Genomes and Genes
Affiliation: Johns Hopkins University
- Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domainJun Yang
Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
BMC Mol Biol 8:101. 2007..In this study, we aimed to identify if HDGF is a DNA binding protein, map the functional DNA binding domain and DNA binding element for HDGF...
- Community use of the amplatzer atrial septal defect occluder: results of the multicenter MAGIC atrial septal defect studyAllen D Everett
Department of Pediatrics, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
Pediatr Cardiol 30:240-7. 2009....
- Development of the MAGIC congenital heart disease catheterization database for interventional outcome studiesAllen D Everett
Johns Hopkins University, Baltimore, Maryland 21287, and Children s Hospital of Central California, Madera, USA
J Interv Cardiol 19:173-7. 2006....
- Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factorAllen D Everett
Department of Pediatrics, Cardiovascular Research Center, University of Virginia Health System, Charlottesville, 22908, USA
Am J Physiol Lung Cell Mol Physiol 286:L1194-201. 2004..We conclude that HDGF is a highly expressed vascular endothelial cell protein in vivo and is a potent endothelial mitogen and regulator of endothelial cell migration by mechanisms distinct from VEGF...
- Mitotic phosphorylation activates hepatoma-derived growth factor as a mitogenAllen D Everett
Department of Pediatrics, Cardiology Division, Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
BMC Cell Biol 12:15. 2011..Mass spectrometry based methods have identified HDGF as a phosphoprotein without validation or a functional consequence of this post-translational modification...
- Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomasRyan P Lange
The Johns Hopkins University, School of Medicine, Departments of1 Pediatrics2 Emergency Medicine3 Neurosurgery, 4 and Oncology, 5 Baltimore, MD, USA The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA 6
Cancer Invest 32:423-9. 2014..Compared to the healthy controls, none of the proteins appeared to be specific for glioblastomas. However, the data are suggestive of higher protein levels in gliosarcomas (n = 2), which may deserve further exploration. ..
- Can proteomics yield insight into aging aorta?Zongming Fu
Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA
Proteomics Clin Appl 7:477-89. 2013..Such proteins, including milk fat globule-EGF factor 8, matrix metalloproteinase type-2, and vitronectin, could be used as indicators of vascular health, or even explored as therapeutic targets for aging-related vascular diseases. ..
- Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenationMelania M Bembea
Department of Anesthesiology and Critical Care, Johns Hopkins University, Baltimore, MD, USA mbembea1jhmi edu
Pediatr Crit Care Med 12:572-9. 2011..To determine whether, in children, plasma glial fibrillary acidic protein is associated with brain injury during extracorporeal membrane oxygenation and with mortality...
- Biomarkers in pediatrics: children as biomarker orphansWilliam J Savage
Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Proteomics Clin Appl 4:915-21. 2010..This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research...
- Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and strokeWilliam J Savage
Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
Acta Haematol 125:103-6. 2011..Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful...
- Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding proteinJun Yang
Department of Pediatrics, Division of Pediatric Cardiology, Johns Hopkins University, Baltimore, MD 21205, USA
J Mol Biol 386:938-50. 2009..Because of moderate conservation of the CtBP binding motif in HDGF family members, trans-repressive activity mediated by CtBP may be a common function among HDGF proteins...
- Intact protein separation by one- and two-dimensional liquid chromatography for the comparative proteomic separation of partitioned serum or plasmaSimon Sheng
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Methods Mol Biol 728:29-46. 2011....
- Plasma glial fibrillary acidic protein levels in children with sickle cell diseaseWilliam J Savage
Divisions of Transfusion Medicine and Pediatric Hematology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Am J Hematol 86:427-9. 2011..Plasma GFAP is elevated among children with SCD and may be associated with subclinical brain injury...
- Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomasHatim Husain
Brain Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, 1M 16, Baltimore, MD, 21287, USA
J Neurooncol 109:123-7. 2012..GFAP remains a potentially informative plasma biomarker for gliomas. Longitudinal studies are required to correlate pGFAP levels with patient outcomes...
- Hemoglobin depletion from plasma: considerations for proteomic discovery in sickle cell disease and other hemolytic processesLisa M Williams
Department Pediatrics, Division of Pediatric Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proteomics Clin Appl 4:926-30. 2010..The aim of this study was to explore the potential of using nickel-beads for Hb depletion of plasma...
- High resolution structure of the HDGF PWWP domain: a potential DNA binding domainStephen M Lukasik
Department of Chemistry, University of Virginia, Charlottesville, VA 22906, USA
Protein Sci 15:314-23. 2006..Based on the NMR titrations, we propose a model of the interaction of the PWWP domain with DNA...
- Hepatoma derived growth factor is a nuclear targeted mitogenAllen D Everett
Department of Pediatrics and the Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia 22908 1356, USA
Curr Drug Targets 4:367-71. 2003..Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development...
- Hepatoma-derived growth factor is expressed after vascular injury in the rat and stimulates smooth muscle cell migrationJill V Narron
Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Pediatr Res 59:778-83. 2006..We speculate that HDGF is involved in the SMC proliferative and migratory response to injury resulting in neointimal formation...
- Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasionZongming Fu
Laboratory of Cardiovascular Science, National Institute on Aging National Institutes of Health, Baltimore, MD 21224, USA
Circ Res 104:1337-46. 2009..Thus, targeting of MFG-E8 within this signaling axis pathway is a potential novel therapy for the prevention and treatment of the age-associated vascular diseases such as atherosclerosis...
- Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiationAllen D Everett
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Lung Cell Mol Physiol 282:L1266-71. 2002..We propose that B56gamma is expressed at a particular stage of lung development to modulate PP2A action on the Wnt/beta-catenin signaling pathway during lung airway morphogenesis...
- Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cellsNikolaos A Tountas
Center for Cell Signaling, University of Virginia School of Medicine, PO Box 800577, Charlottesville, VA 22908, USA
Histochem Cell Biol 121:343-50. 2004..The common tissue distribution but different cellular localization of PHI-1 and CPI-17 suggest distinctive physiological roles for these two PP1 inhibitors...
- Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)Maina Lepourcelet
Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Development 132:415-27. 2005..Our findings also advance understanding of HDGF functions and implicate this developmentally regulated gene in RNA metabolic pathways that may influence malignant behaviors in colorectal cancer...
- Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancerHening Ren
Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Oncol 22:3230-7. 2004..We hypothesize that HDGF plays an important role in biologic behavior of early-stage non-small-cell lung cancer (NSCLC)...
- Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factorYorihide Okuda
Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871
Cancer Sci 94:1034-41. 2003..Thus, these findings suggested that HDGF-induced tumor formation in vivo involves induction of VEGF as well as direct angiogenic activity...
- Functional proteomic analysis of melanoma progressionKarine Bernard
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA
Cancer Res 63:6716-25. 2003..Thus, expression of this antigen likely reports a reduced dependence of protein expression on epidermal interactions...
- Hepatoma-derived growth factor is highly expressed in developing liver and promotes fetal hepatocyte proliferationHirayuki Enomoto
Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Hepatology 36:1519-27. 2002..In conclusion, HDGF helps regulate the hepatocyte proliferation in liver development...
- The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cellsSiang Yo Lin
Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
Exp Cell Res 314:3107-17. 2008..Two proteins, cyclophilin B and hepatoma-derived growth factor were then further characterized and shown to promote MSC chemotaxis...
- Hepatoma derived growth factor and vascular smooth muscle cell proliferationAllen D Everett; Fiscal Year: 2010..We propose here to determine the mechanism regulating the activity of this protein to provide the basis for the future design of new drugs to treat cardiovascular disease. ..