Christopher J Endres
Affiliation: Johns Hopkins University
- Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humansChristopher J Endres
Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Nucl Med 53:330-5. 2012..Whole-body PET/CT was used to characterize the radiation dosimetry of (11)C-DPA-713, a specific PET ligand for the assessment of translocator protein...
- Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humansChristopher J Endres
Division of Neuroradiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
J Nucl Med 50:1276-82. 2009..Here, we report the first examination of (11)C-DPA-713 in human subjects using PET...
- Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIVChristopher J Endres
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Phys Med Biol 56:2499-513. 2011..This work shows that parameter coupling reduces the variance of parameter estimates and may better discriminate between-group differences in specific binding...
- Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomographyYongjun Gao
Department of Radiology, Division of Nuclear Medicine, PET Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 0816, USA
Bioorg Med Chem 17:4367-77. 2009..Three of these novel nAChR ligands were radiolabeled with the positron-emitting isotope (11)C and evaluated in animal studies as potential PET radiotracers for imaging of cerebral nAChRs with improved brain kinetics...
- Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine cravingDavid A Gorelick
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
Biol Psychiatry 57:1573-82. 2005..Human data regarding this phenomenon are limited. We previously used positron emission tomography (PET) with [11C]-carfentanil to show increased mOR binding in brain regions of 10 cocaine-dependent men after 1 and 28 days of abstinence...
- An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challengeYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
Neuroimage 33:550-63. 2006..Violations of this assumption may result in unreliable estimation of the amphetamine-induced percent change in the binding potential (DeltaBP%)...
- Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptorsYongjun Gao
Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
J Med Chem 50:3814-24. 2007..2.1]heptane, exhibited good properties as a first practical PET radioligand for imaging of extrathalamic nAChR in baboon brain and holds promise for further investigation for human studies...
- Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIVDima A Hammoud
Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, USA
Neuroimage 49:2588-95. 2010..The goal of this study was to evaluate the involvement of serotonergic transmission in HIV-associated depression using [(11)C]DASB, a serotonin transporter (5-HTT)-specific radiopharmaceutical for positron emission tomography (PET)...
- Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)Andrew G Horti
Division of Nuclear Medicine, Department of Radiology, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287 0816, USA
Bioorg Med Chem 18:5202-7. 2010..These data establish a proof of principle that CB2 receptors binding in the neuroinflammation and related disorders can be measured in vivo...
- Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokersJames Robert Brasic
Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Synapse 63:339-58. 2009..We conclude that 5-[(123)I]IA is a safe, well-tolerated, and effective pharmacologic agent for human subjects to estimate high-affinity alpha4/beta2 nAChRs in the living human brain...
- Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDSDima A Hammoud
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-2182, USA
J Neurovirol 11:346-55. 2005..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
- Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatientsUdi E Ghitza
Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Biol Psychiatry 68:697-703. 2010..In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown...
- Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue modelYun Zhou
Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neuroimage 18:975-89. 2003..We conclude that the new linear equations yield a reliable, computationally efficient, and robust LRSC algorithm to generate parametric images of ligand-receptor dynamic PET studies...
- Biodistribution, tumor detection, and radiation dosimetry of 18F-DCFBC, a low-molecular-weight inhibitor of prostate-specific membrane antigen, in patients with metastatic prostate cancerSteve Y Cho
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland 21287 0014, USA
J Nucl Med 53:1883-91. 2012..Here, we describe the initial clinical experience and radiation dosimetry of (18)F-DCFBC in men with metastatic PCa...
- Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methodsChristopher J Endres
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
Nucl Med Biol 30:177-86. 2003..It was determined that both a graphical method, and a simplified reference tissue model, were more accurate than the tissue-ratio method for quantification of CFN binding...
- Decreased microglial activation in MS patients treated with glatiramer acetateJohn N Ratchford
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe St, Pathology 627, Baltimore, MD 21287 6985, USA
J Neurol 259:1199-205. 2012..Future research will focus on whether the level of baseline microglial activation predicts future tissue damage in MS and whether [(11)C]-R-PK11195 uptake in cortical gray matter correlates with cortical lesion load...
- Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubisMohab Alexander
Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Synapse 56:94-9. 2005..Viewed collectively, the present data indicate that typical clinical doses of phentermine and (+/-)-ephedrine may not release central DA in humans, a hypothesis that should ultimately be tested in controlled clinical studies...