Neal Fedarko

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Serum markers of apoptosis decrease with age and cancer stage
    Nilay Kavathia
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Aging (Albany NY) 1:652-63. 2009
  2. ncbi request reprint Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer
    N S Fedarko
    Division of Geriatrics, Department of Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Cancer Res 7:4060-6. 2001
  3. ncbi request reprint Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases
    Neal S Fedarko
    Division of Geriatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 18:734-6. 2004
  4. pmc The biology of aging and frailty
    Neal S Fedarko
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Geriatr Med 27:27-37. 2011
  5. ncbi request reprint Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers
    Larry W Fisher
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Cancer Res 10:8501-11. 2004
  6. ncbi request reprint The physical and biological characterization of a frail mouse model
    Jeremy Walston
    The Biology of Frailty Working Group, Johns Hopkins University, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 63:391-8. 2008
  7. pmc Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma
    Esther S Oh
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 21:769-73. 2010
  8. pmc Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 46:679-84. 2011
  9. pmc Glutathione peroxidase enzyme activity in aging
    Sara E Espinoza
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 63:505-9. 2008
  10. ncbi request reprint Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack
    Alka Jain
    Division of Geriatrics, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 277:13700-8. 2002

Collaborators

  • Linda P Fried
  • Qian Li Xue
  • Grace A McComsey
  • Luigi Ferrucci
  • L W Fisher
  • Sean X Leng
  • Sara E Espinoza
  • Abdullah Karadag
  • Jeremy D Walston
  • Kai Y Xu
  • Kalu U E Ogbureke
  • Alka Jain
  • Esther S Oh
  • Nilay Kavathia
  • Kim Walter
  • Akeila Bellahcene
  • William H Hoffman
  • Brock A Beamer
  • Naresh M Punjabi
  • Michael Goggins
  • Holly J Garringer
  • Jeong Seok Nam
  • Jens Koopmann
  • Pankaj D Mehta
  • Michelle M Mielke
  • Constantine G Lyketsos
  • Paul B Rosenberg
  • Elizabeth B Humphreys
  • Sinead Nyhan
  • Dianalee A McKnight
  • Alan W Partin
  • Frank Kuhajda
  • Marcia Canto
  • Seung Mo Hong
  • Alison Klein
  • Margaret Griffith
  • Leslie A Mangold
  • SUSAN MEDGHALCHI
  • Noriyuki Omura
  • Vincent Castronovo
  • Harold Chen
  • Monique E Spencer
  • Niamh Conlon
  • Jan Pinkas
  • Mi Jin Kang
  • Adam M Suchar
  • Mohamad S Draman
  • Daniel L Koller
  • Siobhan I Davis
  • Tobias E Larsson
  • Kenneth E White
  • Scott Lonning
  • Aleksandra M Michalowska
  • Corinne Fisher
  • Binwu Tang
  • Christina H Stuelten
  • Bhaskar Dasgupta
  • Lalage M Wakefield
  • Michael J Cullen
  • Charles J Yeo
  • Ralph H Hruban
  • Anirban Maitra
  • Christine Iacobuzio-Donahue
  • Ayman Rahman
  • Berthold Fohr

