Yong Du

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies
    Y Du
    The Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, 601 N Caroline Street, JHOC 4263, Baltimore, MD, 21287, USA
    J Nucl Cardiol 21:329-40. 2014
  2. doi Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging
    Yong Du
    The Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, 601 N Caroline St, JHOC 4263, Baltimore, MD 21287, USA
    J Nucl Cardiol 20:84-98. 2013
  3. ncbi Model-based crosstalk compensation for simultaneous 99mTc/123I dual-isotope brain SPECT imaging
    Yong Du
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 34:3530-43. 2007
  4. ncbi Model-based compensation for quantitative 123I brain SPECT imaging
    Yong Du
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    Phys Med Biol 51:1269-82. 2006
  5. pmc Quantitative evaluation of simultaneous reconstruction with model-based crosstalk compensation for 99mTc/123I dual-isotope simultaneous acquisition brain SPECT
    Yong Du
    Department of Radiology, Division of Medical Imaging Physics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 36:2021-33. 2009
  6. ncbi Partial volume effect compensation for quantitative brain SPECT imaging
    Yong Du
    Department of Radiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 24:969-76. 2005
  7. pmc Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 48:150-7. 2007
  8. pmc Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--patient studies
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 36:1595-601. 2009
  9. pmc Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0859, USA
    Med Phys 36:612-9. 2009
  10. ncbi Assessment of severity of coronary artery stenosis in a canine model using the PET agent 18F-fluorobenzyl triphenyl phosphonium: comparison with 99mTc-tetrofosmin
    Igal Madar
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 48:1021-30. 2007

