Christopher Earley

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Is ferroportin-hepcidin signaling altered in restless legs syndrome?
    Stacey L Clardy
    Department of Neurosurgery, M S Hershey Medical Center, 500 University Drive, H110, Hershey, PA 17033, USA
    J Neurol Sci 247:173-9. 2006
  2. pmc Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease
    Stephanie M Patton
    Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA
    Fluids Barriers CNS 10:20. 2013
  3. pmc Increased synaptic dopamine in the putamen in restless legs syndrome
    Christopher J Earley
    Departments of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep 36:51-7. 2013
  4. ncbi request reprint Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 28:1069-75. 2005
  5. ncbi request reprint MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:458-61. 2006
  6. ncbi request reprint Response to Clinical Corners case (Sleep Medicine 6/2: 83-4): Pregnancy associated with daytime sleepiness and nighttime restlessness
    Christopher J Earley
    Neurology Department, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, AAC, 1B 82, Baltimore, MD 21224, USA
    Sleep Med 6:475. 2005
  7. ncbi request reprint Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Sleep Med 6:301-5. 2005
  8. pmc A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, AAC 1B 82, Baltimore, MD 21224, USA
    Sleep Med 10:206-11. 2009
  9. ncbi request reprint Circadian changes in CSF dopaminergic measures in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:263-8. 2006
  10. pmc The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 10:1155-7. 2009

Research Grants

  1. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
  2. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2004
  3. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2003
  4. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001