Detail Information

Publications25

  1. pmc Serum markers of apoptosis decrease with age and cancer stage
    Nilay Kavathia
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Aging (Albany NY) 1:652-63. 2009
    ..The shift toward less global apoptosis with increasing age in normal subjects is consistent with increased incidence of diseases whose pathophysiology involves apoptosis dysregulation...
  2. ncbi request reprint Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer
    N S Fedarko
    Division of Geriatrics, Department of Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Cancer Res 7:4060-6. 2001
    ..We hypothesized that measuring total BSP and OPN levels would provide informative markers for the detection of cancer...
  3. ncbi request reprint Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases
    Neal S Fedarko
    Division of Geriatrics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 18:734-6. 2004
    ..These data suggest that the SIBLING family offers an alternative method of controlling the activity of at least three MMPs...
  4. pmc The biology of aging and frailty
    Neal S Fedarko
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Clin Geriatr Med 27:27-37. 2011
    ..The following article provides an overview of the homeostatic pathways emphasized in research on aging and explains how this science may help to stimulate frailty research...
  5. ncbi request reprint Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers
    Larry W Fisher
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Cancer Res 10:8501-11. 2004
    ....
  6. ncbi request reprint The physical and biological characterization of a frail mouse model
    Jeremy Walston
    The Biology of Frailty Working Group, Johns Hopkins University, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 63:391-8. 2008
    ..We hypothesized that with increasing age, IL-10(tm/tm) mice would develop physical and biological characteristics similar to those of human frailty as compared to C57BL/6J control mice...
  7. pmc Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-β in plasma
    Esther S Oh
    Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Alzheimers Dis 21:769-73. 2010
    ..However, the advantages of electrochemiluminescence detection technology include short processing time and small sample volume. This comparison demonstrates the need for a further study in optimizing this system...
  8. pmc Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults
    Sean X Leng
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Gerontol 46:679-84. 2011
    ..These findings suggest that detection of CMV viral DNA in monocytes may be an informative tool to evaluate chronic CMV infection and its potential role in monocyte/macrophage-mediated immune activation in the elderly...
  9. pmc Glutathione peroxidase enzyme activity in aging
    Sara E Espinoza
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gerontol A Biol Sci Med Sci 63:505-9. 2008
    ..Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability...
  10. ncbi request reprint Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack
    Alka Jain
    Division of Geriatrics, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 277:13700-8. 2002
    ..The required order of the assembly of the complex suggests that this cofactor activity is limited to short diffusional distances...
  11. ncbi request reprint Elevated levels of neopterin in sleep-disordered breathing
    Naresh M Punjabi
    Johns Hopkins University, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 132:1124-30. 2007
    ..Thus, this investigation sought to determine whether neopterin, a marker released by activated macrophages, is increased in SDB...
  12. pmc Serum fatty acid synthase as a marker of pancreatic neoplasia
    Kim Walter
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 18:2380-5. 2009
    ..In conclusion, serum FAS levels are elevated in patients with pancreatic cancer and IPMNs and are associated with neoplastic overexpression of FAS...
  13. pmc Associations of inflammatory markers with AIDS and non-AIDS clinical events after initiation of antiretroviral therapy: AIDS clinical trials group A5224s, a substudy of ACTG A5202
    Grace A McComsey
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH Harvard School of Public Health, Boston, MA Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Social and Scientific Systems, Inc, Silver Spring, MD Gilead Sciences, Foster City, CA GlaxoSmithKline, Research Triangle, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Frontier Science and Technology Research Foundation, Amherst, NY Department of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, MD Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA
    J Acquir Immune Defic Syndr 65:167-74. 2014
    ..The association of inflammatory biomarkers with clinical events after antiretroviral therapy initiation is unclear...
  14. pmc Structural requirements for bone sialoprotein binding and modulation of matrix metalloproteinase-2
    Alka Jain
    Johns Hopkins University School of Medicine, USA
    Biochemistry 47:10162-70. 2008
    ....
  15. pmc Small integrin-binding proteins as serum markers for prostate cancer detection
    Alka Jain
    Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Cancer Res 15:5199-207. 2009
    ..Previous studies have separately reported elevated expression of BSP, OPN, or DSPP in prostate tumor paraffin sections. We hypothesized that SIBLINGs may be informative serum markers for subjects with prostate cancer...
  16. ncbi request reprint Activation of (Na+ + K+)-ATPase induces positive inotropy in intact mouse heart in vivo
    Kai Y Xu
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 349:582-7. 2006
    ..Demonstration of whether activation of (Na+ + K+)-ATPase affects heart function in animal in vivo was the object of this investigation...
  17. pmc Bone sialoprotein binding to matrix metalloproteinase-2 alters enzyme inhibition kinetics
    Alka Jain
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Biochemistry 47:5986-95. 2008
    ..BSP modulation of MMP-2 activity and inhibition may define its biological role in promoting tumor progression...
  18. ncbi request reprint Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma
    Jens Koopmann
    Department of Pathology and Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:487-91. 2004
    ..One candidate tumor marker recently identified by global gene expression analysis of pancreatic cancer is the secreted glycophosphoprotein osteopontin (OPN). In this study, we evaluate OPN as a serum marker of pancreatic adenocarcinoma...
  19. ncbi request reprint Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    Larry W Fisher
    Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
    Connect Tissue Res 44:33-40. 2003
    ..Two possible mechanisms for inhibiting the lytic pathway of alternate complement are presented...
  20. pmc Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Cancer Res 65:11545-52. 2005
    ....
  21. pmc Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
    Akeila Bellahcene
    Metastasis Research Laboratory, University of Liege, Tour de Pathologie, 1, Bat B23, Sart Tilman via 4000 Liege, Belgium
    Nat Rev Cancer 8:212-26. 2008
    ....
  22. pmc Matrix extracellular phosphoglycoprotein (MEPE) correlates with serum phosphorus prior to and during octreotide treatment and following excisional surgery in hypophosphatemic linear sebaceous nevus syndrome
    William H Hoffman
    Department of Pediatrics, Pediatric Endocrinology, Medical College of Georgia, Augusta, Georgia
    Am J Med Genet A 146:2164-8. 2008
  23. ncbi request reprint The role of mutant UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 in regulating serum intact fibroblast growth factor 23 and matrix extracellular phosphoglycoprotein in heritable tumoral calcinosis
    Holly J Garringer
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB130, Indianapolis, IN 46202, USA
    J Clin Endocrinol Metab 91:4037-42. 2006
    ..Recessive loss-of-function mutations in UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) and fibroblast growth factor-23 (FGF23) result in TC...
  24. ncbi request reprint Bone sialoprotein, matrix metalloproteinase 2, and alpha(v)beta3 integrin in osteotropic cancer cell invasion
    Abdullah Karadag
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 4320, USA
    J Natl Cancer Inst 96:956-65. 2004
    ..Its role in tumor biology, however, remains unclear. We investigated whether BSP enhances cancer cell invasiveness by forming a trimolecular complex with MMP-2 and cell-surface integrin alpha(v)beta3...
  25. pmc Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer
    Jeong Seok Nam
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, MD 20892 5055, USA
    Cancer Res 66:6327-35. 2006
    ....

Research Grants7

  1. BONE SIALOPROTEIN AND BREAST CANCER METASTASIS
    Neal Fedarko; Fiscal Year: 2002
    ....
  2. Small integrin-binding proteins and tumor progression
    Neal Fedarko; Fiscal Year: 2006
    ....
  3. 2007 Small Intergin Binding Proteins Gordon Research Conference
    Neal Fedarko; Fiscal Year: 2007
    ..The principal topics to be addressed are: intracellular processing and function of SIBLINGs/CCNs; genetic regulation of SIBLING and CCN genes; SIBLINGs and CCNs in cancer and inflammation; and bioactive fragments of SIBLINGs/CCNs. ..
  4. Research Training in Gerontology & Geriatrics
    Neal Fedarko; Fiscal Year: 2006
    ..He is supported in this role by two Associate Program Directors, Ross Andersen, Ph.D., and Neal Fedarko, Ph.D...
  5. Small integrin-binding proteins and tumor progression
    Neal Fedarko; Fiscal Year: 2007
    ....