Peter Espenshade

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast
    Alfica Sehgal
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 36:2024-31. 2008
  2. ncbi request reprint SREBPs: sterol-regulated transcription factors
    Peter J Espenshade
    Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MA 21205, USA
    J Cell Sci 119:973-6. 2006
  3. ncbi request reprint Regulation of sterol synthesis in eukaryotes
    Peter J Espenshade
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Genet 41:401-27. 2007
  4. ncbi request reprint SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 120:831-42. 2005
  5. ncbi request reprint Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Metab 5:143-9. 2007
  6. pmc Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Lipid Res 49:2001-12. 2008
  7. pmc Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast
    John S Burg
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Metab 8:522-31. 2008
  8. pmc Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis
    Clara M Bien
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eukaryot Cell 9:352-9. 2010

Research Grants

  1. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2004
  2. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2005
  3. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2006
  4. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2007
  5. Regulation of Cellular Cholesterol Homeostasis
    PETER JOHN ESPENSHADE; Fiscal Year: 2010
  6. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2009
  7. OXYGEN SENSING AND ADAPTATION TO HOST TISSUE HYPOXIA IN C. NEOFORMANS
    Peter Espenshade; Fiscal Year: 2007
  8. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2009

Collaborators

  • Adam L Hughes
  • Clara M Bien
  • Alfica Sehgal
  • John S Burg
  • Andrew J Link
  • David W Powell
  • Raymond Chai
  • Emerson V Stewart
  • Bridget T Hughes
  • James Eckstein
  • Robert Barbuch
  • Martin Bard
  • Bridget L Todd

Detail Information

Publications8

  1. pmc Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast
    Alfica Sehgal
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 36:2024-31. 2008
    ..Together, these results describe a new mechanism for oxygen-dependent control of gene expression and provide an example of negative regulation of protein expression by an SREBP homolog...
  2. ncbi request reprint SREBPs: sterol-regulated transcription factors
    Peter J Espenshade
    Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MA 21205, USA
    J Cell Sci 119:973-6. 2006
  3. ncbi request reprint Regulation of sterol synthesis in eukaryotes
    Peter J Espenshade
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Genet 41:401-27. 2007
    ..A comparative analysis of SREBP and HMG-CoA reductase regulation in mammals, yeast, and flies points toward an equilibrium model for how lipid signals regulate the activity of sterol-sensing proteins and their downstream effectors...
  4. ncbi request reprint SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 120:831-42. 2005
    ..Based on these findings, we propose and test a model in which Sre1 and Scp1 monitor oxygen-dependent sterol synthesis as an indirect measure of oxygen supply and mediate a hypoxic response in fission yeast...
  5. ncbi request reprint Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Metab 5:143-9. 2007
    ..These findings demonstrate that PGRMC1 is required for P450 activity and suggest that interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism...
  6. pmc Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP
    Adam L Hughes
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Lipid Res 49:2001-12. 2008
    ..These results suggest that the sterol-sensing mechanism of Scap and the functional requirements for SREBP activation are different between fission yeast and mammals...
  7. pmc Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast
    John S Burg
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Metab 8:522-31. 2008
    ..Thus, in fission yeast, Insig regulates sterol synthesis by a different mechanism than in mammalian cells, controlling HMGR phosphorylation in response to nutrient supply...
  8. pmc Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis
    Clara M Bien
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Eukaryot Cell 9:352-9. 2010
    ..In these organisms, SREBP is required for virulence and resistance to antifungal drugs, making the SREBP pathway a potential target for antifungal therapy...

Research Grants10

  1. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2004
    ..pombe will have identifiable orthologues in mammals, thus providing new insight into our studies of cholesterol homeostasis in humans and potential therapeutic targets for prevention and treatment of heart disease. ..
  2. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2005
    ..pombe will have identifiable orthologues in mammals, thus providing new insight into our studies of cholesterol homeostasis in humans and potential therapeutic targets for prevention and treatment of heart disease. ..
  3. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2006
    ..pombe will have identifiable orthologues in mammals, thus providing new insight into our studies of cholesterol homeostasis in humans and potential therapeutic targets for prevention and treatment of heart disease. ..
  4. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2007
    ..pombe will have identifiable orthologues in mammals, thus providing new insight into our studies of cholesterol homeostasis in humans and potential therapeutic targets for prevention and treatment of heart disease. ..
  5. Regulation of Cellular Cholesterol Homeostasis
    PETER JOHN ESPENSHADE; Fiscal Year: 2010
    ....
  6. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2009
    ....
  7. OXYGEN SENSING AND ADAPTATION TO HOST TISSUE HYPOXIA IN C. NEOFORMANS
    Peter Espenshade; Fiscal Year: 2007
    ..In this project, we will identify genes required for adaptation of this pathogen to the low oxygen environment of the host and for progression of fungal infection. These genes represent candidate targets for future anti-fungal therapy. ..
  8. Regulation of Cellular Cholesterol Homeostasis
    Peter Espenshade; Fiscal Year: 2009
    ....