile form recognition...
  20. pmc Receptive field properties of the macaque second somatosensory cortex: representation of orientation on different finger pads
    Paul J Fitzgerald
    Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:6473-84. 2006
    ..Finally, comparison of the tuning properties showed that there are small but significant differences between the posterior, central, and anterior fields of the SII region...
  21. pmc Analogous intermediate shape coding in vision and touch
    Jeffrey M Yau
    Zanvyl Krieger Mind Brain Institute and Solomon H Snyder Department of Neuroscience, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 106:16457-62. 2009
    ..We found similar patterns of shape sensitivity characterized by tuning for curvature direction. These parallel tuning patterns imply analogous shape coding mechanisms in intermediate visual and somatosensory cortex...
  22. pmc A tactile stimulator for studying passive shape perception
    John W Lane
    Zanvyl Krieger Mind Brain Institute, Department of Neuroscience, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
    J Neurosci Methods 185:221-9. 2010
    ..Because the two components of the stimulator are independently controlled, the stimulator allows for parametric study of the mechanoreceptive and proprioceptive contributions to 3D tactile shape perception...
  23. pmc Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding
    Andrew Holmes
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 15:1359-61. 2012
    ..These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear...
  24. pmc Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice
    Jessica L Ihne
    Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852 9411, USA
    Neuropharmacology 62:464-73. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  25. pmc Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
    Paul J Fitzgerald
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20852 9411, USA
    Neurobiol Dis 40:608-21. 2010
    ..Collectively, these findings demonstrate mania-related abnormalities in GluA1 KO and, combined with previous findings, suggest this mutant may provide a novel model of features of schizoaffective disorder...
  26. pmc Receptive field properties of the macaque second somatosensory cortex: evidence for multiple functional representations
    Paul J Fitzgerald
    Zanvyl Krieger Mind Brain Institute, Departments of Neuroscience and Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 24:11193-204. 2004
    ....