Elia Duh

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 9277, USA
    Am J Pathol 160:711-9. 2002
  2. ncbi Persistence of fetal vasculature in a patient with Knobloch syndrome: potential role for endostatin in fetal vascular remodeling of the eye
    Elia J Duh
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 111:1885-8. 2004
  3. ncbi Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis
    Elia J Duh
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Ophthalmol 137:668-74. 2004
  4. ncbi Long-term survival in a patient with uveal melanoma and liver metastasis
    Elia J Duh
    Arch Ophthalmol 122:285-7. 2004
  5. ncbi AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization
    Keisuke Mori
    Departments of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, USA
    Invest Ophthalmol Vis Sci 43:1994-2000. 2002
  6. ncbi Protein transport to choroid and retina following periocular injection: theoretical and experimental study
    Feilim Mac Gabhann
    Department of Biomedical Engineering, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
    Ann Biomed Eng 35:615-30. 2007
  7. ncbi Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray
    Itay Chowers
    Guerrieri Center at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 44:3732-41. 2003
  8. ncbi Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive
    Yuji Oshima
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    FASEB J 19:963-5. 2005
  9. ncbi A system for inducible gene expression in retinal ganglion cells
    John B Kerrison
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2932-9. 2005
  10. ncbi Vascular endothelial growth factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling
    Zhenhua Xu
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Invest Ophthalmol Vis Sci 47:4059-66. 2006

