Research Topics
| A S DobsSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trialAdrian S Dobs
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
Lancet Oncol 14:335-45. 2013..This randomised, double-blind, placebo-controlled phase 2 trial assessed the efficacy and safety of enobosarm, a selective androgen receptor modulator, in patients with cancer...
Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal womenAdrian S Dobs
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 87:1509-16. 2002..There were no noteworthy side effects. In conclusion, E/A replacement therapy can improve body composition, lower-body muscle strength, quality of life, and sexual functioning in postmenopausal women...- Does testosterone therapy increase the risk of prostate cancer?Adrian S Dobs
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Endocr Pract 14:904-11. 2008..To review factors affecting use of testosterone therapy for hypogonadism including the persistent controversial link between testosterone therapy and prostate cancer... - Drug-induced gynecomastiaAri Eckman
Johns Hopkins University School of Medicine, 1830 E Monument Street, Baltimore, MD 21287, USA
Expert Opin Drug Saf 7:691-702. 2008..When a man is euogonadal, a trial of the anti-estrogen, tamoxifen or an aromatase inhibitor may be an option... - The role of accurate testosterone testing in the treatment and management of male hypogonadismAdrian S Dobs
Johns Hopkins University School of Medicine, JHU Division of Endocrinology and Metabolism, 1830 E Monument St, Suite 328, Baltimore, MD 21287, United States
Steroids 73:1305-10. 2008..Both clinicians and researchers need better assays to better understand basic mechanisms, diagnose, treat, and monitor men with testosterone deficiency... - Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal menA S Dobs
Johns Hopkins Medical Center, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 84:3469-78. 1999..m. in minimizing excessive stimulation of erythropoiesis, preventing/ameliorating gynecomastia, and not over-suppressing gonadotropins... - Short-term pharmacokinetic comparison of a novel testosterone buccal system and a testosterone gel in testosterone deficient menA S Dobs
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Curr Med Res Opin 20:729-38. 2004..The primary objective of the study was to compare the percentage of men with mean serum total T (C(ave(0-24))) within normal range during the 24-h pharmacokinetic (PK) sampling period on Days 14 and 15... - Metabolic abnormalities in HIV disease and injection drug useAdrian Dobs
The John Hopkins University School of Medicine, Baltimore, Maryland, USA
J Acquir Immune Defic Syndr 31:S70-7. 2002..The issues covered are current estimations of prevalence, risk factors, underlying pathophysiology, diagnosis, and interventions (prevention and treatment) for metabolic complications of HIV and drug abuse... - Interrelationships among lipoprotein levels, sex hormones, anthropometric parameters, and age in hypogonadal men treated for 1 year with a permeation-enhanced testosterone transdermal systemA S Dobs
The Johns Hopkins Medical Center, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 86:1026-33. 2001..In hypogonadal men the effects of transdermal testosterone replacement on serum lipoproteins appear consistent with the physiological effects of testosterone in eugonadal men... - Effect of methyl testosterone administration on plasma viscosity in postmenopausal womenShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Endocrinol (Oxf) 57:209-14. 2002..The combination regimen did not result in major side-effects. Based on these results, we feel confident in recommending low-dose androgens to postmenopausal women with a history of sexual dysfunction and decreased libido... - Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal womenS Basaria
Department of Internal Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Endocrinol Invest 32:150-5. 2009..Isoflavones, a class of plant estrogens, have structural similarities to estradiol. Hence, isoflavones may exert beneficial estrogenic health effects in postmenopausal women with fewer adverse effects... - Hypogonadism and androgen replacement therapy in elderly menS Basaria
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med 110:563-72. 2001..This review summarizes the trials of testosterone replacement therapy in elderly men and outlines a diagnostic approach to these patients... - Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal womenAmy B Wisniewski
Department of Pediatrics, Division of Pediatric Endocrinology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Horm Res 58:150-5. 2002..To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women... 
