Jed W Fahey

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates
    Jed W Fahey
    Lewis B and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 435:1-7. 2013
  2. doi request reprint Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora
    Jed W Fahey
    Lewis B and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street WBSB 406, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 5:603-11. 2012
  3. ncbi request reprint The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
  4. ncbi request reprint Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatography
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 406 WBSB, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Chromatogr A 996:85-93. 2003
  5. ncbi request reprint Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
    Carcinogenesis 26:1247-55. 2005
  6. ncbi request reprint Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes
    Jed W Fahey
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Agric Food Chem 50:7472-6. 2002
  7. pmc Pathogen detection, testing, and control in fresh broccoli sprouts
    Jed W Fahey
    Department of Pharmacology and Molecular Sciences, Lewis B, and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutr J 5:13. 2006
  8. pmc Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 99:7610-5. 2002
  9. ncbi request reprint Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial
    Jed W Fahey
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 406 WBSB, Baltimore, MD 21205 2185, USA
    Cancer Epidemiol Biomarkers Prev 13:1610-6. 2004
  10. ncbi request reprint Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006

Collaborators

Detail Information

Publications41

  1. doi request reprint Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates
    Jed W Fahey
    Lewis B and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 435:1-7. 2013
    ..The bactericidal effects of SF and other ITC against Helicobacter are therefore not obligatorily linked to urease inactivation, but may reduce the inflammatory component of Helicobacter infections...
  2. doi request reprint Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora
    Jed W Fahey
    Lewis B and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street WBSB 406, Baltimore, MD 21205, USA
    Cancer Prev Res (Phila) 5:603-11. 2012
    ..Although no demographic factors affecting conversion efficiency have been identified, there are clearly diurnal variations: conversion of GS to DTC was greater during the day, but conversion of ITC to DTC was more efficient at night...
  3. ncbi request reprint The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
    ....
  4. ncbi request reprint Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatography
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 406 WBSB, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    J Chromatogr A 996:85-93. 2003
    ..Pooled sequential runs with broccoli seed extract yielded about 20 g of its predominant glucosinolate, glucoraphanin, which was produced at > 95% purity and reduced to powdered form...
  5. ncbi request reprint Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
    Carcinogenesis 26:1247-55. 2005
    ....
  6. ncbi request reprint Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes
    Jed W Fahey
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Agric Food Chem 50:7472-6. 2002
    ..110,000 units/g) is even higher than that of broccoli and the potencies of fingerroot oil and powdered rhizome (ca. 500,000 units/g) rival that of broccoli sprouts...
  7. pmc Pathogen detection, testing, and control in fresh broccoli sprouts
    Jed W Fahey
    Department of Pharmacology and Molecular Sciences, Lewis B, and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nutr J 5:13. 2006
    ..Contamination may occur when these guidelines are not followed...
  8. pmc Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 99:7610-5. 2002
    ....
  9. ncbi request reprint Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial
    Jed W Fahey
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 406 WBSB, Baltimore, MD 21205 2185, USA
    Cancer Epidemiol Biomarkers Prev 13:1610-6. 2004
    ..For the least variable quartile, as few as 12 subjects would be needed; for the most variable quartile, at least 147 subjects would be required in each arm...
  10. ncbi request reprint Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006
    ..No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed...
  11. pmc Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Photochem Photobiol Sci 9:597-600. 2010
    ....
  12. pmc Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Carcinogenesis 33:101-7. 2012
    ..No significant differences were seen between the effects of SFR versus GRR. Intervention with broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks...
  13. doi request reprint A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB Room 406, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:859-65. 2008
    ....
  14. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  15. ncbi request reprint Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005
    ..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions...
  16. ncbi request reprint Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:847-51. 2007
    ..5- and 4.5-fold after application of 150 nmol doses, once or three times (at 24 h-intervals), respectively, thus providing direct evidence for induction of the phase 2 response in humans...
  17. pmc Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Top Curr Chem 329:163-77. 2013
    ....
  18. pmc Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17500-5. 2007
    ..7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting...
  19. ncbi request reprint Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 240:243-52. 2006
    ..Thus, topical application of sulforaphane-containing broccoli sprout extracts is a promising strategy for protecting against skin tumor formation after exposure to UV radiation...
  20. pmc Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors
    Zachary R Healy
    Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Photodermatol Photoimmunol Photomed 25:45-50. 2009
    ..These methods have permitted evaluation of the efficacy of protectors, such as sulforaphane from crucifers, that defend cells through induction of cytoprotective (phase 2) genes...
  21. pmc Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Nutr Res 28:539-43. 2008
    ..Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults...
  22. ncbi request reprint Structure-activity analysis of flavonoids: direct and indirect antioxidant, and antiinflammatory potencies and toxicities
