Susan Dorman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Impact and cost-effectiveness of culture for diagnosis of tuberculosis in HIV-infected Brazilian adults
    David W Dowdy
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 3:e4057. 2008
  2. pmc Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug-resistant tuberculosis in South Africa
    Maunank Shah
    Johns Hopkins University School of Medicine, Department of Medicine, Division of Infectious Disease, 1503 East Jefferson St, Room 118, Baltimore, MD 21231, USA
    BMC Infect Dis 13:352. 2013
  3. ncbi request reprint Substitution of rifapentine for rifampin during intensive phase treatment of pulmonary tuberculosis: study 29 of the tuberculosis trials consortium
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Infect Dis 206:1030-40. 2012
  4. pmc Performance characteristics of the Cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e43307. 2012
  5. pmc Genotype MTBDRplus for direct detection of Mycobacterium tuberculosis and drug resistance in strains from gold miners in South Africa
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 50:1189-94. 2012
  6. pmc Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study
    Kathleen R Page
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Public Health 8:158. 2008
  7. pmc T-SPOT.TB responses during treatment of pulmonary tuberculosis
    Samantha Ribeiro
    Instituto de Doenças do Torax Hospital Clementino Fraga Filho Universidade Federal do Rio de Janeiro, Brazil
    BMC Infect Dis 9:23. 2009
  8. pmc Cost-effectiveness analysis of the gen-probe amplified mycobacterium tuberculosis direct test as used routinely on smear-positive respiratory specimens
    David W Dowdy
    Johns Hopkins Bloomberg School of Public Health Johns Hopkins Hospital Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Clin Microbiol 41:948-53. 2003
  9. doi request reprint Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis
    Susan E Dorman
    Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland 21231, USA
    Am J Respir Crit Care Med 180:273-80. 2009
  10. doi request reprint New diagnostic tests for tuberculosis: bench, bedside, and beyond
    Susan E Dorman
    Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland 21212, USA
    Clin Infect Dis 50:S173-7. 2010

Collaborators

Detail Information

Publications35

  1. pmc Impact and cost-effectiveness of culture for diagnosis of tuberculosis in HIV-infected Brazilian adults
    David W Dowdy
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 3:e4057. 2008
    ....
  2. pmc Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug-resistant tuberculosis in South Africa
    Maunank Shah
    Johns Hopkins University School of Medicine, Department of Medicine, Division of Infectious Disease, 1503 East Jefferson St, Room 118, Baltimore, MD 21231, USA
    BMC Infect Dis 13:352. 2013
    ..In South Africa, the Xpert MTB/Rif assay and the GenoType MTBDRplus have been implemented into reference laboratories for diagnosis of TB and drug-resistance, but their costs have not been fully elucidated...
  3. ncbi request reprint Substitution of rifapentine for rifampin during intensive phase treatment of pulmonary tuberculosis: study 29 of the tuberculosis trials consortium
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Infect Dis 206:1030-40. 2012
    ..We compared the antimicrobial activity and safety of rifapentine vs rifampin during the first 8 weeks of pulmonary tuberculosis treatment...
  4. pmc Performance characteristics of the Cepheid Xpert MTB/RIF test in a tuberculosis prevalence survey
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e43307. 2012
    ..Objectives were to determine Xpert performance and costs in the context of a TB prevalence survey...
  5. pmc Genotype MTBDRplus for direct detection of Mycobacterium tuberculosis and drug resistance in strains from gold miners in South Africa
    Susan E Dorman
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 50:1189-94. 2012
    ..Our results support recommendations that the MTBDRplus test not be used for direct testing of smear-negative or paucibacillary sputum samples...
  6. pmc Timing of therapy for latent tuberculosis infection among immigrants presenting to a U.S. public health clinic: a retrospective study
    Kathleen R Page
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Public Health 8:158. 2008
    ..Current guidelines recommend screening and treatment for latent TB infection (LTBI) within 5 years of arrival to the U.S. This study evaluates the timing of LTBI therapy among immigrants presenting for care to a public health TB clinic...