Low free testosterone in HIV-infected men is not associated with subclinical cardiovascular diseaseA K Monroe
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
HIV Med 13:358-66. 2012..This study examined the relationships among free testosterone (FT), subclinical CVD, and HIV disease...- Clinical review: Controversies regarding transdermal androgen therapy in postmenopausal womenShehzad Basaria
Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 91:4743-52. 2006..Until the patch gets approval, a short trial of oral methyltestosterone in deserving estrogenized women may be justified... - Current and future testosterone delivery systems for treatment of the hypogonadal maleEmily Pfeil
Johns Hopkins University, School of Medicine, Department of Medicine, Division of Endocrinology and Metabolism, 1830 E Monument Street, Suite 328, Baltimore, MD 21205, USA
Expert Opin Drug Deliv 5:471-81. 2008.... - Long-term effects of androgen deprivation therapy in prostate cancer patientsShehzad Basaria
Division of Endocrinolgy and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Endocrinol (Oxf) 56:779-86. 2002..Meanwhile, this information will assist both physicians and patients with prostate cancer to make informed decisions regarding androgen deprivation therapy... - The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal womenRita Rastogi Kalyani
Departments of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 94:4127-35. 2009..Previous studies have not explored possible factors explaining these relationships... - New modalities of transdermal testosterone replacementShehzad Basaria
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Treat Endocrinol 2:1-9. 2003..There are no harmful effects on the prostate and lipids. Acne, polycythemia, and gynecomastia are less common with this form of therapy than with the intramuscular esters... - The effects of illicit drug use and HIV infection on sex hormone levels in womenJoseph Cofrancesco
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0941, USA
Gynecol Endocrinol 22:244-51. 2006..001). Alcohol and crack cocaine use was not associated with sex hormone levels. Age, race, body mass index and degree of HIV immunosuppression were also associated with differences in sex hormone levels... - Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities studyShiyama Mudali
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 90:1202-9. 2005..Our data suggest that endogenous sex hormones may play a role in regulating lipid metabolism in postmenopausal women... - Handedness, functional cerebral hemispheric lateralization, and cognition in male-to-female transsexuals receiving cross-sex hormone treatmentAmy B Wisniewski
Department of Pediatrics, Division of Pediatric Endocrinology, The Johns Hopkins University, Baltimore, Maryland, USA
Arch Sex Behav 34:167-72. 2005..Previous observations of female-typical patterns in cerebral lateralization and cognitive performance in male-to-female transsexuals were not found in the current study... - Hip bone geometry in HIV/HCV-co-infected men and healthy controlsV Walker Harris
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Osteoporos Int 23:1779-87. 2012..We compared hip strength between HIV/HCV-co-infected men and healthy men and found that HIV/HCV-co-infected men had decreased hip strength due to lower lean body mass... - Endocrine disorders in men infected with human immunodeficiency virusA S Dobs
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Am J Med 84:611-6. 1988..Indices of thyroid function were normal with the exception of one ARC man with a low free thyroxine index. In conclusion, hypogonadism is common in men with HIV infection and may be the first or most sensitive endocrine abnormality... - Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapyM Braga-Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
Int J Impot Res 18:494-8. 2006..Long-term prospective studies are needed to determine the time of onset of changes in these lipoproteins while on ADT and the influence of these changes on cardiovascular mortality... - Body shape and composition in HIV-infected women: an urban cohortS L Karmon
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
HIV Med 6:245-52. 2005..03). CONCLUSIONS: Self-reported changes in body shape were common. Obesity and complications of illicit drug use were more prevalent than lipodystrophy in this inner-city population of HIV-positive women... - Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseasesS Basaria
The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 86:5108-17. 2001.... - Endogenous sex hormones and glucose tolerance status in postmenopausal womenSherita Hill Golden
