Eric C Donny

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Differential effects of response-contingent and response-independent nicotine in rats
    E C Donny
    Department of Psychology, University of Pittsburgh, 412 Langley Hall, Pittsburgh, PA 15260, USA
    Eur J Pharmacol 402:231-40. 2000
  2. ncbi request reprint High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:202-12. 2002
  3. ncbi request reprint Choosing to take cocaine in the human laboratory: effects of cocaine dose, inter-choice interval, and magnitude of alternative reinforcement
    Eric C Donny
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 69:289-301. 2003
  4. ncbi request reprint Assessing the initiation of cocaine self-administration in humans during abstinence: effects of dose, alternative reinforcement, and priming
    Eric C Donny
    Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 172:316-23. 2004
  5. ncbi request reprint Using growth models to relate acquisition of nicotine self-administration to break point and nicotinic receptor binding
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 75:23-35. 2004
  6. pmc The role of nicotine in smoking: a dual-reinforcement model
    Anthony R Caggiula
    Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nebr Symp Motiv 55:91-109. 2009
  7. ncbi request reprint Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 189:27-36. 2006
  8. pmc Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement schedule
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 190:353-62. 2007
  9. pmc Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 194:463-73. 2007
  10. pmc Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 195:235-43. 2007

Detail Information

Publications43

  1. ncbi request reprint Differential effects of response-contingent and response-independent nicotine in rats
    E C Donny
    Department of Psychology, University of Pittsburgh, 412 Langley Hall, Pittsburgh, PA 15260, USA
    Eur J Pharmacol 402:231-40. 2000
    ..These differences indicate that nicotine's acute effects are powerfully modified by the presence of a contingency relationship between drug administration and the animal's behavior and that this relationship develops very rapidly...
  2. ncbi request reprint High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 161:202-12. 2002
    ..The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin...
  3. ncbi request reprint Choosing to take cocaine in the human laboratory: effects of cocaine dose, inter-choice interval, and magnitude of alternative reinforcement
    Eric C Donny
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 69:289-301. 2003
    ..Inter-choice interval did not affect cocaine choices. These results illustrate the persistence of cocaine self-administration once cocaine-taking has been initiated...
  4. ncbi request reprint Assessing the initiation of cocaine self-administration in humans during abstinence: effects of dose, alternative reinforcement, and priming
    Eric C Donny
    Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 172:316-23. 2004
    ..One potential trigger of cocaine-taking is exposure to cocaine (i.e. priming)...
  5. ncbi request reprint Using growth models to relate acquisition of nicotine self-administration to break point and nicotinic receptor binding
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 75:23-35. 2004
    ..The relationships revealed demonstrate the usefulness of growth models in the quantitative analysis of individual differences in drug self-administration behavior...
  6. pmc The role of nicotine in smoking: a dual-reinforcement model
    Anthony R Caggiula
    Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nebr Symp Motiv 55:91-109. 2009
    ....
  7. ncbi request reprint Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 189:27-36. 2006
    ....
  8. pmc Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement schedule
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 190:353-62. 2007
    ....
  9. pmc Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 194:463-73. 2007
    ..Recent studies have demonstrated that nicotine can enhance operant responding for other nonpharmacological reinforcing stimuli. However, the nature of the reinforcement-enhancing effect of nicotine remains largely unknown...
  10. pmc Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 195:235-43. 2007
    ..We have proposed that the reinforcement derived from these conditional stimuli can be inflated by a nonassociative "reinforcement-enhancing" effect of nicotine...
  11. ncbi request reprint Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:391-400. 2006
    ..It serves as a primary reinforcer by increasing the probability of behaviors that result in nicotine delivery. However, nicotine also potently enhances behaviors that result in the delivery of nonpharmacological reinforcers...
  12. pmc The reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers and increase with repeated drug injections
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 89:52-9. 2007
    ....
  13. pmc Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 33:2139-47. 2008
    ..These findings are consistent with other studies suggesting that mGlu5 receptors mediate nicotine seeking, but do not alter the reinforcement enhancing effects of nicotine...
