Research Topics
| ANDREW FEINBERGSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Cancer epigenetics is no Mickey MouseAndrew P Feinberg
Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, Baltimore, MD 21205, USA
Cancer Cell 8:267-8. 2005..Hypomethylation appears to be a critical determinant of cancer, affecting chromosomal stability and specific gene targets...
Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regionsBo Wen
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
BMC Genomics 13:566. 2012..The microstructure of these regions has not previously been explored...- Epigenetic mechanisms in human diseaseAndrew P Feinberg
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 62:6784-7. 2002 - Phenotypic plasticity and the epigenetics of human diseaseAndrew P Feinberg
Department of Medicine and Center for Epigenetics, Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Nature 447:433-40. 2007..Increased understanding of epigenetic-disease mechanisms could lead to disease-risk stratification for targeted intervention and to targeted therapies... 
Epigenetics at the epicenter of modern medicineAndrew P Feinberg
Department of Medicine and Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
JAMA 299:1345-50. 2008..Thus, including epigenetics into epidemiologic studies of human disease may help explain the relationship between the genome and the environment and may provide new clues to modifying these effects in disease prevention and therapy...- The epigenetics of cancer etiologyAndrew P Feinberg
Epigenetics Unit, Departments of Medicine, Oncology, and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 1064 Ross, Johns Hopkins Medical School, 720 Rutland Ave, Baltimore, MD 21205, USA
Semin Cancer Biol 14:427-32. 2004.... - The epigenetic progenitor origin of human cancerAndrew P Feinberg
Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Nat Rev Genet 7:21-33. 2006..Therefore, non-neoplastic but epigenetically disrupted stem/progenitor cells might be a crucial target for cancer risk assessment and chemoprevention... - Genome-scale approaches to the epigenetics of common human diseaseAndrew P Feinberg
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 855 N Wolfe St, Rangos 570, Baltimore, MD 21205, USA
Virchows Arch 456:13-21. 2010..Some of these genome-scale technologies are beginning to be applied to create the new field of epigenetic epidemiology... - The history of cancer epigeneticsAndrew P Feinberg
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Rev Cancer 4:143-53. 2004 - Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and diseaseAndrew P Feinberg
Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:1757-64. 2010.... - Interview: Professor Andrew Feinberg speaks to EpigenomicsANDREW FEINBERG
Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Epigenomics 1:25-7. 2009b>Andrew Feinberg studied mathematics and humanities at Yale University (CT, USA) in the Directed Studies honors program, and he received his BA (1973) and MD (1976) from the accelerated medical program at Johns Hopkins University (MD, USA).. - Epigenomics reveals a functional genome anatomy and a new approach to common diseaseAndrew P Feinberg
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Biotechnol 28:1049-52. 2010..Much of the seemingly inconclusive genetic data related to common diseases could therefore become meaningful in an epigenomic context... - Personalized epigenomic signatures that are stable over time and covary with body mass indexAndrew P Feinberg
Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Sci Transl Med 2:49ra67. 2010..This work suggests an epigenetic strategy for identifying patients at risk of common disease... - DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanismsAndrew P Feinberg
Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
Semin Cancer Biol 12:389-98. 2002..LOI may precede the development of cancer and may thus serve as a common marker for risk, but also as a model for understanding the developmental mechanism for normal imprinting... - The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresRafael A Irizarry
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Nat Genet 41:178-86. 2009.... - Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor riskAtsushi Kaneda
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:20926-31. 2007.... - Loss of IGF2 imprinting: a potential marker of colorectal cancer riskHengmi Cui
Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Science 299:1753-5. 2003..14 to 11.37; P = 0.026), and 21.7 for patients with CRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed with a DNA-based blood test, and it may be a valuable predictive marker of an individual's risk for CRC... - Accurate genome-scale percentage DNA methylation estimates from microarray dataMartin J Aryee
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
Biostatistics 12:197-210. 2011..We illustrate the method on data generated to detect methylation differences between tissues and between normal and tumor colon samples... - Epigenetic silencing of tumour suppressor gene p15 by its antisense RNAWenqiang Yu
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Nature 451:202-6. 2008..Thus, natural antisense RNA may be a trigger for heterochromatin formation and DNA methylation in TSG silencing in tumorigenesis... - DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsIna Rhee
