Stacey D Finley
Affiliation: Johns Hopkins University
- A two-compartment model of VEGF distribution in the mousePhillip Yen
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e27514. 2011..As the VEGF system becomes better characterized in other tissues and cell types, the model can be expanded to include additional compartments and vascular elements...
- Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing miceStacey D Finley
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Front Oncol 3:196. 2013..The model predictions also have implications for biomarker discovery with anti-angiogenic therapies. ..
- Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictionsStacey D Finley
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Natl Cancer Inst 105:802-11. 2013..These models complement experimental studies and aid in the development of effective therapies targeting angiogenesis...
- Predicting the effects of anti-angiogenic agents targeting specific VEGF isoformsStacey D Finley
Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
AAPS J 14:500-9. 2012..Targeting VEGF(121) reduces tumor free VEGF and is an effective treatment strategy. Our results provide a basis for clinical investigation of isoform-specific anti-VEGF agents...
- Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodiesStacey D Finley
Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
BMC Syst Biol 5:193. 2011..The model is applied to investigate the action of VEGF-neutralizing agents (called "anti-VEGF") in the treatment of cancer...