Affiliation: Johns Hopkins University
Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez Cabrero D, et al
. DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. Nat Commun. 2018;9:2397 pubmed publisher
..Our integrative approach provides insights into the molecular mechanisms of MS susceptibility and suggests putative therapeutic strategies targeting a methylation-mediated regulation of the major risk gene. ..
Feinberg A. Epigenetics at the epicenter of modern medicine. JAMA. 2008;299:1345-50 pubmed publisher
..Thus, including epigenetics into epidemiologic studies of human disease may help explain the relationship between the genome and the environment and may provide new clues to modifying these effects in disease prevention and therapy. ..
Feinberg A. Genome-scale approaches to the epigenetics of common human disease. Virchows Arch. 2010;456:13-21 pubmed publisher
..Some of these genome-scale technologies are beginning to be applied to create the new field of epigenetic epidemiology. ..
Feinberg A. The nucleolus gets the silent treatment. Cell Stem Cell. 2014;15:675-6 pubmed publisher
..2014) and Kim etÂ al. (2014) provide insight into how global heterochromatin condensation and LIN28 sequestration in embryonic stem cells are independent mechanisms regulating pluripotency in the oft-overlooked nucleolus. ..
Multhaup M, Seldin M, Jaffe A, Lei X, Kirchner H, Mondal P, et al
. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015;21:138-49 pubmed publisher
Vandiver A, Irizarry R, Hansen K, Garza L, Rúnarsson A, Li X, et al
. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol. 2015;16:80 pubmed publisher
..These data implicate large scale epigenomic change in mediating the effects of environmental damage with photo-aging. ..
Liu Y, Li X, Aryee M, Ekström T, Padyukov L, Klareskog L, et al
. GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease. Am J Hum Genet. 2014;94:485-95 pubmed publisher
..This type of correlated methylation structure has implications for both biological functions of DNA methylation and for the design, analysis, and interpretation of epigenome-wide association studies. ..
Marioni R, Shah S, McRae A, Chen B, Colicino E, Harris S, et al
. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biol. 2015;16:25 pubmed publisher
..The heritability of ?age was 0.43. DNA methylation-derived measures of accelerated aging are heritable traits that predict mortality independently of health status, lifestyle factors, and known genetic factors. ..
Feinberg A, Irizarry R. Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc Natl Acad Sci U S A. 2010;107 Suppl 1:1757-64 pubmed publisher