RHOEL DAVID DINGLASAN

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, HSF2 414, Baltimore, MD 21201, USA
    Vaccine 23:2717-24. 2005
  2. ncbi Flipping the paradigm on malaria transmission-blocking vaccines
    Rhoel R Dinglasan
    Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Parasitol 24:364-70. 2008
  3. ncbi Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:13461-6. 2007
  4. ncbi Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine
    D K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland, USA
    Infect Immun 80:1606-14. 2012
  5. ncbi An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes
    Anil K Ghosh
    Johns Hopkins University School of Public Health, Dept of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA
    Malar J 9:194. 2010
  6. ncbi Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:15882-7. 2007
  7. ncbi Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W4008, Baltimore, MD 21205, USA
    Infect Immun 73:7797-807. 2005
  8. ncbi Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Infect Immun 71:6995-7001. 2003
  9. ncbi Plasmodium yoelii: axenic development of the parasite mosquito stages
    Johanna M Porter-Kelley
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Exp Parasitol 112:99-108. 2006
  10. ncbi Sugar epitopes as potential universal disease transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Insect Biochem Mol Biol 35:1-10. 2005

Research Grants

  1. Plasmodium carbohydrate receptors in Anopheles gambiae
    RHOEL DAVID DINGLASAN; Fiscal Year: 2007
  2. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, HSF2 414, Baltimore, MD 21201, USA
    Vaccine 23:2717-24. 2005
    ..Therefore, it is imperative that peptides not only need to be functional mimics but also complete mimotopes to effectively direct the vertebrate immune response towards the nominal, protective carbohydrate epitope on mosquito microvilli...
  2. ncbi Flipping the paradigm on malaria transmission-blocking vaccines
    Rhoel R Dinglasan
    Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Parasitol 24:364-70. 2008
    ..Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development...
  3. ncbi Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:13461-6. 2007
    ..These results advance our understanding of malaria parasite-mosquito host interactions and guide in the design of transmission-blocking vaccines...
  4. ncbi Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine
    D K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland, USA
    Infect Immun 80:1606-14. 2012
    ....
  5. ncbi An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes
    Anil K Ghosh
    Johns Hopkins University School of Public Health, Dept of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA
    Malar J 9:194. 2010
    ..This article reports on investigations of five different ookinete media, in an effort to improve the in vitro transformation efficiency of P. falciparum gametocytes into mature ookinetes and their infectivity of the mosquito midgut...
  6. ncbi Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:15882-7. 2007
    ..We provide evidence for the in vivo role of chondroitin sulfate proteoglycans in Plasmodium falciparum invasion of the midgut and insight into the molecular mechanisms mediating parasite-mosquito interactions...
  7. ncbi Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, W4008, Baltimore, MD 21205, USA
    Infect Immun 73:7797-807. 2005
  8. ncbi Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Infect Immun 71:6995-7001. 2003
    ..Future investigation of the carbohydrate epitope as well as gene identification should provide valuable insight into the possible mechanisms of ookinete attachment and invasion of mosquito midgut epithelial cells...
  9. ncbi Plasmodium yoelii: axenic development of the parasite mosquito stages
    Johanna M Porter-Kelley
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Exp Parasitol 112:99-108. 2006
    ..Our cell free system for development of the mosquito stages of P. yoelii provides a simplified approach to generate sporozoites that may be for biological assays and genetic manipulations...
  10. ncbi Sugar epitopes as potential universal disease transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Insect Biochem Mol Biol 35:1-10. 2005
    ..As such, these glycotopes may represent potential transmission blocking vaccine targets for a wide range of vector-borne pathogens...

Research Grants4

  1. Plasmodium carbohydrate receptors in Anopheles gambiae
    RHOEL DAVID DINGLASAN; Fiscal Year: 2007
    ..This line of experimentation will open up new avenues of research through the basic, glycobiological analysis of the mosquito midgut biology. ..
  2. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2010
    ....