  7. pmc T-SPOT.TB responses during treatment of pulmonary tuberculosis
    Samantha Ribeiro
    Instituto de Doenças do Torax Hospital Clementino Fraga Filho Universidade Federal do Rio de Janeiro, Brazil
    BMC Infect Dis 9:23. 2009
    ..Immune responses to Mycobacterium tuberculosis antigens could serve as surrogate markers of treatment response...
  8. pmc Cost-effectiveness analysis of the gen-probe amplified mycobacterium tuberculosis direct test as used routinely on smear-positive respiratory specimens
    David W Dowdy
    Johns Hopkins Bloomberg School of Public Health Johns Hopkins Hospital Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Clin Microbiol 41:948-53. 2003
    ....
  9. doi request reprint Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis
    Susan E Dorman
    Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland 21231, USA
    Am J Respir Crit Care Med 180:273-80. 2009
    ..Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis (TB) chemotherapy, but data regarding its activity in humans are limited...
  10. doi request reprint New diagnostic tests for tuberculosis: bench, bedside, and beyond
    Susan E Dorman
    Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland 21212, USA
    Clin Infect Dis 50:S173-7. 2010
    ..Several promising new tools are at advanced stages of development and evaluation. This review describes some of those promising new technologies and the key barriers to their effective implementation...
  11. pmc Repeated administration of high-dose intermittent rifapentine reduces rifapentine and moxifloxacin plasma concentrations
    Kelly Dooley
    Divisions of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Antimicrob Agents Chemother 52:4037-42. 2008
    ..Changes consistent with rifapentine autoinduction of metabolism were seen. Adverse reactions in two subjects may have represented rifamycin hypersensitivity syndrome, although some features were atypical...
  12. pmc Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis
    Kelly E Dooley
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Trop Med Hyg 80:634-9. 2009
    ..51). In conclusion, DM was a risk factor for death in Maryland TB patients. There was a trend toward increased time to culture conversion; two-month culture conversion proportions, however, were similar...
  13. ncbi request reprint Use of the amplified mycobacterium tuberculosis direct test in a public health laboratory: test performance and impact on clinical care
    Renata L Guerra
    School of Medicine, Johns Hopkins University, Room 1M 06, 1550 Orleans St, Baltimore, MD 21231, USA
    Chest 132:946-51. 2007
    ..In a routine public health setting, test accuracy and impact on clinical decisions are unknown...
  14. pmc Diagnostic accuracy of a urine lipoarabinomannan enzyme-linked immunosorbent assay for screening ambulatory HIV-infected persons for tuberculosis
    Celine R Gounder
    Center for TB Research, Division of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 58:219-23. 2011
    ..To assess the diagnostic accuracy of the urine lipoarabinomannan (LAM) test among ambulatory HIV-infected persons...
  15. pmc Cost-effectiveness of different strategies for amplified Mycobacterium tuberculosis direct testing for cases of pulmonary tuberculosis
    Renata L Guerra
    Johns Hopkins University Center for Tuberculosis Research, 1550 Orleans Street, Room 1M 06, Baltimore, MD 21231, USA
    J Clin Microbiol 46:3811-2. 2008
    ..The most cost-effective strategy was one in which smear-positive specimens but not smear-negative specimens were diluted prior to MTD testing...
  16. ncbi request reprint The potential impact of enhanced diagnostic techniques for tuberculosis driven by HIV: a mathematical model
    David W Dowdy
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    AIDS 20:751-62. 2006
    ..To explore the potential impact of enhanced tuberculosis (TB) diagnostic techniques as a TB control strategy in an adult population with high HIV prevalence...
  17. ncbi request reprint Fluoroquinolone resistance in patients with newly diagnosed tuberculosis
    Amy Sarah Ginsburg
    Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 37:1448-52. 2003
    ..The incidence of M. tuberculosis fluoroquinolone resistance in this small sample of patients with newly diagnosed tuberculosis was high, particularly among patients with prior fluoroquinolone exposure...