    Petra A Tsuji
    a Department of Biological Sciences, Towson University, Towson, Maryland, USA
    Nutr Cancer 65:1014-25. 2013
    ..Evaluation in vivo will reveal whether differential protective advantages support their possible evaluation in a cancer prevention setting. ..
  23. ncbi request reprint Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    Brian S Cornblatt
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 28:1485-90. 2007
    ..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer...
  24. pmc Stimulation of phagocytosis by sulforaphane
    Hiroyuki Suganuma
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 405:146-51. 2011
    ..7 cells attenuated phagocytosis, but sulforaphane-inactivated MIF did not affect phagocytosis. The inactivation of MIF may therefore be involved in the phagocytosis-enhancing activity of sulforaphane...
  25. ncbi request reprint Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1)
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Science, Lewis B and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 382:423-48. 2004
  26. doi request reprint Induction of chemoprotective phase 2 enzymes by ginseng and its components
    Lawrence S Lee
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Planta Med 75:1129-33. 2009
    ..The most potent inducing red ginseng extract also had the highest panaxytriol content, 120.8 microg/g. We found that ginseng induced NQO1 and that polyacetylenes are the most active components...
  27. ncbi request reprint Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
    T A Shapiro
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 10:501-8. 2001
    ..These findings will assist in the design of dosing regimens for clinical studies of broccoli sprout efficacy...
  28. ncbi request reprint Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism
    P Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 131:3027S-33S. 2001
    ..Thus, in addition to detoxifying electrophiles, these proteins exercise versatile, long-lasting and catalytic antioxidant protection...
  29. pmc Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the "Diffusion of innovations" theory
    Melanie D Thurber
    Johns Hopkins University Bloomberg School of Public Health, Center for Human Nutrition, Baltimore, Maryland 21205 2185, USA
    Ecol Food Nutr 48:212-25. 2009
    ..oleifera continues to increase. The "Diffusion of innovations theory" describes well, the evidence for growth and adoption of dietary M. oleifera leaves, and it highlights the need for a scientific consensus on the nutritional benefits...
  30. pmc Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes
    Jed W Fahey
    Department of Pharmacology, International Health, and Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 20:572-6. 2007
  31. ncbi request reprint The "Prochaska" microtiter plate bioassay for inducers of NQO1
    Jed W Fahey
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 382:243-58. 2004
  32. doi request reprint Black cohosh: coming full circle?
    Teresa L Johnson
    Johns Hopkins University, Bloomberg School of Public Health, Department of International Health, Center for Human Nutrition, Baltimore, MD, USA
    J Ethnopharmacol 141:775-9. 2012
    ..Black cohosh has been used for many centuries both in Europe and in the US (by indigenous people and subsequent Caucasian medical practitioners), most notably for indications of premenstrual syndrome (PMS), menstrual pain and cramping...
  33. pmc Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolates
    Kristina L Wade
    Johns Hopkins School of Medicine, Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, 725 N Wolfe Street, 406 WBSB, Baltimore, MD 21205, USA
    J Chromatogr A 1154:469-72. 2007
    ..Furthermore, the HILIC system that we report herein permits much greater alteration of the mobile phase composition for customized separation of glucosinolates from plant extracts, across a wide spectrum of polarity...
  34. ncbi request reprint Analysis of glucosinolates from broccoli and other cruciferous vegetables by hydrophilic interaction liquid chromatography
    J K Troyer
    Brassica Protection Products, Baltimore, MD 21202, USA
    J Chromatogr A 919:299-304. 2001
    ..Hydrophilic interaction chromatography offers a novel method for analyzing intact glucosinolates and when performed along with ion-pair reversed-phase chromatography offers a powerful and complementary method for glucosinolate analysis...
  35. ncbi request reprint Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 54:9370-6. 2006
    ..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer...
  36. ncbi request reprint Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes
    Fernanda Maria Valente Pereira
    Department of Plant Science and Agricultural Engineering, Universidade de Tras os Montes e Alto Douro, Apartado 1013, 5001 911 Vila Real, Portugal
    J Agric Food Chem 50:6239-44. 2002
    ..Temperature stress or its associated developmental anomalies induce higher glucosinolate levels, specific elevations in glucoraphanin content, and parallel induction of phase 2 chemoprotective enzymes...
  37. ncbi request reprint Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori
    Xavier Haristoy
    Laboratoire de Bacteriologie virologie, UMR CNRS 7565, Faculte de Medecine, Universite Henri Poincare, Nancy, France
    Planta Med 71:326-30. 2005
    ..Overall, our data indicate that ITCs have a potent antibacterial effect against H. pylori and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. pylori eradication...
  38. ncbi request reprint Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:935-44. 2006
    ..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates...
  39. doi request reprint Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    Rex Munday
    AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
    Cancer Res 68:1593-600. 2008
    ..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion...
  40. ncbi request reprint Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: application of the 'method of triads' to a food-specific biomarker
    Jay H Fowke
    Vanderbilt Ingram Cancer Center, Vanderbilt Center for Health Services Research, Nashville, TN 37232 8300, USA
    Public Health Nutr 5:791-9. 2002
    ..We compared urinary DTC levels to intake as measured by two self-reported dietary assessment techniques...
  41. ncbi request reprint Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay
    Rex Munday
    AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
    Nutr Cancer 54:223-31. 2006
    ....