Thomas P Erlinger
Affiliation: Johns Hopkins University
- Relationship between systemic markers of inflammation and serum beta-carotene levelsT P Erlinger
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Arch Intern Med 161:1903-8. 2001..This pattern of findings raises the possibility that confounding by other factors might explain the association between serum beta-carotene level and disease risk...
- C-reactive protein and the risk of incident colorectal cancerThomas P Erlinger
Department of Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
JAMA 291:585-90. 2004..Inflammation may play a role in the pathogenesis of colorectal cancer; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse...
- The potential impact of nonpharmacologic population-wide blood pressure reduction on coronary heart disease events: pronounced benefits in African-Americans and hypertensivesThomas P Erlinger
Welch Center for Prevention, Epidemiology and Clinical Research, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Prev Med 37:327-33. 2003..However, several nonpharmacologic interventions reduce BP to a greater degree in hypertensives and African-Americans...
- Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adultsThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Kidney Dis 42:256-63. 2003..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
- Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trialThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 108:150-4. 2003..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet...
- The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysisT P Erlinger
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Hum Hypertens 16:391-7. 2002..In contrast, the DASH diet had no significant effect on markers of fibrinolysis in whites or African-Americans...
- Postchallenge hyperglycemia in a national sample of U.S. adults with type 2 diabetesT P Erlinger
Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University School of Hygiene and Public Health, Baltimore, USA
Diabetes Care 24:1734-8. 2001..Postchallenge hyperglycemia (PCH) is known to contribute to suboptimal glycemic control in adults with non-insulin-requiring type 2 diabetes. The objective of this study was to estimate the prevalence of PCH among individuals with diabetes...
- WBC count and the risk of cancer mortality in a national sample of U.S. adults: results from the Second National Health and Nutrition Examination Survey mortality studyThomas P Erlinger
Department of Medicine, Johns Hopkins Medical University School of Medicine, Baltimore, MD 21201, USA
Cancer Epidemiol Biomarkers Prev 13:1052-6. 2004..Additional studies are needed to determine whether circulating levels of inflammatory markers are associated with increased risk of incident cancer...
- The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trialsEdgar R Miller
National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
Curr Atheroscler Rep 8:460-5. 2006..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
- A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding studyEdgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
Atherosclerosis 183:175-82. 2005..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...
- C-reactive protein and colorectal adenoma in the CLUE II cohortKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Cancer Causes Control 19:559-67. 2008..Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study...
- Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21201, USA
Am J Kidney Dis 53:596-605. 2009..Inflammation and hemostasis may increase the risk of kidney function decline; however, data from prospective studies are sparse...
- Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000Elizabeth Selvin
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Circulation 110:738-43. 2004..Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely...
- C-reactive protein and colorectal cancer risk: a systematic review of prospective studiesKonstantinos K Tsilidis
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Int J Cancer 123:1133-40. 2008..More work is needed to understand the extent to which circulating high-sensitivity C-reactive protein or other blood inflammatory markers are related to colonic inflammation...
- Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trialLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
JAMA 294:2455-64. 2005..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
- C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort studyKathy J Helzlsouer
Prevention and Research Center, Mercy Medical Center, 6th Floor, 227 St Paul Place, Baltimore, MD 21202, USA
Eur J Cancer 42:704-7. 2006..However, the potential benefits of anti-inflammatory chemopreventive agents must be weighed against their adverse effects before widespread use is recommended...
- No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancerElizabeth A Platz
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Prostate 59:393-400. 2004..We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer...
- Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
Hypertension 40:612-8. 2002..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control...
- The effect of weight loss on C-reactive protein: a systematic reviewElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21287, USA
Arch Intern Med 167:31-9. 2007..Our objective was to test the hypothesis that weight loss is directly related to a decline in CRP level...
- Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trialLaura P Svetkey
Division of Nephrology, Department of Medicine, Duke Hypertension Center and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
JAMA 299:1139-48. 2008..Behavioral weight loss interventions achieve short-term success, but re-gain is common...
- Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994Keiko Asao
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA
Diabetes Care 29:1632-7. 2006..To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance...
- Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination SurveyDaniel E Ford
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Intern Med 164:1010-4. 2004..Our objective was to determine the association between major depression and elevated C-reactive protein (CRP) level in a nationally representative cohort...
- Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularizationEdgar R Miller
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
Coron Artery Dis 14:163-9. 2003..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established...
- Blood pressure change and risk of hypertension associated with parental hypertension: the Johns Hopkins Precursors StudyNae Yuh Wang
Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Arch Intern Med 168:643-8. 2008..Parental hypertension is used to classify hypertension risk in young adults, but the long-term association of parental hypertension with blood pressure (BP) change and risk of hypertension over the adult life span has not been well studied...
- Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndromeLillian F Lien
Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA
Hypertension 50:609-16. 2007..Our data suggest that strategies for lowering BP in individuals with metabolic syndrome may be enhanced by recommendations to adopt the DASH dietary pattern...
- Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities studyPhilip B Mellen
Section of General Medicine, Department of Internal Medicine, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 27157, USA
Hypertension 48:1037-42. 2006..More research is warranted concerning the physiological and clinical consequences of hyperuricemia, especially in blacks...
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trialPatricia J Elmer
Kaiser Permanente Northwest, Portland, Oregon 97227, USA
Ann Intern Med 144:485-95. 2006..The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure...
- The DASH diet enhances the blood pressure response to losartan in hypertensive patientsPaul R Conlin
Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 16:337-42. 2003..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
- Smoking cessation and cardiovascular disease risk factors: results from the Third National Health and Nutrition Examination SurveyArvind Bakhru
University of Rochester Medical Center, School of Medicine, Rochester, New York, USA
PLoS Med 2:e160. 2005..It also remains unclear as to whether traditional risk factors can adequately explain the observed decline in cardiovascular risk following smoking cessation...