Research Topics
| P A EgglestonSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Home environmental intervention in inner-city asthma: a randomized controlled clinical trialPeyton A Eggleston
Department of Pediatrics Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann Allergy Asthma Immunol 95:518-24. 2005..Airborne pollutants and indoor allergens increase asthma morbidity in inner-city children; therefore, reducing exposure, if feasible, should improve asthma morbidity...- Control of environmental allergens as a therapeutic approachPeyton A Eggleston
Department of Pediatrics, Johns Hopkins University, Johns Hopkins Hospital, 600 North Wolfe Street, CMSC 1102, Baltimore, MD 21287, USA
Immunol Allergy Clin North Am 23:533-47, viii-ix. 2003..Clinically, practitioners have to address reduction of exposure to more than one allergen, and it is likely that the complexity of dealing with several treatment regimes decreases compliance... - Environmental control for fungal allergen exposurePeyton A Eggleston
Department of Pediatrics, Johns Hopkins University School of Medicine CMSC 1102, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Curr Allergy Asthma Rep 3:424-9. 2003..Few abatement trials have been published, but several suggest that such measures can reduce mold exposure... - The environment and asthma in US inner citiesPeyton A Eggleston
Department of Pediatrics, School of Medicine, The Johns Hopkins University, CMCSC 1102, Baltimore, MD 21287 3923, USA
Chest 132:782S-788S. 2007.... 
Complex interactions of pollutant and allergen exposures and their impact on people with asthmaPeyton A Eggleston
Johns Hopkins Hospital, CMSC 1105, Department of Pediatrics, Division of Allergy and Immunology, 600 North Wolfe St, Baltimore, MD 21287, USA
Pediatrics 123:S160-7. 2009..We know that environmental exposures such as allergens, irritants, and pollutants are quite complex in their composition; further examination of this complexity may improve our understanding of this complex and highly prevalent disease...- Methods and effectiveness of indoor environmental controlP A Eggleston
Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Ann Allergy Asthma Immunol 87:44-7. 2001..The purpose of this review is to describe recommended methods of decreasing exposure to indoor allergens... - Improving indoor environments: reducing allergen exposuresPeyton A Eggleston
Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA
J Allergy Clin Immunol 116:122-6. 2005..Once allergen levels have been reduced, continued efforts are necessary to maintain the home free of allergen sources... - Mouse allergen-specific immunoglobulin G4 and risk of mouse skin test sensitivityE C Matsui
Johns Hopkins University, Baltimore, MD, USA
Clin Exp Allergy 36:1097-103. 2006..High serum levels of cat-specific IgG and IgG4 are associated with protection against allergic sensitization to cat, but whether this association applies to other animal allergens remains unclear... - Asthma-related health status determinants of environmental control practices for inner-city preschool childrenNadia N Hansel
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Ann Allergy Asthma Immunol 97:409-17. 2006..Rhinitis was consistently linked to ECPs, which suggests that caregivers may make changes in the home environment for upper airway but not lower airway symptoms... - Room-specific characteristics of suburban homes as predictors of indoor allergen concentrationsTamara T Perry
Department of Pediatrics, Division of Allergy and Immunology, University of Arkansas for Medical Sciences College of Medicine, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
Ann Allergy Asthma Immunol 97:628-35. 2006..Room characteristics predicting indoor allergen exposure in suburban homes have not been clearly identified... - House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management ProgramK Huss
Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
J Allergy Clin Immunol 107:48-54. 2001..For all allergens studied, the degree of atopy, determined by the total number of positive skin test responses or by total serum IgE levels, is an important contributing risk factor for sensitization... - Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city BaltimorePatrick N Breysse
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street Room W6010A, Baltimore, MD 21205, USA
Environ Res 98:167-76. 2005..Understanding this combined insult may help to explain the differential asthma burden between inner-city and non-inner-city children... - Occupational challenge studies with laboratory workers allergic to ratsP A Eggleston
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD
J Allergy Clin Immunol 86:63-72. 1990..This occupational challenge procedure thus was able to measure the nasal and lower respiratory tract response to airborne allergen exposure in a work environment. It can be used to define further the determinants of this response... - Parent report of pests and pets and indoor allergen levels in inner-city homesJean Curtin-Brosnan
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Ann Allergy Asthma Immunol 101:517-23. 2008..Parent report of indoor allergen exposure is a potentially convenient and inexpensive surrogate measure of exposure, although validity of parent report to estimate indoor allergen levels is not well established... 