Research Grants

  1. Role and regulation of MEF2C in retinal angiogenesis
    Elia J Duh; Fiscal Year: 2010
  2. Inhibition of CNV using a transgenic PEDF model
    Elia Duh; Fiscal Year: 2004
  3. Role and regulation of MEF2C in retinal angiogenesis
    Elia Duh; Fiscal Year: 2007
  4. Role and regulation of MEF2C in retinal angiogenesis
    Elia Duh; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. ncbi Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment
    Kyoko Ohno-Matsui
    Department of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 9277, USA
    Am J Pathol 160:711-9. 2002
    ..Mice with inducible expression of VEGF in the retina provide a valuable new model of ocular neovascularization...
  2. ncbi Persistence of fetal vasculature in a patient with Knobloch syndrome: potential role for endostatin in fetal vascular remodeling of the eye
    Elia J Duh
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 111:1885-8. 2004
    ..Our typing results for the reported COL18A1 mutations confirm the genetic heterogeneity of KS...
  3. ncbi Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis
    Elia J Duh
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Ophthalmol 137:668-74. 2004
    ..In this study, we sought to measure the levels of PEDF and vascular endothelial growth factor (VEGF) in the vitreous of patients with and without ocular neovascular disorders...
  4. ncbi Long-term survival in a patient with uveal melanoma and liver metastasis
    Elia J Duh
    Arch Ophthalmol 122:285-7. 2004
  5. ncbi AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization
    Keisuke Mori
    Departments of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9277, USA
    Invest Ophthalmol Vis Sci 43:1994-2000. 2002
    ..CONCLUSIONS: These data suggest that intraocular expression of PEDF or other antiangiogenic proteins with AAV vectors may provide a new treatment approach for ocular neovascularization...
  6. ncbi Protein transport to choroid and retina following periocular injection: theoretical and experimental study
    Feilim Mac Gabhann
    Department of Biomedical Engineering, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 720 Rutland Ave, 613 Traylor, Baltimore, MD 21205, USA
    Ann Biomed Eng 35:615-30. 2007
    ..This is the first model of ocular drug delivery to explicitly account for transport properties of each eye layer...
  7. ncbi Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray
    Itay Chowers
    Guerrieri Center at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 44:3732-41. 2003
    ..In addition, the retina custom array should provide a useful resource for comparing expression profiles between normal and diseased human retinas...
  8. ncbi Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive
    Yuji Oshima
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    FASEB J 19:963-5. 2005
    ....
  9. ncbi A system for inducible gene expression in retinal ganglion cells
    John B Kerrison
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 46:2932-9. 2005
    ..To develop a system for inducible gene expression in retinal ganglion cells, Thy1 and ckit promoters were used to direct expression of a second-generation reverse tetracycline transactivator (rtTA2S-M2)...
  10. ncbi Vascular endothelial growth factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling
    Zhenhua Xu
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Invest Ophthalmol Vis Sci 47:4059-66. 2006
    ..Therefore, VEGF upregulation of ADAMTS1, a potent angiogenesis inhibitor, may represent a mechanism for feedback inhibition of angiogenesis and retinal neovascularization...
  11. ncbi Vascular endothelial growth factor induces MEF2C and MEF2-dependent activity in endothelial cells
    Debasish Maiti
    Department of Ophthalmology, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Invest Ophthalmol Vis Sci 49:3640-8. 2008
    ..The purpose of this study was to investigate the regulation of MEF2C expression and MEF2-dependent activity in endothelial cells by VEGF...
  12. ncbi Increased expression of iron-regulating genes in monkey and human glaucoma
    Ronald H Farkas
    Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Ophthalmological Institute, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 45:1410-7. 2004
    ..To understand the mechanisms mediating retinal ganglion cell loss in glaucoma, the gene expression patterns were compared for transferrin, ceruloplasmin, and ferritin between normal and glaucomatous retina in monkey and human eyes...
  13. ncbi Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor
    Hiroyasu Takita
    Department of Ophthalmology, Saitama Medical School, Saitama, Japan
    Invest Ophthalmol Vis Sci 44:4497-504. 2003
    ..The protective effect may result from inhibition of ischemia-induced apoptosis. This study provides proof of concept for a gene transfer approach directed at interrupting programmed cell death induced by retinal ischemic insult...
  14. ncbi Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth
    Elia J Duh
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Maumenee 809, 600 N. Wolfe Street, Baltimore, MD 21287, USA
    Invest Ophthalmol Vis Sci 43:821-9. 2002
    ..These findings suggest that localized administration of PEDF may be an effective approach for the treatment of ischemia-induced retinal neovascular disorders...
  15. ncbi Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism
    Yong Gang Yao
    Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Jefferson 3 109, Baltimore, MD 21287, USA
    FEBS Lett 579:1227-34. 2005
    ....
  16. ncbi Use of topical human amniotic fluid in the treatment of acute ocular alkali injuries in mice
    Samantha Herretes
    The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Ophthalmol 142:271-8. 2006
    ..CONCLUSION: Topical preterm/term HAF was an effective topical therapy for limiting the damage after acute alkali burns of the eye in this animal model...
  17. ncbi Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier
    Peter Gehlbach
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287-9277, USA
    Hum Gene Ther 14:129-41. 2003
    ..These data suggest that periocular gene transfer of sFlt-1 should be considered for treatment of choroidal neovascularization and diabetic macular edema...
  18. ncbi Tissue factor pathway inhibitor-2 is upregulated by vascular endothelial growth factor and suppresses growth factor-induced proliferation of endothelial cells
    Zhenhua Xu
    Department of Ophthalmology, The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Arterioscler Thromb Vasc Biol 26:2819-25. 2006
    ..The purpose of this study is to investigate the expression and regulation of type-2 tissue factor pathway inhibitor (TFPI-2) in endothelial cells, as well as the regulation of human endothelial cell (EC) function by TFPI-2...
  19. ncbi VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis?
    Yong Gang Yao
    Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Biochem Biophys Res Commun 321:648-56. 2004
    ..Our results indicate that DSCR1 up-regulation may represent a potential molecular mechanism underlying the regulation of angiogenic genes activated by the calcineurin-NFAT signaling pathway in endothelial cells...

Research Grants5

  1. Role and regulation of MEF2C in retinal angiogenesis
    Elia J Duh; Fiscal Year: 2010
    ..Further understanding of the regulation and role of MEF2C could similarly lead to new therapeutic strategies for treating retinal NV and other ocular angiogenic disorders. ..
  2. Inhibition of CNV using a transgenic PEDF model
    Elia Duh; Fiscal Year: 2004
    ..In addition, our studies will provide a new experimental approach for the study of candidate inhibitors of CNV, providing important data regarding efficacy, therapeutic dose, frequency of administration, and toxicity. ..
  3. Role and regulation of MEF2C in retinal angiogenesis
    Elia Duh; Fiscal Year: 2007
    ..Further understanding of the regulation and role of MEF2C could similarly lead to new therapeutic strategies for treating retinal NV and other ocular angiogenic disorders. ..
  4. Role and regulation of MEF2C in retinal angiogenesis
    Elia Duh; Fiscal Year: 2009
    ..Further understanding of the regulation and role of MEF2C could similarly lead to new therapeutic strategies for treating retinal NV and other ocular angiogenic disorders. ..