Research Topics
Genomes and Genes | Priya DuggalSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in childrenPriya Duggal
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Clin Invest 121:1191-8. 2011..These findings suggest that leptin signaling is important in mucosal defense against amebiasis and that polymorphisms in the leptin receptor explain differences in susceptibility of children in the Bangladesh cohort to amebiasis...- Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye StudyAlison P Klein
Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
Arch Ophthalmol 127:649-55. 2009..However, the measured phenotype of spherical equivalent is in large part dictated by the relationship between the underlying optical components of axial length, corneal curvature, and anterior chamber depth... 
Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1qAlison P Klein
Departments of Oncology and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Arch Ophthalmol 125:80-5. 2007....- Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibriumPriya Duggal
Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
BMC Genet 6:S73. 2005..In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased... - Genome-wide linkage analysis of multiple metabolic factors: evidence of genetic heterogeneityChing Yu Cheng
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 18:146-52. 2010..We found evidence of genetic heterogeneity by FHD for the three metabolic factors. The results also confirmed findings of previous studies that mapped components of the metabolic syndrome to a chromosome 1q region... - Linkage analysis of quantitative refraction and refractive errors in the Beaver Dam Eye StudyAlison P Klein
Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Invest Ophthalmol Vis Sci 52:5220-5. 2011.... - Influence of human leukocyte antigen class II alleles on susceptibility to Entamoeba histolytica infection in Bangladeshi childrenPriya Duggal
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
J Infect Dis 189:520-6. 2004..This association may explain why amebiasis does not occur in some children who are exposed to the parasite and implicates HLA class II-restricted immune responses in protection against E. histolytica infection... - Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye StudyPriya Duggal
Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
Arch Ophthalmol 125:74-9. 2007..To identify genetic loci that control intraocular pressure (IOP)... - Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccineRavit Arav-Boger
Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, Maryland 21287 4933, USA
BMC Res Notes 5:140. 2012..A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines... - Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traitsAlison P Klein
Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
BMC Genet 6:S20. 2005..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed... - Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virusTimothy L Mosbruger
Johns Hopkins University, Baltimore, MD, USA
J Infect Dis 201:1371-80. 2010..In this large-scale analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene regions that are likely candidates for a role in HCV clearance or persistence in both African Americans and European Americans... - The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug usersPriya Duggal
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 38:584-9. 2005..Because RANTES is a critical chemokine and competitively inhibits HIV-1 by binding to its receptor CCR5, treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load... - Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean populationPeter B Chi
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Genet Epidemiol 30:609-19. 2006..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits... - Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenitaErin M Parry
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans St, CRB 186, Baltimore, MD 21287, USA
J Med Genet 48:327-33. 2011..These data identify decreased dyskerin levels as a novel mechanism of DC, and indicate that intact dyskerin levels, in the absence of coding mutations, are critical for telomerase RNA stability and for in vivo telomere maintenance... - Identification of functional genetic variation in exome sequence analysisAndrew Jaffe
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
BMC Proc 5:S13. 2011..Analysis was conducted without knowledge of the simulation model. Agreement between programs was modest ranging from 59.4% to 71.4% and only 3.5% of variants were classified as deleterious and 10.9% as tolerated across all four programs... - Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear sclerosisAlison P Klein
Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, MD, USA
Am J Epidemiol 161:707-13. 2005..Cigarette smoking was an important covariate in these analyses. Overall, results highlight the complex etiology of nuclear sclerosis... - Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysisYoonhee Kim
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Suite 1200, Baltimore, Maryland 21224, USA
BMC Proc 1:S152. 2007..Surprisingly, the linkage plots for these traits were similar, suggesting that although heritability increases when traits are normalized within pedigrees, the strength of linkage evidence does not necessarily change substantially...