  14. pmc Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training dose
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 196:365-75. 2008
    ..In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed...
  15. pmc Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats
    Matthew I Palmatier
    Department of Psychology, Kansas State University, Manhattan, KS 66502, USA
    Psychopharmacology (Berl) 207:381-90. 2009
    ..One of the most successful pharmacotherapies for smoking cessation, bupropion, also increases responding for nondrug reinforcers such as food and brain stimulation rewards...
  16. pmc The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotine
    Matthew I Palmatier
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 32:1098-108. 2007
    ..The two reinforcement-related effects of nicotine are mediated by nAChRs but can be dissociated by acute and chronic profiles...
  17. pmc Adolescent exposure to nicotine results in reinforcement enhancement but does not affect adult responding in rats
    Matthew T Weaver
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 125:307-12. 2012
    ....
  18. pmc Precipitated withdrawal from nicotine reduces reinforcing effects of a visual stimulus for rats
    Matthew T Weaver
    Department of Psychology, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 14:824-32. 2012
    ..However, the effects of continuous nicotine exposure on responding for a non-nicotine reinforcer are unknown, as are the effects of abruptly withdrawing continuous nicotine on behavior maintained by the same reinforcer...
  19. ncbi request reprint Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement
    Eric C Donny
    Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychopharmacology (Berl) 169:68-76. 2003
    ..However, stimulant drugs also potentiate the rewarding effects of other reinforcers when administered noncontingently...
  20. doi request reprint The relationship between cigarette use, nicotine dependence, and craving in laboratory volunteers
    Eric C Donny
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 10:934-42. 2008
    ..Further research into the sources of this variance is critical to understanding the process of and risk for nicotine dependence...
  21. ncbi request reprint Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in rats
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 180:258-66. 2005
    ....
  22. ncbi request reprint Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement
    Nadia Chaudhri
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 184:353-66. 2006
    ..Although considerable progress has been made, we do not yet fully understand the behavioral and neurobiological basis of nicotine reinforcement, and without this knowledge, treatment strategies aimed at reducing smoking remain deficient...
  23. pmc Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotine
    Melissa E Levin
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 14:299-305. 2012
    ..We assessed the effects of VAR alone and in combination with NIC (0.4 mg/kg) while rats pressed the lever for a moderately reinforcing visual stimulus (VS)...
  24. ncbi request reprint Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Addiction 100:1496-509. 2005
    ..This greater efficacy may result from greater cross-tolerance to the reinforcing effects of heroin...
  25. pmc Self-administered and yoked nicotine produce robust increases in blood pressure and changes in heart rate with modest effects of behavioral contingency in rats
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 99:459-67. 2011
    ..Effects of behavioral contingency were observed, but differences were limited. Other non-pharmacological factors such as baseline shifts potentially related to nicotine-associated cues deserve further attention...
  26. pmc Prolonged exposure to denicotinized cigarettes with or without transdermal nicotine
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15217, USA
    Drug Alcohol Depend 104:23-33. 2009
    ....
  27. pmc Impact of tobacco regulation on animal research: new perspectives and opportunities
    Eric C Donny
    Department of Psychology, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Nicotine Tob Res 14:1319-38. 2012
    ..However, this approach is laden with potentially complex issues. Many of these complications can be studied using animal models, but they require a particular perspective...
  28. ncbi request reprint Importance of nonpharmacological factors in nicotine self-administration
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:683-7. 2002
    ....
  29. doi request reprint Delay discounting and smoking: association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per day
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 10:1571-5. 2008
    ..These results suggest that DD among smokers is not simply the result of nicotine exposure, but may be an important marker for dependence, especially urgency to smoke in the morning...
  30. ncbi request reprint Comparing the physiological and subjective effects of self-administered vs yoked cocaine in humans
    Eric C Donny
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 186:544-52. 2006
    ..Studies with laboratory animals demonstrating different effects of self- vs experimenter-administered drug suggest that the ability to control or predict drug delivery may be an important determinant of drug action...