The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 416:552-6. 2002..Here we demonstrate that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and provide compelling evidence that such methylation is essential for optimal neoplastic proliferation... - Comprehensive high-throughput arrays for relative methylation (CHARM)Rafael A Irizarry
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Genome Res 18:780-90. 2008..Furthermore, unlike the other approaches, CHARM is highly quantitative, a substantial advantage in application to the study of human disease... - An epigenetic approach to cancer etiologyAndrew P Feinberg
Division of Molecular Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cancer J 13:70-4. 2007..We review studies of loss of imprinting of insulin-like growth factor 2 in colorectal cancer as an example of such a target for preventive oncology... - Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblastsAkiko Doi
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Genet 41:1350-3. 2009.... - Comprehensive high-throughput arrays for relative methylation (CHARM)Christine Ladd-Acosta
Department of Medicine, Johns Hopkins University School of Medicine, Center for Epigenetics, Baltimore, Maryland, USA
Curr Protoc Hum Genet . 2010..It can be applied to studying epigenomic changes in DNAm for normal and diseased samples... - Redefining CpG islands using hidden Markov modelsHao Wu
Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205, USA
Biostatistics 11:499-514. 2010..A CGI list and the probability scores, as a function of genome location, for each species are available at http://www.rafalab.org... - Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 geneMarcia Cruz-Correa
Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico, USA
Epigenetics 4:114-8. 2009..However, whether LOI of IGF2 is transitory or remains a permanent epigenetic alteration is unknown... - The emerging science of epigenomicsPauline A Callinan
Division of Molecular Medicine, Department of Medicine and Center for the Epigenetics of Common Human Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Mol Genet 15:R95-101. 2006..Many groups are joining forces toward developing an organized Human Epigenome Project to exploit these new technologies to better understand the basis of normal development and human disease... - Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1James B Potash
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008..Further work is needed to confirm these results and uncover the functional variation underlying the association signal... - Epigenetic specificity of loss of imprinting of the IGF2 gene in Wilms tumorsHans T Bjornsson
Center for Epigenetics, Institute of Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Natl Cancer Inst 99:1270-3. 2007..Thus, epigenetic alterations in Wilms tumors are not widespread, supporting the gene and lineage specificity of LOI of IGF2... - A species-generalized probabilistic model-based definition of CpG islandsRafael A Irizarry
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, E3620, Baltimore, MD 21205, USA
Mamm Genome 20:674-80. 2009..Lists of CGI for some species are available at http://www.rafalab.org ... - Comprehensive methylome map of lineage commitment from haematopoietic progenitorsHong Ji
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 570 Rangos, 725 N Wolfe St, Baltimore, Maryland 21205, USA
Nature 467:338-42. 2010.... - Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modificationBo Wen
Department of Medicine and Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genome Res 18:1806-13. 2008..Furthermore, we developed a novel approach to identifying allele-specific marks that is SNP independent, by fractionating using H3K4Me2 antibodies followed by DNA methylation analysis... - An integrated epigenetic and genetic approach to common human diseaseHans T Bjornsson
Department of Epidemiology, John Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
Trends Genet 20:350-8. 2004.... - Epigenetics and assisted reproductive technology: a call for investigationEmily L Niemitz
Predoctoral Program in Human Genetics and Epigenetics Unit, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Hum Genet 74:599-609. 2004.... - A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genesLiora Z Strichman-Almashanu
Department of Medicine, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Genome Res 12:543-54. 2002..These sequences will provide a valuable resource in the search for novel imprinted genes, for defining the molecular substrates of the normal methylome, and for identifying novel targets for mammalian chromatin formation... - Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineagesPatrick Onyango
Institute of Genetic Medicine and Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:10599-604. 2002..This model should allow experimental manipulation of epigenetic modifications of cultured EG cells that may not be possible in human stem cell studies... - Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor riskAtsushi Kaneda