  18. pmc Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting
    Maunank Shah
    Department of Medicine, Johns Hopkins University Center for Tuberculosis Research, Baltimore, MD 21231, USA
    J Acquir Immune Defic Syndr 52:145-51. 2009
    ..Effective tuberculosis (TB) control in HIV-prevalent settings is hindered by absence of accurate, rapid TB diagnostic tests. We evaluated the accuracy of a urine lipoarabinomannan (LAM) test for TB diagnosis in South Africa...
  19. ncbi request reprint Molecular epidemiology of pleural and other extrapulmonary tuberculosis: a Maryland state review
    Jessie Torgersen
    Maryland Department of Health and Mental Hygiene, Baltimore, Maryland 21201, USA
    Clin Infect Dis 42:1375-82. 2006
    ..Our objective was to use molecular epidemiological techniques to describe the occurrence of pleural and other extrapulmonary tuberculosis in Maryland, a state with moderate tuberculosis incidence...
  20. pmc Performance of the microscopic observation drug susceptibility assay in drug susceptibility testing for Mycobacterium tuberculosis
    Walter G Park
    Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Clin Microbiol 40:4750-2. 2002
    ..Levels of agreement for streptomycin tested at 2.0 and 6.0 micro g/ml were 77 and 51%, respectively. For isoniazid and rifampin drug susceptibility testing, MODS is as accurate as and more rapid than the reference method...
  21. ncbi request reprint Improved adherence and less toxicity with rifampin vs isoniazid for treatment of latent tuberculosis: a retrospective study
    Kathleen R Page
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Intern Med 166:1863-70. 2006
    ..In this study, we compared treatment completion and clinically recognized adverse drug reactions in patients prescribed 9 months of isoniazid therapy or 4 months of rifampin therapy for LTBI...
  22. pmc QuantiFERON-TB gold in-tube implementation for latent tuberculosis diagnosis in a public health clinic: a cost-effectiveness analysis
    Maunank Shah
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Infect Dis 12:360. 2012
    ..In 2010, BCHD introduced adjunctive QuantiFERON-TB Gold In-Tube (QFT-GIT) testing for TST-positive referrals. We evaluated costs and cost-effectiveness of this new diagnostic algorithm...
  23. pmc Impact of enhanced tuberculosis diagnosis in South Africa: a mathematical model of expanded culture and drug susceptibility testing
    David W Dowdy
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Suite W6508, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:11293-8. 2008
    ..In South Africa, expanding TB culture and DST could substantially reduce TB, and particularly MDR-TB, mortality. Control of XDR-TB will require additional interventions, the impact of which may be enhanced by improved TB diagnosis...
  24. ncbi request reprint Mycobacterium tuberculosis cell envelope lipids and the host immune response
    Petros C Karakousis
    Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, 1503 E Jefferson St, Room 105, Baltimore, MD 21231, USA
    Cell Microbiol 6:105-16. 2004
  25. pmc Field evaluation of a rapid immunochromatographic test for tuberculosis
    Celine Gounder
    Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21231, USA
    J Clin Microbiol 40:1989-93. 2002
    ..However, further evaluation of these tests in specific epidemiologic settings may be warranted...
  26. ncbi request reprint From magic bullets back to the magic mountain: the rise of extensively drug-resistant tuberculosis
    Susan E Dorman
    Center for Tuberculosis Research, 1550 Orleans Street, Room 1M 08, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Nat Med 13:295-8. 2007
  27. pmc Specimen dilution improves sensitivity of the amplified Mycobacterium tuberculosis direct test for smear microscopy-positive respiratory specimens
    Renata L Guerra
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Microbiol 46:314-6. 2008
    ..The difference in MTD test sensitivity between the dilution and conventional methods was 15.9% (P = 0.001) for smear microscopy-positive specimens and -3.6% (P = 0.38) for smear microscopy-negative specimens...