Detail Information

Publications48

  1. ncbi request reprint Is ferroportin-hepcidin signaling altered in restless legs syndrome?
    Stacey L Clardy
    Department of Neurosurgery, M S Hershey Medical Center, 500 University Drive, H110, Hershey, PA 17033, USA
    J Neurol Sci 247:173-9. 2006
    ..Nonetheless, these data support the mounting evidence that there is a biological basis for RLS and the underlying mechanism involves iron management...
  2. pmc Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease
    Stephanie M Patton
    Department of Neurosurgery, Penn State University, Milton S, Hershey Medical Center, 500 University Drive, Hershey, Pennsylvania PA 17033, USA
    Fluids Barriers CNS 10:20. 2013
    ..The purpose of this study was to determine if biomarkers in the cerebrospinal fluid can distinguish RLS/WED patients from neurological controls...
  3. pmc Increased synaptic dopamine in the putamen in restless legs syndrome
    Christopher J Earley
    Departments of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep 36:51-7. 2013
    ..Thus, differences in D2R-BP reflect changes in these primary factors. PET techniques are currently available to estimate D2R β(max) and K(d)...
  4. ncbi request reprint Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 28:1069-75. 2005
    ....
  5. ncbi request reprint MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:458-61. 2006
    ..In this study our primary hypothesis was that substantia nigra (SN) iron index would be decreased in early-onset RLS compared to controls...
  6. ncbi request reprint Response to Clinical Corners case (Sleep Medicine 6/2: 83-4): Pregnancy associated with daytime sleepiness and nighttime restlessness
    Christopher J Earley
    Neurology Department, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, AAC, 1B 82, Baltimore, MD 21224, USA
    Sleep Med 6:475. 2005
  7. ncbi request reprint Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Sleep Med 6:301-5. 2005
    ..To evaluate in RLS patients the efficacy and safety of repeated infusions of iron in order to maintain symptomatic improvements achieved with a prior single 1000 mg infusion of iron...
  8. pmc A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, AAC 1B 82, Baltimore, MD 21224, USA
    Sleep Med 10:206-11. 2009
    ..The aim of this study was to ascertain whether high-dose intravenous (IV) iron sucrose could improve symptoms and change brain iron concentrations in idiopathic RLS...
  9. ncbi request reprint Circadian changes in CSF dopaminergic measures in restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 7:263-8. 2006
    ..The dopaminergic (DAergic) system, which plays a role in RLS, entails circadian changes that parallel RLS symptom changes. The aim of this study was to look for relative and diurnal differences in DAergic activity...
  10. pmc The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 10:1155-7. 2009
    ..Changes at the cellular level in dopaminergic metabolism or at the distal synapse with changes in receptors or transporters were not evaluated in this study...
  11. ncbi request reprint The treatment of restless legs syndrome with intravenous iron dextran
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Sleep Med 5:231-5. 2004
    ..To evaluate the safety and efficacy of a single 1000 mg iron infusion in treating Restless Legs Syndrome (RLS)...
  12. pmc Altered iron metabolism in lymphocytes from subjects with restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Sleep 31:847-52. 2008
    ..Thus the study aim was to determine whether patients with RLS and control subjects show differences in lymphocyte iron regulator proteins...
  13. pmc The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome
    Christopher J Earley
    Department of Neurology, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
    Sleep 34:341-7. 2011
    ..The current studies assessed real-time DAT binding potentials (BP) in striatum of RLS patients using (11)C-methylphenidate and PET techniques...
  14. ncbi request reprint Cognitive deficits associated with restless legs syndrome (RLS)
    Virginia E Pearson
    Dept of Psychology and Brain Sciences, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 7:25-30. 2006
    ..e. involving mostly pre-frontal cortical (PFC) functioning...
  15. ncbi request reprint Restless legs syndrome: a clinical update
    Charlene E Gamaldo
    Department of Neurology, Neurology and Sleep Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Chest 130:1596-604. 2006
    ..However, due to their potential long-term side effects, these agents should not be considered the sole treatment of choice. In the end, the therapeutic plan should be individualized to suit each patient's presentation and needs...
  16. ncbi request reprint Race and restless legs syndrome symptoms in an adult community sample in east Baltimore
    Hochang B Lee
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Sleep Med 7:642-5. 2006
    ..We compared the prevalence of RLS in African-Americans and Caucasians in a biracial community sample as part of Wave IV of the Baltimore Health and Mental Health Study...
  17. ncbi request reprint Childhood and adult factors associated with restless legs syndrome (RLS) diagnosis
    Charlene E Gamaldo
    Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, 21224 Baltimore, MD, USA
    Sleep Med 8:716-22. 2007
    ..RLS appears to be caused by a complex interaction of genetic and environmental factors. This study sought to identify some environmental risk factors significantly associated with the occurrence of RLS...
  18. pmc Evaluating daytime alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controls
    Charlene Gamaldo
    Department of Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Building 1B 75A, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 10:134-8. 2009
    ..In this study we used more objective measures of alertness and compared RLS subjects who are off treatments and chronically sleep restricted to chronic sleep-restricted controls...
  19. pmc Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis
    Richard P Allen
    Johns Hopkins University, School of Medicine, Department of Neurology, Asthma and Allergy Building, 1B76B 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 10:123-8. 2009
    ..It would then also reflect both the more severe iron insufficiency pathology of RLS and greater clinical severity, shown by the objective measure of PLMS/hr...
  20. doi request reprint Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community
    Hochang B Lee
    Division of Geriatric Psychiatry and Neuropsychiartry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neuropsychiatry Clin Neurosci 20:101-5. 2008
    ..9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder...
  21. ncbi request reprint Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movements
    Paul V Birinyi
    Department of Neuroscience, Baltimore, The Johns Hopkins University School of Art and Sciences, MD, USA
    Sleep Med 7:480-5. 2006
    ..To evaluate periodic limb movements during sleep (PLMS) in first-degree relatives of both restless legs syndrome (RLS) patients and matched controls without RLS in order to analyze patterns of this motor sign of RLS...
  22. pmc Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury
    Ann C Halbower
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e301. 2006
    ..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...
  23. ncbi request reprint Clinical practice. Restless legs syndrome
    Christopher J Earley
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA
    N Engl J Med 348:2103-9. 2003
  24. pmc A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS)
    Charlene E Gamaldo
    Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, Baltimore, MD 21224, United States
    Sleep Med 9:500-5. 2008
    ..In this study, we compared the cognitive function of RLS patients who were off treatment to sleep-restricted control subjects...
  25. doi request reprint Restless legs syndrome symptomatology, attitudes and beliefs among treated and untreated individuals
