Research Topics
| Jed W FaheySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microfloraJed W Fahey
Lewis B and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street WBSB 406, Baltimore, MD 21205, USA
Cancer Prev Res (Phila) 5:603-11. 2012..Although no demographic factors affecting conversion efficiency have been identified, there are clearly diurnal variations: conversion of GS to DTC was greater during the day, but conversion of ITC to DTC was more efficient at night...
The chemical diversity and distribution of glucosinolates and isothiocyanates among plantsJ W Fahey
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Phytochemistry 56:5-51. 2001....
Pathogen detection, testing, and control in fresh broccoli sproutsJed W Fahey
Department of Pharmacology and Molecular Sciences, Lewis B, and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nutr J 5:13. 2006..Contamination may occur when these guidelines are not followed...
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumorsJed W Fahey
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
Proc Natl Acad Sci U S A 99:7610-5. 2002....- Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genesJed W Fahey
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
Carcinogenesis 26:1247-55. 2005.... - Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymesJed W Fahey
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
J Agric Food Chem 50:7472-6. 2002..110,000 units/g) is even higher than that of broccoli and the potencies of fingerroot oil and powdered rhizome (ca. 500,000 units/g) rival that of broccoli sprouts... - Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trialJed W Fahey
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 406 WBSB, Baltimore, MD 21205 2185, USA
Cancer Epidemiol Biomarkers Prev 13:1610-6. 2004..For the least variable quartile, as few as 12 subjects would be needed; for the most variable quartile, at least 147 subjects would be required in each arm... - Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatographyJed W Fahey
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 406 WBSB, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
J Chromatogr A 996:85-93. 2003..Pooled sequential runs with broccoli seed extract yielded about 20 g of its predominant glucosinolate, glucoraphanin, which was produced at > 95% purity and reduced to powdered form... - Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I studyTheresa A Shapiro
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Nutr Cancer 55:53-62. 2006..No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed... - Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless miceAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Photochem Photobiol Sci 9:597-600. 2010.... - A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated miceAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB Room 406, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 367:859-65. 2008.... - Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, ChinaThomas W Kensler
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Carcinogenesis 33:101-7. 2012..No significant differences were seen between the effects of SFR versus GRR. Intervention with broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks... - Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extractsAlbena T Dinkova Kostova
Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 16:847-51. 2007..5- and 4.5-fold after application of 150 nmol doses, once or three times (at 24 h-intervals), respectively, thus providing direct evidence for induction of the phase 2 response in humans... - Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of ChinaThomas W Kensler
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions... - Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extractsAlbena T Dinkova-Kostova
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N. Wolfe Street, Baltimore, MD 21205, USA
Cancer Lett 240:243-52. 2006..Thus, topical application of sulforaphane-containing broccoli sprout extracts is a promising strategy for protecting against skin tumor formation after exposure to UV radiation... - Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, ChinaPatricia A Egner
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Cancer Prev Res (Phila) 4:384-95. 2011..Cancer Prev Res; 4(3); 384-95. ©2011 AACR... - Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectorsZachary R Healy
Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Photodermatol Photoimmunol Photomed 25:45-50. 2009..These methods have permitted evaluation of the efficacy of protectors, such as sulforaphane from crucifers, that defend cells through induction of cytoprotective (phase 2) genes... - Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless miceAlbena T Dinkova-Kostova
Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Nutr Res 28:539-43. 2008..Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults... - Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiationPaul Talalay
Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:17500-5. 2007..7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting... - Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breastBrian S Cornblatt
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Carcinogenesis 28:1485-90. 2007..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer... - Keap1-nrf2 signaling: a target for cancer prevention by sulforaphaneThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA
Top Curr Chem 329:163-77. 2013.... - Induction of chemoprotective phase 2 enzymes by ginseng and its componentsLawrence S Lee
