G Feldmann

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    Savita Bisht
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Cancer Ther 9:2255-64. 2010
  2. pmc Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts
    Georg Feldmann
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Mol Diagn 10:111-22. 2008
  3. pmc An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2725-35. 2008
  4. pmc Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
    G Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA
    Gut 57:1420-30. 2008
  5. ncbi request reprint Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer
    G Feldmann
    Deparment of Internal Medicine 1, University of Bonn, Germany
    Endoscopy 38:604-9. 2006
  6. ncbi request reprint Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma
    Georg Feldmann
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Clin Cancer Res 12:4491-8. 2006
  7. pmc Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 67:2187-96. 2007
  8. ncbi request reprint Partial remission of a newly diagnosed diffuse large B-cell Non-Hodgkin's lymphoma in a hemodialysis patient after administration of immuno-chemotherapy with rituximab-CHOP
    G Feldmann
    Department of Internal Medicine 1, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Int J Lab Hematol 29:469-73. 2007
  9. ncbi request reprint The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection
    J Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    J Viral Hepat 13:42-6. 2006
  10. ncbi request reprint Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5
    J Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitaet, Bonn, Germany
    J Viral Hepat 11:519-26. 2004

Collaborators

Detail Information

Publications35

  1. pmc Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    Savita Bisht
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Mol Cancer Ther 9:2255-64. 2010
    ..NanoCurc is a promising new formulation that is able to overcome a major impediment for the clinical translation of curcumin to cancer patients by improving systemic bioavailability, and by extension, therapeutic efficacy...
  2. pmc Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts
    Georg Feldmann
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Mol Diagn 10:111-22. 2008
    ..Here in we present a review of recent literature on the molecular genetics of pancreatic cancer and emphasize clinical implications for the development of novel diagnostic and therapeutic approaches...
  3. pmc An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 316, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:2725-35. 2008
    ....
  4. pmc Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
    G Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA
    Gut 57:1420-30. 2008
    ..Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and that Hedgehog blockade has the potential to prevent disease progression and metastatic spread...
  5. ncbi request reprint Detection of human aspartyl (asparaginyl) beta-hydroxylase and homeobox B7 mRNA in brush cytology specimens from patients with bile duct cancer
    G Feldmann
    Deparment of Internal Medicine 1, University of Bonn, Germany
    Endoscopy 38:604-9. 2006
    ..Both markers are overexpressed in biliary cancer cell lines and possibly involved in the pathogenesis of bile duct cancer...
  6. ncbi request reprint Induction of interleukin-6 by hepatitis C virus core protein in hepatitis C-associated mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma
    Georg Feldmann
    Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Clin Cancer Res 12:4491-8. 2006
    ..To clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis of HCV-associated MC or B-NHL...
  7. pmc Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 67:2187-96. 2007
    ....
  8. ncbi request reprint Partial remission of a newly diagnosed diffuse large B-cell Non-Hodgkin's lymphoma in a hemodialysis patient after administration of immuno-chemotherapy with rituximab-CHOP
    G Feldmann
    Department of Internal Medicine 1, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Int J Lab Hematol 29:469-73. 2007
    ..Of note, this patient had a previous history of hairy cell leukemia. A review of the literature was performed and the potential etiologic link of these two B-cell malignancies is discussed in the light of available information...
  9. ncbi request reprint The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection
    J Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    J Viral Hepat 13:42-6. 2006
    ..05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy...
  10. ncbi request reprint Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5
    J Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitaet, Bonn, Germany
    J Viral Hepat 11:519-26. 2004
    ..Our results suggest that interaction of HCV E2 with CD81 leads to increased RANTES secretion by CD8+ lymphocytes which induces down-regulation of CCR5 surface via receptor internalization resulting in altered lymphocyte migration...
  11. pmc Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
    Collins A Karikari
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, CRB2 Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 6:957-66. 2007
    ..These preclinical results suggest that targeting of the apoptotic machinery in pancreatic cancers with XAntags is a promising therapeutic option that warrants further evaluation...
  12. pmc The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic target
    Jan Bart M Koorstra
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 8:618-26. 2009
    ..The Axl receptor tyrosine kinase is implicated in cellular transformation and tumor progression, although its role in pancreatic cancer has not been previously documented...
  13. pmc Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
    Georg Feldmann
    Departments of Pathology, Oncology, and Medicine, and The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 70:4460-9. 2010
    ..Conversely, restoring Ral function rescued the effects of CDK5 inhibition in pancreatic cancer cells. Our findings identify CDK5 as a pharmacologically tractable target to degrade Ras signaling in pancreatic cancer...
  14. pmc In vivo and in vitro propagation of intraductal papillary mucinous neoplasms
    Hirohiko Kamiyama
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lab Invest 90:665-73. 2010
    ..Patient origin was confirmed using DNA fingerprinting. Most non-invasive IPMNs grow in NOG mice. We successfully established one IPMN cell line, and plan to use it to clarify the molecular pathogenesis of IPMNs...
  15. pmc A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
    Antonio Jimeno