Division of Molecular Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cancer Res 65:11236-40. 2005.... - Children with idiopathic hemihypertrophy and beckwith-wiedemann syndrome have different constitutional epigenotypes associated with wilms tumorEmily L Niemitz
Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Hum Genet 77:887-91. 2005..0028). These results indicate that children with IH and Wilms tumor have different constitutional epigenotypes from those of children with BWS and Wilms tumor... - Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2Hengmi Cui
Institute of Genetic Medicine and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 62:6442-6. 2002.... - Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in miceTakashi Sakatani
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 307:1976-8. 2005..A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk... - Intra-individual change over time in DNA methylation with familial clusteringHans T Bjornsson
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
JAMA 299:2877-83. 2008..However, changes in methylation or other epigenetic marks over time in a given individual have not yet been investigated... - A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transductionWinston Timp
Department of Medicine, Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell Cycle 8:383-90. 2009.... - SNP-specific array-based allele-specific expression analysisHans T Bjornsson
Department of Medicine and Center for Epigenetics, Institute of Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genome Res 18:771-9. 2008..The approach is scalable to the whole genome and can be used for discovery of functional epigenetic modifications in patient samples... - Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patientsAimee S Chang
Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Fertil Steril 83:349-54. 2005..The only consistent finding was that all 12 women received some type of ovarian stimulation medication. CONCLUSION(S): Large epidemiologic studies are needed to further study the association between BWS and ART... - DNA methylation signatures within the human brainChristine Ladd Acosta
Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Am J Hum Genet 81:1304-15. 2007..These results were validated for all six genes tested in a replicate set of 57 samples. Our data suggest that DNA methylation signatures distinguish brain regions and may help account for region-specific functional specialization... - Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predispositionMarcia Cruz-Correa
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Gastroenterology 126:964-70. 2004..Whether LOI of IGF2 is associated with known environmental risk factors for CRN is unknown... - DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylationLunching Sun
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 68:2726-35. 2008..These results suggest that DNMT1 and DNMT3B regulate BAG-1 expression via insulator protein DNA-binding and chromatin dynamics by regulating histone dimethylation... - Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cellsBo Wen
Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 41:246-50. 2009..We term these regions large organized chromatin K9 modifications (LOCKs). LOCKs are substantially lost in cancer cell lines, and they may provide a cell type-heritable mechanism for phenotypic plasticity in development and disease... - Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumorStephanie K Mummert
Graduate Program in Biochemistry, Cell and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genes Chromosomes Cancer 43:155-61. 2005..Finally, haploinsufficiency of CTCF may be the basis of this association, given that CTCF expression in tumors with 16q LOH was 48% that of tumors without LOH... - Microdeletion of LIT1 in familial Beckwith-Wiedemann syndromeEmily L Niemitz
Predoctoral Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Hum Genet 75:844-9. 2004..When inherited paternally, there is no phenotype, suggesting that the LIT1 RNA itself is not necessary for normal development in humans... - Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulationWenqiang Yu
Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
Nat Genet 36:1105-10. 2004..We suggest that poly(ADP-ribosyl)ation imparts chromatin insulator properties to CTCF at both imprinted and nonimprinted loci, which has implications for the regulation of expression domains and their demise in pathological lesions... - Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19Michael R Debaun
Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, St Louis, USA
Am J Hum Genet 72:156-60. 2003..We discuss the implications of our finding that ART is associated with human overgrowth, similar to the large offspring syndrome reported in ruminants... - Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cellsWilliam C Reinhold
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 5056, Bethesda, MD 20892 4255, USA
Mol Cancer Ther 6:391-403. 2007..As has been shown in recent years, DNA methylation status can serve as a biomarker for use in choosing therapy... - Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defectsMichael R Debaun
Division of Pediatric Hematology Oncology, Department of Pediatrics, Washington University School of Medicine, Saint Louis, USA