The environment and asthma in U.S. inner citiesP A Eggleston
School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21287 3923, USA
Environ Health Perspect 107:439-50. 1999..However, to examine the relationship of morbidity in genetically predisposed individuals, it will be important to determine the most relevant method of making this assessment...- Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school childrenMeredith C McCormack
Department of Medicine, Johns Hopkins University, Pulmonary and Critical Care Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21231, USA
Environ Res 106:148-55. 2008..Further investigation of the health effects of indoor PM exposure is warranted, as are studies to evaluate the efficacy of PM reduction strategies on asthma health of inner-city children... - Indoor environmental differences between inner city and suburban homes of children with asthmaElinor Simons
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Urban Health 84:577-90. 2007..002). Compared with the homes of suburban children with asthma, the homes of inner city Baltimore children with asthma had higher levels of airborne pollutants and home characteristics that predispose to greater asthma morbidity... - Cockroach allergen exposure and sensitization in suburban middle-class children with asthmaElizabeth C Matsui
Department of Pediatrics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA
J Allergy Clin Immunol 112:87-92. 2003..Moreover, the data suggest that low-level cockroach exposure is a risk factor for cockroach sensitization... - Long-term immunologic effects of broad-spectrum aeroallergen immunotherapySusan L Limb
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md. 21224, USA
Int Arch Allergy Immunol 140:245-51. 2006..Broad-spectrum immunotherapy does not appear to affect the acquisition of new inhalant sensitivities... - Biological potency of German cockroach allergen extracts determined in an inner city populationJ E Slater
Center for Biologics Evaluation and Research, U S Food and Drug Administration, Bethesda, MD, USA
Clin Exp Allergy 37:1033-9. 2007..To perform valid studies on the diagnosis and treatment of cockroach allergy, biological potencies of test extracts need to be established, and a surrogate in vitro test for biological potency should be chosen... - Airway hyperreactivity in cystic fibrosis. Clinical correlates and possible effects on the course of the diseaseP A Eggleston
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore
Chest 94:360-5. 1988.... - Cockroach allergen abatement with extermination and sodium hypochlorite cleaning in inner-city homesR A Wood
Department of Pediatrics, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Ann Allergy Asthma Immunol 87:60-4. 2001..Although the importance of cockroach allergen in chronic asthma has now been well defined, little progress has been made in the control of cockroach allergen in infested homes... - Does current asthma control predict future health care use among black preschool-aged inner-city children?Hemant P Sharma
Division of Pediatric Allergy and Immunology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pediatrics 120:e1174-81. 2007..We investigated whether current asthma control predicts future asthma-related health care use among inner-city preschool-aged children with asthma... - Household mouse allergen exposure and asthma morbidity in inner-city preschool childrenElizabeth C Matsui
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA
Ann Allergy Asthma Immunol 97:514-20. 2006..Inner-city children experience disproportionate asthma morbidity, and suspected reasons include indoor environmental exposures... - Mouse allergen-specific antibody responses in inner-city children with asthmaElizabeth C Matsui
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Allergy Clin Immunol 119:910-5. 2007..Although mouse allergen exposure is common in inner-city homes, little is known about the relationships between exposure and humoral immune responses to mouse allergen in this population... - Airborne mouse allergen in the homes of inner-city children with asthmaElizabeth C Matsui
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Allergy Clin Immunol 115:358-63. 2005..Airborne mouse allergen has not previously been measured in inner-city homes, and its relationship to settled dust mouse allergen levels is unknown... - Caregiver-physician medication concordance and undertreatment of asthma among inner-city childrenKristin A Riekert
Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD 21224, USA
