Research Topics
Species | Christopher EarleySummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Is ferroportin-hepcidin signaling altered in restless legs syndrome?Stacey L Clardy
Department of Neurosurgery, M S Hershey Medical Center, 500 University Drive, H110, Hershey, PA 17033, USA
J Neurol Sci 247:173-9. 2006..Nonetheless, these data support the mounting evidence that there is a biological basis for RLS and the underlying mechanism involves iron management...
Increased synaptic dopamine in the putamen in restless legs syndromeChristopher J Earley
Departments of Neurology, Johns Hopkins University, Baltimore, MD, USA
Sleep 36:51-7. 2013..Thus, differences in D2R-BP reflect changes in these primary factors. PET techniques are currently available to estimate D2R β(max) and K(d)...- The treatment of restless legs syndrome with intravenous iron dextranChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Sleep Med 5:231-5. 2004..To evaluate the safety and efficacy of a single 1000 mg iron infusion in treating Restless Legs Syndrome (RLS)... - A randomized, double-blind, placebo-controlled trial of intravenous iron sucrose in restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, 5501 Hopkins Bayview Circle, AAC 1B 82, Baltimore, MD 21224, USA
Sleep Med 10:206-11. 2009..The aim of this study was to ascertain whether high-dose intravenous (IV) iron sucrose could improve symptoms and change brain iron concentrations in idiopathic RLS... - MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Sleep Med 7:458-61. 2006..In this study our primary hypothesis was that substantia nigra (SN) iron index would be decreased in early-onset RLS compared to controls... - Circadian changes in CSF dopaminergic measures in restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Sleep Med 7:263-8. 2006..The dopaminergic (DAergic) system, which plays a role in RLS, entails circadian changes that parallel RLS symptom changes. The aim of this study was to look for relative and diurnal differences in DAergic activity... - Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypesChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Sleep 28:1069-75. 2005.... - Response to Clinical Corners case (Sleep Medicine 6/2: 83-4): Pregnancy associated with daytime sleepiness and nighttime restlessnessChristopher J Earley
Neurology Department, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, AAC, 1B-82, Baltimore, MD 21224, USA
Sleep Med 6:475. 2005 - Repeated IV doses of iron provides effective supplemental treatment of restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Sleep Med 6:301-5. 2005..To evaluate in RLS patients the efficacy and safety of repeated infusions of iron in order to maintain symptomatic improvements achieved with a prior single 1000 mg infusion of iron... - Altered iron metabolism in lymphocytes from subjects with restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Sleep 31:847-52. 2008..Thus the study aim was to determine whether patients with RLS and control subjects show differences in lymphocyte iron regulator proteins... - The dopaminergic neurons of the A11 system in RLS autopsy brains appear normalChristopher J Earley
Department of Neurology, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Sleep Med 10:1155-7. 2009..Changes at the cellular level in dopaminergic metabolism or at the distal synapse with changes in receptors or transporters were not evaluated in this study... - The dopamine transporter is decreased in the striatum of subjects with restless legs syndromeChristopher J Earley
Department of Neurology, Division of Nuclear Medicine, Johns Hopkins University, Baltimore, MD, USA
Sleep 34:341-7. 2011..The current studies assessed real-time DAT binding potentials (BP) in striatum of RLS patients using (11)C-methylphenidate and PET techniques... - Cognitive deficits associated with restless legs syndrome (RLS)Virginia E Pearson
Dept of Psychology and Brain Sciences, Johns Hopkins University, Baltimore, MD 21224, USA
Sleep Med 7:25-30. 2006..1) on the third. The other three tests showed no significant differences. CONCLUSIONS: The results indicate that RLS patients show cognitive deficits similar to that reported for one night of sleep loss... - Childhood and adult factors associated with restless legs syndrome (RLS) diagnosisCharlene E Gamaldo
Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, 21224 Baltimore, MD, USA
Sleep Med 8:716-22. 2007..RLS appears to be caused by a complex interaction of genetic and environmental factors. This study sought to identify some environmental risk factors significantly associated with the occurrence of RLS... - Undiagnosed individuals with first-degree relatives with restless legs syndrome have increased periodic limb movementsPaul V Birinyi
Department of Neuroscience, Baltimore, The Johns Hopkins University School of Art and Sciences, MD, USA
Sleep Med 7:480-5. 2006..The increase in PLMS with age, reported in healthy controls, may in fact occur in part as a partial expression of familial or genetic factors associated with RLS... - Race and restless legs syndrome symptoms in an adult community sample in east BaltimoreHochang B Lee
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
Sleep Med 7:642-5. 2006..We compared the prevalence of RLS in African-Americans and Caucasians in a biracial community sample as part of Wave IV of the Baltimore Health and Mental Health Study... - Evaluating daytime alertness in individuals with Restless Legs Syndrome (RLS) compared to sleep restricted controlsCharlene Gamaldo
Department of Neurology and Sleep Medicine, Johns Hopkins University, Asthma and Allergy Building 1B 75A, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Sleep Med 10:134-8. 2009..In this study we used more objective measures of alertness and compared RLS subjects who are off treatments and chronically sleep restricted to chronic sleep-restricted controls... - A further evaluation of the cognitive deficits associated with restless legs syndrome (RLS)Charlene E Gamaldo
Johns Hopkins University School of Medicine, Department of Neurology, 5501 Hopkins Bayview Circle, Room 1B 75, Baltimore, MD 21224, United States
Sleep Med 9:500-5. 2008..In this study, we compared the cognitive function of RLS patients who were off treatment to sleep-restricted control subjects... - Restless legs syndrome: a clinical updateCharlene E Gamaldo
Department of Neurology, Neurology and Sleep Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Chest 130:1596-604. 2006..However, due to their potential long-term side effects, these agents should not be considered the sole treatment of choice. In the end, the therapeutic plan should be individualized to suit each patient's presentation and needs... 
Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injuryAnn C Halbower
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS Med 3:e301. 2006..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...- Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesisRichard P Allen
Johns Hopkins University, School of Medicine, Department of Neurology, Asthma and Allergy Building, 1B76B 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Sleep Med 10:123-8. 2009..It would then also reflect both the more severe iron insufficiency pathology of RLS and greater clinical severity, shown by the objective measure of PLMS/hr... - Clinical practice. Restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA
N Engl J Med 348:2103-9. 2003 
Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the communityHochang B Lee
Division of Geriatric Psychiatry and Neuropsychiartry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neuropsychiatry Clin Neurosci 20:101-5. 2008..9 [3.6, 46.0]) and comorbidity of major depressive disorder and panic disorder (9.7 [1.4, 69.0]) in the past 12 months suggested a strong association between restless legs syndrome and major depressive disorder and/or panic disorder...- Validation of the Hopkins telephone diagnostic interview for restless legs syndromeWayne A Hening
RLS Center, Asthma and Allergy, SBTBLJH Bayview, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Sleep Med 9:283-9. 2008..A previous validation was performed on a patient group. In the current report, we have extended that validation to a non-patient group drawn from on ongoing family study... - Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmissionCesar Quiroz
National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
Exp Neurol 224:292-8. 2010..These results indicate that brain iron deficiency induces a functional up-regulation of both striatal pre- and postsynaptic A(2A) receptor, which could be involved in sensory-motor disorders associated with iron deficiency such as RLS... - Pregnancy accounts for most of the gender difference in prevalence of familial RLSNicholas P Pantaleo
Dept of Psychology and Brain Science, Johns Hopkins Univ, Baltimore, MD, USA
Sleep Med 11:310-3. 2010..This study was designed to evaluate the associated risk of RLS with pregnancy in relation to the family history and the age of symptom onset of RLS... - Validation of the self-completed Cambridge-Hopkins questionnaire (CH-RLSq) for ascertainment of restless legs syndrome (RLS) in a population surveyRichard P Allen
Department of Neurology, Johns Hopkins University, Baltimore, MD 21224, USA
Sleep Med 10:1097-100. 2009..This validation study sought to determine the sensitivity and specificity of the RLS diagnosis based on this questionnaire... - Iron-deficiency anaemia enhances red blood cell oxidative stressEnika Nagababu
Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Free Radic Res 42:824-9. 2008..Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia... - An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorderWayne A Hening
Johns Hopkins Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
Sleep 27:560-83. 2004..This paper reviews the literature on levodopa, dopaminergic agonists (pergolide, pramipexole, ropinirole, talipexole, cabergoline, piribidel, DHEC), and other dopaminergic agents (amantadine, selegiline)... - Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndromeRichard P Allen
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Asthma and Allergy Bldg 1B76b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Sleep Med 6:429-34. 2005..This study uses the SIT at different times of the day and analyzes time-of-day and duration-of-rest effects and their interaction on the PLMW... - The role of iron in restless legs syndromeRichard P Allen
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
Mov Disord 22:S440-8. 2007..Study of the iron model of RLS offers hope for developing new treatment approaches and perhaps methods to prevent or cure the disorder... - Restless legs syndrome symptomatology, attitudes and beliefs among treated and untreated individualsChristine M Ramsey
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Sleep Med 13:1226-31. 2012.... - Investigation into the correlation between sensation and leg movement in restless legs syndromePaul V Birinyi
The Johns Hopkins School of Arts and Sciences, Department of Neuroscience, Baltimore, MD 21224, USA
Mov Disord 20:1097-103. 2005..The temporal dissociation between sensory and motor events supports viewing these motor and sensory events as separate but loosely linked manifestations of RLS... - Acquired immunodeficiency syndrome and the risk of strokeJohn W Cole
Department of Neurology, University of Maryland, Baltimore 21201, USA