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231 1000, USA
    Mol Cancer Ther 8:310-4. 2009
    ..Direct tumor xenografts are a valid platform to test multicompartment therapeutic approaches in pancreatic cancer...
  16. doi request reprint Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Germany
    Immunol Invest 38:1-13. 2009
    ..Interruption of the CCR5 signalling pathway due to CCR5-n32 may potentially result in subtle reduction of HCV specific IFN-gamma responses in anti-HCV-positive haemophiliac patients...
  17. pmc Application of a global proteomic approach to archival precursor lesions: deleted in malignant brain tumors 1 and tissue transglutaminase 2 are upregulated in pancreatic cancer precursors
    Wang Cheung
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pancreatology 8:608-16. 2008
    ..Biomarker discovery in precursor lesions has been hampered by the ready availability of fresh specimens, and limited yields of proteins suitable for large scale screening...
  18. pmc Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer
    Michael E Mullendore
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 15:2291-301. 2009
    ..Aberrant activation of the Notch signaling pathway is commonly observed in human pancreatic cancer, although the mechanism(s) for this activation has not been elucidated...
  19. pmc MicroRNA miR-155 is a biomarker of early pancreatic neoplasia
    Nils Habbe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Biol Ther 8:340-6. 2009
    ..Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented...
  20. doi request reprint In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities
    Savita Bisht
    Department of Pathology, Johns Hopkins University School of Medicine, CRB2, Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 7:3878-88. 2008
    ..01) compared with control tumors. These data indicate that NMA622 nanoparticles provide a suitable platform for oral delivery of water-insoluble drugs like rapamycin for cancer therapy...
  21. ncbi request reprint Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum
    Volker Fendrich
    Department of Pathology, John Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Endocr Relat Cancer 14:865-74. 2007
    ..In conclusion, we describe for the first time that Snail and SHH are overexpressed in a large subset of NETs of the ileum. Aberrant activation of these pathways might be involved in invasion and metastatic spread in NETs...
  22. pmc Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer
    Kwang Hyuck Lee
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Pancreatology 9:293-301. 2009
    ....
  23. pmc Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    Nils Habbe
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:18913-8. 2008
    ....
  24. ncbi request reprint Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Immunol Invest 38:284-96. 2009
    ..Interruption of the CCR5 signalling pathway due to CCR5-Delta32 may potentially result in subtle reduction of HCV specific IFN-gamma responses in anti-HCV-positive haemophiliac patients...
  25. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53...
  26. ncbi request reprint Epidermal growth factor receptor and hedgehog signaling pathways are active in esophageal cancer cells from rat reflux model
    Guoping Sui
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Surg Res 134:1-9. 2006
    ..Advancements in experimental therapeutics for esophageal cancers have been hampered by the lack of a reliable preclinical model that recapitulates the biology of human cancer, including in vivo growth in an animal model...
  27. pmc Hedgehog signaling is required for effective regeneration of exocrine pancreas
    Volker Fendrich
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 135:621-31. 2008
    ..Given the known role of Hh signaling in exocrine pancreatic cancer, these findings may provide a mechanistic link between injury-induced activation of pancreatic progenitors and subsequent pancreatic neoplasia...
  28. pmc Molecular genetics of pancreatic intraepithelial neoplasia
    Georg Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Ross Bldg 632, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Hepatobiliary Pancreat Surg 14:224-32. 2007
    ..Recent evidence suggests that noninvasive precursor lesions, classified as pancreatic intraepithelial neoplasia (PanIN), can progress to invasive pancreatic cancer. This review will discuss the major genetic alterations in PanIN lesions...
  29. ncbi request reprint Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: initial imaging in experimental models of pancreatic cancer
    Catherine A Foss
    Department of Radiology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Univeristy, Baltimore, MD 21287 2182, USA
    Mol Imaging 6:131-9. 2007
    ..6PL orthotopic xenograft model showed strong tumor and spleen uptake at 5 days postinjection. Both anti-claudin 4 and anti-PSCA demonstrate promise as radiodiagnostic and possibly radiotherapeutic agents for human pancreatic cancers...
  30. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..These results uncover a universal size-control mechanism in metazoan...
  31. ncbi request reprint Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery
    Aik Choon Tan
    The Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Biol Ther 7:135-44. 2008
    ....
  32. ncbi request reprint HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells
    Jacob Nattermann
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Antivir Ther 10:95-107. 2005
    ..These results propose HIV-mediated up-regulation of HLA-E expression as an additional evasion strategy targeting the antiviral activities of NK cells, which may contribute to the capability of the virus in establishing chronic infection...
  33. ncbi request reprint C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma
    Thomas Gerhardt
    Department of Internal Medicine I, University Hospital, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    World J Gastroenterol 12:5495-500. 2006
    ..To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort...
  34. ncbi request reprint Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    AIDS 22:203-10. 2008
    ..This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines...
  35. doi request reprint Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
    Hector Alvarez
    Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:2631-8. 2008
    ..Gallbladder cancer (GBC) is an uncommon neoplasm in the United States, but one with high mortality rates. This malignancy remains largely understudied at the molecular level such that few targeted therapies or predictive biomarkers exist...