Research Topics
| N FaradaySummaryAffiliation: Johns Hopkins University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Past history of skin infection and risk of surgical site infection after elective surgeryNauder Faraday
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 257:150-4. 2013..To identify baseline patient characteristics associated with increased susceptibility to surgical site infection (SSI) after elective surgery...
A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery diseaseRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
BMC Med Genomics 3:22. 2010..In this study, we leverage independent information from genome-wide linkage and association data to determine loci controlling platelet phenotypes before and after treatment with ASA...- Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expressionNauder Faraday
Department of Anesthesiology and Critical Care Medicine, J ohns Hopkins University School of Medicine, Baltimore, MD, USA
Blood 118:3367-75. 2011.... - Leukocyte count is associated with increased platelet reactivity and diminished response to aspirin in healthy individuals with a family history of coronary artery diseaseNauder Faraday
Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Thromb Res 124:311-7. 2009..Leukocytes may promote platelet reactivity and thrombus formation, providing a basis for increased risk, but a relation between leukocyte count and platelet function has not been studied... 
Pharmacogenomics of platelet responsiveness to aspirinNauder Faraday
Johns Hopkins University School of Medicine, Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, 298 Meyer Bldg, 600 N Wolfe St, Baltimore, MD 21287, USA
Pharmacogenomics 8:1413-25. 2007....- Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1Nauder Faraday
Department of Anesthesiology Critical Care Medicine, Division of Cardiac Surgical Intensive Care, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 115:2490-6. 2007..Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness... - Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention populationNauder Faraday
Division of Cardiac Surgical Intensive Care, Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Cardiol 98:774-9. 2006..quot;.. - Pro: Should aspirin be continued after cardiac surgery in the setting of thrombocytopenia?Nauder Faraday
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Cardiothorac Vasc Anesth 20:112-3. 2006 - Platelet gene polymorphisms and cardiac risk assessment in vascular surgical patientsNauder Faraday
Critical Care Medicine and Department of Surgery Vascular, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Anesthesiology 101:1291-7. 2004..The authors hypothesized that platelet genotype would be an independent predictor of postoperative myocardial ischemia and would improve risk assessment when added to clinical factors... - Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromesNauder Faraday
Division of Cardiac Surgical Intensive Care, Department of Anesthesiology adn Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Platelets 15:9-14. 2004..84, P < 0.05). TRAP induced platelet-neutrophil conjugate formation is related to in vivo ischemic risk in ACS patients... - Utility of whole blood hemostatometry using the clot signature analyzer for assessment of hemostasis in cardiac surgeryNauder Faraday
Department of Anesthesiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Anesthesiology 96:1115-22. 2002..The Clot Signature Analyzer is a hemostatometer that measures global hemostasis in whole blood. The authors hypothesized that point-of-care hemostatometry could detect a clinical coagulopathic state in cardiac surgical patients... - Leukocytes can enhance platelet-mediated aggregation and thromboxane release via interaction of P-selectin glycoprotein ligand 1 with P-selectinN Faraday
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Anesthesiology 94:145-51. 2001..The aims of this study were to determine the ability of leukocytes to modulate platelet agonist--induced aggregation and secretion in the blood milieu, and to investigate the role of P-selectin and PSGL-1 in mediating these responses... - A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregabilityJ Enrique Herrera-Galeano
Departments of Medicine and Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Arterioscler Thromb Vasc Biol 28:1484-90. 2008..We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets... - In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expressionN Faraday
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Anesthesiology 88:1579-85. 1998..To clarify the effect of temperature on intrinsic platelet function, platelet GPllb-IIIa activation and P-selectin expression were assessed under normothermic and hypothermic conditions in vitro... - Quantitation of soluble fibrinogen binding to platelets by fluorescence-activated flow cytometryN Faraday
Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
J Lab Clin Med 123:728-40. 1994..The simplicity, sensitivity, and quantifiability of this method may make it a useful technique for basic and clinical research involving GPIIb-IIIa function... - Neuroendocrine stress hormones do not recreate the postoperative hypercoagulable stateB A Rosenfeld
Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Anesth Analg 86:640-5. 1998..Alternatively, these five hormones caused increased levels of fibrinolytic proteins (tissue plasminogen activator) and endogenous anticoagulants (protein C antigen and activity)... - Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapyAlan R Shuldiner
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 W Redwood St, Room 494, Baltimore, MD 21201, USA
JAMA 302:849-57. 2009..However, nonresponsiveness is widely recognized and is related to recurrent ischemic events... - Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activationHenry Sun
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 105:595-603. 2009..Each is well characterized in the central nervous system, but glutamate has important signaling roles in peripheral tissues as well, including a role in regulating platelet function... - Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its componentsDhananjay Vaidya
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Metab Syndr Relat Disord 7:289-96. 2009..We determined the extent to which persons with increased risk for CAD with and without the metabolic syndrome accrued antiplatelet benefits from aspirin therapy... - Platelet inhibition by aspirin 81 and 325 mg/day in men versus women without clinically apparent cardiovascular diseaseRehan Qayyum
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 101:1359-63. 2008..In conclusion, women continue to have greater residual platelet activity after high-dose aspirin compared with men treated with a lower dose of aspirin... - Glutamate mediates platelet activation through the AMPA receptorCraig N Morrell
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Exp Med 205:575-84. 2008..Importantly, mice lacking GluR1 have a prolonged time to thrombosis in vivo. Our data identify glutamate as a regulator of platelet activation, and suggest that the AMPA receptor is a novel antithrombotic target... - Cardiac troponin I predicts short-term mortality in vascular surgery patientsLauren J Kim
Johns Hopkins University School of Medicine, Department of Anesthesiology and Critical Care Medicine, Baltimore, MD 21287-7294, USA
Circulation 106:2366-71. 2002..Further research is needed to determine whether intervention in these patients can improve outcome... - Sex differences in platelet reactivity and response to low-dose aspirin therapyDiane M Becker
Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 295:1420-7. 2006..Failure of aspirin to suppress platelet aggregation in women is one hypothesized mechanism... - Effect of ischemia and reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lungJeffrey M Dodd-o
Department of Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 9106, USA
J Appl Physiol 95:1971-8. 2003..We conclude that short periods of I/R, without airway occlusion, increase pulmonary vascular permeability in the in vivo mouse, providing a useful model to study molecular mechanisms of I/R lung injury... - Casual chocolate consumption and inhibition of platelet functionBryan Bordeaux
Department of Medicine, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Prev Cardiol 10:175-80. 2007..The authors concluded that even consuming modest amounts of commercial chocolate has important antiplatelet effects... - Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgeryElena Blasco-Colmenares
Department of Anesthesiology, Johns Hopkins Hospital, 298 Meyer Bldg, 600 N Wolfe St, Baltimore, MD 21287, USA
Arch Intern Med 169:788-96. 2009..Pharmacologic suppression of platelet function may increase the risk of postoperative infection by inhibiting hemostasis, immunity, or both... - Regulation of platelet granule exocytosis by S-nitrosylationCraig N Morrell
Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:3782-7. 2005..Platelets lacking endothelial NO synthase show increased rolling on venules, increased thrombosis in arterioles, and increased exocytosis in vivo. Regulation of exocytosis is thus a mechanism by which NO regulates thrombosis... - Platelets, perioperative hemostasis, and anesthesiaNauder Faraday
Anesthesiology 96:1042-3. 2002 - Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemiaElizabeth A Martinez
The Johns Hopkins University School of Medicine, Department of Anesthesiology/Critical Care Medicine, USA
Crit Care Med 31:2302-8. 2003..Because detecting electrocardiogram evidence suggestive of prolonged postoperative myocardial ischemia is important, physicians should consider alternative strategies to detect myocardial ischemia...