N Faraday

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e71447. 2013
  2. doi request reprint Past history of skin infection and risk of surgical site infection after elective surgery
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 257:150-4. 2013
  3. pmc A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    BMC Med Genomics 3:22. 2010
  4. pmc Pro: Should aspirin be continued after cardiac surgery in the setting of thrombocytopenia?
    Nauder Faraday
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Cardiothorac Vasc Anesth 20:112-3. 2006
  5. ncbi request reprint Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population
    Nauder Faraday
    Division of Cardiac Surgical Intensive Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Cardiol 98:774-9. 2006
  6. ncbi request reprint Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 115:2490-6. 2007
  7. ncbi request reprint Pharmacogenomics of platelet responsiveness to aspirin
    Nauder Faraday
    Johns Hopkins University School of Medicine, Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, 298 Meyer Bldg, 600 N Wolfe St, Baltimore, MD 21287, USA
    Pharmacogenomics 8:1413-25. 2007
  8. pmc Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery disease
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Thromb Res 124:311-7. 2009
  9. pmc Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression
    Nauder Faraday
    Department of Anesthesiology and Critical Care Medicine, J ohns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 118:3367-75. 2011
  10. ncbi request reprint Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients
    Nauder Faraday
    Critical Care Medicine and Department of Surgery Vascular, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 101:1291-7. 2004