  28. ncbi request reprint Lymphadenitis in an 18-month-old traveler to Mexico
    Tafadzwa S Kasambira
    Johns Hopkins University School of Medicine, Center for Tuberculosis Research, Baltimore, MD, USA
    Pediatr Infect Dis J 26:968, 973-4. 2007
  29. pmc Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits
    Susan E Dorman
    Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
    Infect Immun 72:1700-5. 2004
    ..Preliminary evidence is presented for a cell-mediated immune defect with lower DTH responses and macrophages that have a decreased ability to respond to in vitro stimulation with LPS or M. tuberculosis infection...
  30. pmc Quantitative analysis of a urine-based assay for detection of lipoarabinomannan in patients with tuberculosis
    Maunank Shah
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 48:2972-4. 2010
    ..Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful...
  31. pmc Clinical evaluation of the microscopic observation drug susceptibility assay for detection of Mycobacterium tuberculosis resistance to isoniazid or rifampin
    Fernanda C Q Mello
    Federal University of Rio de Janeiro, Brazil
    J Clin Microbiol 45:3387-9. 2007
    ..9 to 98.8%), respectively, for rifampin resistance. For both rifampin and isoniazid testing, the likelihood ratio for a negative test was < or =0.05, indicating that the MODS assay may be useful for ruling out drug resistance...
  32. ncbi request reprint Clinical evaluation of the microscopic-observation drug-susceptibility assay for detection of tuberculosis
    Mayra Arias
    University of Alabama at Birmingham, Birmingham, AL, USA
    Clin Infect Dis 44:674-80. 2007
    ..The microscopic-observation drug-susceptibility (MODS) assay is a relatively low-cost and simple liquid culture method that has been proposed for use in resource-limited environments...
  33. ncbi request reprint Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies
    Susan E Dorman
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, CRC B3 419, 10 Center Drive, MSC 1684, Bethesda, MD 20892 1684, USA
    Lancet 364:2113-21. 2004
    ..We aimed to compare the clinical features of recessive and dominant IFNgammaR1 deficiencies...
  34. pmc Immunoglobulin A (IgA) and IgG immune responses against P-90 antigen for diagnosis of pulmonary tuberculosis and screening for Mycobacterium tuberculosis infection
    Marcus B Conde
    Unidade de Pesquisa em Tuberculose, Instituto de Doenças do Tórax, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil
    Clin Diagn Lab Immunol 11:94-7. 2004
    ..tuberculosis exposure and development of disease...
  35. ncbi request reprint The rapid development of fluoroquinolone resistance in M. tuberculosis
    Amy Sarah Ginsburg
    N Engl J Med 349:1977-8. 2003

Research Grants7

  1. Mycobacterium tuberculosis cell wall virulence factors
    Susan Dorman; Fiscal Year: 2004
    ..Finally, new information from the proposed self-contained pilot studies will serve as the foundation for future comprehensive dissection of macrophage response pathways affected by specific cell wall components. ..
  2. Rapid Detection of Mycobacterium tuberculosis
    Susan Dorman; Fiscal Year: 2007
    ..Relevance: Results of these studies will improve our understanding of the laboratory performance and clinical benefit of this test, and lead to improved detection and treatment of TB. ..
  3. Phase II Study of Daily Rifapentine for Pulmonary Tuberculosis (IND 62,611; 1/2/0
    Susan Dorman; Fiscal Year: 2009
    ....
  4. Extensively Drug-Resistant Tuberculosis Among Gold Miners in South Africa
    Susan Dorman; Fiscal Year: 2009
    ....
  5. Phase II Study of Daily Rifapentine for Pulmonary Tuberculosis (IND 62,611; 1/2/0
    Susan E Dorman; Fiscal Year: 2010
    ....
  6. Extensively Drug-Resistant Tuberculosis Among Gold Miners in South Africa
    Susan E Dorman; Fiscal Year: 2010
    ....