    Christine M Ramsey
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Sleep Med 13:1226-31. 2012
    ....
  26. ncbi request reprint Validation of the Hopkins telephone diagnostic interview for restless legs syndrome
    Wayne A Hening
    RLS Center, Asthma and Allergy, SBTBLJH Bayview, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Sleep Med 9:283-9. 2008
    ..A previous validation was performed on a patient group. In the current report, we have extended that validation to a non-patient group drawn from on ongoing family study...
  27. pmc Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission
    Cesar Quiroz
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    Exp Neurol 224:292-8. 2010
    ..These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A(2A) receptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS...
  28. ncbi request reprint Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 6:429-34. 2005
    ..This study uses the SIT at different times of the day and analyzes time-of-day and duration-of-rest effects and their interaction on the PLMW...
  29. pmc Iron-deficiency anaemia enhances red blood cell oxidative stress
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Free Radic Res 42:824-9. 2008
    ..Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia...
  30. doi request reprint Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population survey
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
    Sleep Med 10:1097-100. 2009
    ..This validation study sought to determine the sensitivity and specificity of the RLS diagnosis based on this questionnaire...
  31. ncbi request reprint An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder
    Wayne A Hening
    Johns Hopkins Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
    Sleep 27:560-83. 2004
    ..This paper reviews the literature on levodopa, dopaminergic agonists (pergolide, pramipexole, ropinirole, talipexole, cabergoline, piribidel, DHEC), and other dopaminergic agents (amantadine, selegiline)...
  32. ncbi request reprint The role of iron in restless legs syndrome
    Richard P Allen
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    Mov Disord 22:S440-8. 2007
    ..Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder...
  33. pmc Pregnancy accounts for most of the gender difference in prevalence of familial RLS
    Nicholas P Pantaleo
    Dept of Psychology and Brain Science, Johns Hopkins Univ, Baltimore, MD, USA
    Sleep Med 11:310-3. 2010
    ..This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS...
  34. ncbi request reprint Acquired immunodeficiency syndrome and the risk of stroke
    John W Cole
    Department of Neurology, University of Maryland, Baltimore 21201, USA
    Stroke 35:51-6. 2004
    ..Although acquired immunodeficiency syndrome (AIDS) is thought to increase the risk of stroke, few data exist to quantify this risk. This is the first population-based study to quantify the AIDS-associated risk of stroke...
  35. pmc Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells
    Seema Gulyani
    Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 215:236-42. 2009
    ..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system...
  36. ncbi request reprint The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population
    Wayne A Hening
    Department of Neurology, University of Medicine and Dentistry of New Jersey RW Johnson Medical School, New Brunswick, NJ, USA
    Sleep Med 4:137-41. 2003
    ..To develop and validate a telephone diagnostic interview (the Johns Hopkins telephone diagnostic interview for restless legs, abbreviated TDI) for diagnosis of the restless legs syndrome (RLS)...
  37. ncbi request reprint Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnoses
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Hum Hered 62:157-64. 2006
    ..The objective of this study was to ascertain the most likely inheritance pattern of restless legs syndrome (RLS) using segregation analysis...
  38. ncbi request reprint Investigation into the correlation between sensation and leg movement in restless legs syndrome
    Paul V Birinyi
    The Johns Hopkins School of Arts and Sciences, Department of Neuroscience, Baltimore, MD 21224, USA
    Mov Disord 20:1097-103. 2005
    ..The temporal dissociation between sensory and motor events supports viewing these motor and sensory events as separate but loosely linked manifestations of RLS...
  39. ncbi request reprint An algorithm for the management of restless legs syndrome
    Michael H Silber
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:916-22. 2004
    ..The role of carbidopa/levodopa, dopamine agonists, opioids, benzodiazepines, and anticonvulsants for the different types of the disorder is delineated...
  40. doi request reprint Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats
    Laura E Bianco
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurochem 106:205-15. 2008
    ..These experiments provide new evidence that ID results in altered synthesis and functioning of DAT and perhaps suggests some compensatory changes in NE metabolism...
  41. ncbi request reprint The effects of dietary iron deprivation on murine circadian sleep architecture
    Terry Dean
    The University of Pennsylvania School of Medicine, Department of Neuroscience, USA
    Sleep Med 7:634-40. 2006
    ..To this end, we hypothesized that the iron-deprived mice would exhibit a sleep-wake circadian pattern characteristic of the human syndrome: increased wakefulness during the hours immediately preceding the sleep-predominant period...
  42. ncbi request reprint Systems genetic analysis of peripheral iron parameters in the mouse
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
    Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007
    ..The results show that iron homeostasis is a complex trait and is influenced by multiple genes...
  43. ncbi request reprint Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Sleep Med 8:520-30. 2007
    ..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification...
  44. ncbi request reprint Antiphospholipid antibodies and stroke in young women
    Robin L Brey
    University of Texas Health Science Center, San Antonio, Tex 78229 3900, USA
    Stroke 33:2396-400. 2002
    ..Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies...
  45. ncbi request reprint Validation of the Restless Legs Syndrome Quality of Life questionnaire
    Linda Abetz
    Mapi Values Ltd, Macclesfield, Cheshire, UK
    Value Health 8:157-67. 2005
    ..The Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) assesses the impact of RLS on daily life, emotional well-being, social life, and work life. This study investigates its validity and reliability...
  46. ncbi request reprint Ferritin subunits in CSF are decreased in restless legs syndrome
    Stacey L Clardy
    Department of Neurosurgery, M S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Lab Clin Med 147:67-73. 2006
    ..These data suggest that CSF ferritin levels may provide a biomarker for assisting in the diagnosis of RLS...
  47. ncbi request reprint Restless legs syndrome augmentation associated with tramadol
    Christopher J Earley
    Sleep Med 7:592-3. 2006
  48. pmc Epidemiology of restless legs syndrome in Korean adults
    Yong Won Cho
    Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, Korea
    Sleep 31:219-23. 2008
    ..To investigate the prevalence of restless legs syndrome (RLS) in Korea...

Research Grants16

  1. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    ..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
  2. Response to Iron Treatment for Restless Leg Syndrome
    Christopher Earley; Fiscal Year: 2004
    ..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
  3. DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2003
    ....
  4. DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROME
    Christopher Earley; Fiscal Year: 2001
    ..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..