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Endocrinol Metab 92:1289-95. 2007..Most studies have not examined these associations in a large group of postmenopausal women... - Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapyMilena Braga-Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
J Clin Oncol 24:3979-83. 2006..Because male hypogonadism is a risk factor for metabolic syndrome and men with PCa have high cardiovascular mortality, we evaluated the prevalence of metabolic syndrome in men undergoing long-term ADT... - Effects of testosterone on body composition of the aging maleShiyama Mudali
Johns Hopkins University School of Medicine, Baltimore, MD 21208, USA
Mech Ageing Dev 125:297-304. 2004..However, hypogonadism must be diagnosed carefully, and therapy should be monitored regularly in order to avoid the adverse effects associated with testosterone supplementation... - The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetesB L Laube
Division of Radiation Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
Chest 114:1734-9. 1998..To determine the efficacy of the lung as an alternative route of delivery for insulin in controlling glucose below diabetic levels (11.2 mmol/L) 2 h after the ingestion of a meal in patients with type 2 diabetes mellitus... - Longitudinal anthropometric changes in HIV-infected and HIV-uninfected menTodd Brown
Johns Hopkins University, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 43:356-62. 2006.... - Safety and adverse effects of androgens: how to counsel patientsShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 E Monument St, Suite 333, Baltimore, MD 21287, USA
Mayo Clin Proc 79:S25-32. 2004..We believe that long-term studies are necessary to observe the potential effect of androgen replacement on cardiovascular mortality, breast and endometrial tissues, and mood and anger before this therapy can be used routinely in women... - Androgen deficiency, diabetes, and the metabolic syndrome in menRita R Kalyani
Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Curr Opin Endocrinol Diabetes Obes 14:226-34. 2007..This article focuses on the mechanisms underlying the interdependent relationship between these conditions... - Is hypogonadism a risk factor for sexual dysfunction?Akinlolu Ojumu
Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Androl 24:S46-51. 2003 - Opiate drug use: a potential contributor to the endocrine and metabolic complications in human immunodeficiency virus diseaseOdelia B Cooper
Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
Clin Infect Dis 37:S132-6. 2003..Although much of the evidence should be viewed as preliminary, these potential abnormalities should be kept in mind when treating opiate-dependent patients infected with HIV... - Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapyTodd T Brown
Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
AIDS 21:1731-8. 2007..The relative contributions of the different classes of antiretroviral therapy (ART), HIV infection per se, and aging to body shape changes in HIV-infected patients have not been clearly defined in longitudinal studies... - Body composition, gender, and illicit drug use in an urban cohortJoseph Cofrancesco
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Am J Drug Alcohol Abuse 33:467-74. 2007..3 vs.19.9 kg, p = .01) and lower body mass index (21.9 vs. 25.1, p = .01) versus less frequent or nonusers. These data suggest a sex difference in body composition associated with drug use... - Depressive symptoms, quality of life, and neuropsychological performance in HIV/AIDS: the impact of gender and injection drug useAmy B Wisniewski
Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
J Neurovirol 11:138-43. 2005..Thus, further study and development of treatment protocols targeted at including women and IDU are needed... - Male hypogonadism in systemic diseaseRita R Kalyani
Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, 1830 E Monument Street, Baltimore, MD 21287, USA
Endocrinol Metab Clin North Am 36:333-48. 2007..More information is needed regarding the risk benefits of testosterone treatment on health outcomes in men who have systemic illness... - Fish oil supplementation in the treatment of cachexia in pancreatic cancer patientsTodd T Brown
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Center for Complementary and Alternative Medicine, Baltimore, MD 21287, USA
