Wenzhen Duan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Targeting sirtuin-1 in Huntington's disease: rationale and current status
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    CNS Drugs 27:345-52. 2013
  2. ncbi request reprint Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Curr Drug Targets 11:1281-92. 2010
  3. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008
  4. pmc The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    Qi Peng
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 210:154-63. 2008
  5. pmc Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease
    Naoki Masuda
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:293-302. 2008
  6. pmc Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
    Jing Jin
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurochem 123:477-90. 2012
  7. ncbi request reprint Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    Zhihong Guo
    Laboratory of Neurosciences and National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Biol Chem 283:1754-63. 2008
  8. pmc Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease
    Jing Jin
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 125:410-9. 2013
  9. ncbi request reprint Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    Endocrinology 144:2446-53. 2003
  10. ncbi request reprint Paroxetine retards disease onset and progression in Huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Ann Neurol 55:590-4. 2004

Collaborators

Detail Information

Publications33

  1. pmc Targeting sirtuin-1 in Huntington's disease: rationale and current status
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    CNS Drugs 27:345-52. 2013
    ..This review summarizes recent progress in SIRT1 research, with a focus on the specificity of this protein as a potential therapeutic target for HD, as well as existing challenges for developing SIRT1 modulators for clinical use...
  2. ncbi request reprint Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Curr Drug Targets 11:1281-92. 2010
    ..We focus in particular on recent findings on sirtuins for prevention of neurodegenerative diseases...
  3. pmc Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
    Wenzhen Duan
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:312-22. 2008
    ..Additionally, the effective levels of sertraline are comparable to the safe levels achievable in humans. The findings suggest that sertraline is a potential candidate for treatment of HD patients...
  4. pmc The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
    Qi Peng
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Exp Neurol 210:154-63. 2008
    ..Our findings suggest that a clinical trial of SSRI treatment in order to retard disease progression in human HD may be warranted...
  5. pmc Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease
    Naoki Masuda
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8 121, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Dis 30:293-302. 2008
    ..These results suggest that tiagabine may have beneficial effects in the treatment of HD. Because tiagabine is an FDA-approved drug, it may be a promising candidate for future clinical trials for the treatment of HD...
  6. pmc Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
    Jing Jin
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurochem 123:477-90. 2012
    ....
  7. ncbi request reprint Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
    Zhihong Guo
    Laboratory of Neurosciences and National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Biol Chem 283:1754-63. 2008
    ..By enhancing mitochondrial resistance to apoptosis and excitotoxicity, our findings suggest that leptin signaling serves a neurotrophic function in the developing and adult hippocampus...
  8. pmc Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease
    Jing Jin
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 125:410-9. 2013
    ..Our results suggest that modifying the PPAR-γ pathway plays a beneficial role in rescuing motor function as well as glucose metabolic abnormalities in HD...
  9. ncbi request reprint Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    Endocrinology 144:2446-53. 2003
    ..Dietary and pharmacological manipulations of BDNF signaling may prove useful in the prevention and treatment of obesity and insulin resistance syndrome-related diseases...
  10. ncbi request reprint Paroxetine retards disease onset and progression in Huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Ann Neurol 55:590-4. 2004
    ..Paroxetine was beneficial when treatment was initiated before or after the onset of motor dysfunction, suggesting a potential for such antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients...
  11. pmc Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model
    Yong Cheng
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroimage 56:1027-34. 2011
    ..Our present studies provide the first evidence that longitudinal structural MRI measures can detect the therapeutic effect in HD mice, suggesting that such measures in brain could be valuable biomarkers in HD clinical trials...
  12. pmc Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease
    Mali Jiang
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 22:2462-70. 2013
    ..These data highlight consideration of TrkB as a therapeutic target in HD and suggest that small-molecule TrkB agonists that penetrate the brain have high potential to be further tested in clinical trials of HD...
  13. pmc Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 100:2911-6. 2003
    ..Our findings suggest a dietary intervention that may suppress the disease process and increase the life span of humans that carry the mutant huntingtin gene...
  14. pmc Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging
    Manisha Aggarwal
    Division of NMR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 60:2086-95. 2012