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Planta Med 75:1129-33. 2009..The most potent inducing red ginseng extract also had the highest panaxytriol content, 120.8 microg/g. We found that ginseng induced NQO1 and that polyacetylenes are the most active components... - Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolismP Talalay
Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
J Nutr 131:3027S-33S. 2001..Thus, in addition to detoxifying electrophiles, these proteins exercise versatile, long-lasting and catalytic antioxidant protection... - Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humansT A Shapiro
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Epidemiol Biomarkers Prev 10:501-8. 2001..These findings will assist in the design of dosing regimens for clinical studies of broccoli sprout efficacy... - Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the "Diffusion of innovations" theoryMelanie D Thurber
Johns Hopkins University Bloomberg School of Public Health, Center for Human Nutrition, Baltimore, Maryland 21205 2185, USA
Ecol Food Nutr 48:212-25. 2009..The "Diffusion of innovations theory" describes well, the evidence for growth and adoption of dietary M. oleifera leaves, and it highlights the need for a scientific consensus on the nutritional benefits... - Stimulation of phagocytosis by sulforaphaneHiroyuki Suganuma
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 405:146-51. 2011..7 cells attenuated phagocytosis, but sulforaphane-inactivated MIF did not affect phagocytosis. The inactivation of MIF may therefore be involved in the phagocytosis-enhancing activity of sulforaphane... - The "Prochaska" microtiter plate bioassay for inducers of NQO1Jed W Fahey
Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Methods Enzymol 382:243-58. 2004 - Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymesJed W Fahey
Department of Pharmacology, International Health, and Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland 21205, USA
Chem Res Toxicol 20:572-6. 2007 - Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1)Albena T Dinkova-Kostova
Department of Pharmacology and Molecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Methods Enzymol 382:423-48. 2004 - Black cohosh: coming full circle?Teresa L Johnson
Johns Hopkins University, Bloomberg School of Public Health, Department of International Health, Center for Human Nutrition, Baltimore, MD, USA
J Ethnopharmacol 141:775-9. 2012..Black cohosh has been used for many centuries both in Europe and in the US (by indigenous people and subsequent Caucasian medical practitioners), most notably for indications of premenstrual syndrome (PMS), menstrual pain and cramping... - Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolatesKristina L Wade
Johns Hopkins School of Medicine, Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, 725 N Wolfe Street, 406 WBSB, Baltimore, MD 21205, USA
J Chromatogr A 1154:469-72. 2007..Furthermore, the HILIC system that we report herein permits much greater alteration of the mobile phase composition for customized separation of glucosinolates from plant extracts, across a wide spectrum of polarity... - Analysis of glucosinolates from broccoli and other cruciferous vegetables by hydrophilic interaction liquid chromatographyJ K Troyer
Brassica Protection Products, Baltimore, MD 21202, USA
J Chromatogr A 919:299-304. 2001..Hydrophilic interaction chromatography offers a novel method for analyzing intact glucosinolates and when performed along with ion-pair reversed-phase chromatography offers a powerful and complementary method for glucosinolate analysis... - Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pyloriXavier Haristoy
, UMR-CNRS 7565, , , Nancy, France
Planta Med 71:326-30. 2005..Overall, our data indicate that ITCs have a potent antibacterial effect against H. pylori and these naturally occurring phytochemicals might have potential as novel therapeutic agents for H. pylori eradication... - Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymesFernanda Maria Valente Pereira
Department of Plant Science and Agricultural Engineering, , Apartado 1013, 5001-911 Vila Real, Portugal
J Agric Food Chem 50:6239-44. 2002..Temperature stress or its associated developmental anomalies induce higher glucosinolate levels, specific elevations in glucoraphanin content, and parallel induction of phase 2 chemoprotective enzymes... - Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sproutsYuesheng Zhang
Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
J Agric Food Chem 54:9370-6. 2006..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer... - Inhibition of urinary bladder carcinogenesis by broccoli sproutsRex Munday
AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
Cancer Res 68:1593-600. 2008..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion... - Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extractLi Tang
Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
Mol Cancer Ther 5:935-44. 2006..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates... - Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassayRex Munday
AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
Nutr Cancer 54:223-31. 2006.... - Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: application of the 'method of triads' to a food-specific biomarkerJay H Fowke
Vanderbilt Ingram Cancer Center, Vanderbilt Center for Health Services Research, Nashville, TN 37232 8300, USA
Public Health Nutr 5:791-9. 2002..We compared urinary DTC levels to intake as measured by two self-reported dietary assessment techniques...