A T Dinkova-Kostova

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes
    A T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mini Rev Med Chem 2:595-610. 2002
  2. ncbi request reprint Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
  3. ncbi request reprint The role of Keap1 in cellular protective responses
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 18:1779-91. 2005
  4. ncbi request reprint Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 245:341-9. 2007
  5. ncbi request reprint Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants
    A T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology, and Moleclar Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Chem 3:261-8. 2007
  6. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
  7. pmc Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane
    X Gao
    Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:15221-6. 2001

Detail Information

Publications7

  1. ncbi request reprint Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes
    A T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mini Rev Med Chem 2:595-610. 2002
    ..This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis...
  2. ncbi request reprint Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  3. ncbi request reprint The role of Keap1 in cellular protective responses
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 18:1779-91. 2005
  4. ncbi request reprint Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 245:341-9. 2007
    ..The concentration-dependent differential effects on these two pathways should be carefully considered in mechanistic explanations and strategic designs...
  5. ncbi request reprint Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants
    A T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology, and Moleclar Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Med Chem 3:261-8. 2007
    ..e., acting indirectly, but with much more diverse and long-lasting effects...
  6. pmc Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
    A T Dinkova-Kostova
    Department of Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:3404-9. 2001
    ..Surprisingly, these ortho-hydroxyl groups display a propensity for extensive intermolecular hydrogen bond formation, which may raise the reactivity and facilitate addition of mercaptans, thereby raising inducer potencies...
  7. pmc Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane
    X Gao
    Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:15221-6. 2001
    ..It is therefore highly likely that the multifaceted and prolonged antioxidant protection provided by sulforaphane is a general phenomenon that is mediated through induction of the Phase 2 enzyme response...