  31. ncbi request reprint Smoking in the absence of nicotine: behavioral, subjective and physiological effects over 11 days
    Eric C Donny
    Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Addiction 102:324-34. 2007
    ..The purpose of this experiment was to characterize the effects of smoking stimuli delivered in the absence of nicotine over an extended (11-day) exposure...
  32. doi request reprint The relationship between cigarette use, nicotine dependence, and craving in laboratory volunteers
    Eric C Donny
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 10:447-55. 2008
    ..Further research into the sources of this variance is critical to understanding the process of and risk for nicotine dependence...
  33. pmc The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weight
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Physiol Behav 104:143-8. 2011
    ..Better understanding of the mechanisms underlying the reinforcement-enhancing effects of nicotine broadly, and the effects on food reinforcement per se, may aid in the development of new treatments with better long term outcomes...
  34. pmc Prevalence of and associations with waterpipe tobacco smoking among U.S. university students
    Brian A Primack
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Behav Med 36:81-6. 2008
    ..Although waterpipe tobacco smoking seems to be increasing on U.S. university campuses, these data have come from convenience samples...
  35. doi request reprint Trajectories of smoking among freshmen college students with prior smoking history and risk for future smoking: data from the University Project Tobacco Etiology Research Network (UpTERN) study
    Craig R Colder
    Department of Psychology, State University of New York, University at Buffalo, Buffalo, NY, USA
    Addiction 103:1534-43. 2008
    ..Little is known about smoking during the transition to college. The current study examined trajectories of smoking among college freshmen, how trajectories predicted later smoking and the social context of smoking...
  36. pmc Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 123:S59-71. 2012
    ..Here, we present a model for merging these technologies to trace the links between genes, brain, and addictive behavior...
  37. ncbi request reprint Experimental evidence for a causal relationship between smoking lapse and relapse
    Laura M Juliano
    Department of Psychology, American University, Washington, DC 20016, USA
    J Abnorm Psychol 115:166-73. 2006
    ..Smoking outcomes did not differ between nicotine-containing and denicotinized cigarettes. The data suggest that stimulus factors may play an important role in lapse to relapse processes...
  38. pmc The absence of DSM-IV nicotine dependence in moderate-to-heavy daily smokers
    Eric C Donny
    Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
    Drug Alcohol Depend 89:93-6. 2007
    ..Current theoretical models of nicotine dependence assume a close relationship between use and dependence; however, previous data suggest that many daily smokers fail to develop nicotine dependence...
  39. ncbi request reprint Environmental stimuli promote the acquisition of nicotine self-administration in rats
    Anthony R Caggiula
    Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 163:230-7. 2002
    ....
  40. pmc Dependence and withdrawal-induced craving predict abstinence in an incentive-based model of smoking relapse
    Maggie M Sweitzer
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nicotine Tob Res 15:36-43. 2013
    ..Development of laboratory models of relapse can provide a framework for identifying underlying mechanisms that may contribute to vulnerability. Here, we explored predictors of abstinence in a novel incentive-based model of relapse...
  41. ncbi request reprint Analyzing the acquisition of drug self-administration using growth curve models
    Stephanie T Lanza
    The Methodology Center, The Pennsylvania State University, 159 South Henderson, University Park, PA 16802, USA
    Drug Alcohol Depend 75:11-21. 2004
    ..Growth curve modeling captures the process of acquisition of drug self-administration and facilitates a greater understanding of the individual differences in change in drug-taking behavior over time...
  42. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
  43. pmc Different lengths of times for progressions in adolescent substance involvement
    Ty A Ridenour
    The Pennsylvania State University, Prevention Research Center, State College 16801, United States
    Addict Behav 31:962-83. 2006
    ..Females had shorter transition times, though gender differences were small. Some evidence was found for a familial influence on transition times above what was accounted for by differences between substances...