RHOEL DAVID DINGLASAN

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, HSF2 414, Baltimore, MD 21201, USA
    Vaccine 23:2717-24. 2005
  2. doi request reprint Flipping the paradigm on malaria transmission-blocking vaccines
    Rhoel R Dinglasan
    Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Parasitol 24:364-70. 2008
  3. pmc Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:13461-6. 2007
  4. pmc A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut
    Derrick K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 9:e1003757. 2013
  5. pmc A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites
    Ceereena Ubaida Mohien
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 12:120-31. 2013
  6. pmc Ookinete-interacting proteins on the microvillar surface are partitioned into detergent resistant membranes of Anopheles gambiae midguts
    Lindsay A Parish
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Proteome Res 10:5150-62. 2011
  7. pmc A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands
    Jennifer S Armistead
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Biochem J 438:475-83. 2011
  8. pmc Transcriptome of the adult female malaria mosquito vector Anopheles albimanus
    Jesus Martinez-Barnetche
    Centro De Investigacion sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    BMC Genomics 13:207. 2012
  9. pmc Single-dose microparticle delivery of a malaria transmission-blocking vaccine elicits a long-lasting functional antibody response
    R R Dinglasan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Mol Med 13:479-87. 2013
  10. pmc Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine
    D K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland, USA
    Infect Immun 80:1606-14. 2012

Collaborators

  • Marcelo Jacobs-Lorena
  • Abdu Azad
  • John B Sacci
  • Akhilesh Pandey
  • X Jiang
  • Stefan M Kanzok
  • Akio Saito
  • Johanna M Porter-Kelley
  • Mohammed Shahabuddin
  • Ceereena Ubaida Mohien
  • Derrick K Mathias
  • Jesus Martinez-Barnetche
  • Jennifer S Armistead
  • Antonis Rokas
  • John G Gibbons
  • D K Mathias
  • David R Colquhoun
  • David R Graham
  • Lindsay A Parish
  • Anil K Ghosh
  • Takafumi Tsuboi
  • Elisabetta Ranucci
  • Natalie A Borg
  • Gerhard G Thallinger
  • Gregory O Staples
  • Luisella Verotta
  • Dingyin Tao
  • Rebecca Pastrana-Mena
  • Jürgen Hartler
  • Paolo Ferruti
  • Nathan J Edwards
  • Joseph Zaia
  • Maria C Rodriguez
  • Eizo Takashima
  • Corrie Ortega
  • MARIO HENRY RODRIGUEZ
  • J L Plieskatt
  • Mario H Rodríguez López
  • M J Aryee
  • J M Bethony
  • Robert M MacCallum
  • Juan Téllez-Sosa
  • Marbella Ovilla-Muñoz
  • A McMillan
  • W Rezende
  • Salvador Hernandez-Martinez
  • Carlos A Machado
  • Seth N Redmond
  • Febe E Cazares-Raga
  • B Keegan
  • M E Bottazzi
  • P J Hotez
  • Rosa E Gómez-Barreto
  • B Zhan
  • P Gillespie
  • J S Armistead
  • D G Scorpio
  • A R Jariwala
  • E Angov
  • K B Abdul-Majid
  • Lilia Gonzalez-Ceron
  • David E García López
  • Alexey E Lyashkov
  • Iain B H Wilson
  • Toin H van Kuppevelt
  • Hiromi Ikadai