Am J Hum Genet 70:604-11. 2002..003), cancer (P=.03), and hypoglycemia (P=.05). These results define an epigenotype-phenotype relationship in BWS, in which aberrant methylation of H19 and LIT1 and UPD are strongly associated with cancer risk and specific birth defects... - Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approachDavid Gius
Radiation Oncology Branch, Radiation Oncology Sciences Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Cancer Cell 6:361-71. 2004..In addition, a 75 kb cluster of metallothionein genes was coordinately regulated... - Genetics and epigenetics--nature's pen-and-pencil setRoger G Gosden
N Engl J Med 356:731-3. 2007 - CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated regionPhuongmai Nguyen
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Cancer Res 68:5546-51. 2008.... - BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the somaDmitri I Loukinov
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
Proc Natl Acad Sci U S A 99:6806-11. 2002..Because BORIS bears the same DNA-binding domain that CTCF employs for recognition of methylation marks in soma, BORIS is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line... - The commonality of plasticity underlying multipotent tumor cells and embryonic stem cellsLynne Marie Postovit
Program in Cancer Biology and Epigenomics, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
J Cell Biochem 101:908-17. 2007..These stem cell-derived mediators, as well as the genes they regulate, provide therapeutic targets designed to specifically differentiate and eradicate aggressive cancers... - Inheritance pattern of Beckwith-Wiedemann syndrome is heterogeneous in 291 families with an affected probandMichael F Wangler
Doris Duke Clinical Research Fellowship, Washington University School of Medicine, St. Louis, Missouri, USA
Am J Med Genet A 137:16-21. 2005..Familial BWS does not appear to be consistent with autosomal dominant transmission, and is likely a complex mixture of different inheritance patterns... - Factors associated with preterm delivery in mothers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS registryMichael F Wangler
Doris Duke Clinical Research Fellowship Washington University School of Medicine and the University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
Am J Med Genet A 134:187-91. 2005..Preterm delivery of a child with BWS is associated with an increased frequency of polyhydramnios, gestational hypertension, and vaginal bleeding in the mother. However, preterm delivery also occurs in the absence of these risk factors... - Epigenetic variability and the evolution of human cancerRolf Ohlsson
Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden
Adv Cancer Res 88:145-68. 2003.... - Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumorsSigrid M Kraggerud
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway
Cancer Genet Cytogenet 147:1-8. 2003..In summary, our results support the theory that a nonimprinted 11p15 tumor suppressor gene is involved in the development of a subgroup of TGCTs... - Moving AHEAD with an international human epigenome projectPeter A Jones
Nature 454:711-5. 2008 - BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expressionPhuongmai Nguyen
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell Biol 28:6720-9. 2008..Thus, we propose that BORIS acts as a platform upon which BAT3 and SET1A assemble and exert effects upon chromatin structure and gene expression... - Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificityGalina N Filippova
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Res 62:48-52. 2002..These observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific "change of function" rather than complete "loss of function.".. - An X chromosome gene, WTX, is commonly inactivated in Wilms tumorMiguel N Rivera
Massachusetts General Hospital Cancer Center, Harvard Medical Center, Boston, MA 02114, USA
Science 315:642-5. 2007....
Research Grants
- BWS AND EMBRYONAL TUMOR SUPPRESSOR GENES ON 11P15ANDREW FEINBERG; Fiscal Year: 2007..abstract_text> ..
- GENOMIC IMPRINTING IN CANCERANDREW FEINBERG; Fiscal Year: 2007....
- FUNCTIONAL ALLELOTYPINGANDREW FEINBERG; Fiscal Year: 2007..We believe that the work will be an integral part of the tools used by the TCGA program, and will also have independent value to cancer researchers in discovering new tumor suppressor genes and genes abnormally activated in cancer. ..
- Center for the Epigenetics of Common Human DiseaseANDREW FEINBERG; Fiscal Year: 2007..We believe our Center will have a major impact in genomic science in providing a foundation for this novel, important, and exciting field. ..
- GENOMIC IMPRINTING IN CANCERANDREW FEINBERG; Fiscal Year: 2009....
- GENOMIC IMPRINTING IN CANCERANDREW FEINBERG; Fiscal Year: 2006..In addition, since LOI represents the first common genetic abnormality of any type found in the normal cells of cancer patients, these studies may have a substantial impact on cancer surveillance and mortality. ..
- GENOMIC IMPRINTING IN CANCERANDREW FEINBERG; Fiscal Year: 2001..Aim 4. The mechanism of loss of imprinting in cancer will be assessed, by precise localization of cis-acting sequences that mediate LOI, and identification of trans-acting factors whose gain or loss mediate abnormal. ..
- GENOMIC IMPRINTING IN CANCERAndrew P Feinberg; Fiscal Year: 2010....