Thomas P Erlinger
Affiliation: Johns Hopkins University
- Relationship between systemic markers of inflammation and serum beta-carotene levelsT P Erlinger
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Arch Intern Med 161:1903-8. 2001..This pattern of findings raises the possibility that confounding by other factors might explain the association between serum beta-carotene level and disease risk...
- C-reactive protein and the risk of incident colorectal cancerThomas P Erlinger
Department of Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
JAMA 291:585-90. 2004..Inflammation may play a role in the pathogenesis of colorectal cancer; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse...
- The potential impact of nonpharmacologic population-wide blood pressure reduction on coronary heart disease events: pronounced benefits in African-Americans and hypertensivesThomas P Erlinger
Welch Center for Prevention, Epidemiology and Clinical Research, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Prev Med 37:327-33. 2003..However, several nonpharmacologic interventions reduce BP to a greater degree in hypertensives and African-Americans...
- Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adultsThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Kidney Dis 42:256-63. 2003..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
- Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trialThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 108:150-4. 2003..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet...
- The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysisT P Erlinger
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Hum Hypertens 16:391-7. 2002..In contrast, the DASH diet had no significant effect on markers of fibrinolysis in whites or African-Americans...
- Postchallenge hyperglycemia in a national sample of U.S. adults with type 2 diabetesT P Erlinger
Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA
Diabetes Care 24:1734-8. 2001..Postchallenge hyperglycemia (PCH) is known to contribute to suboptimal glycemic control in adults with non-insulin-requiring type 2 diabetes. The objective of this study was to estimate the prevalence of PCH among individuals with diabetes...
- WBC count and the risk of cancer mortality in a national sample of U.S. adults: results from the Second National Health and Nutrition Examination Survey mortality studyThomas P Erlinger
Department of Medicine, Johns Hopkins Medical University School of Medicine, Baltimore, MD 21201, USA
Cancer Epidemiol Biomarkers Prev 13:1052-6. 2004..Additional studies are needed to determine whether circulating levels of inflammatory markers are associated with increased risk of incident cancer...
- The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trialsEdgar R Miller
National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
Curr Atheroscler Rep 8:460-5. 2006..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
- A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding studyEdgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
Atherosclerosis 183:175-82. 2005..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...
- C-reactive protein and colorectal adenoma in the CLUE II cohortKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Cancer Causes Control 19:559-67. 2008..Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study...
- Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21201, USA
Am J Kidney Dis 53:596-605. 2009..Inflammation and hemostasis may increase the risk of kidney function decline; however, data from prospective studies are sparse...
- Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000Elizabeth Selvin
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Circulation 110:738-43. 2004..PAD prevalence increases dramatically with age and disproportionately affects blacks. The vast majority of individuals with PAD have 1 or more cardiovascular disease risk factors that should be targeted for therapy...
- C-reactive protein and colorectal cancer risk: a systematic review of prospective studiesKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 123:1133-40. 2008..More work is needed to understand the extent to which circulating high-sensitivity C-reactive protein or other blood inflammatory markers are related to colonic inflammation...
- Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trialLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
JAMA 294:2455-64. 2005..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
- C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort studyKathy J Helzlsouer
Prevention and Research Center, Mercy Medical Center, 6th Floor, 227 St Paul Place, Baltimore, MD 21202, USA
Eur J Cancer 42:704-7. 2006..However, the potential benefits of anti-inflammatory chemopreventive agents must be weighed against their adverse effects before widespread use is recommended...
- No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Prostate 59:393-400. 2004..We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer...
- Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
Hypertension 40:612-8. 2002..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control...
- The effect of weight loss on C-reactive protein: a systematic reviewElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
Arch Intern Med 167:31-9. 2007..Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level...
- Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trialLaura P Svetkey
Division of Nephrology, Department of Medicine, Duke Hypertension Center and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
JAMA 299:1139-48. 2008..Behavioral weight loss interventions achieve short-term success, but re-gain is common...
- Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994Keiko Asao
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA
Diabetes Care 29:1632-7. 2006..CONCLUSIONS: Our study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population...
- Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination SurveyDaniel E Ford
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Intern Med 164:1010-4. 2004..Our objective was to determine the association between major depression and elevated C-reactive protein (CRP) level in a nationally representative cohort...
- Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularizationEdgar R Miller
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
Coron Artery Dis 14:163-9. 2003..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established...
- Blood pressure change and risk of hypertension associated with parental hypertension: the Johns Hopkins Precursors StudyNae Yuh Wang
Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Arch Intern Med 168:643-8. 2008..Parental hypertension is used to classify hypertension risk in young adults, but the long-term association of parental hypertension with blood pressure (BP) change and risk of hypertension over the adult life span has not been well studied...
- Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndromeLillian F Lien
Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA
Hypertension 50:609-16. 2007..Our data suggest that strategies for lowering BP in individuals with metabolic syndrome may be enhanced by recommendations to adopt the DASH dietary pattern...
- Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities studyPhilip B Mellen
Section of General Medicine, Department of Internal Medicine, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 27157, USA
Hypertension 48:1037-42. 2006..More research is warranted concerning the physiological and clinical consequences of hyperuricemia, especially in blacks...
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trialPatricia J Elmer
Kaiser Permanente Northwest, Portland, Oregon 97227, USA
Ann Intern Med 144:485-95. 2006..CONCLUSIONS: Over 18 months, persons with prehypertension and stage 1 hypertension can sustain multiple lifestyle modifications that improve control of blood pressure and could reduce the risk for chronic disease...
- The DASH diet enhances the blood pressure response to losartan in hypertensive patientsPaul R Conlin
Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 16:337-42. 2003..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
- Smoking cessation and cardiovascular disease risk factors: results from the Third National Health and Nutrition Examination SurveyArvind Bakhru
University of Rochester Medical Center, School of Medicine, Rochester, New York, USA
PLoS Med 2:e160. 2005..It also remains unclear as to whether traditional risk factors can adequately explain the observed decline in cardiovascular risk following smoking cessation...