Pediatrics 111:e214-20. 2003..To assess the extent to which caregivers and their child's physician agree about the prescribed asthma medication regimen and evaluate factors associated with medication concordance... - Adult asthma severity in individuals with a history of childhood asthmaSusan L Limb
Division of Allergy and Clinical Immunology, Bloomberg School of Public Health, Johns Hopkinds University, Baltimore, MD, USA
J Allergy Clin Immunol 115:61-6. 2005..Childhood asthma can have a range of outcomes in adulthood... - Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse specific IgG and IgG4 levelsElizabeth C Matsui
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Allergy Asthma Immunol 93:171-8. 2004..Although there is evidence that contact with mice is associated with IgE-mediated mouse sensitization and mouse specific antibody responses, the exposure-response relationships remain unclear... - Home indoor pollutant exposures among inner-city children with and without asthmaGregory B Diette
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Environ Health Perspect 115:1665-9. 2007..To look for systematic differences in early life domestic exposures between inner-city preschool children with and without asthma, we performed a study of home indoor air pollutants and allergens... - Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthmaElizabeth C Matsui
Department of Pediatrics, Johns Hopkins University, Johns Hopkins Hospital, CMSC 1102, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Allergy Clin Immunol 113:910-5. 2004..Exposure to mouse allergen is prevalent in inner-city homes and is associated with an increased risk of mouse skin test sensitivity in inner-city children with asthma... - Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthmaWanda Phipatanakul
Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Allergy Asthma Immunol 92:420-5. 2004..Recent studies have suggested that mouse allergen exposure and sensitization are common in urban children with asthma. The effectiveness of environmental intervention in reducing mouse allergen exposure has not been established... - Knowledge and practice of dust mite control by specialty careKaren A Callahan
Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
Ann Allergy Asthma Immunol 90:302-7. 2003..Dust mites are the primary indoor allergen risk for increasing asthma attacks and morbidity. Adherence to allergen avoidance recommendations decreases bronchial reactivity and asthma morbidity... - Mouse allergen-specific immunoglobulin G and immunoglobulin G4 and allergic symptoms in immunoglobulin E-sensitized laboratory animal workersE C Matsui
Johns Hopkins University, Baltimore, MD 21287, USA
Clin Exp Allergy 35:1347-53. 2005..High levels of allergen-specific IgG have been associated with clinical efficacy in immunotherapy studies, but whether this antibody isotype is associated with clinical tolerance in the setting of environmental exposure remains unclear... - Ecology and elimination of cockroaches and allergens in the homeP A Eggleston
Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Allergy Clin Immunol 107:S422-9. 2001..This article covers the characteristics of the major cockroach species that invade homes, assesses the role of environmental exposure to cockroaches in asthma, and provides an intervention program for their extermination... - Methods and issues in conducting a community-based environmental randomized trialLee J Swartz
Department of Pediatrics, School of Medicine, Johns Hopkins University, CMSC 1102 600 N Wolfe Street, Baltimore, MD 21287-3923, USA
Environ Res 95:156-65. 2004..Asthma morbidity and adherence was assessed quarterly. Collaboration with the community proved very beneficial in creating a study design and procedures acceptable to an inner-city community... - Allergenic proteins are fragmented in low concentrations of sodium hypochloriteP Chen
Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA
Clin Exp Allergy 31:1086-93. 2001..CONCLUSIONS: We concluded that NaOCl at concentrations commonly used in household products is capable of dramatically affecting allergenic protein... - Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cellsP A Eggleston
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Am Rev Respir Dis 141:960-4. 1990..Although the mechanism of this selective cellular response is not clear, these in vitro observations have important therapeutic and pathophysiologic implications for the airway response to hyperosmolar stimuli... - Impact of the 2002 Canadian forest fires on particulate matter air quality in Baltimore cityAmir Sapkota
Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Sci Technol 39:24-32. 2005..This research highlights the significance of transboundary air pollution and the need for studies that assess the public health impacts associated with such sources and transport processes... - The impact of a building implosion on airborne particulate matter in an urban communityChristopher M Beck
Center for Urban Environmental Health, John Hopkins Medical Institutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Air Waste Manag Assoc 53:1256-64. 2003..These results demonstrate that a building implosion can have a severe but short-lived impact on community air quality. Effective protection is offered by being indoors or upwind... - Irreversible lung function deficits in young adults with a history of childhood asthmaSusan L Limb
Division of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 116:1213-9. 2005..Childhood spirometry, duration of asthma, methacholine sensitivity, and birth prematurity might identify such individuals at a young age... - Allergic potency of recombinant Fel d 1 is reduced by low concentrations of chlorine bleachElizabeth Matsui
Departments of Pediatrics and Medicine, Johns Hopkins School of Medicine, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287, USA
J Allergy Clin Immunol 111:396-401. 2003..CONCLUSIONS: NaOCl modifies rFel d 1, resulting in loss of immunogenicity and attenuation of biologic activity, as measured by its ability to stimulate basophil histamine release... - The efficacy of montelukast in the treatment of cat allergen-induced asthma in childrenWanda Phipatanakul
Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital, Harvard Medical School, Boston, Mass 02115, USA
J Allergy Clin Immunol 109:794-9. 2002.... - Lessons Learned for the Study of Childhood Asthma from the Centers for Children's Environmental Health and Disease Prevention ResearchPeyton A Eggleston
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Environ Health Perspect 113:1430-6. 2005..Medications confounded the definition of asthma disease activity, and must be repeatedly and systematically estimated. Despite these many challenges, the Children's Centers successfully conducted long-term studies of asthma... - Reducing exposure to laboratory animal allergensIsabelle B Schweitzer
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Comp Med 53:487-92. 2003..9% reported symptoms in rooms with the highest concentration (2.3 +/- 0.4 ng/m3). These data indicate that existing technology can significantly reduce exposure to laboratory animal allergens and improve the health of animal caretakers... - Cockroach allergen abatement in inner-city homesPeyton A Eggleston
Ann Allergy Asthma Immunol 91:512-4. 2003 - Chlorinated pools and the risk of asthmaPeyton A Eggleston
Environ Health Perspect 115:A240; author reply A240-1. 2007 - Cockroach allergen abatement: the good, the bad, and the uglyPeyton A Eggleston
J Allergy Clin Immunol 112:265-7. 2003 - Does neighborhood violence lead to depression among caregivers of children with asthma?Emily S Tonorezos
Department of Medicine, New York University, 462 First Aveunue, New York, NY 10016, United States
Soc Sci Med 67:31-7. 2008..Based on our findings, personal experience with neighborhood violence may be more important than simple awareness. Health care workers should consider screening for depression among patients exposed to community violence... - Mouse allergen levels vary over time in inner-city homesElizabeth C Matsui
J Allergy Clin Immunol 120:956-9. 2007 - Environmental detection of mouse allergen by means of immunoassay for recombinant Mus m 1Elena Ferrari
Department of Experimental Medicine Section of Chemistry and Structural Biochemistry University of Parma, Italy
J Allergy Clin Immunol 114:341-6. 2004..99; P <.001). CONCLUSIONS: A highly sensitive ELISA has been developed with rMus m 1. This assay is suitable for monitoring domestic and environmental exposure to mouse urinary allergens... - Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trialStanley J Szefler
National Jewish Health, Denver, CO, USA
Lancet 372:1065-72. 2008....
Research Grants
- INNER CITY COCKROACH ALLERGEN REDUCTION TRIALPeyton Eggleston; Fiscal Year: 1999..Secondary variables, including symptom scores, PEFR, acute care visits, school loss, cockroach numbers and methacholine responsiveness will also be compared. ..
- INNER CITY COCKROACH ALLERGEN REDUCTION TRIALPeyton Eggleston; Fiscal Year: 2002..Secondary variables, including medication use, acute care visits, school loss, FEVI and methacholine responsiveness will also be compared. ..
- HOME BASED ENVIRONMENTAL ADHERENCE TRIALPeyton Eggleston; Fiscal Year: 2002....