Stroke 35:51-6. 2004..Although acquired immunodeficiency syndrome (AIDS) is thought to increase the risk of stroke, few data exist to quantify this risk. This is the first population-based study to quantify the AIDS-associated risk of stroke... - Segregation analysis of restless legs syndrome: possible evidence for a major gene in a family study using blinded diagnosesRasika A Mathias
Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
Hum Hered 62:157-64. 2006.... - The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control populationWayne A Hening
Department of Neurology, University of Medicine and Dentistry of New Jersey RW Johnson Medical School, New Brunswick, NJ, USA
Sleep Med 4:137-41. 2003..To develop and validate a telephone diagnostic interview (the Johns Hopkins telephone diagnostic interview for restless legs, abbreviated TDI) for diagnosis of the restless legs syndrome (RLS)... - Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cellsSeema Gulyani
Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Neurol 215:236-42. 2009..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system... - An algorithm for the management of restless legs syndromeMichael H Silber
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
Mayo Clin Proc 79:916-22. 2004..The role of carbidopa/levodopa, dopamine agonists, opioids, benzodiazepines, and anticonvulsants for the different types of the disorder is delineated... - The effects of dietary iron deprivation on murine circadian sleep architectureTerry Dean
The University of Pennsylvania School of Medicine, Department of Neuroscience, USA
Sleep Med 7:634-40. 2006..To this end, we hypothesized that the iron-deprived mice would exhibit a sleep-wake circadian pattern characteristic of the human syndrome: increased wakefulness during the hours immediately preceding the sleep-predominant period... - Validation of the Restless Legs Syndrome Quality of Life questionnaireLinda Abetz
Mapi Values Ltd, Macclesfield, Cheshire, UK
Value Health 8:157-67. 2005..The Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) assesses the impact of RLS on daily life, emotional well-being, social life, and work life. This study investigates its validity and reliability... - Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck InstituteDiego Garcia-Borreguero
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
Sleep Med 8:520-30. 2007..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification... - Antiphospholipid antibodies and stroke in young womenRobin L Brey
University of Texas Health Science Center, San Antonio, Tex 78229-3900, USA
Stroke 33:2396-400. 2002..87 (95% confidence interval, 1.24 to 2.83; P=0.0027). CONCLUSIONS: The results from this study support the importance of antiphospholipid antibodies as an independent risk factor for stroke in young women... - Systems genetic analysis of peripheral iron parameters in the mouseByron C Jones
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007..The results show that iron homeostasis is a complex trait and is influenced by multiple genes... - Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley ratsLaura E Bianco
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurochem 106:205-15. 2008..These experiments provide new evidence that ID results in altered synthesis and functioning of DAT and perhaps suggests some compensatory changes in NE metabolism... - Ferritin subunits in CSF are decreased in restless legs syndromeStacey L Clardy
Department of Neurosurgery, M.S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Lab Clin Med 147:67-73. 2006..These data suggest that CSF ferritin levels may provide a biomarker for assisting in the diagnosis of RLS... - Epidemiology of restless legs syndrome in Korean adultsYong Won Cho
Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, Korea
Sleep 31:219-23. 2008..To investigate the prevalence of restless legs syndrome (RLS) in Korea... - Restless legs syndrome augmentation associated with tramadolChristopher J Earley
Sleep Med 7:592-3. 2006
Research Grants
- Dopamine and Iron in Restless Legs SyndromeChristopher Earley; Fiscal Year: 2006..Using CSF and MRI measurements of iron will assess the CNS iron status. RLS severity will be based on subjective (rating scale and diary) and objective (PSG) measurements. ..
- Response to Iron Treatment for Restless Leg SyndromeChristopher Earley; Fiscal Year: 2004..An expected finding that IV iron reduces the brain iron insufficiency and dramatically reduces the RLS symptoms strongly supports our model of RLS caused by brain iron insufficiency. ..
- DETERMINING THE GENETICS OF RESTLESS LEGS SYNDROMEChristopher Earley; Fiscal Year: 2003....
- DOPAMINERGIC FUNCTION IN RESTLESS LEGS SYNDROMEChristopher Earley; Fiscal Year: 2001..The authors would also explore relationships between iron and CSF measures of dopaminergic activities, which could provide the basis for entirely new research and treatment approaches to RLS. ..