Detail Information

Publications17

  1. ncbi request reprint Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, HSF2 414, Baltimore, MD 21201, USA
    Vaccine 23:2717-24. 2005
    ..Therefore, it is imperative that peptides not only need to be functional mimics but also complete mimotopes to effectively direct the vertebrate immune response towards the nominal, protective carbohydrate epitope on mosquito microvilli...
  2. doi request reprint Flipping the paradigm on malaria transmission-blocking vaccines
    Rhoel R Dinglasan
    Johns Hopkins Malaria Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Parasitol 24:364-70. 2008
    ..Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development...
  3. pmc Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:13461-6. 2007
    ..These results advance our understanding of malaria parasite-mosquito host interactions and guide in the design of transmission-blocking vaccines...
  4. pmc A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut
    Derrick K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Pathog 9:e1003757. 2013
    ..We envision that such compounds when used as partner drugs with current antimalarial regimens and with RTS,S vaccine delivery could prevent the transmission of drug-resistant and vaccine-breakthrough strains. ..
  5. pmc A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites
    Ceereena Ubaida Mohien
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 12:120-31. 2013
    ..gambiae and An. albimanus...
  6. pmc Ookinete-interacting proteins on the microvillar surface are partitioned into detergent resistant membranes of Anopheles gambiae midguts
    Lindsay A Parish
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Proteome Res 10:5150-62. 2011
    ..Our study vastly expands the number of candidate malarial TBV targets for subsequent analysis by the broader community and provides an inferred role for midgut plasmalemma microdomains in ookinete cell invasion...
  7. pmc A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands
    Jennifer S Armistead
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Biochem J 438:475-83. 2011
    ....
  8. pmc Transcriptome of the adult female malaria mosquito vector Anopheles albimanus
    Jesus Martinez-Barnetche
    Centro De Investigacion sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    BMC Genomics 13:207. 2012
    ..To better understand the biological basis of malaria transmission and to develop novel and effective means of vector control, there is a need to explore the mosquito biology beyond the An. gambiae complex...
  9. pmc Single-dose microparticle delivery of a malaria transmission-blocking vaccine elicits a long-lasting functional antibody response
    R R Dinglasan
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Mol Med 13:479-87. 2013
    ..We conclude by identifying the remaining critical gaps in knowledge and opportunities for moving SSM-TBVs to the field...
  10. pmc Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine
    D K Mathias
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Malaria Research Institute, Baltimore, Maryland, USA
    Infect Immun 80:1606-14. 2012
    ....
  11. pmc An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes
    Anil K Ghosh
    Johns Hopkins University School of Public Health, Dept of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA
    Malar J 9:194. 2010
    ..This article reports on investigations of five different ookinete media, in an effort to improve the in vitro transformation efficiency of P. falciparum gametocytes into mature ookinetes and their infectivity of the mosquito midgut...
  12. pmc Plasmodium falciparum ookinetes require mosquito midgut chondroitin sulfate proteoglycans for cell invasion
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:15882-7. 2007
    ..We provide evidence for the in vivo role of chondroitin sulfate proteoglycans in Plasmodium falciparum invasion of the midgut and insight into the molecular mechanisms mediating parasite-mosquito interactions...
  13. pmc Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens
    Rhoel R Dinglasan
    Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, W4008, Baltimore, MD 21205, USA
    Infect Immun 73:7797-807. 2005
  14. pmc Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Infect Immun 71:6995-7001. 2003
    ..Future investigation of the carbohydrate epitope as well as gene identification should provide valuable insight into the possible mechanisms of ookinete attachment and invasion of mosquito midgut epithelial cells...
  15. ncbi request reprint Plasmodium yoelii: axenic development of the parasite mosquito stages
    Johanna M Porter-Kelley
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Exp Parasitol 112:99-108. 2006
    ..Our cell free system for development of the mosquito stages of P. yoelii provides a simplified approach to generate sporozoites that may be for biological assays and genetic manipulations...
  16. ncbi request reprint Sugar epitopes as potential universal disease transmission blocking targets
    Rhoel R Dinglasan
    Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Insect Biochem Mol Biol 35:1-10. 2005
    ..As such, these glycotopes may represent potential transmission blocking vaccine targets for a wide range of vector-borne pathogens...

Research Grants4

  1. Plasmodium carbohydrate receptors in Anopheles gambiae
    RHOEL DAVID DINGLASAN; Fiscal Year: 2007
    ..This line of experimentation will open up new avenues of research through the basic, glycobiological analysis of the mosquito midgut biology. ..
  2. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID DINGLASAN; Fiscal Year: 2009
    ....
  3. Small molecule protein-glycan inhib. as malaria transmission-blocking therapuetic
    RHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2010
    ....