Xinzhong Dong


Affiliation: Johns Hopkins University
Country: USA


  1. Green D, Dong X. The cell biology of acute itch. J Cell Biol. 2016;213:155-61 pubmed publisher
    ..Here, we discuss recent advances in our understanding of itch and the molecular players that mediate this sensory modality. ..
  2. Li Z, Tseng P, Tiwari V, Xu Q, He S, Wang Y, et al. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017;114:E1996-E2005 pubmed publisher
    ..Our findings suggest that humanized MrgprX1 mice provide a promising preclinical model and that activating MRGPRX1 is an effective way to treat persistent pain. ..
  3. Xu Q, Dong X. Calcium imaging approaches in investigation of pain mechanism in the spinal cord. Exp Neurol. 2019;317:129-132 pubmed publisher
    ..We will also discuss possible directions for the study of spinal pain circuits in the future. ..
  4. Green D, Limjunyawong N, Gour N, Pundir P, Dong X. A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain. Neuron. 2019;101:412-420.e3 pubmed publisher
    ..These results identify Mrgprb2/X2 as an important neuroimmune modulator and a potential target for treating inflammatory pain. ..
  5. Dong X, Dong X. Peripheral and Central Mechanisms of Itch. Neuron. 2018;98:482-494 pubmed publisher
    ..In this review, we summarize the current understanding of the molecular and neural mechanisms of itch by starting in the periphery, where itch is initiated, and discussing the circuits involved in itch processing in the CNS. ..
  6. Sun S, Dong X. Trp channels and itch. Semin Immunopathol. 2016;38:293-307 pubmed publisher
    ..The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments. ..
  7. Han L, Limjunyawong N, Ru F, Li Z, Hall O, Steele H, et al. Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness. Nat Neurosci. 2018;21:324-328 pubmed publisher
    ..These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma. ..
  8. Wang N, Che D, Zhang T, Liu R, Cao J, Wang J, et al. Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo. Biochem Pharmacol. 2018;148:147-154 pubmed publisher
    ..As a conclusion, SSA could inhibits IgE-independent allergy, but not IgE-dependent allergy, and this effect involves the Mrgprx2 pathway. This study provided a new sight on pseudo-allergy and its therapy. ..
  9. Sun S, Xu Q, Guo C, Guan Y, Liu Q, Dong X. Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Neuron. 2017;93:840-853.e5 pubmed publisher
    ..Our new model serves as an example of non-monotonic coding in the spinal cord and better explains observations in human psychophysical studies. ..

More Information


  1. Han S, Lv Y, Kong L, Che D, Liu R, Fu J, et al. Use of the relative release index for histamine in LAD2 cells to evaluate the potential anaphylactoid effects of drugs. Sci Rep. 2017;7:13714 pubmed publisher
  2. Liu R, Che D, Zhao T, Pundir P, Cao J, Lv Y, et al. MRGPRX2 is essential for sinomenine hydrochloride induced anaphylactoid reactions. Biochem Pharmacol. 2017;146:214-223 pubmed publisher
    ..The results showed a kind of mechanism that SH-induced anaphylactoid reactions were mediated by MRGPRX2 via activating PLC molecular signaling pathways to provoke mast cells Ca2+ mobilization and degranulation. ..
  3. Anderson M, Zheng Q, Dong X. Investigation of Pain Mechanisms by Calcium Imaging Approaches. Neurosci Bull. 2018;34:194-199 pubmed publisher
    ..Here, we review the current findings in pain research using GCaMP imaging as well as discussing potential methodological considerations. ..
  4. He S, Han L, Li Z, Xu Q, Tiwari V, Yang F, et al. Temporal changes in MrgC expression after spinal nerve injury. Neuroscience. 2014;261:43-51 pubmed publisher
    ..These findings extend our knowledge about the distribution of MrgC in rodent DRG neurons and the regulation of its expression by nerve injury. ..
  5. Kim Y, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, et al. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron. 2016;91:1085-1096 pubmed publisher
    ..Therefore, neuronal coupling represents a new form of neuronal plasticity in the DRG and contributes to pain hypersensitivity by "hijacking" neighboring neurons through gap junctions. ..
  6. Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, et al. Pirt contributes to uterine contraction-induced pain in mice. Mol Pain. 2015;11:57 pubmed publisher
    ..Taken together, we speculate that Pirt plays an important role in mice uterine contraction-induced pain. ..
  7. Li Z, He S, Tseng P, Xu Q, Tiwari V, Yang F, et al. The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms. Neuroscience. 2015;300:393-403 pubmed publisher
    ..These findings suggest that activation of MrgC11 may inhibit HVA ICa in mouse DRG neurons through a voltage-independent mechanism that involves activation of the PLC, but not Gαi or Gαs, pathway. ..
  8. Weng H, Patel K, Jeske N, Bierbower S, Zou W, Tiwari V, et al. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015;85:833-46 pubmed publisher
    ..Our study unveils a context-dependent modulation of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy. ..