    ..The findings of this report can be used for future testing and comparison of potential therapeutics in mouse models of HD...
  15. ncbi request reprint p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
    Wenzhen Duan
    Laboratory of Neurosciences, Gerontology Research Center 4F01, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ann Neurol 52:597-606. 2002
    ..Our findings demonstrate a pivotal role for p53 in experimental parkinsonism and identify a novel class of synthetic p53 inhibitors with clinical potential...
  16. pmc Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin
    Elaine Waldron-Roby
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 32:183-93. 2012
    ....
  17. ncbi request reprint Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model
    Wenfei Wang
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2109, USA
    Neurobiol Dis 20:500-8. 2005
    ..We also tested a broad spectrum caspase inhibitor Z-VAD-fmk and previously proposed candidate compounds. This cell model can provide a method to screen potential therapeutic compounds for treating Huntington's disease...
  18. pmc Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease
    Zhihong Guo
    Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mov Disord 27:1379-86. 2012
    ..Our findings suggest that neuronal loss and atrophy in striatum and neuronal loss in subthalamic nuclei contribute specifically to the motor impairment of HD, but not to chorea...
  19. doi request reprint Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
    Mali Jiang
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 18:153-8. 2012
    ..These findings show a neuroprotective role for Sirt1 in mammalian Huntington's disease models and open new avenues for the development of neuroprotective strategies in Huntington's disease...
  20. pmc Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    NeuroRx 1:111-6. 2004
    ....
  21. ncbi request reprint Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center 4F01, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 23:695-705. 2002
    ..The recent application of modem methods of molecular and cellular biology to the problem of brain aging is revealing a remarkable capacity within brain cells for adaptation to aging and resistance to disease...
  22. ncbi request reprint Folic acid and homocysteine in age-related disease
    Mark P Mattson
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 1:95-111. 2002
    ....
  23. pmc Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism
    Mali Jiang
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurochem 114:419-29. 2010
    ..Baicalein has potential as a tool to understand the relation between different aggregation species and toxicity, and might be a candidate compound for further validation by using in vivo alpha-syn genetic PD models...
  24. pmc Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images
    Jiangyang Zhang
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 49:2340-51. 2010
    ..This is the first report of longitudinal characterization of brain atrophy in a mouse model of Huntington's disease by using automatic morphological analysis...
  25. pmc trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease
    Jinrong Fu
    Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 287:24460-72. 2012
    ..Our results suggest that increasing mitochondrial SIRT3 might be considered as a new therapeutic approach to counteract HD, as well as other neurodegenerative diseases with similar mechanisms...
  26. ncbi request reprint Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 84:417-31. 2003
    ....
  27. ncbi request reprint Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    Jaewon Lee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 82:1367-75. 2002
    ....
  28. pmc Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender
    Xiangru Xu
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Genome Biol 8:R234. 2007
    ..The structural and functional complexity of the mammalian central nervous system (CNS) is organized and modified by complicated molecular signaling processes that are poorly understood...
  29. ncbi request reprint Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    Physiol Rev 82:637-72. 2002
    ..The recent application of modern methods of molecular and cellular biology to the problem of brain aging is revealing a remarkable capacity within brain cells for adaptation to aging and resistance to disease...
  30. ncbi request reprint Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease
    Wenzhen Duan
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 80:101-10. 2002
    ..The ability of folate deficiency and elevated homocysteine levels to sensitize dopaminergic neurons to environmental toxins suggests a mechanism whereby dietary folate may influence risk for PD...
  31. ncbi request reprint How does the brain control lifespan?
    Mark P Mattson
    Laboratory of Neurosciences 4F02, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 1:155-65. 2002
    ..Roles for other evolutionarily conserved brain signaling pathways in lifespan determination are likely to be discovered in the near future...
  32. ncbi request reprint Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models
    Benjamin Sredni
    CAIR Institute, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Keren Hayessod St, Ramat Gan, Israel
    FASEB J 21:1870-83. 2007
    ....

Research Grants4

  1. Therapeutic Neuroprotective Trials of Tiagabine in HD Mouse Models
    Wenzhen Duan; Fiscal Year: 2007
    ..The significance of proposed study is that if this compound has consistent protection in different mouse models, it might lead to therapeutic trials in human and a potential therapy for HD. ..
  2. Cell Model of Parkinson's Disease and Screening for Therapeutic Compounds
    Wenzhen Duan; Fiscal Year: 2007
    ..Our proposed research has potential to find compounds which are neuroprotective and further be taken to preclinical and clinical trials of PD. ..