Collaborators

Detail Information

Publications24

  1. ncbi Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies
    Y Du
    The Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, 601 N Caroline Street, JHOC 4263, Baltimore, MD, 21287, USA
    J Nucl Cardiol 21:329-40. 2014
    ..We have developed a model-based compensation (MBC) method to compensate for this crosstalk. The method has previously been validated with phantom and simulation studies. In this study, we evaluated the MBC method using a canine model...
  2. doi Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging
    Yong Du
    The Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, 601 N Caroline St, JHOC 4263, Baltimore, MD 21287, USA
    J Nucl Cardiol 20:84-98. 2013
    ..It is important to compensate for both effects to achieve accurate quantification. In this study, an image-based partial volume compensation (PVC) method was developed and validated for cardiac PET...
  3. ncbi Model-based crosstalk compensation for simultaneous 99mTc/123I dual-isotope brain SPECT imaging
    Yong Du
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 34:3530-43. 2007
    ..Compensation using MBCC improved image contrast and removed the artifacts for both Monte Carlo simulated and experimentally acquired data. The results were in good agreement with images acquired without any crosstalk contamination...
  4. ncbi Model-based compensation for quantitative 123I brain SPECT imaging
    Yong Du
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    Phys Med Biol 51:1269-82. 2006
    ..55% to 4.87% after compensation. The model-based method provided accurate downscatter estimation and, when combined with iterative reconstruction-based compensations, accurate quantitation was obtained with minimal loss of precision...
  5. pmc Quantitative evaluation of simultaneous reconstruction with model-based crosstalk compensation for 99mTc/123I dual-isotope simultaneous acquisition brain SPECT
    Yong Du
    Department of Radiology, Division of Medical Imaging Physics, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 36:2021-33. 2009
    ..Both proposed compensation approaches can potentially be applied clinically, but when reconstruction time is a limiting factor, the alternating model-based compensation may be preferable...
  6. ncbi Partial volume effect compensation for quantitative brain SPECT imaging
    Yong Du
    Department of Radiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    IEEE Trans Med Imaging 24:969-76. 2005
    ..2%. For experimental data, PVC using pGTM reduced the underestimation of striatal activities from 36% to less than 7.8%. The underestimation of the striatum to background activity ratio was also improved from 31% to 2.7%...
  7. pmc Therapeutic potential of 90Y- and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin's lymphoma with pulmonary involvement: a Monte Carlo-based dosimetric analysis
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 48:150-7. 2007
    ..In this work, we used Monte Carlo-based dosimetry to compare the potential of (90)Y and (131)I, based purely on their emission properties, in targeted therapy for NHL lung metastases of various nodule sizes and tumor burdens...
  8. pmc Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning--patient studies
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 36:1595-601. 2009
    ..More sophisticated methods, such as the hybrid SPECT/planar method investigated here, are likely to be better predictors of organ dose and, as a result, organ toxicities...
  9. pmc Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and uptake
    Bin He
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 0859, USA
    Med Phys 36:612-9. 2009
    ..The QPlanar or hybrid QPlanar/QSPECT methods had mean errors and standard deviations of errors that approached those of pure QSPECT while providing simplified image acquisition protocols, and thus may be more clinically practical...
  10. ncbi Assessment of severity of coronary artery stenosis in a canine model using the PET agent 18F-fluorobenzyl triphenyl phosphonium: comparison with 99mTc-tetrofosmin
    Igal Madar
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Nucl Med 48:1021-30. 2007
    ....
  11. pmc Development and evaluation of an improved quantitative (90)Y bremsstrahlung SPECT method
    Xing Rong
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287 0859, USA
    Med Phys 39:2346-58. 2012
    ..The aim of this work was to develop and evaluate an improved quantitative (90)Y bremsstrahlung SPECT reconstruction method appropriate for these imaging applications...
  12. ncbi A Monte Carlo and physical phantom evaluation of quantitative In-111 SPECT
    Bin He
    Division of Medical Imaging Physics, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, 601 N Caroline St JHOC 4250, Baltimore, MD 21287 0859, USA
    Phys Med Biol 50:4169-85. 2005
    ..PVC was important for small structures such as tumours or for organs in close proximity to regions with high activity. The improved quantitative accuracy from QSPECT methods has the potential for improving organ dose estimations in TRT...
  13. pmc Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1985-94. 2006
    ..In this work we demonstrated the use of MCNP, a Monte Carlo electron and photon transport code, in a 3-dimensional (3D) imaging-based absorbed dose calculation for tumor and normal lungs...
  14. ncbi Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium
    Igal Madar
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 47:1359-66. 2006
    ..Here, we characterize the 18F-FBnTP uptake and retention kinetics, in vitro and in vivo, as well as the myocardial and whole-body biodistribution in healthy dogs, using PET...
  15. pmc A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: application to Y-90 bremsstrahlung SPECT imaging
    Xing Rong
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins University, Baltimore, MD, USA
    Phys Med Biol 57:3711-25. 2012
    ....
  16. pmc Development and evaluation of a model-based downscatter compensation method for quantitative I-131 SPECT
    Na Song
    Division of Medical Imaging Physics, Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Med Phys 38:3193-204. 2011
    ..The goal of this study was to develop and evaluate a model-based downscatter compensation method specifically designed for the compensation of high-energy photons emitted by 131I and detected in the imaging energy window...
  17. ncbi Design of a digital phantom population for myocardial perfusion SPECT imaging research
    Michael Ghaly
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA
    Phys Med Biol 59:2935-53. 2014
    ....
  18. ncbi Simultaneous Tc-99m/I-123 dual-radionuclide myocardial perfusion/innervation imaging using Siemens IQ-SPECT with SMARTZOOM collimator
    Yong Du
    Department of Radiology, Johns Hopkins University, 601 N Caroline Street, JOHC 4263, Baltimore, MD 21287, USA
    Phys Med Biol 59:2813-28. 2014
    ..The proposed model-based method can be used to improve simultaneous dual-radionuclide images acquired using IQ-SPECT. This work also demonstrates that ESSE scatter modeling can be applied to non-parallel-beam projection geometries. ..
  19. pmc Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging
    Ying J Cao
    Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Br J Clin Pharmacol 74:1013-22. 2012
    ..These methods are needed to develop rationally rectal microbicides to target and prevent HIV infection...
  20. ncbi A theoretical investigation of P-hydroxyphenacyl caged phototrigger compounds: how water induces the photodeprotection and subsequent rearrangement reactions
    Xuebo Chen
    Department of Chemistry, The University of Hong Kong, Hong Kong SAR, PR China
    J Phys Chem B 111:11832-42. 2007
    ..Finally, the H atom of the hydroxyl in 1,1'-di-hydroxyl-spiroketon transfers back to the p-O atom aided by water molecules to generate the p-hydroxyphenyl-acetic acid final rearrangement product...
  21. ncbi The impact of 18F-FDG PET/CT in patients with liver metastases
    Siew C Chua
    Institute of Nuclear Medicine, UCL Hospital, University College London, 235 Euston Road, London, UK
    Eur J Nucl Med Mol Imaging 34:1906-14. 2007
    ..The aim of this study was to assess the performance of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) versus dedicated contrast-enhanced CT (CECT) in the detection of metastatic liver disease...
  22. ncbi Microscopic intratumoral dosimetry of radiolabeled antibodies is a critical determinant of successful radioimmunotherapy in B-cell lymphoma
    Yong Du
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    Cancer Res 67:1335-43. 2007
    ..We believe that these new insights should influence the selection of new antigen targets and the design of dosimetric methods in radioimmunotherapy of lymphoma...
  23. ncbi High-grade mucoepidermoid carcinoma of the accessory parotid gland with distant metastases identified by 18F-FDG PET-CT
    Marcelo Gomes
    Institute of Nuclear Medicine, University College of London Hospital, London, United Kingdom
    Pediatr Blood Cancer 50:395-7. 2008
    ..In view of the findings and poor prognosis of the patient, surgical intervention and radiotherapy were not given and palliative measures offered. This case shows the potential of molecular imaging with (18)F-FDG PET-CT in these patients...
  24. ncbi Antibody-induced intracellular signaling works in combination with radiation to eradicate lymphoma in radioimmunotherapy
    Yong Du
    Cancer Sciences Division, School of Medicine, Southampton University Hospital, United Kingdom
    Blood 103:1485-94. 2004
    ..Together these data illustrate that using 1 mAb to target radiation to tumor and a second to induce cell signaling is an effective new strategy in RIT...