Int J Gastrointest Cancer 34:143-50. 2003..Concerns about standardization and quality control should also be considered. With the current available evidence, a recommendation for the use of omega 3 polyunsaturated fatty acids in pancreatic cancer cachexia is premature... - Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapyShehzad Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, and National Institut on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Cancer 106:581-8. 2006.... - New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal menChristina Wang
Department of Medicine, Harbor University of California, Los Angeles Medical Center and Research and Education Institute, Torrance, California 90509 2910, USA
J Clin Endocrinol Metab 89:3821-9. 2004..The T buccal system is a novel T formulation that offers a safe, effective, and convenient alternative to existing formulations for physiological T replacement therapy in hypogonadal men... - Androgen levels in older men who have or who are at risk of acquiring HIV infectionRobert S Klein
Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
Clin Infect Dis 41:1794-803. 2005.... - Hypothalamic-pituitary-gonadal function in men and women using heroin and cocaine, stratified by HIV statusAmy B Wisniewski
Department of Biology, Drake University, Des Moines, Iowa 50311 4505, USA
Gend Med 4:35-44. 2007..Most studies of hypothalamic-pituitary-gonadal (HPG) function in illicit drug users either focus on men or do not consider the impact of HIV... - Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort studyTodd T Brown
Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
Arch Intern Med 165:1179-84. 2005..The risk of diabetes mellitus (DM) in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) has not been well defined... - Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort StudyTodd T Brown
Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
AIDS 19:1375-83. 2005..To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in a cohort of HIV-infected persons with comparison to HIV-seronegative controls... - Changes in the incidence and predictors of wasting syndrome related to human immunodeficiency virus infection, 1987-1999Ellen Smit
Department of Social and Preventive Medicine, School of Medicine and Biological Sciences, University at Buffalo, Buffalo, NY 14214 3000, USA
Am J Epidemiol 156:211-8. 2002..05) and potent ART (p = 0.097). Predictors of wasting have changed with potent ART. Further research is needed to determine whether lipodystrophy may be misdiagnosed as wasting syndrome... - Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemiaJonathan Isaacsohn
Metabolic and Atherosclerosis Research Center, Cincinnati, Ohio, USA
Clin Cardiol 26:18-24. 2003..05 - < 0.001). CONCLUSION: The results of this study demonstrate the beneficial effects of simvastatin in patients with hypertriglyceridemia... - Cortisol levels and depression in men and women using heroin and cocaineAmy B Wisniewski
Department of Biology, Drake University, 328 Olin Hall, 1344 27th Street, Des Moines, IA 50311 4505, USA
Psychoneuroendocrinology 31:250-5. 2006.... - Nebido: a long-acting injectable testosterone for the treatment of male hypogonadismLindsey Harle
University of Texas, Medical Branch at Galveston, TX, USA
Expert Opin Pharmacother 6:1751-9. 2005..In this paper, the structure, pharmacokinetics, efficacy and side-effect profile of testosterone undecanoate will be reviewed and also compared with other existing testosterone esters... - Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemiaTodd T Brown
Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
J Clin Endocrinol Metab 89:1200-6. 2004..Bone resorption is independently associated with female gender and dyslipidemia. HIV-infected patients with metabolic abnormalities may represent a population that would benefit from bone density screening... - Omega-3 fatty acids for the treatment of cancer cachexia: issues in designing clinical trials of dietary supplementsLindsey Harle
University of Texas Medical Branch, Galveston, TX, USA
J Altern Complement Med 11:1039-46. 2005..The methodology of the clinical trial is reviewed here and the unique problems faced by investigators in designing studies of dietary supplements are discussed... - Testosterone making an entry into the cardiometabolic worldShehzad Basaria
Circulation 116:2658-61. 2007
Research Grants
- Cognitive Consequences of Endocrine Dysfunction in IDUAdrian Dobs; Fiscal Year: 2007..We will obtain a better understanding of the relationship between drug use and cognition, and also expand our understanding of the effects of sex steroids on cognitive performance, in an under-studied population. ..
- GONADAL HORMONES ON BODY COMPOSITION, HIV AND DRUG USEAdrian Dobs; Fiscal Year: 2002..These studies can provide information to further our understanding of gender differences in disease progression and treatment. ..