Detail Information

Publications30

  1. pmc Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e71447. 2013
    ..These experiments demonstrate that neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo and has potential as a target for novel anti-thrombotic therapies. ..
  2. doi request reprint Past history of skin infection and risk of surgical site infection after elective surgery
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 257:150-4. 2013
    ..To identify baseline patient characteristics associated with increased susceptibility to surgical site infection (SSI) after elective surgery...
  3. pmc A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    BMC Med Genomics 3:22. 2010
    ..In this study, we leverage independent information from genome-wide linkage and association data to determine loci controlling platelet phenotypes before and after treatment with ASA...
  4. pmc Pro: Should aspirin be continued after cardiac surgery in the setting of thrombocytopenia?
    Nauder Faraday
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Cardiothorac Vasc Anesth 20:112-3. 2006
  5. ncbi request reprint Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population
    Nauder Faraday
    Division of Cardiac Surgical Intensive Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Cardiol 98:774-9. 2006
    ....
  6. ncbi request reprint Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 115:2490-6. 2007
    ..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness...
  7. ncbi request reprint Pharmacogenomics of platelet responsiveness to aspirin
    Nauder Faraday
    Johns Hopkins University School of Medicine, Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, 298 Meyer Bldg, 600 N Wolfe St, Baltimore, MD 21287, USA
    Pharmacogenomics 8:1413-25. 2007
    ....
  8. pmc Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery disease
    Nauder Faraday
    Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Thromb Res 124:311-7. 2009
    ..Leukocytes may promote platelet reactivity and thrombus formation, providing a basis for increased risk, but a relation between leukocyte count and platelet function has not been studied...
  9. pmc Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression
    Nauder Faraday
    Department of Anesthesiology and Critical Care Medicine, J ohns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 118:3367-75. 2011
    ....
  10. ncbi request reprint Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patients
    Nauder Faraday
    Critical Care Medicine and Department of Surgery Vascular, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 101:1291-7. 2004
    ..The authors hypothesized that platelet genotype would be an independent predictor of postoperative myocardial ischemia and would improve risk assessment when added to clinical factors...
  11. ncbi request reprint Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes
    Nauder Faraday
    Division of Cardiac Surgical Intensive Care, Department of Anesthesiology adn Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Platelets 15:9-14. 2004
    ..84, P < 0.05). TRAP induced platelet-neutrophil conjugate formation is related to in vivo ischemic risk in ACS patients...
  12. ncbi request reprint Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of P-selectin glycoprotein ligand 1 with P-selectin
    N Faraday
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 94:145-51. 2001
    ..The aims of this study were to determine the ability of leukocytes to modulate platelet agonist--induced aggregation and secretion in the blood milieu, and to investigate the role of P-selectin and PSGL-1 in mediating these responses...
  13. ncbi request reprint Utility of whole blood hemostatometry using the clot signature analyzer for assessment of hemostasis in cardiac surgery
    Nauder Faraday
    Department of Anesthesiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Anesthesiology 96:1115-22. 2002
    ..The Clot Signature Analyzer is a hemostatometer that measures global hemostasis in whole blood. The authors hypothesized that point-of-care hemostatometry could detect a clinical coagulopathic state in cardiac surgical patients...
  14. pmc A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability
    J Enrique Herrera-Galeano
    Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Arterioscler Thromb Vasc Biol 28:1484-90. 2008
    ..We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets...
  15. ncbi request reprint In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression
    N Faraday
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 88:1579-85. 1998
    ..To clarify the effect of temperature on intrinsic platelet function, platelet GPllb-IIIa activation and P-selectin expression were assessed under normothermic and hypothermic conditions in vitro...
  16. ncbi request reprint Quantitation of soluble fibrinogen binding to platelets by fluorescence-activated flow cytometry
    N Faraday
    Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
    J Lab Clin Med 123:728-40. 1994
    ..The simplicity, sensitivity, and quantifiability of this method may make it a useful technique for basic and clinical research involving GPIIb-IIIa function...
  17. ncbi request reprint Neuroendocrine stress hormones do not recreate the postoperative hypercoagulable state
    B A Rosenfeld
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesth Analg 86:640-5. 1998
    ..These changes are consistent with an inhibition of coagulation and improved fibrinolysis. These data suggest that this combination of neuroendocrine hormones is not responsible for the postoperative hypercoagulable state...
  18. pmc Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    Alan R Shuldiner
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
    JAMA 302:849-57. 2009
    ..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events...
  19. pmc Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation
    Henry Sun
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 105:595-603. 2009
    ..Each is well characterized in the central nervous system, but glutamate has important signaling roles in peripheral tissues as well, including a role in regulating platelet function...
  20. pmc Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components
    Dhananjay Vaidya
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Metab Syndr Relat Disord 7:289-96. 2009
    ..We determined the extent to which persons with increased risk for CAD with and without the metabolic syndrome accrued antiplatelet benefits from aspirin therapy...
  21. ncbi request reprint Effect of ischemia and reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lung
    Jeffrey M Dodd-o
    Department of Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 9106, USA
    J Appl Physiol (1985) 95:1971-8. 2003
    ..We conclude that short periods of I/R, without airway occlusion, increase pulmonary vascular permeability in the in vivo mouse, providing a useful model to study molecular mechanisms of I/R lung injury...
  22. ncbi request reprint Cardiac troponin I predicts short-term mortality in vascular surgery patients
    Lauren J Kim
    Johns Hopkins University School of Medicine, Department of Anesthesiology and Critical Care Medicine, Baltimore, MD 21287 7294, USA
    Circulation 106:2366-71. 2002
    ..We evaluated the association between postoperative cTnI levels and 6-month mortality and perioperative myocardial infarction (MI) after vascular surgery...
  23. ncbi request reprint Sex differences in platelet reactivity and response to low-dose aspirin therapy
    Diane M Becker
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 295:1420-7. 2006
    ..Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism...
  24. pmc Glutamate mediates platelet activation through the AMPA receptor
    Craig N Morrell
    Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Exp Med 205:575-84. 2008
    ..Importantly, mice lacking GluR1 have a prolonged time to thrombosis in vivo. Our data identify glutamate as a regulator of platelet activation, and suggest that the AMPA receptor is a novel antithrombotic target...
  25. pmc Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular disease
    Rehan Qayyum
    Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 101:1359-63. 2008
    ..In conclusion, women continue to have greater residual platelet activity after high-dose aspirin compared with men treated with a lower dose of aspirin...
  26. doi request reprint Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery
    Elena Blasco-Colmenares
    Department of Anesthesiology, Johns Hopkins Hospital, 298 Meyer Bldg, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Intern Med 169:788-96. 2009
    ..Pharmacologic suppression of platelet function may increase the risk of postoperative infection by inhibiting hemostasis, immunity, or both...
  27. ncbi request reprint Casual chocolate consumption and inhibition of platelet function
    Bryan Bordeaux
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Prev Cardiol 10:175-80. 2007
    ..The authors concluded that even consuming modest amounts of commercial chocolate has important antiplatelet effects...
  28. pmc Regulation of platelet granule exocytosis by S-nitrosylation
    Craig N Morrell
    Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:3782-7. 2005
    ..Platelets lacking endothelial NO synthase show increased rolling on venules, increased thrombosis in arterioles, and increased exocytosis in vivo. Regulation of exocytosis is thus a mechanism by which NO regulates thrombosis...
  29. ncbi request reprint Platelets, perioperative hemostasis, and anesthesia
    Nauder Faraday
    Anesthesiology 96:1042-3. 2002
  30. ncbi request reprint Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemia
    Elizabeth A Martinez
    The Johns Hopkins University School of Medicine, Department of Anesthesiology Critical Care Medicine, USA
    Crit Care Med 31:2302-8. 2003
    ....